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Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 96 - 104
Liver first-pass metabolism differs considerably among organic nitrates, but little information exists on the mechanism of denitration of these compounds in... 
INHIBITION | PHARMACOKINETICS | FERULIC ACID | IN-VIVO | ANGINA-PECTORIS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | FLURBIPROFEN | GLYCERYL TRINITRATE | OXIDE-RELEASING DERIVATIVES | NCX 2057 | Butanes - pharmacology | Free Radical Scavengers - pharmacology | Nitro Compounds - metabolism | Liver - enzymology | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Cytosol - drug effects | Male | Nitroglycerin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cytochrome P-450 CYP1A2 Inhibitors | Cytosol - enzymology | Butanes - metabolism | Liver - drug effects | Microsomes, Liver - drug effects | Vasodilator Agents - metabolism | Nitro Compounds - pharmacology | Female | Microsomes, Liver - enzymology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Nitroglycerin - metabolism | Flurbiprofen - analogs & derivatives | Cyclooxygenase Inhibitors - metabolism | Vasodilator Agents - pharmacology | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Liver - metabolism | Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP1A2 - metabolism | Mitochondria, Liver - enzymology | Cyclooxygenase Inhibitors - pharmacology | Mitochondria, Liver - drug effects | Metabolic Detoxication, Phase I | Cytosol - metabolism | Kinetics | Nitric Oxide - metabolism | Flurbiprofen - metabolism | Flurbiprofen - pharmacology
Journal Article
Neuropharmacology, ISSN 0028-3908, 08/2013, Volume 71, pp. 204 - 215
Damaging of peripheral nerves may result in chronic neuropathic pain for which the likelihood is increased in the elderly. We assessed in mice if age-dependent... 
Nociception | Inhibitory control | Cyclooxygenase | Pain | Cannabinoid receptor | Aging | Fatty acid amide hydrolase | 2-Arachidonoylglycerol | R-flurbiprofen | Endocannabinoids | Anandamide | Anandamide 2-Arachidonoylglycerol | CB1 CANNABINOID RECEPTORS | ACTIVATION | INHIBITORY SYNAPSES | ENDOCANNABINOID SYSTEM | FLURBIPROFEN | NEUROSCIENCES | METABOLISM | ACID AMIDE HYDROLASE | ENZYMES | NEURONS | PHARMACOLOGY & PHARMACY | STRESS | Endocannabinoids - metabolism | Cyclooxygenase Inhibitors - blood | Flurbiprofen - therapeutic use | Spinal Cord - drug effects | Spinal Cord - metabolism | Arachidonic Acids - deficiency | Cytochrome P-450 CYP2D6 - biosynthesis | Spinal Cord - growth & development | Stereoisomerism | Neuralgia - metabolism | Male | Brain - growth & development | Peripheral Nerves - drug effects | Brain - metabolism | Arachidonic Acids - metabolism | Amidohydrolases - biosynthesis | Nerve Tissue Proteins - biosynthesis | Neuralgia - etiology | Behavior, Animal - drug effects | Membrane Proteins - metabolism | Peripheral Nerves - metabolism | Disease Models, Animal | Amidohydrolases - metabolism | Flurbiprofen - pharmacokinetics | Cyclooxygenase 1 - biosynthesis | Mice, Inbred C57BL | Enzyme Induction | Polyunsaturated Alkamides - metabolism | Neuralgia - drug therapy | Brain - drug effects | Cyclooxygenase Inhibitors - pharmacokinetics | Nerve Tissue Proteins - metabolism | Flurbiprofen - blood | Membrane Proteins - biosynthesis | Animals | Neuralgia - blood | Cytochrome P-450 CYP2D6 - metabolism | Mice | Cyclooxygenase 1 - metabolism | Peripheral Nerves - growth & development | Cyclooxygenase Inhibitors - therapeutic use | Endocannabinoids - deficiency | COX-2 inhibitors | Enzymes | Care and treatment | Analysis | Cytochrome P-450 | Physiological aspects | Hydrolases | Fatty acids | Flurbiprofen | Age
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, p. e43965
Aldo-keto reductase 1C3 (AKR1C3) catalyses the NADPH dependent reduction of carbonyl groups in a number of important steroid and prostanoid molecules. The... 
