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Nature Medicine, ISSN 1078-8956, 08/2016, Volume 22, Issue 8, pp. 851 - 860
Single-agent immunotherapy has achieved limited clinical benefit to date in patients with pancreatic ductal adenocarcinoma (PDAC). This may be a result of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | SKIN WOUND REPAIR | DUCTAL ADENOCARCINOMA | DECREASES GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-INFILTRATING MACROPHAGES | 2 KNOCKOUT MICE | ACTIN CYTOSKELETAL REARRANGEMENT | TISSUE STIFFNESS | CELL BIOLOGY | FAK | ANTIGEN RECEPTOR | T-CELLS | Immunohistochemistry | Pancreatic Neoplasms - metabolism | Humans | Carcinoma, Pancreatic Ductal - metabolism | Tumor Microenvironment | Deoxycytidine - pharmacology | Immunoblotting | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Immunotherapy | Antimetabolites, Antineoplastic - pharmacology | Carcinoma, Pancreatic Ductal - immunology | Disease Models, Animal | Tumor Escape - immunology | Immunotherapy, Adoptive - methods | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Pancreatic Neoplasms - pathology | Reverse Transcriptase Polymerase Chain Reaction | Carcinoma, Pancreatic Ductal - pathology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Disease Progression | Animals | Aminopyridines - pharmacology | Pancreatic Neoplasms - immunology | Fibrosis | Cell Proliferation - drug effects | Mice | CD8-Positive T-Lymphocytes - immunology | Deoxycytidine - analogs & derivatives | Molecular targeted therapy | Care and treatment | Pancreatic cancer | Patient outcomes | Innovations | Genetic aspects | Properties | Phosphotransferases | Methods | Kinases | Cell adhesion & migration | Index Medicus | pancreatic cancer | PDAC | CXCL12 | VS-4718 | immunotherapy | fibrosis | tumor microenvironment | PD-1
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, deletion and activation of results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and... 
CELLCYCLE | SIGNALING | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOGENIC K-RAS | CANCER-CELLS | SUPPRESSOR | GENE | ONCOLOGY | SRC | KINASE INHIBITOR | EXPRESSION PROFILES | MUTATIONS | TUMORIGENESIS | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
Journal Article
Cell, ISSN 0092-8674, 09/2015, Volume 163, Issue 1, pp. 160 - 173
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2008, Volume 68, Issue 6, pp. 1935 - 1944
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 4032 - 12
Journal Article
Journal Article
Breast Cancer Research, ISSN 1465-5411, 09/2009, Volume 11, Issue 5, pp. R68 - R68
Introduction Mammary tumorigenesis is associated with the increased expression of several proteins in the focal adhesion complex, including focal adhesion... 
GROWTH-FACTOR-BETA | ONCOLOGY | KINASE FAK | PHOSPHORYLATION | INTEGRIN | BREAST-CANCER PROGRESSION | UP-REGULATION | EXPRESSION | TUMORIGENESIS | CARCINOMA | MAMMARY EPITHELIAL-CELLS | RNA, Small Interfering - genetics | Humans | Quinolones - pharmacology | Mammary Neoplasms, Experimental - metabolism | Sulfones - pharmacology | Cell Movement - physiology | Breast Neoplasms - metabolism | Drug Delivery Systems | Breast Neoplasms - therapy | Mammary Neoplasms, Experimental - pathology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Transforming Growth Factor beta - antagonists & inhibitors | Indoles - pharmacology | p38 Mitogen-Activated Protein Kinases - metabolism | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Mammary Neoplasms, Experimental - therapy | Focal Adhesion Protein-Tyrosine Kinases - genetics | Cell Movement - drug effects | Integrin beta3 - metabolism | Animals | Receptors, Transforming Growth Factor beta - antagonists & inhibitors | Receptors, Transforming Growth Factor beta - metabolism | Breast Neoplasms - pathology | Mice | Mice, Inbred BALB C | RNA, Small Interfering - administration & dosage | Transforming Growth Factor beta - metabolism | Index Medicus | Research article
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 11/2011, Volume 10, Issue 11, pp. 2135 - 2145
Journal Article
Journal Article