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Blood, ISSN 0006-4971, 02/2013, Volume 121, Issue 6, pp. 1008 - 1015
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked... 
PULMONARY-HYPERTENSION | PERMEABILITY | 5-HYDROXYTRYPTAMINE | ENDOTHELIAL-CELLS | MAST-CELLS | P-SELECTIN | RECEPTOR | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SELECTIN-DEFICIENT MICE | Blood Platelets - immunology | Endothelium, Vascular - drug effects | Male | Shock, Septic - immunology | Lipopolysaccharides | Serotonin - blood | Inflammation - metabolism | L-Selectin - immunology | Leukocytosis - metabolism | Weibel-Palade Bodies - metabolism | Chemotaxis - immunology | Neutrophils - metabolism | Serotonin - immunology | Serotonin Uptake Inhibitors - immunology | Endothelium, Vascular - immunology | Neutrophil Infiltration - immunology | Fluoxetine - pharmacology | Acute Disease | Neutrophils - drug effects | Leukocytosis - immunology | Chemotaxis - drug effects | Mice, Knockout | Blood Platelets - metabolism | Endothelium, Vascular - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Leukocyte Rolling - drug effects | Weibel-Palade Bodies - immunology | Histamine - immunology | L-Selectin - metabolism | Flow Cytometry | Tryptophan Hydroxylase - deficiency | Blood Platelets - drug effects | Fluoxetine - immunology | Shock, Septic - genetics | Leukocyte Rolling - genetics | Histamine - pharmacology | Shock, Septic - chemically induced | Mice, Inbred C57BL | Kaplan-Meier Estimate | Neutrophils - immunology | Inflammation - immunology | Leukocyte Rolling - immunology | Tryptophan Hydroxylase - genetics | Weibel-Palade Bodies - drug effects | Animals | Serotonin - metabolism | Inflammation - genetics | Leukocytosis - genetics | Phagocytes, Granulocytes, and Myelopoiesis | Platelets and Thrombopoiesis
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4923 - 17
Multiple Sclerosis (MS) require medications controlling severity of the pathology and depression, affecting more than half of the patients. In this study, the... 
RAT SPINAL-CORD | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MULTIDISCIPLINARY SCIENCES | OPEN-LABEL | SUBVENTRICULAR ZONE | MAJOR DEPRESSION | CEREBROSPINAL-FLUID | PRECURSOR CELLS | FLUOXETINE | LOOP-HELIX GENES | T-CELLS | Glial Fibrillary Acidic Protein - genetics | Neurons - pathology | Oligodendroglia - metabolism | Embryo, Mammalian | Astrocytes - pathology | Rats, Inbred Lew | Encephalomyelitis, Autoimmune, Experimental - immunology | Glial Fibrillary Acidic Protein - immunology | Myelin Basic Protein - genetics | Neural Stem Cells - immunology | Ki-67 Antigen - immunology | Neuroprotective Agents - pharmacology | Oligodendroglia - drug effects | Female | Cell Differentiation | Neurons - metabolism | Encephalomyelitis, Autoimmune, Experimental - genetics | Interferon-gamma - genetics | Interleukin-4 - genetics | Neurons - drug effects | Astrocytes - drug effects | Cell Survival - drug effects | Encephalomyelitis, Autoimmune, Experimental - pathology | Signal Transduction | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Gene Expression Regulation | Neural Stem Cells - drug effects | Rats | Receptor, Notch1 - immunology | Fluvoxamine - pharmacology | Neural Stem Cells - pathology | Myelin Basic Protein - immunology | Oligodendroglia - pathology | Interleukin-4 - immunology | Transcription Factor HES-1 - immunology | Animals | Ki-67 Antigen - genetics | Transcription Factor HES-1 - genetics | Interferon-gamma - immunology | Primary Cell Culture | Receptor, Notch1 - genetics | Serotonin Uptake Inhibitors - pharmacology | Immunologic Factors - pharmacology | Astrocytes - metabolism | Cell proliferation | Multiple sclerosis | Encephalomyelitis | Central nervous system | Stem cell transplantation | Mental depression | Interleukin 4 | Allografts | Antidepressants | Demyelination | Rodents | Oligodendrocytes | Serotonin | Myelin | Astrocytes | Glial fibrillary acidic protein | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Serum levels | γ-Interferon | Stem cells | Neural stem cells | Interferon | Lactic acid | Fluvoxamine
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2016, Volume 53, pp. 207 - 222
Highlights • Foot shock stress increased mouse hippocampal levels of 18 cytokines. • Prior stress accelerated the rate of increase of stress-induced... 
