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Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 03/2018, Volume 26, Issue 5, pp. 1102 - 1115
A series of 4′-OH-flurbiprofen-chalcone hybrids were designed, synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's... 
Aβ aggregation inhibitors | Monoamine oxidase inhibitors | Multifunctional agents | Flurbiprofen-chalcone hybrids | Alzheimer's disease | Anti-inflammatory agents | MONOAMINE-OXIDASE | CHEMISTRY, MEDICINAL | ASSAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | MAO-B | FLURBIPROFEN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | BETA-AMYLOID PLAQUES | ANTIOXIDANT | BIOLOGICAL EVALUATION | A beta aggregation inhibitors | INHIBITORS | DERIVATIVES | Chalcones - chemistry | Antioxidants - chemistry | Humans | Structure-Activity Relationship | Monoamine Oxidase - genetics | Recombinant Proteins - biosynthesis | Alzheimer Disease - pathology | Monoamine Oxidase - chemistry | Copper - chemistry | Amyloid beta-Peptides - metabolism | Drug Design | Monoamine Oxidase Inhibitors - therapeutic use | Cell Line | Cell Survival - drug effects | Monoamine Oxidase Inhibitors - pharmacology | Peptide Fragments - metabolism | Lipopolysaccharides - toxicity | Chelating Agents - chemistry | Alzheimer Disease - drug therapy | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Antioxidants - pharmacology | Flurbiprofen - chemistry | Blood-Brain Barrier - drug effects | Blood-Brain Barrier - metabolism | Amyloid beta-Peptides - antagonists & inhibitors | Antioxidants - therapeutic use | Peptide Fragments - antagonists & inhibitors | Monoamine Oxidase Inhibitors - chemistry | Chelating Agents - chemical synthesis | Nitric Oxide - metabolism | Monoamine Oxidase - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e43965 - e43965
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The... 
POTENT INHIBITOR | CYCLOOXYGENASE INHIBITION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROSTAGLANDIN-F-SYNTHASE | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | MACROMOLECULAR CRYSTALLOGRAPHY | PRE-RECEPTOR REGULATION | CANCER CELL-MIGRATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Meclofenamic Acid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Tolmetin - analogs & derivatives | Indomethacin - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Mefenamic Acid - chemistry | Naproxen - metabolism | Sulindac - metabolism | Ibuprofen - chemistry | Mefenamic Acid - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hydroxyprostaglandin Dehydrogenases - chemistry | Tolmetin - metabolism | Sulindac - chemistry | Flurbiprofen - chemistry | Meclofenamic Acid - chemistry | Ibuprofen - metabolism | Naproxen - chemistry | Tolmetin - chemistry | Flufenamic Acid - metabolism | Aldo-Keto Reductase Family 1 Member C3 | Flufenamic Acid - chemistry | Indomethacin - chemistry | 3-Hydroxysteroid Dehydrogenases - chemistry | Flurbiprofen - metabolism | Oxidoreductases | Research | Nonsteroidal anti-inflammatory drugs | Structure | Properties | Drugs | Dehydrogenases | Drug development | Cancer therapies | Crystallography | Cell adhesion & migration | Proteins | Signal transduction | Distributed control systems | Naproxen | Sulindac | Ibuprofen | Inhibition | Catalysis | NADP | Flurbiprofen | Crystal structure | Carbonyls | Medical research | Enzymes | Antiinflammatory agents | Breast cancer | Inflammation | Aldo-keto reductase | Nonsteroidal antiinflammatory drugs | Carbonyl groups | Testosterone | Signaling | Acids | Mefenamic acid | Ligands | Indomethacin | Drug discovery | Prostate cancer | Prostate | Tumors | Cancer | Index Medicus
Journal Article
International Journal of Pharmaceutics, ISSN 0378-5173, 2011, Volume 420, Issue 2, pp. 412 - 418
Journal Article
Colloids and Surfaces B: Biointerfaces, ISSN 0927-7765, 2010, Volume 81, Issue 2, pp. 412 - 421
Packaging small drug molecules, such as non-steroidal anti-inflammatory drugs (NSAIDs) into nanoparticulate systems has been reported as a promising approach... 
