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Journal of Structural Biology, ISSN 1047-8477, 11/2019, Volume 208, Issue 2, pp. 165 - 173
The inherent amyloidogenic potential of wild type transthyretin (TTR) is enhanced by a large number of point mutations, which destabilize the TTR tetramer,... 
Amyloidogenic proteins | Ligand binding design | Transthyretin stabilizers | Amyloidogenesis inhibitors | Transthyretin | Gene mutations | Analysis | Thyroxine | Crystals | Amyloidosis | Diflunisal | Structure | Protein binding | Flurbiprofen | Blood proteins
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 09/2005, Volume 48, Issue 18, pp. 5705 - 5720
Journal Article
Archiv der Pharmazie, ISSN 0365-6233, 01/2015, Volume 348, Issue 1, pp. 55 - 61
Journal Article
Journal Article
Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2014, Volume 13, Issue 2, p. 128
Journal Article
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2013, Volume 720, Issue 1-3, pp. 383 - 390
Journal Article
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, ISSN 0277-0008, 02/2014, Volume 34, Issue 2, pp. 114 - 122
Journal Article
Journal Article
Cellular Physiology and Biochemistry, ISSN 1015-8987, 01/2018, Volume 44, Issue 5, pp. 1726 - 1740
Background/Aims: In response to traumatic brain injury (TBI), activated microglia exhibit changes in their morphology from the resting ramified phenotype... 
Original Paper | Traumatic brain injury | Neurogenic acute lung injury | γ-secretase | Microglia | CELLS | ACTIVATION | PHYSIOLOGY | ALZHEIMERS-DISEASE | gamma-secretase | RESOLUTION | CHF5074 | BLOOD-FLOW | CELL BIOLOGY | TRAUMATIC BRAIN-INJURY | INFLAMMATION | MOUSE MODEL | MICE | Microglia - metabolism | Neutrophils - cytology | Brain Injuries, Traumatic - prevention & control | Male | Cerebral Cortex - physiopathology | Alanine - analogs & derivatives | Neuroprotective Agents - pharmacology | Acute Lung Injury - prevention & control | Acute Lung Injury - metabolism | Bronchoalveolar Lavage Fluid - cytology | Neutrophils - metabolism | Alanine - pharmacology | Cyclopropanes - pharmacology | Disease Models, Animal | Flurbiprofen - analogs & derivatives | Lung - pathology | Cytokines - metabolism | Microglia - drug effects | Rats | Acute Lung Injury - pathology | Blood-Brain Barrier - drug effects | Rats, Sprague-Dawley | Azepines - pharmacology | Amyloid Precursor Protein Secretases - metabolism | Animals | Brain Injuries, Traumatic - pathology | Brain - pathology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Bronchoalveolar Lavage Fluid - chemistry | Flurbiprofen - pharmacology | Adenosine | Ischemia | Cytokines | Surgery | Morphology | Rodents | Neutrophils | Tumor necrosis factor-TNF | Contusions
Journal Article