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PLoS One, ISSN 1932-6203, 2012, Volume 7, Issue 5, p. e37933
Journal Article
European Journal of Clinical Pharmacology, ISSN 0031-6970, 10/2011, Volume 67, Issue 10, pp. 993 - 1006
The objectives of this study were (1) to develop a population pharmacokinetic model of high-dose methotrexate (HD-MTX) in children with acute lymphoblastic... 
Population pharmacokinetics | Pharmacogenetics | Biomedicine | Toxicity | Acute lymphoblastic leukaemia | Children | Pharmacology/Toxicology | Methotrexate | THYMIDYLATE SYNTHASE | HIGH-DOSE METHOTREXATE | CARRIER GENE | RHEUMATOID-ARTHRITIS PATIENTS | METHYLENETETRAHYDROFOLATE REDUCTASE | BREAST-CANCER | METHIONINE SYNTHASE REDUCTASE | BFM 90 | PHARMACOLOGY & PHARMACY | PLASMA HOMOCYSTEINE | Antimetabolites, Antineoplastic - pharmacokinetics | Humans | Methotrexate - pharmacokinetics | Child, Preschool | Male | Lymphoma - metabolism | Thrombocytopenia - genetics | Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy | Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism | Lymphoma - drug therapy | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Female | Retrospective Studies | Odds Ratio | Lymphoma - genetics | Reduced Folate Carrier Protein - genetics | Genotype | Methotrexate - blood | Polymorphism, Genetic | Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics | Methotrexate - adverse effects | Metabolic Networks and Pathways | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Antimetabolites, Antineoplastic - adverse effects | Folic Acid - metabolism | ATP Binding Cassette Transporter, Sub-Family B | Mucositis - genetics | Folic Acid - genetics | Nonlinear Dynamics | Analysis | Genetic research | Lymphomas | Genetic aspects | Dosage and administration | Universities and colleges | Folic acid | Leukemia | Genetics | Pharmacology | Drug therapy | Children & youth | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 6, p. e21102
Background: One-carbon metabolism appears to play an important role in DNA methylation reaction. Evidence suggests that a low intake of B vitamins or high... 
POPULATION-BASED SAMPLE | DNA METHYLATION | METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | SPORADIC COLORECTAL-CANCER | MGMT PROMOTER METHYLATION | MULTIVITAMIN USE | COMPETING RISKS | DIETARY-FOLATE | ONE-CARBON METABOLISM | MutL Protein Homolog 1 | Colonic Neoplasms - genetics | Folic Acid - pharmacology | Humans | Middle Aged | Suppressor of Cytokine Signaling 1 Protein | Methionine - pharmacology | Folic Acid - administration & dosage | Receptors, Retinoic Acid - genetics | Poly-ADP-Ribose Binding Proteins | Insulin-Like Growth Factor II - genetics | Polymerase Chain Reaction | Cell Cycle Proteins - genetics | Adult | Female | Surveys and Questionnaires | Calcium Channels, T-Type - genetics | Neoplasm Proteins - genetics | Nuclear Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Risk Factors | Colonic Neoplasms - epidemiology | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Suppressor of Cytokine Signaling Proteins - genetics | DNA Methylation - genetics | Methionine - administration & dosage | Nerve Tissue Proteins - genetics | Ubiquitin-Protein Ligases | Proto-Oncogene Proteins B-raf - genetics | Adaptor Proteins, Signal Transducing - genetics | Core Binding Factor Alpha 3 Subunit - genetics | CpG Islands - genetics | Mutation | DNA Methylation - drug effects | Kruppel-Like Transcription Factors - genetics | Oncology, Experimental | Amino acids | Drinking of alcoholic beverages | Research | Epidemiology | Risk factors | Folic acid | Colon cancer | Gene mutations | Gastrointestinal diseases | Nurses | Physiological aspects | Genetic aspects | Methylation | Cancer | Colorectal carcinoma | Colorectal cancer | DNA methylation | Insulin-like growth factor-binding protein 3 | Nutrients | Colon | Insulin-like growth factor II | Deoxyribonucleic acid--DNA | CpG islands | Medical personnel | Statistical analysis | MLH1 protein | Health risks | Methionine | Metabolism | Carbon | Low level | Vitamins | Alcoholic beverages | Health risk assessment | Vitamin B6 | Runx3 protein | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 05/2017, Volume 127, Issue 5, pp. 1856 - 1872
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, p. e0193298
Background Pancreatic cancer is the third leading cause of cancer related deaths in the United States. Several dietary factors have been identified that modify... 
METHYLENETETRAHYDROFOLATE REDUCTASE | MICROBIOLOGICAL ASSAY | SYNTHASE D919G POLYMORPHISM | DNA STRAND BREAKS | DUCTAL ADENOCARCINOMA | NEURAL-TUBE DEFECTS | THYMIDYLATE SYNTHASE | MULTIDISCIPLINARY SCIENCES | COMMON MUTATION | PLASMA HOMOCYSTEINE | FOLIC-ACID | Pancreatic Neoplasms - blood | United States | Humans | Middle Aged | Risk Factors | Male | Pancreatic Neoplasms - genetics | Neoplasm Proteins - metabolism | Alleles | Erythrocytes - metabolism | Folic Acid - blood | Aged, 80 and over | Adult | Female | Aged | Polymorphism, Single Nucleotide | Folic Acid - genetics | Neoplasm Proteins - genetics | Care and treatment | Pancreatic cancer | Physiological aspects | Development and progression | Genetic aspects | Research | Single nucleotide polymorphisms | Folic acid | Dehydrogenases | Choline dehydrogenase | Serine | Genes | Methyltransferase | Risk | Biosynthesis | Methylenetetrahydrofolate reductase | Single-nucleotide polymorphism | Autophagy | Blood | Confidence intervals | Red blood cells | Vitamin B | DNA methylation | Genetic factors | Genotypes | Public health | Deoxyribonucleic acid--DNA | Tetrahydrofolic acid | Ethanolamine | Statistical analysis | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Nutrition | Health risks | Environmental health | Methionine | Metabolism | Variance analysis | Studies | Diet | Medical prognosis | Choline | Biomarkers | Health risk assessment | Homocysteine | Cancer | Deoxyribonucleic acid | DNA
Journal Article
2002, ISBN 0896039366, xii, 359
Book
Journal Article
Journal Article