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1. Full Text Folic acid deficiency and vision: a review
by Sijilmassi, Ouafa
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 8/2019, Volume 257, Issue 8, pp. 1573 - 1580
Folic acid (FA), also termed folate, is an essential vitamin for health at all ages since it participates in the biosynthesis of nucleotides, amino acids,... 
Folate receptors | Folic acid deficiency | Eye disease | Ophthalmology | Medicine & Public Health | HOMOCYSTEINE | MACROPHAGES | FUNCTIONAL-CHARACTERIZATION | BETA | ERYTHROCYTE FOLATE | REGULATORY T-CELLS | OPHTHALMOLOGY | HEREDITARY OPTIC NEUROPATHY | MEMBRANE-TRANSPORT | EXPRESSION | FOLATE RECEPTOR-ALPHA | Carrier proteins | Physiological aspects | Amino acids | Eye diseases | Nucleotides | Folic acid | Literature reviews | Neurotransmitters | Vitamin B | Fetuses | Vitamins
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2. Full Text The neurology of folic acid deficiency
by Reynolds, E.H
2014, ISBN 0702040878, Volume 120
The metabolism of folic acid and the metabolism of vitamin B are intimately linked such that deficiency of either vitamin leads to an identical megaloblastic... 
Megaloblastic anemia | methylation | neuropathy | dementia | vitamin B12 | depression | aging | folic acid | Aging | Depression | Neuropathy | Methylation | Folic acid | Dementia | Neurology | Folic Acid Deficiency - complications | Mental Disorders - therapy | Humans | Nervous System Diseases - etiology | Mental Disorders - diagnosis | Mental Disorders - etiology | Nervous System Diseases - diagnosis | Nervous System Diseases - therapy
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3. Full Text Intergenerational impact of paternal lifetime exposures to both folic acid deficiency and supplementation on reproductive outcomes and imprinted gene methylation
by Ly, Lundi and Chan, Donovan and Aarabi, Mahmoud and Landry, Mylène and Behan, Nathalie A and MacFarlane, Amanda J and Trasler, Jacquetta
Molecular Human Reproduction, ISSN 1360-9947, 07/2017, Volume 23, Issue 7, pp. 461 - 477
Do paternal exposures to folic acid deficient (FD), and/or folic acid supplemented (FS) diets, throughout germ cell development adversely affect male germ... 
Sperm | DNA methylation | Epigenetics | Developmental programming | Paternal effects | Male-mediated | Intergenerational effects | Folate | Folic acid | paternal effects | intergenerational effects | NEURAL-TUBE DEFECTS | FOLATE METABOLISM | MOUSE EMBRYOS | TESTICULAR CANCER | PLACENTAL DEVELOPMENT | sperm | male-mediated | DEVELOPMENTAL BIOLOGY | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE | epigenetics | OBSTETRICS & GYNECOLOGY | folate | REPRODUCTIVE BIOLOGY | SINGLE-BASE RESOLUTION | PREGNANCY OUTCOMES | folic acid | DIETARY-FOLATE | developmental programming | Folic Acid Deficiency - metabolism | Genomic Imprinting | Spermatogenesis - genetics | Embryo, Mammalian | Weaning | Epigenesis, Genetic | Male | Spermatozoa - metabolism | snRNP Core Proteins - metabolism | Folic Acid - administration & dosage | Kruppel-Like Transcription Factors - metabolism | Female | snRNP Core Proteins - genetics | Folic Acid Deficiency - genetics | Animals, Newborn | Spermatogenesis - drug effects | Reproduction - genetics | Spermatozoa - growth & development | RNA, Long Noncoding - genetics | Prenatal Exposure Delayed Effects - physiopathology | Spermatozoa - drug effects | Prenatal Exposure Delayed Effects - metabolism | Folic Acid Deficiency - physiopathology | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Reproduction - drug effects | Animals | Prenatal Exposure Delayed Effects - mortality | Survival Analysis | Folic Acid Deficiency - mortality | Mice | DNA Methylation - drug effects | Dietary Supplements | Kruppel-Like Transcription Factors - genetics | RNA, Long Noncoding - metabolism | Original Research
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4. Full Text Folic acid deficiency induces premature hearing loss through mechanisms involving cochlear oxidative stress and impairment of homocysteine metabolism
by Martínez-Vega, Raquel and Garrido, Francisco and Partearroyo, Teresa and Cediel, Rafael and Zeisel, Steven H and Martínez-Álvarez, Concepción and Varela-Moreiras, Gregorio and Varela-Nieto, Isabel and Pajares, María A
FASEB Journal, ISSN 0892-6638, 02/2015, Volume 29, Issue 2, pp. 418 - 432
Nutritional imbalance is emerging as a causative factor of hearing loss. Epidemiologic studies have linked hearing loss to elevated plasma total homocysteine... 
