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1. Full Text Formulation of Docetaxel by folic acid-conjugated d -α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS2k ) micelles for targeted and synergistic chemotherapy
by Mi, Yu and Liu, Yutao and Feng, Si-Shen
Biomaterials, ISSN 0142-9612, 2011, Volume 32, Issue 16, pp. 4058 - 4066
Abstract Although high efficacy has been showed, Paclitaxel and Docetaxel cause serious side effects due to the adjuvant used in their clinical formulation... 
Advanced Basic Science | Dentistry | Cancer nanotechnology | Pharmaceutical nanotechnology | Drug formulation | Chemotherapeutic engineering | Nanomedicine | Biodegradable polymers | DIBLOCK COPOLYMERS | MATERIALS SCIENCE, BIOMATERIALS | DRUG-DELIVERY | ENGINEERING, BIOMEDICAL | BLOCK-COPOLYMER MICELLES | ENDOCYTOSIS | CANCER | PACLITAXEL | NANOPARTICLES | IN-VITRO | E ANALOGS | Taxoids - chemistry | Cell Survival - drug effects | NIH 3T3 Cells | Taxoids - pharmacology | Humans | Folic Acid - chemistry | Vitamin E - analogs & derivatives | Polyethylene Glycols - chemistry | Taxoids - pharmacokinetics | Microscopy, Confocal | Animals | Micelles | Cell Line, Tumor | Polymers - chemistry | Mice | Vitamin E - chemistry | Nanotechnology
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2. Full Text A binary functional substrate for enrichment and ultrasensitive SERS spectroscopic detection of folic acid using graphene oxide/Ag nanoparticle hybrids
by Ren, Wen and Fang, Youxing and Wang, Erkang
ACS Nano, ISSN 1936-0851, 08/2011, Volume 5, Issue 8, pp. 6425 - 6433
Herein graphene oxide/Ag nanoparticle hybrids (GO/PDDA/AgNPs) were fabricated according to a self-assembly procedure. Using the obtained GO/PDDA/AgNPs as SERS... 
SERS detection | graphene oxide/Ag nanoparticle hybrids | folic acid | serum | GOLD NANOPARTICLES | SEAS detection | MATERIALS SCIENCE, MULTIDISCIPLINARY | SILVER | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | GRAPHITE OXIDE | SCATTERING SPECTROSCOPY | CELL-LINES | CHEMISTRY, MULTIDISCIPLINARY | SURFACE-ENHANCED RAMAN | LABEL-FREE DETECTION | DELIVERY | NANOCOMPOSITES | ACTIVE CATALYSTS | Humans | Metal Nanoparticles - chemistry | Oxides - chemistry | Folic Acid - chemistry | Silver - chemistry | Spectrum Analysis, Raman - methods | Quaternary Ammonium Compounds - chemistry | Static Electricity | Folic Acid - analysis | Surface Properties | Folic Acid - blood | Water - chemistry | Graphite - chemistry | Polyethylenes - chemistry | Enrichment | Nanoparticles | Self assembly | Silver | Graphene | Oxides | Nanostructure | Serums | Folic acid
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3. Full Text Encapsulation of folic acid in food hydrocolloids through nanospray drying and electrospraying for nutraceutical applications
by Pérez-Masiá, Rocío and López-Nicolás, Rubén and Periago, Maria Jesús and Ros, Gaspar and Lagaron, Jose M and López-Rubio, Amparo
Food Chemistry, ISSN 0308-8146, 02/2015, Volume 168, pp. 124 - 133
In this work, two different technologies (electrospraying and nanospray drying) were evaluated for the encapsulation of folic acid using both a whey protein... 
