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Journal of Biological Chemistry, ISSN 0021-9258, 04/2012, Volume 287, Issue 15, pp. 11810 - 11819
gamma-Secretase-mediated cleavage of amyloid precursor protein (APP) results in the production of Alzheimer disease-related amyloid-beta (A beta) peptides. The... 
TARGET | PROTEIN | PATTERN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSMEMBRANE DOMAIN | INHIBITORS | BINDING-SITES | EXPRESSION | FAILURE | PRESENILIN-1 | Pyridines - chemistry | Receptors, Notch - metabolism | Humans | Receptor, EphA4 - metabolism | Pyrimidines - chemistry | Brain - metabolism | Alanine - analogs & derivatives | Dibenzazepines - pharmacology | Drug Interactions | Azepines - chemistry | Piperidines - pharmacology | Protein Processing, Post-Translational - drug effects | Pyrans - chemistry | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Female | Pyrans - pharmacology | Alanine - pharmacology | Carbamates - pharmacology | Binding, Competitive | Guinea Pigs | Amyloid beta-Peptides - biosynthesis | Dipeptides - pharmacology | Mice, Inbred C57BL | Rats | Imidazoles - pharmacology | Pyrimidines - pharmacology | Receptor, EphB2 - metabolism | Sulfonamides - pharmacology | Azepines - pharmacology | Brain - drug effects | Sulindac - analogs & derivatives | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell-Free System | Protein Binding | Mice | Pyridines - pharmacology | Amyloid Precursor Protein Secretases - antagonists & inhibitors | Flurbiprofen - pharmacology | Sulindac - pharmacology | Neurodegenerative Diseases | Secretases | Neurobiology | Intramembrane Proteolysis | Amyloid | Pharmacology | Alzheimer Disease
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, p. e0139212
Background Increased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a... 
IBUPROFEN | ENZYME | COX-2 | OXYGENATION | ENDOCANNABINOIDS | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | INDOMETHACIN | FLURBIPROFEN | LINEAR-MODELS | ANTIINFLAMMATORY DRUGS | Endocannabinoids - metabolism | Stereoisomerism | Humans | Brain - enzymology | Male | Arachidonic Acids - metabolism | Isoenzymes - metabolism | Benzamides - pharmacology | Carbamates - pharmacology | Amides - pharmacology | Amidohydrolases - metabolism | Amidohydrolases - antagonists & inhibitors | Polyunsaturated Alkamides - metabolism | Cyclooxygenase Inhibitors - pharmacology | Hydrolysis | Animals | Arachidonic Acid - pharmacology | Cyclooxygenase 2 - metabolism | Lipid Metabolism - drug effects | Lipopolysaccharides - pharmacology | Amides - chemistry | Ionomycin - pharmacology | RAW 264.7 Cells | Mice | Cyclooxygenase 1 - metabolism | Flurbiprofen - pharmacology | Interferon-gamma - pharmacology | Prostaglandins - metabolism | Brain | COX-2 inhibitors | Neurosciences | Lipids | Enantiomers | Arachidonic acid | Macrophages | Prostaglandin endoperoxide synthase | Pain | 2-Arachidonylglycerol | Rodents | Nonsteroidal anti-inflammatory drugs | Flurbiprofen | Functional foods & nutraceuticals | Fatty-acid amide hydrolase | Enzymes | Hydrolase | Substrate inhibition | Pharmacology | Prostaglandin D2 | Fatty acids | Substrates | Anandamide | Environmental science | Inhibitors | Cyclooxygenase-1 | Interferon | Cyclooxygenase-2 | Oxygenation | Pharmaceuticals | Basic Medicine | Farmakologi och toxikologi | Medical and Health Sciences | Pharmacology and Toxicology | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2013, Volume 288, Issue 40, pp. 28641 - 28655
Journal Article
Journal of Ethnopharmacology, ISSN 0378-8741, 2006, Volume 104, Issue 3, pp. 336 - 344
The aim of this study is to investigate the mechanisms of the vasorelaxant effect of the crude extract of (family: Labiatae), also known as “Danshen”, in rat... 