Dietary restriction | Hyperhomocysteinemia | Hair cell loss | Methionine cycle | Apoptosis | methionine cycle | hyperhomocysteinemia | INNER-EAR | S-METHYLTRANSFERASE | GUINEA-PIG COCHLEA | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | apoptosis | NOISE | GLUTATHIONE SYNTHESIS | CELL BIOLOGY | hair cell loss | REACTIVE OXYGEN | ADENOSINE KINASE | BIOLOGY | MICE | METHIONINE METABOLISM | dietary restriction | Hair Cells, Auditory - cytology | Oxidative Stress | Hearing Loss - etiology | Homocysteine - metabolism | Chromatography, High Pressure Liquid | Hyperhomocysteinemia - physiopathology | Homocysteine - deficiency | Female | Glutathione Synthase - metabolism | In Situ Nick-End Labeling | Glutathione Peroxidase - metabolism | Hearing Loss - physiopathology | Oxidation-Reduction | Methionine - metabolism | Mice, Inbred C57BL | Cochlea - physiopathology | Mice, Transgenic | Folic Acid Deficiency - physiopathology | Catalase - metabolism | Animals | Folic Acid Deficiency - complications | Folic Acid - blood | Mice | Hyperhomocysteinemia - complications | Betaine-Homocysteine S-Methyltransferase - genetics | Research Communication
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5. Full Text Alteration of lens and retina textures from mice embryos with folic acid deficiency: image processing analysis
by Sijilmassi, Ouafa and López-Alonso, José Manuel and Barrio Asensio, María Del Carmen and Del Río Sevilla, Aurora
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN 0721-832X, 1/2019, Volume 257, Issue 1, pp. 111 - 123
Folic acid (FA) is an essential vitamin for embryonic development. It plays particularly a critical role in RNA, DNA and protein synthesis. On the other hand,... 
Laminin-1 | Medicine & Public Health | Folic acid deficiency | Retina | Matlab texture analysis | Lens | Ophthalmology | Type IV collagen | LOCALIZATION | LAMININ | IV COLLAGEN | MOUSE | ADHESION | EPITHELIAL-CELLS | MESSENGER-RNA | FIBRONECTIN | OPHTHALMOLOGY | EXTRACELLULAR-MATRIX | BRAIN | Immunohistochemistry | Grain size | Segmentation | Transcription | Image processing | Protein biosynthesis | Ribonucleic acid--RNA | Folic acid | DNA biosynthesis | Embryogenesis | Laminin | Collagen | Collagen (type IV) | Deoxyribonucleic acid--DNA | Eye lens
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6. Full Text Folic acid deficiency increases brain cell injury via autophagy enhancement after focal cerebral ischemia
by Zhao, Yaqian and Huang, Guowei and Chen, Shuang and Gou, Yun and Dong, Zhiping and Zhang, Xumei
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 12/2016, Volume 38, pp. 41 - 49
Folic acid (FA) deficiency is not only associated with an increased risk of ischemic stroke, but also with increased oxidative DNA damage and brain injury... 
Oxidative stress | Folic acid deficiency | Autophagy | Cerebral ischemia–reperfusion | Cortex | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEURON DEATH | ENDOPLASMIC-RETICULUM STRESS | RAT MODEL | NEUROPROTECTION | NUTRITION & DIETETICS | Cerebral ischemia-reperfusion | CONTRIBUTES | Folic Acid Deficiency - metabolism | Neurons - pathology | Cell Body - drug effects | Microtubule-Associated Proteins - metabolism | Cerebral Cortex - pathology | Brain Ischemia - metabolism | Male | Cell Body - ultrastructure | Autophagy - drug effects | Cerebral Cortex - metabolism | Cerebral Cortex - ultrastructure | Autophagosomes - drug effects | Neurons - ultrastructure | Adenine - therapeutic use | Neurons - metabolism | Cerebral Cortex - drug effects | Neurons - drug effects | Biomarkers - metabolism | Brain Ischemia - complications | DNA Damage - drug effects | Microscopy, Electron, Transmission | Adenine - analogs & derivatives | Specific Pathogen-Free Organisms | Cell Body - pathology | Cell Body - metabolism | Autophagosomes - metabolism | Random Allocation | Rats, Sprague-Dawley | Autophagosomes - pathology | Autophagosomes - ultrastructure | Nerve Tissue Proteins - metabolism | Up-Regulation - drug effects | Animals | Folic Acid Deficiency - complications | Reperfusion Injury - prevention & control | Folic Acid Deficiency - pathology | Brain Ischemia - pathology | Oxidative Stress - drug effects | Beclin-1 - metabolism | Stroke (Disease) | Brain | Cerebral ischemia | Neurons | Cell death | Brain damage | Injuries | Folic acid | Safety and security measures | Food
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7. Full Text Optic Nerve Degeneration and Reduced Contrast Sensitivity Due to Folic Acid Deficiency: A Behavioral and Electrophysiological Study in Rhesus Monkeys
by Santandrea, Elisa and Sani, Ilaria and Sani, Ilaria and Morbioli, Gianpaolo and Multari, Domenico and Multari, Domenico and Marchini, Giorgio and Chelazzi, Leonardo and Chelazzi, Leonardo
Investigative ophthalmology & visual science, ISSN 0146-0404, 12/2018, Volume 59, Issue 15, pp. 6045 - 6056
PURPOSE. The purpose of the research was to elucidate the role of folic acid (B9) deficiency in the development of nutritional optic neuritis and to... 