Encapsulation | Spray drying | Food hydrocolloids | Electrospraying | Folic acid | SOY PROTEIN | STABILITY | FOOD SCIENCE & TECHNOLOGY | MICROPARTICLES | INGREDIENTS | DELIVERY | NUTRITION & DIETETICS | MICROCAPSULES | CHEMISTRY, APPLIED | Chemistry, Pharmaceutical - instrumentation | Whey Proteins - chemistry | Colloids - chemistry | Starch - chemistry | Chemistry, Pharmaceutical - methods | Folic Acid - chemistry | Capsules - chemistry | Dietary Supplements - analysis | Functional foods
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4. Full Text Structural basis for molecular recognition of folic acid by folate receptors
by Chen, Chen and Ke, Jiyuan and Edward Zhou, X and Yi, Wei and Brunzelle, Joseph S and Li, Jun and Yong, Eu-Leong and Xu, H. Eric and Melcher, Karsten and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature, ISSN 0028-0836, 2013, Volume 500, Issue 7463, pp. 486 - 489
Folate receptors (FR alpha, FR beta and FR gamma) are cysteine-rich cell-surface glycoproteins that bind folate with high affinity to mediate cellular uptake... 
CHEMISTRY | CELLS | DIFFRACTION | CONJUGATE | TISSUES | MULTIDISCIPLINARY SCIENCES | Humans | Folic Acid - chemistry | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Binding Sites - genetics | Folate Receptor 1 - chemistry | Folate Receptor 1 - genetics | Folate Receptor 1 - metabolism | Folic Acid - metabolism | Protein Binding | Ligands | Mutation | Proteins | Research | Properties | Structure | Cellular control mechanisms | Testing | Hydrogen bonds | Vitamin B | Chromatography
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5. Full Text Photocontrolled targeted drug delivery: Photocaged biologically active folic acid as a light-responsive tumor-targeting molecule
by Fan, Nien-Chu and Cheng, Fong-Yu and Ho, Ja-An Annie and Yeh, Chen-Sheng
Angewandte Chemie - International Edition, ISSN 1433-7851, 08/2012, Volume 51, Issue 35, pp. 8806 - 8810
Light-controlled: Biodegradable nanoparticles encapsulating an anticancer drug (red dots in picture) have been synthesized that carry photocaged folate groups... 
photocaging | nanoparticles | drug delivery | prodrugs | cytotoxicity | GOLD NANOPARTICLES | CANCER-CELLS | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | LINES | CHEMISTRY | TISSUES | FOLATE RECEPTOR ISOFORMS | Cell Survival - drug effects | Paclitaxel - chemistry | Lipids - chemistry | Paclitaxel - toxicity | Ultraviolet Rays | Nanoparticles - chemistry | Humans | Folic Acid - chemistry | Cell Line, Tumor | Polyglactin 910 - chemistry | Drug Carriers - chemistry | Drugs | Drug delivery systems | Folic acid | Vehicles | Nanoparticles | Uptakes | Cellular | Receptors | Biodegradability | Surface chemistry | Encapsulating
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6. Full Text Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers
by Park, Joonyoung and Brust, Tarsis F and Lee, Hong Jae and Lee, Sang Cheon and Watts, Val J and Yeo, Yoon
ACS Nano, ISSN 1936-0851, 04/2014, Volume 8, Issue 4, pp. 3347 - 3356
The surface of a polymeric nanoparticle (NP) is often functionalized with cell-interactive ligands and/or additional polymeric layers to control NP interaction... 
drug delivery | polymeric nanoparticles | surface modification | cell-nanoparticle interactions | dopamine polymerization | GENE DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | CONJUGATED NANOPARTICLES | NANOSCIENCE & NANOTECHNOLOGY | PLGA-PEG NANOPARTICLES | TUMORS | CHEMISTRY, MULTIDISCIPLINARY | CANCER-THERAPY | IMMOBILIZATION | LIPID NANOPARTICLE | FUNCTIONALIZATION | IN-VIVO | MUSSEL-INSPIRED POLYDOPAMINE | Drug Carriers - metabolism | Polylactic Acid-Polyglycolic Acid Copolymer | Lactic Acid | Humans | KB Cells | Polyglycolic Acid | Folic Acid - chemistry | Drug Carriers - toxicity | Indoles - toxicity | Polymethacrylic Acids - chemistry | Drug Carriers - chemistry | Nanoparticles | Particle Size | Betaine - chemistry | Indoles - metabolism | Biological Transport | Surface Properties | Polymers - toxicity | Polymers - chemistry | Safety | Indoles - chemistry | Oligopeptides - chemistry | Polymers - metabolism | Index Medicus | Carriers | Carriers, Drug | Drugs | Dopamine | Addition polymerization | Polymerization | Ligands | Nanostructure | Polymeric nanoparticles | cell-nanoparticle interaction
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7. Full Text Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
by Lee, Hyukjin and Lytton-Jean, Abigail K. R and Chen, Yi and Love, Kevin T and Park, Angela I and Karagiannis, Emmanouil D and Sehgal, Alfica and Querbes, William and Zurenko, Christopher S and Jayaraman, Muthusamy and Peng, Chang G and Charisse, Klaus and Borodovsky, Anna and Manoharan, Muthiah and Donahoe, Jessica S and Truelove, Jessica and Nahrendorf, Matthias and Langer, Robert and Anderson, Daniel G
Nature Nanotechnology, ISSN 1748-3387, 2012, Volume 7, Issue 6, pp. 389 - 393
Nanoparticles are used for delivering therapeutics into cells(1,2). However, size, shape, surface chemistry and the presentation of targeting ligands on the... 
