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Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 04/2011, Volume 26, Issue 4, pp. 730 - 738
Mesenchymal stem cells (MSCs) cultured on extracellular matrices with different stiffness have been shown to possess diverse lineage commitment owing to the... 
mesenchymal stem cell | matrix stiffness | integrin | mechanotransduction | osteogenic differentiation | MATRIX STIFFNESS | OSTEOBLAST DIFFERENTIATION | GROWTH-HORMONE | INTEGRIN | ENDOCRINOLOGY & METABOLISM | OSTEOGENIC DIFFERENTIATION | FOCAL ADHESION KINASE | LINEAGE | MESENCHYMAL STEM CELL | RHOA | MECHANOTRANSDUCTION | RNA, Small Interfering - genetics | Osteogenesis - physiology | Gene Expression - drug effects | Gene Expression - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen Type I - chemistry | Osteocalcin - genetics | Acrylic Resins - chemical synthesis | Integrin alpha2 - metabolism | Mechanotransduction, Cellular - physiology | rho-Associated Kinases - antagonists & inhibitors | Elasticity - physiology | Mesenchymal Stromal Cells - cytology | Collagen Type I - genetics | rho-Associated Kinases - metabolism | Extracellular Matrix - physiology | Myosin-Light-Chain Phosphatase - metabolism | Osteoblasts - cytology | Phosphorylation - drug effects | Cell Differentiation - physiology | Focal Adhesion Kinase 1 - metabolism | Mesenchymal Stromal Cells - drug effects | Calcification, Physiologic - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Osteoblasts - drug effects | Calcification, Physiologic - physiology | Mesenchymal Stromal Cells - metabolism | Acrylic Resins - chemistry | beta Catenin - metabolism | Biomechanical Phenomena | Integrin alpha2 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Protein Kinase Inhibitors - pharmacology | Osteoblasts - metabolism | Focal Adhesion Kinase 1 - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - genetics | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 10/2013, Volume 105, Issue 19, pp. 1485 - 1495
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 13, pp. 1527 - 1533
Purpose PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK). The objectives of this study were to identify the recommended phase II dose (RP2D) and... 
FAK OVEREXPRESSION | INVASIVENESS | MIGRATION | CELLS | HEPATOCELLULAR-CARCINOMA | METASTASIS | ONCOLOGY | PYK2 | PHOSPHORYLATION | CANCER | PROGRESSION | United States | Humans | Middle Aged | Male | Positron-Emission Tomography | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Focal Adhesion Kinase 2 - antagonists & inhibitors | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Focal Adhesion Kinase 2 - metabolism | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Radiopharmaceuticals | Focal Adhesion Kinase 1 - metabolism | Protein Kinase Inhibitors - pharmacokinetics | Drug Administration Schedule | Pyrimidines - administration & dosage | Neoplasms - enzymology | Treatment Outcome | Neoplasms - diagnostic imaging | Sulfonamides - pharmacokinetics | Neoplasms - drug therapy | Canada | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Pyrimidines - adverse effects | Midazolam - metabolism | Pyrimidines - pharmacokinetics | Sulfonamides - adverse effects | Fluorodeoxyglucose F18 | Aged | Australia | Neoplasm Staging | Neoplasms - pathology | Nonlinear Dynamics | Focal Adhesion Kinase 1 - antagonists & inhibitors | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 08/2016, Volume 59, Issue 16, pp. 7478 - 7496
Journal Article
Molecular Cancer, ISSN 1476-4598, 06/2014, Volume 13, Issue 1, p. 138
Background: Fatty acid synthase (FAS) has been proven over-expressed in human breast cancer cells and consequently, has been recognized as a target for breast... 
Fatty acid synthase | Inhibitor | Alpha-mangostin | Breast cancer cells | Cell apoptosis | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLE ARREST | TUMOR | XANTHONES | GARCINIA-MANGOSTANA | ONCOLOGY | SIGNALING PATHWAY | FOCAL-ADHESION KINASE | TISSUE DISTRIBUTION | HUMAN COLON-CANCER | PROSTATE-CANCER | NF-KAPPA-B | Fatty Acid Synthase, Type I - genetics | Focal Adhesion Kinase 1 - genetics | RNA, Small Interfering - genetics | Apoptosis - drug effects | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Mammary Glands, Human - metabolism | Xanthones - pharmacology | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Mitogen-Activated Protein Kinase 1 - genetics | Female | Proto-Oncogene Proteins c-akt - metabolism | Focal Adhesion Kinase 1 - metabolism | Mammary Glands, Human - drug effects | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Mammary Glands, Human - pathology | Fatty Acid Synthase, Type I - metabolism | Fatty Acid Synthase, Type I - antagonists & inhibitors | Poly(ADP-ribose) Polymerases - metabolism | Poly(ADP-ribose) Polymerases - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Antineoplastic Agents, Phytogenic - pharmacology | Focal Adhesion Kinase 1 - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Care and treatment | Analysis | Cancer | Rodents | Medical prognosis | Cytotoxicity | Breast cancer | Life sciences | Biosynthesis | Bioavailability | Adipocytes | Fatty acids | Experiments | Cancer therapies | Apoptosis
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 05/2016, Volume 89, Issue 5, pp. 521 - 540
Metastasis is a complex process that is regulated by multiple signaling pathways, with the focal adhesion kinase (FAK)/paxillin pathway playing a major role in... 
Paxillin - metabolism | Focal Adhesion Kinase 1 - genetics | Prostatic Neoplasms - metabolism | Paxillin - agonists | Colonic Neoplasms - drug therapy | Humans | Male | Neoplasm Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - metabolism | Focal Adhesions - pathology | Neoplasm Proteins - metabolism | Colonic Neoplasms - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein Processing, Post-Translational - drug effects | RNA Interference | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Thiosemicarbazones - pharmacology | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Focal Adhesion Kinase 1 - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Prostatic Neoplasms - drug therapy | Recombinant Proteins - metabolism | Prostatic Neoplasms - pathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Recombinant Proteins - chemistry | Paxillin - antagonists & inhibitors | Cell Adhesion - drug effects | Enzyme Activation - drug effects | Cell Movement - drug effects | Collagen - metabolism | Focal Adhesions - drug effects | Neoplasm Proteins - agonists | Signal Transduction - drug effects | Colonic Neoplasms - pathology | Focal Adhesions - metabolism | Cell Line, Tumor | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Focal Adhesion Kinase 1 - antagonists & inhibitors | Focal Adhesion Kinase 1 - chemistry
Journal Article
Journal Article
Journal Article
Science Translational Medicine, ISSN 1946-6234, 05/2014, Volume 6, Issue 237, pp. 237ra68 - 237ra68
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e92059
Focal adhesion kinase (FAK) plays an important role in signal transduction pathways initiated at sites of integrin-mediated cell adhesion to the extracellular...