Psychiatry | Allergy and Immunology | Neuroinflammation | Depression | Fluoxetine | Glycogen synthase kinase-3 | Stress | Toll-like receptor 4 | CORTICOTROPIN-RELEASING HORMONE | TOLL-LIKE-RECEPTORS | MESSENGER-RNA EXPRESSION | GLYCOGEN-SYNTHASE KINASE-3 | NLRP3 INFLAMMASOME ACTIVATION | CHRONIC MILD STRESS | NECROSIS-FACTOR-ALPHA | FACTOR-KAPPA-B | IMMUNOLOGY | ANXIETY-LIKE BEHAVIOR | NEUROSCIENCES | INDUCED SICKNESS BEHAVIOR | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Up-Regulation | Inflammasomes - metabolism | Male | NF-kappa B - metabolism | Glycogen Synthase Kinase 3 - immunology | Depression - genetics | HMGB1 Protein - genetics | Depression - metabolism | Inflammation - metabolism | HMGB1 Protein - metabolism | Cytokines - immunology | Stress, Physiological - physiology | Fluoxetine - pharmacology | Cytokines - metabolism | Signal Transduction | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Stress, Physiological - genetics | Toll-Like Receptor 4 - genetics | Hippocampus - pathology | Toll-Like Receptor 4 - immunology | Glycogen Synthase Kinase 3 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Hippocampus - metabolism | Animals | Inflammasomes - immunology | Inflammation - genetics | Mice | Neuroimmunomodulation | Depression - immunology | Nervous system diseases | Chromosomal proteins | Synthesis | Glycogen | Antidepressants | Analysis | Depression, Mental | Inflammation | Stress (Psychology) | stress | fluoxetine | glycogen synthase kinase-3 | depression | neuroinflammation
Journal Article
Journal Article
Experimental Neurology, ISSN 0014-4886, 2007, Volume 206, Issue 1, pp. 33 - 42
Circumstantial evidence has suggested that activated microglia may be associated with the pathogenesis of depression. Pro-inflammatory cytokines may also be... 
SQ 22536 | cAMP | Antidepressants | Lithium chloride | PKA | Microglia | lithium chloride | ADULT NEUROGENESIS | antidepressants | NECROSIS-FACTOR-ALPHA | MAJOR DEPRESSION | FLUOXETINE | NEUROSCIENCES | BREAST-CANCER | CYTOKINE PRODUCTION | PATHWAY | MICE | TNF-ALPHA | microglia | HIPPOCAMPAL NEUROGENESIS | MAP Kinase Signaling System - physiology | Neurotransmitter Uptake Inhibitors - pharmacology | Depressive Disorder - drug therapy | Dose-Response Relationship, Drug | Microglia - immunology | Lithium Chloride - pharmacology | Cyclic AMP-Dependent Protein Kinase Type II | Antidepressive Agents - pharmacology | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Cyclic AMP - metabolism | Interleukin-6 - metabolism | Cyclic AMP-Dependent Protein Kinases - metabolism | Cell Line | Nitric Oxide - immunology | Antiviral Agents - pharmacology | Microglia - secretion | Antimanic Agents - pharmacology | Microglia - drug effects | Brain - physiopathology | Mice, Inbred C57BL | Depressive Disorder - immunology | Enzyme Inhibitors - pharmacology | Interleukin-6 - secretion | Brain - drug effects | Up-Regulation - drug effects | Cyclic AMP - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Up-Regulation - immunology | Depressive Disorder - physiopathology | Interleukin-6 - immunology | Mice | Nitric Oxide - metabolism | Brain - immunology | Interferon-gamma - pharmacology
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Neuroimmunology, ISSN 0165-5728, 12/2017, Volume 313, pp. 77 - 81
In patients with multiple sclerosis, the selective serotonin reuptake inhibitor, fluoxetine, resulted in less acute disease activity. We tested the immune... 
EAE | Experimental autoimmune encephalomyelitis | SSRI | Neuroinflammation | Multiple sclerosis | Fluoxetine | Neuroinflamrnation | PARALYSIS | Multiple | DENDRITIC CELLS | RATS | IMMUNOLOGY | NEUROSCIENCES | sclerosis | MYELIN | MULTIPLE-SCLEROSIS BRAIN | DISEASE | CENTRAL-NERVOUS-SYSTEM | SEROTONIN | PROMOTES | T-LYMPHOCYTES | Myelin Proteolipid Protein - immunology | Encephalomyelitis, Autoimmune, Experimental - immunology | Membrane Potential, Mitochondrial - drug effects | fas Receptor - metabolism | Freund's Adjuvant - immunology | Myelin Basic Protein - genetics | T-Lymphocytes - drug effects | Peptide Fragments - immunology | Freund's Adjuvant - adverse effects | Anti-Inflammatory Agents - therapeutic use | Female | Cell Death - drug effects | Fluoxetine - therapeutic use | T-Lymphocytes - pathology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - pathology | Cytokines - metabolism | Receptors, Antigen, T-Cell - metabolism | Mice, Transgenic | Myelin Proteolipid Protein - adverse effects | Animals | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Macrophages - drug effects | Cell Proliferation - drug effects | Mice | Peptide Fragments - adverse effects | Receptors, Antigen, T-Cell - genetics | CD11b Antigen - metabolism | Apoptosis | Antigens | Encephalomyelitis | Dendritic cells | Cell death | Analysis | Tryptophan | Paralysis | T cells | Mitogens | Myelin proteins | Index Medicus
Journal Article