POTENT INHIBITOR | CYCLOOXYGENASE INHIBITION | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J | PROSTAGLANDIN-F-SYNTHASE | 5 17-BETA-HYDROXYSTEROID-DEHYDROGENASE | MACROMOLECULAR CRYSTALLOGRAPHY | PRE-RECEPTOR REGULATION | CANCER CELL-MIGRATION | 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE | Meclofenamic Acid - metabolism | Anti-Inflammatory Agents, Non-Steroidal - chemistry | Tolmetin - analogs & derivatives | Indomethacin - metabolism | Hydroxyprostaglandin Dehydrogenases - metabolism | Mefenamic Acid - chemistry | Naproxen - metabolism | Sulindac - metabolism | Ibuprofen - chemistry | Mefenamic Acid - metabolism | 3-Hydroxysteroid Dehydrogenases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Hydroxyprostaglandin Dehydrogenases - chemistry | Tolmetin - metabolism | Sulindac - chemistry | Flurbiprofen - chemistry | Meclofenamic Acid - chemistry | Ibuprofen - metabolism | Naproxen - chemistry | Tolmetin - chemistry | Flufenamic Acid - metabolism | Aldo-Keto Reductase Family 1 Member C3 | Flufenamic Acid - chemistry | Indomethacin - chemistry | 3-Hydroxysteroid Dehydrogenases - chemistry | Flurbiprofen - metabolism | Oxidoreductases | Research | Nonsteroidal anti-inflammatory drugs | Structure | Properties | Drugs | Dehydrogenases | Drug development | Cancer therapies | Crystallography | Cell adhesion & migration | Proteins | Signal transduction | Distributed control systems | Naproxen | Sulindac | Ibuprofen | Inhibition | Catalysis | NADP | Flurbiprofen | Crystal structure | Carbonyls | Medical research | Enzymes | Antiinflammatory agents | Breast cancer | Inflammation | Aldo-keto reductase | Carbonyl groups | Testosterone | Signaling | Acids | Mefenamic acid | Ligands | Indomethacin | Drug discovery | Prostate cancer | Prostate | Tumors | Cancer
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 08/2016, Volume 54, Issue 1, pp. 207 - 221
Journal Article
Journal of Alzheimer's Disease, ISSN 1387-2877, 2010, Volume 22, Issue 4, pp. 1135 - 1155
Profens like ibuprofen, R-flurbiprofen, or CHF5074 are being considered for the treatment of Alzheimer's disease because epidemiological data indicates that... 
R-Flurbiprofen | Actin | NSAIDs | CHF5074 | ibuprofen | astrocytes | IPA3 | Rac1 | Alzheimer's disease | RhoA | Cdc42 | ACTIVATION | ALZHEIMERS-DISEASE | RHO-KINASE | DISTINCT ROLES | NEUROSCIENCES | IN-VITRO | LYSOPHOSPHATIDIC ACID | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | MOUSE MODEL | INHIBITORS | GAMMA-SECRETASE | Immunohistochemistry | Cerebellum - drug effects | Extracellular Signal-Regulated MAP Kinases - metabolism | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Dose-Response Relationship, Drug | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Cerebral Cortex - drug effects | Cyclopropanes - pharmacology | Flurbiprofen - analogs & derivatives | Astrocytes - cytology | Astrocytes - drug effects | Ibuprofen - pharmacology | Cerebellum - metabolism | Cells, Cultured | Cyclopropanes - metabolism | Rats | Rats, Sprague-Dawley | Blotting, Western | Ibuprofen - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Analysis of Variance | Signal Transduction - drug effects | rho GTP-Binding Proteins - metabolism | Cerebellum - cytology | Cyclooxygenase 2 - metabolism | Cytoskeleton - metabolism | Signal Transduction - physiology | Flurbiprofen - metabolism | Flurbiprofen - pharmacology | Cytoskeleton - drug effects | Astrocytes - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0139212
Background Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a... 
IBUPROFEN | ENZYME | COX-2 | OXYGENATION | ENDOCANNABINOIDS | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | INDOMETHACIN | FLURBIPROFEN | LINEAR-MODELS | ANTIINFLAMMATORY DRUGS | Endocannabinoids - metabolism | Stereoisomerism | Humans | Brain - enzymology | Male | Arachidonic Acids - metabolism | Isoenzymes - metabolism | Benzamides - pharmacology | Carbamates - pharmacology | Amides - pharmacology | Amidohydrolases - metabolism | Amidohydrolases - antagonists & inhibitors | Polyunsaturated Alkamides - metabolism | Cyclooxygenase Inhibitors - pharmacology | Hydrolysis | Animals | Arachidonic Acid - pharmacology | Cyclooxygenase 2 - metabolism | Lipid Metabolism - drug effects | Lipopolysaccharides - pharmacology | Amides - chemistry | Ionomycin - pharmacology | RAW 264.7 Cells | Mice | Cyclooxygenase 1 - metabolism | Flurbiprofen - pharmacology | Interferon-gamma - pharmacology | Prostaglandins - metabolism | Brain | COX-2 inhibitors | Neurosciences | Lipids | Enantiomers | Arachidonic acid | Macrophages | Prostaglandin endoperoxide synthase | Pain | 2-Arachidonylglycerol | Rodents | Nonsteroidal anti-inflammatory drugs | Flurbiprofen | Functional foods & nutraceuticals | Fatty-acid amide hydrolase | Enzymes | Hydrolase | Substrate inhibition | Pharmacology | Prostaglandin D2 | Fatty acids | Substrates | Anandamide | Environmental science | Inhibitors | Cyclooxygenase-1 | Interferon | Cyclooxygenase-2 | Oxygenation | Pharmaceuticals | Basic Medicine | Farmakologi och toxikologi | Medical and Health Sciences | Pharmacology and Toxicology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal Article
Journal Article
Molecular medicine (Cambridge, Mass.), ISSN 1076-1551, 2012, Volume 18, Issue 7, pp. 1128 - 1135
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 10/2001, Volume 21, Issue 20, pp. 8026 - 8033
Nonsteroid anti-inflammatory drugs (NSAIDs) are major drugs against inflammation and pain. They are well known inhibitors of cyclooxygenases (COXs). However,... 
Nociception | Aspirin | Inflammation | Dorsal root ganglion | NSAID | Acid-sensing ion channel | GENE-RELATED PEPTIDE | acid-sensing ion channel | ROOT GANGLION NEURONS | nociception | CAPSAICIN-RECEPTOR | NEUROSCIENCES | SENSORY NEURONS | IN-VITRO | MESSENGER-RNA | inflammation | LOW PH | dorsal root ganglion |