Ultrasounds | Nanostructured lipid carriers (NLC) | Eytex ® test | Draize test | Turbiscan | Ocular administration | Factorial design | Flurbiprofen | test | Eytex | MATERIALS SCIENCE, BIOMATERIALS | STABILITY | Eytex (R) test | DELIVERY-SYSTEMS | CHEMISTRY, PHYSICAL | CATARACT-SURGERY | SOLID LIPID NANOPARTICLES | IN-VITRO | BIOPHYSICS | SLN | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | PHYSICOCHEMICAL CHARACTERIZATION | PARTICLE-SIZE | SIZE DISTRIBUTION | Predictive Value of Tests | Animal Testing Alternatives - methods | Nanoparticles - chemistry | Polysorbates - chemistry | Drug Carriers - administration & dosage | Flurbiprofen - toxicity | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Drug Carriers - toxicity | Drug Carriers - chemistry | Irritants - chemistry | Flurbiprofen - administration & dosage | Surface Properties | Drug Design | Eye - drug effects | Tissue Engineering | Irritants - chemical synthesis | Rabbits | Skin Irritancy Tests - methods | Drug Stability | Drug Tolerance | Castor Oil - chemistry | Drug Carriers - chemical synthesis | Flurbiprofen - chemistry | Irritants - toxicity | Nanoparticles - toxicity | Stearic Acids - chemistry | Anti-Inflammatory Agents, Non-Steroidal - toxicity | Irritants - administration & dosage | Ultrasonics | Particle Size | Animals | Anti-Inflammatory Agents, Non-Steroidal - administration & dosage | Nanoparticles - administration & dosage | Universities and colleges | Surface active agents | Castor oil | Saturated fatty acids | Analysis | Formulations | Drugs | Nanocomposites | Nanomaterials | Lipids | Tolerances | Nanostructure | Dispersions | Index Medicus
Journal Article
International Journal of Biological Macromolecules, ISSN 0141-8130, 11/2017, Volume 104, Issue Pt A, pp. 1229 - 1237
Journal Article
International Journal of Nanomedicine, ISSN 1176-9114, 01/2015, Volume 10, pp. 609 - 631
In this work, a peptide for ocular delivery (POD) and human immunodeficiency virus transactivator were conjugated with biodegradable poly(lactic-co-glycolic... 
Ocular tolerance | Peptide for ocular delivery | Anti-inflammatory | Controlled release | Flurbiprofen | Cell Survival - drug effects | Rabbits | Chorioallantoic Membrane - chemistry | Lactic Acid - chemistry | Nanoparticles - chemistry | Anti-Inflammatory Agents - pharmacology | Epithelium, Corneal - cytology | Apoptosis Regulatory Proteins - chemistry | Humans | Recombinant Fusion Proteins - chemistry | Glycolates - chemistry | Drug Carriers - chemistry | Drug Delivery Systems | Hep G2 Cells | tat Gene Products, Human Immunodeficiency Virus - chemistry | Microscopy, Confocal | Cell-Penetrating Peptides - pharmacology | Animals | Chickens | Polyglycolic Acid - chemistry | Epithelium, Corneal - drug effects | Female | HeLa Cells | Basic Helix-Loop-Helix Transcription Factors - chemistry | Nanoparticles | Drugs | Complications and side effects | Drug delivery systems | Polyethylene glycol | Ophthalmic drugs | Physiological aspects | Dosage and administration | Research | Chemical properties | Vehicles | Cataracts | Solvents | Peptides | Polylactic acid | Cytotoxicity | Bioavailability | Proteins | Biomedical materials | Human immunodeficiency virus--HIV | Herpes viruses | Nonsteroidal anti-inflammatory drugs | Polymers | Deoxyribonucleic acid--DNA | Index Medicus | anti-inflammatory | peptide for ocular delivery | controlled release | flurbiprofen | ocular tolerance
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2008, Volume 43, Issue 12, pp. 2688 - 2698
A series of 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives of biphenyl-4-yloxy acetic acid were synthesized in order to obtain new compounds with... 
1,2,4-Triazole | Ulcerogenic | Lipid peroxidation | Analgesic | 1,3,4-Oxadiazole/thiadiazoles | Anti-inflammatory | ESTER | CHEMISTRY, MEDICINAL | CYCLOOXYGENASE-2 | DRUG DESIGN | BIOISOSTERISM | INDOMETHACIN | SERUM | MESSENGER-RNA | ANTIINFLAMMATORY AGENTS | PROSTAGLANDIN SYNTHASE | INHIBITORS | Diphenylacetic Acids - chemistry | Analgesics - pharmacology | Antioxidants - chemistry | Rats, Wistar | Stereoisomerism | Triazoles - chemistry | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Male | Gastric Mucosa - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Liver - drug effects | Analgesics - chemical synthesis | Thiadiazoles - chemistry | Gastric Mucosa - drug effects | Lipid Peroxidation - drug effects | Diphenylacetic Acids - chemical synthesis | Anti-Ulcer Agents - pharmacology | Female | Molecular Structure | Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis | Drug Evaluation, Preclinical | Oxadiazoles - chemistry | Liver - metabolism | Stomach Ulcer - drug therapy | Rats | Edema - drug therapy | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Animals | Anti-Ulcer Agents - chemistry | Analgesics - chemistry | Anti-Ulcer Agents - chemical synthesis | Mice | Carrageenan | Edema - chemically induced | Diphenylacetic Acids - pharmacology | Antioxidants | Carrageenin | Triazoles | Analysis | Acetic acid | Organic acids | Flurbiprofen | Index Medicus
Journal Article
Journal Article
European Journal of Pharmaceutics and Biopharmaceutics, ISSN 0939-6411, 08/2015, Volume 94, pp. 64 - 72
Journal Article