NANOSCIENCE & NANOTECHNOLOGY | DESIGN | RNAI THERAPEUTICS | GENE | DRUG-DELIVERY | MATERIALS SCIENCE, MULTIDISCIPLINARY
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8. Full Text Evaluation of folic acid release from spray dried powder particles of pectin-whey protein nano-capsules
by Assadpour, Elham and Jafari, Seid-Mahdi and Maghsoudlou, Yahya
International Journal of Biological Macromolecules, ISSN 0141-8130, 02/2017, Volume 95, pp. 238 - 247
Our main goal was to evaluate release kinetics of nano-encapsulated folic acid within a double W /O/W emulsion. First, W /O nano-emulsions loaded with folic... 
Nano-encapsulation | Release | Folic acid | DOUBLE EMULSIONS | POLYMER SCIENCE | MALTODEXTRIN | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DELIVERY-SYSTEMS | ENCAPSULATION | EMULSIFICATION | OIL | PROGRESS | CHEMISTRY, APPLIED | GUM | EXTRACT | Particle Size | Whey Proteins - chemistry | Powders | Folic Acid - chemistry | Water - chemistry | Drug Liberation | Oils - chemistry | Nanocapsules - chemistry | Drug Carriers - chemistry | Pectins - chemistry | Milk proteins | Pectin | Analysis
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9. Full Text Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy
by Qin, X.C and Guo, Z.Y and Liu, Z.M and Zhang, W and Wan, M.M and Yang, B.W
Journal of Photochemistry & Photobiology, B: Biology, ISSN 1011-1344, 03/2013, Volume 120, pp. 156 - 162
â–º We investigated functionalized NGO for cancer targeted chemo-photothermal therapy. â–º We developed FA–NGO–PVP loading with doxorubicine (DOX). â–º FA–NGO–PVP... 
Photothermal therapy | Chemotherapy | Graphene oxide | Targeting | Cancer | DRUG-DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RENAL-FUNCTION | ANTICANCER DRUG | GRAPHITE OXIDE | CARBON NANOTUBES | ARSENIC TRIOXIDE | CELL LUNG-CANCER | NANOPARTICLES | IN-VITRO | BIOPHYSICS | Folic Acid Transporters - metabolism | Doxorubicin - therapeutic use | Drug Carriers - metabolism | Humans | Oxides - chemistry | Folic Acid - chemistry | Antineoplastic Agents - therapeutic use | Doxorubicin - chemistry | Hot Temperature | Antineoplastic Agents - chemistry | Drug Carriers - chemistry | Neoplasms - drug therapy | Povidone - chemistry | Biological Transport | Folic Acid - metabolism | Nanostructures - chemistry | Neoplasms - radiotherapy | Graphite - chemistry | HeLa Cells | Neoplasms - pathology | Molecular Targeted Therapy - methods | Graphene | Folic acid | Graphite | Non-governmental organizations
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10. Full Text Folic acid-functionalized fluorescent gold nanoclusters with polymers as linkers for cancer cell imaging
by Qiao, Juan and Mu, Xiaoyu and Qi, Li and Deng, Jingjing and Mao, Lanqun
Chemical Communications, ISSN 1359-7345, 09/2013, Volume 49, Issue 73, pp. 8030 - 8032
A novel nano-conjugate containing ultrasmall water-soluble AuNCs protected by ovalbumin as the fluorescent part, folic acid as the targeting ligand and a... 
