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Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 09/2003, Volume 278, Issue 38, pp. 36661 - 36668
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 05/2012, Volume 30, Issue 13, pp. 1527 - 1533
Purpose PF-00562271 is a novel inhibitor of focal adhesion kinase (FAK). The objectives of this study were to identify the recommended phase II dose (RP2D... 
Life Sciences & Biomedicine | Oncology | Science & Technology | United States | Humans | Middle Aged | Male | Positron-Emission Tomography | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Molecular Targeted Therapy | Focal Adhesion Kinase 2 - antagonists & inhibitors | Dose-Response Relationship, Drug | Enzyme Inhibitors - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Focal Adhesion Kinase 2 - metabolism | Antineoplastic Agents - adverse effects | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Radiopharmaceuticals | Focal Adhesion Kinase 1 - metabolism | Protein Kinase Inhibitors - pharmacokinetics | Drug Administration Schedule | Pyrimidines - administration & dosage | Neoplasms - enzymology | Treatment Outcome | Neoplasms - diagnostic imaging | Sulfonamides - pharmacokinetics | Neoplasms - drug therapy | Canada | Protein Kinase Inhibitors - administration & dosage | Maximum Tolerated Dose | Cytochrome P-450 CYP3A Inhibitors | Cytochrome P-450 CYP3A - metabolism | Pyrimidines - adverse effects | Midazolam - metabolism | Pyrimidines - pharmacokinetics | Sulfonamides - adverse effects | Fluorodeoxyglucose F18 | Aged | Australia | Neoplasm Staging | Neoplasms - pathology | Nonlinear Dynamics | Focal Adhesion Kinase 1 - antagonists & inhibitors | Sulfonamides - administration & dosage | Index Medicus
Journal Article
Journal Article
American Journal of Physiology - Cell Physiology, ISSN 0363-6143, 05/2007, Volume 292, Issue 5, pp. 1701 - 1713
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 07/2016, Volume 22, Issue 8, pp. 851 - 860
.... We identified hyperactivated focal adhesion kinase (FAK) activity in neoplastic PDAC cells as an important regulator of the fibrotic and immunosuppressive TME... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | Index Medicus | FAK | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Journal Article