Rat knee joint | Salvia miltiorrhiza | Prostaglandins | CGRP | Nitric oxide | Danshen | rat knee joint | nitric oxide | CHEMISTRY, MEDICINAL | GENE-RELATED PEPTIDE | STIMULATION | NERVES | BLOOD-FLOW | PLANT SCIENCES | INTEGRATIVE & COMPLEMENTARY MEDICINE | INFLAMMATION | ENDOTHELIAL-CELLS | NITRIC-OXIDE | prostaglandins | PHARMACOLOGY & PHARMACY | VASODILATOR | SUBSTANCE-P | CAPSAICIN | Joints - blood supply | Hindlimb | Capsaicin - pharmacology | Drugs, Chinese Herbal - pharmacology | Nitric Oxide Synthase - antagonists & inhibitors | Peptide Fragments - pharmacology | Dose-Response Relationship, Drug | Adrenergic beta-Antagonists - pharmacology | Propranolol - pharmacology | Muscarinic Antagonists - pharmacology | Histamine Antagonists - pharmacology | NG-Nitroarginine Methyl Ester - pharmacology | Vasodilator Agents - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | Rats | Atropine - pharmacology | Rats, Sprague-Dawley | Cyclooxygenase Inhibitors - pharmacology | Joints - innervation | Prostaglandins - physiology | Animals | Pyrilamine - pharmacology | Cimetidine - pharmacology | Flurbiprofen - pharmacology | Histamine receptors | Propranolol hydrochloride | Histamine | Peptides | Dilatation | Vasodilators | Blood vessels | Flurbiprofen
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 07/2013, Volume 346, Issue 1, pp. 96 - 104
Liver first-pass metabolism differs considerably among organic nitrates, but little information exists on the mechanism of denitration of these compounds in... 
INHIBITION | PHARMACOKINETICS | FERULIC ACID | IN-VIVO | ANGINA-PECTORIS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | FLURBIPROFEN | GLYCERYL TRINITRATE | OXIDE-RELEASING DERIVATIVES | NCX 2057 | Butanes - pharmacology | Free Radical Scavengers - pharmacology | Nitro Compounds - metabolism | Liver - enzymology | Mitochondria, Liver - metabolism | Humans | Microsomes, Liver - metabolism | Cytosol - drug effects | Male | Nitroglycerin - pharmacology | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Cytochrome P-450 CYP1A2 Inhibitors | Cytosol - enzymology | Butanes - metabolism | Liver - drug effects | Microsomes, Liver - drug effects | Vasodilator Agents - metabolism | Nitro Compounds - pharmacology | Female | Microsomes, Liver - enzymology | Anti-Inflammatory Agents, Non-Steroidal - metabolism | Nitroglycerin - metabolism | Flurbiprofen - analogs & derivatives | Cyclooxygenase Inhibitors - metabolism | Vasodilator Agents - pharmacology | Enzyme Inhibitors - metabolism | Free Radical Scavengers - metabolism | Liver - metabolism | Enzyme Inhibitors - pharmacology | Cytochrome P-450 CYP1A2 - metabolism | Mitochondria, Liver - enzymology | Cyclooxygenase Inhibitors - pharmacology | Mitochondria, Liver - drug effects | Metabolic Detoxication, Phase I | Cytosol - metabolism | Kinetics | Nitric Oxide - metabolism | Flurbiprofen - metabolism | Flurbiprofen - pharmacology
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 11/2013, Volume 720, Issue 1-3, pp. 383 - 390
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 02/2013, Volume 75, Issue 2, pp. 450 - 462
Journal Article
Pharmacological Research, ISSN 1043-6618, 03/2014, Volume 81, Issue 100, pp. 74 - 82
The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in... 
Human | 2-Arachidonoylglycerol | Cyclooxygenase | Endocannabinoid | Vasorelaxation | Prostanoid | MIDDLE CEREBRAL-ARTERY | RAT AORTA | ANANDAMIDE | CORONARY-ARTERIES | PROSTANOID RECEPTORS | CANNABINOID RECEPTOR | HYPERPOLARIZING FACTOR | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | HUMAN PULMONARY-ARTERY | ACTIVATED ENDOCANNABINOID SYSTEM | Mesenteric Arteries - physiology | Endocannabinoids - pharmacology | Humans | Cyclooxygenase 1 - physiology | Mesenteric Arteries - drug effects | Arachidonic Acids - pharmacology | Indomethacin - pharmacology | Cyclooxygenase Inhibitors - pharmacology | Glycerides - pharmacology | Vasodilation - drug effects | Vasodilation - physiology | In Vitro Techniques | Flurbiprofen - pharmacology | Physiological aspects | Blood vessels | COX-2 inhibitors | Dilatation | PSS, physiological saline solution | TRPV1, transient receptor potential vanilloid-1 | COX-2, cyclooxygenase two | ECS, endocannabinoid system | PPAR, peroxisome proliferator activated receptor | CB2, cannabinoid receptor two | MAGL, monoacylglycerol lipase | KPSS, high potassium physiological saline solution | 2-AG, 2-arachidonoylglcerol | AEA, anandamide | l-NAME, NG-nitro-l-arginine methyl ester | COX-1, cyclooxygenase one | SEM, standard error of mean | ANOVA, analysis of variance | FAAH, fatty acid amide hydrolase | CB1, cannabinoid receptor one
Journal Article
Journal Article
PROTEOMICS, ISSN 1615-9853, 02/2016, Volume 16, Issue 3, pp. 448 - 458
In this study, we trace developmental stages using epigenome changes in human embryonic stem cells (hESCs) treated with drugs modulating either self‐renewal or... 