VITRO | DRUG | NANOPARTICLES | IN-VIVO | TISSUES | CHEMISTRY, MULTIDISCIPLINARY | LINES | FOLATE | DELIVERY | Gold - chemistry | Fluorescent Dyes - chemistry | Humans | Metal Nanoparticles - chemistry | Folic Acid - chemistry | Molecular Imaging | Spectroscopy, Fourier Transform Infrared | Drug Delivery Systems | Neoplasms - chemistry | Staining and Labeling | Polymers - chemistry | Molecular Structure | HeLa Cells | Microscopy, Fluorescence | Gold | Nanocomposites | Nanomaterials | Ligands | Nanostructure | Polymers | Folic acid | Cancer
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11. Full Text Dual targeting folate-conjugated hyaluronic acid polymeric micelles for paclitaxel delivery
by Liu, Yanhua and Sun, Yinghua and Sun, Jin and Cao, Wen and Yang, Jianhong and Lian, He and Li, Xin and Wang, Yongjun and Wang, Siling and He, Zhonggui
International Journal of Pharmaceutics, ISSN 0378-5173, 12/2011, Volume 421, Issue 1, pp. 160 - 169
A series of novel self-assembled hyaluronic acid derivatives (HA-C ) grafted with hydrophobic octadecyl moiety and further dual targeting folic acid-conjugated... 
Folate-hyaluronic acid-octadecyl | Hyaluronic acid | Polymeric micelles | Paclitaxel | Hyaluronic acid-octadecyl | DOXORUBICIN | CHITOSAN NANOPARTICLES | BIODISTRIBUTION | ANTITUMOR-ACTIVITY | CARRIER | IN-VITRO | PHARMACOKINETICS | SYSTEMS | PHARMACOLOGY & PHARMACY | DERIVATIVES | LIPOSOMES | Polymers - administration & dosage | Humans | Drug Carriers - administration & dosage | Glycerol - administration & dosage | Folic Acid - administration & dosage | Drug Carriers - chemistry | Paclitaxel - chemistry | Antineoplastic Agents, Phytogenic - administration & dosage | MCF-7 Cells | Micelles | Hyaluronan Receptors - metabolism | Glycerol - analogs & derivatives | Glycerol - chemistry | Paclitaxel - administration & dosage | Cell Survival - drug effects | Hyaluronic Acid - administration & dosage | Endocytosis - drug effects | Folic Acid - chemistry | Hyaluronic Acid - chemistry | Antineoplastic Agents, Phytogenic - chemistry | Folate Receptors, GPI-Anchored - metabolism | Endocytosis - physiology | Nanostructures - administration & dosage | Cell Line, Tumor | Nanostructures - chemistry | Polymers - chemistry | Antimitotic agents | Antineoplastic agents | Folic acid
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12. Full Text Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells
by Yang, Shu-Jyuan and Lin, Feng-Huei and Tsai, Kun-Che and Wei, Ming-Feng and Tsai, Han-Min and Wong, Jau-Min and Shieh, Ming-Jium
Bioconjugate Chemistry, ISSN 1043-1802, 04/2010, Volume 21, Issue 4, pp. 679 - 689
Folic acid can be covalently conjugated to chitosan molecules via its gamma-carboxyl moiety and thus retain a high affinity for colorectal cancer cells hearing... 
GENE DELIVERY | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | RELEASE | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | THERAPY | FLUORESCENCE | 5-AMINOLEVULINIC ACID | ANTICANCER DRUGS | CARCINOMA | FOLATE | Caco-2 Cells | Aminolevulinic Acid - chemistry | Folate Receptors, GPI-Anchored | Nanoparticles - chemistry | Humans | Folic Acid - chemistry | Receptors, Cell Surface - metabolism | Protoporphyrins - metabolism | Carrier Proteins - metabolism | Chitosan - chemistry | Aminolevulinic Acid - metabolism | Cell Line, Tumor | Folic Acid - metabolism | Protoporphyrins - chemistry | Colorectal Neoplasms - pathology | Chitosan - metabolism | Colorectal Neoplasms - metabolism
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13. Full Text Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases
by Low, Philip S and Henne, Walter A and Doorneweerd, Derek D
Accounts of Chemical Research, ISSN 0001-4842, 01/2008, Volume 41, Issue 1, pp. 120 - 129
In order to avoid the toxicities associated with prescription drug use today, we have explored novel methods for delivering drugs selectively to pathologic... 
