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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2008, Volume 105, Issue 26, pp. 9059 - 9064
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2015, Volume 58, Issue 17, pp. 6938 - 6959
Journal Article
Journal Article
PLoS Biology, ISSN 1544-9173, 06/2017, Volume 15, Issue 6, p. e2001644
Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,000 each year in the United States alone despite the widespread use of... 
GRAM-NEGATIVE BACTERIA | ANTIMICROBIAL DRUG | ANTIBACTERIAL ACTIVITY | COMBINATION THERAPY | PLASMODIUM-FALCIPARUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI K-12 | BIOLOGY | NUCLEOSIDE DIPHOSPHATE KINASE | VIVO ZEBRAFISH ASSAYS | SOS RESPONSE | FLUCTUATION ANALYSIS | Trimethoprim - chemistry | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Embryo, Nonmammalian - drug effects | Reverse Transcriptase Inhibitors - chemistry | Anti-Infective Agents, Urinary - therapeutic use | Biological Assay | Trimethoprim - agonists | Anti-Infective Agents, Urinary - chemistry | Anti-Infective Agents, Urinary - pharmacology | Escherichia coli Infections - drug therapy | Bacterial Proteins - antagonists & inhibitors | Computational Biology | Trimethoprim - therapeutic use | Mutation Rate | Escherichia coli Infections - metabolism | Drug Synergism | Small Molecule Libraries | Klebsiella pneumoniae - growth & development | Anti-Bacterial Agents - pharmacology | Mutation | Folic Acid Antagonists - pharmacology | Folic Acid Antagonists - chemistry | Trimethoprim - pharmacology | Sulfamethizole - agonists | Embryo, Nonmammalian - metabolism | Klebsiella Infections - metabolism | Reverse Transcriptase Inhibitors - pharmacology | Zebrafish - embryology | Folic Acid Antagonists - therapeutic use | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Sulfamethizole - chemistry | Anti-Bacterial Agents - chemistry | Drug Resistance, Multiple, Bacterial | Sulfamethizole - pharmacology | Drug Design | Escherichia coli - metabolism | Sulfamethizole - therapeutic use | Escherichia coli - growth & development | Klebsiella pneumoniae - metabolism | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination | Klebsiella Infections - drug therapy | Bacterial Proteins - genetics | Escherichia coli Infections - microbiology | Embryo, Nonmammalian - microbiology | Klebsiella Infections - microbiology | Animals | High-Throughput Screening Assays | Bacterial Proteins - metabolism | Pattern Recognition, Automated | Klebsiella | Virulence | Homeostasis | Trimethoprim | Hydroxyurea | Identification | Biosynthesis | Infections | Urinary tract | Drug resistance | Drug development | Synergism | Folic acid | Design | Immunology | Historical account | E coli | New combinations | Antibiotic resistance | Bacteria | Libraries | Deoxyribonucleic acid--DNA | Effectiveness | Bacterial infections | Mutants | Medicine | DNA biosynthesis | Pathology | Sulfamethizole | Antibiotics | Collection | AZT | Zidovudine | Bypasses | Methods | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Biochemistry, ISSN 0006-2960, 02/2016, Volume 55, Issue 7, pp. 1107 - 1119
Mycobacterium tuberculosis (Mtb) Rv2671 is annotated as a 5-amino-6-ribitylamino-2,4­(1H,3H)-pyrimidinedione 5′-phosphate (AROPP) reductase (RibD) in the... 
RIBOFLAVIN | BIFUNCTIONAL DEAMINASE | TRANSITION STRUCTURES | CRYSTAL-STRUCTURE | BIOSYNTHESIS | REFSEQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | KINETIC MECHANISM | ANTIFOLATE | HYDRIDE TRANSFER | Folic Acid Antagonists - chemistry | Trimethoprim - chemistry | Antitubercular Agents - chemistry | Trimethoprim - pharmacology | Tetrahydrofolate Dehydrogenase - chemistry | Molecular Conformation | Bacterial Proteins - chemistry | Drug Resistance, Bacterial | Phylogeny | Trimethoprim - metabolism | Mycobacterium tuberculosis - drug effects | NADP - chemistry | Enzyme Inhibitors - chemistry | NADP - metabolism | Trimetrexate - metabolism | Recombinant Proteins - metabolism | Bacterial Proteins - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - metabolism | Nucleotide Deaminases - chemistry | Trimetrexate - chemistry | Nucleotide Deaminases - metabolism | Antitubercular Agents - pharmacology | Bacterial Proteins - genetics | Enzyme Inhibitors - pharmacology | Models, Molecular | Recombinant Proteins - chemistry | Trimetrexate - pharmacology | Tetrahydrofolate Dehydrogenase - metabolism | Tetrahydrofolates - metabolism | Folic Acid Antagonists - metabolism | Nucleotide Deaminases - antagonists & inhibitors | Nucleotide Deaminases - genetics | Mycobacterium tuberculosis - enzymology | Aminosalicylic Acid - pharmacology | Bacterial Proteins - metabolism | Ligands | Tetrahydrofolates - chemistry | Kinetics | Antitubercular Agents - metabolism | Folic Acid Antagonists - pharmacology | Mycobacterium tuberculosis - growth & development | Tetrahydrofolate Dehydrogenase - genetics | Mycobacterium tuberculosis | Bacterial proteins | Research | Catalysis | Dihydrofolate reductase | Chemical properties | Structure
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 32, pp. 13449 - 13458
Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival.... 
TARGET | IN-VITRO | COMPLEX | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | ANTIFOLATE | INTRACELLULAR STABILITY | INHIBITORS | BINDING | CANCER-THERAPY | Catalytic Domain - drug effects | Folic Acid Antagonists - chemistry | Humans | Protein Conformation - drug effects | Crystallography, X-Ray | Thiophenes - metabolism | Quinazolines - metabolism | Protein Folding - drug effects | Deoxyuracil Nucleotides - metabolism | Binding Sites | Dimerization | Peptide Fragments - genetics | Quinazolines - chemistry | Recombinant Proteins - metabolism | Peptide Fragments - metabolism | Deoxyuracil Nucleotides - chemistry | Mutagenesis, Site-Directed | Allosteric Site - drug effects | Enzyme Stability | Models, Molecular | Recombinant Proteins - chemistry | Thiophenes - pharmacology | Thymidylate Synthase - metabolism | Enzyme Activation - drug effects | Thymidylate Synthase - genetics | Peptide Fragments - chemistry | Folic Acid Antagonists - metabolism | Peptide Fragments - antagonists & inhibitors | Thymidylate Synthase - chemistry | Ligands | Mutation | Thymidylate Synthase - antagonists & inhibitors | Quinazolines - pharmacology | Thiophenes - chemistry | Folic Acid Antagonists - pharmacology | Amino Acid Substitution | Protein Structure and Folding | crystallography | nucleotide | DNA synthesis | thymidylate synthase | drug resistance | conformational change | antifolate
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 8, pp. 2849 - 2863
Journal Article