Histones | Self‐renewal | Differentiation | Embryonic stem cells | Systems biology | Mass spectrometry | Self-renewal | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | BIOCHEMICAL RESEARCH METHODS | PATTERNS | INDUCTION | MASS-SPECTROMETRY | GENOME | SMALL-MOLECULE COMPOUNDS | PROTEINS | LINEAGE | EXPRESSION | PROTEOMICS | Epigenesis, Genetic | Human Embryonic Stem Cells - cytology | Humans | Selegiline - pharmacology | Digitoxin - pharmacology | Gene Expression Profiling | Cell Lineage - drug effects | Human Embryonic Stem Cells - drug effects | Acetylation | Induced Pluripotent Stem Cells - cytology | Cell Lineage - genetics | Induced Pluripotent Stem Cells - metabolism | Tretinoin - pharmacology | Human Embryonic Stem Cells - metabolism | Induced Pluripotent Stem Cells - drug effects | Digoxin - pharmacology | Histones - genetics | Cell Differentiation - drug effects | Fluoroquinolones - pharmacology | Glutamates - pharmacology | Cell Proliferation - drug effects | Protein Processing, Post-Translational | Histones - metabolism | Methylation | Flurbiprofen - pharmacology | Epigenetic inheritance | Digoxin | Analysis | Theanine | Cell differentiation | Gene expression | Flurbiprofen | Flow cytometry | Embryos | Stem cells | Drugs | Profiling | Initiators | Embryo cells | Clustering | Cytometry | Developmental stages | Microscopy | Gatifloxacin | Classification | Signatures | Mesendoderm | Pluripotency | mass spectrometry | histones | differentiation | self-renewal | embryonic stem cells
Journal Article
Biochemistry, ISSN 0006-2960, 08/2010, Volume 49, Issue 33, pp. 7069 - 7079
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2002, Volume 137, Issue 3, pp. 295 - 310
This review examines the biological significance, therapeutic potential and mechanism(s) of action of a range of nitric oxide‐releasing non‐steroidal... 
gastrointestinal | pain | colitis | inflammation | liver | Nitric oxide | non‐steroidal anti‐inflammatory drug | cancer | asthma | ulcers | Pain | Liver | Non-steroidal anti-inflammatory drug | Ulcers | Inflammation | Colitis | Gastrointestinal | Asthma | Cancer | ACETYLSALICYLIC-ACID | nitric oxide | NONSTEROIDAL ANTIINFLAMMATORY DRUG | GASTROINTESTINAL TOLERABILITY | ANTINOCICEPTIVE ACTIVITY | ULCEROGENIC PROPERTIES | non-steroidal anti-inflammatory drug | BONE-RESORPTION | IN-VITRO | FLURBIPROFEN NITROXYBUTYLESTER | PHARMACOLOGY & PHARMACY | MEDIATED LIVER-INJURY | ERECTILE DYSFUNCTION | Arteriosclerosis - drug therapy | Vasodilator Agents - therapeutic use | Humans | Osteoporosis - drug therapy | Antineoplastic Agents - therapeutic use | Neurodegenerative Diseases - drug therapy | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Inflammation - metabolism | Digestive System - drug effects | Osteoporosis - metabolism | Inflammation - drug therapy | Pain - drug therapy | Gastrointestinal Diseases - drug therapy | Platelet Aggregation Inhibitors - pharmacology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - therapeutic use | Nitric Oxide Donors - pharmacology | Platelet Aggregation Inhibitors - therapeutic use | Nitric Oxide Donors - adverse effects | Vasodilator Agents - pharmacology | Neurodegenerative Diseases - metabolism | Coronary Restenosis - drug therapy | Animals | Anti-Inflammatory Agents, Non-Steroidal - adverse effects | Gastrointestinal Diseases - metabolism | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | Arteriosclerosis - metabolism | Nitric Oxide - metabolism | Review
Journal Article