RHEUMATOID-ARTHRITIS | COLLAGEN-INDUCED ARTHRITIS | MEDIATED GENE-THERAPY | IN-VITRO | INTRACELLULAR DRUG-DELIVERY | FOLATE-BINDING PROTEIN | BIOLOGICAL EVALUATION | CULTURED KB CELLS | ACTIVATED MACROPHAGES | ENDOCYTOSIS | CHEMISTRY, MULTIDISCIPLINARY | Folate Receptors, GPI-Anchored | Humans | Folic Acid - chemistry | Antineoplastic Agents - therapeutic use | Neoplasms - diagnosis | Autoimmune Diseases - diagnosis | Antineoplastic Agents - chemistry | Carrier Proteins - drug effects | Neoplasms - drug therapy | Anti-Inflammatory Agents - chemistry | Receptors, Cell Surface - drug effects | Drug Design | Anti-Inflammatory Agents - therapeutic use | Carrier Proteins - chemistry | Receptors, Cell Surface - chemistry | Autoimmune Diseases - drug therapy | Drugs | Product development | Research | Folic acid
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14. Full Text Electrochemical quantification of some water soluble vitamins in commercial multi-vitamin using poly-amino acid caped by graphene quantum dots nanocomposite as dual signal amplification elements
by Shadjou, Nasrin and Hasanzadeh, Mohammad and Omari, Ali
Analytical Biochemistry, ISSN 0003-2697, 12/2017, Volume 539, pp. 70 - 80
Rapid analyses of some water soluble vitamins (Vitamin B2, B9, and C) in commercial multi vitamins could be routinely performed in analytical laboratories.... 
Poly amino acid | Aspartic acid | Graphene quantum dot | Vitamin | Biocompatible polymer | Sensor | CHEMISTRY, ANALYTICAL | GQD NANOCOMPOSITE | HUMAN PLASMA | FILM | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLASSY-CARBON ELECTRODE | CHITOSAN | BIOCHEMICAL RESEARCH METHODS | PHYSIOLOGICAL PH | C DETERMINATION | DOXORUBICIN HYDROCHLORIDE | BETA-CYCLODEXTRIN | Limit of Detection | Riboflavin - chemistry | Ascorbic Acid - analysis | Oxidation-Reduction | Peptides - chemistry | Vitamins - analysis | Vitamins - chemistry | Folic Acid - chemistry | Riboflavin - analysis | Carbon - chemistry | Electrodes | Folic Acid - analysis | Quantum Dots - chemistry | Water - chemistry | Ascorbic Acid - chemistry | Nanostructures - chemistry | Tablets - chemistry | Electrochemical Techniques - methods | Graphite - chemistry | Usage | Graphene | Analysis | Graphite | Aspartate | Sensors | Polymers | Vitamins | Electric properties | Index Medicus
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15. Full Text Engineering folate-drug conjugates to target cancer: From chemistry to clinic
by Vlahov, Iontcho R and Leamon, Christopher P
Bioconjugate Chemistry, ISSN 1043-1802, 07/2012, Volume 23, Issue 7, pp. 1357 - 1369
The folate receptor (FR) is a potentially useful biological target for the management of many human cancers. This membrane protein binds extracellular folates... 
VINCA ALKALOID CONJUGATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | RECEPTOR | TUMOR-CELLS | ENDOCYTOSIS | FOLIC-ACID | CHEMISTRY, MULTIDISCIPLINARY | DELIVERY | IN-VITRO | BIOLOGICAL-ACTIVITY | REGIOSELECTIVE SYNTHESIS | NEW-GENERATION | Neoplasms - metabolism | Antineoplastic Combined Chemotherapy Protocols - metabolism | Antineoplastic Combined Chemotherapy Protocols - chemistry | Humans | Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics | Folic Acid - chemistry | Folate Receptors, GPI-Anchored - metabolism | Folic Acid - pharmacokinetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Drug Delivery Systems | Neoplasms - drug therapy | Animals | Models, Biological | Protein Engineering | Folic Acid - metabolism
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