Folic acid deficiency | Contrast sensitivity | Optic nerve demyelination | Optic neuritis | Mid-tier cortical visual areas | ATTENTION | SERUM | contrast sensitivity | optic neuritis | mid-tier cortical visual areas | VITAMIN-B12 | NEUROPATHY | CORTEX | folic acid deficiency | MACAQUE | NEURONS | OPHTHALMOLOGY | LATENCY | optic nerve demyelination | AREA V4 | FOLATE
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8. Full Text Biometric Alterations of Mouse Embryonic Eye Structures Due to Short-Term Folic Acid Deficiency
by Sijilmassi, Ouafa and López-Alonso, José Manuel and Del Río Sevilla, Aurora and Murillo González, Jorge and Barrio Asensio, María del Carmen
Current Eye Research, ISSN 0271-3683, 04/2019, Volume 44, Issue 4, pp. 428 - 435
Purpose: Folic acid (FA) is an essential nutrient for normal embryonic development. FA deficiency (FAD) in maternal diet increases the risk of several defects... 
Folic acid deficiency | development | statistical analysis | eye abnormalities | ocular biometry | APOPTOSIS | FOLATE-DEFICIENCY | NEURAL-TUBE DEFECTS | RATS | PROLIFERATION | PROGRAMMED CELL-DEATH | MORPHOGENESIS | TRANSPORT | OPHTHALMOLOGY | MICROPHTHALMIA | EXTRACELLULAR-MATRIX
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9. Full Text Folic acid deficiency impairs the gill health status associated with the NF-κB, MLCK and Nrf2 signaling pathways in the gills of young grass carp (Ctenopharyngodon idella)
by Shi, Lei and Feng, Lin and Jiang, Jun and Jiang, Wei-Dan and Liu, Yang and Wu, Pei and Zhao, Juan and Kuang, Sheng-Yao and Tang, Ling and Tang, Wu-Neng and Zhang, Yong-An and Zhou, Xiao-Qiu
Fish and Shellfish Immunology, ISSN 1050-4648, 11/2015, Volume 47, Issue 1, pp. 289 - 301
The aim of this study was to investigate the effect of dietary folic acid on fish growth, the immune and barrier functions of fish gills, and the potential... 
Gills | Grass carp | Immune function | Barrier function | Folic acid | C-REACTIVE PROTEIN | ENZYME-ACTIVITIES | NONSPECIFIC IMMUNE-RESPONSES | MESSENGER-RNA EXPRESSION | INTESTINAL MUCOSAL IMMUNE | IMMUNOLOGY | ANTIOXIDANT CAPACITY | GROWTH-PERFORMANCE | FISHERIES | MARINE & FRESHWATER BIOLOGY | ENDOTHELIAL-CELLS | GENE-EXPRESSION | VETERINARY SCIENCES | TIGHT JUNCTION PROTEINS | Myosin-Light-Chain Kinase - genetics | Folic Acid Deficiency - veterinary | Tight Junction Proteins - genetics | Antioxidants - metabolism | NF-kappa B - metabolism | Gills - immunology | Dietary Supplements - analysis | Fish Proteins - genetics | Folic Acid - analysis | Animal Feed - analysis | Fish Diseases - immunology | NF-E2-Related Factor 2 - genetics | Folic Acid Deficiency - genetics | Tight Junction Proteins - metabolism | Diet - veterinary | Signal Transduction | Myosin-Light-Chain Kinase - metabolism | Gene Expression Regulation | Fish Proteins - metabolism | Immunity, Innate | Fish Diseases - genetics | Carps - immunology | Folic Acid Deficiency - immunology | Animals | NF-kappa B - genetics | NF-E2-Related Factor 2 - metabolism | Folic Acid - metabolism | Carps - genetics | Health Status
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10. Folic acid deficiency and tumorigenesis
by Zhang, Yin-Ling and Xue, Geng and Sun, Shu-Han and Zhang, Yi
Academic Journal of Second Military Medical University, ISSN 0258-879X, 01/2016, Volume 37, Issue 1, pp. 65 - 71
Epigenetics | Neoplasms | Folic acid dificiency
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11. Full Text Maternal folic acid deficiency stimulates neural cell apoptosis via miR-34a associated with Bcl-2 in the rat foetal brain
by Li, Wen and Li, Zhenshu and Zhou, Dezheng and Zhang, Xumei and Yan, Jing and Huang, Guowei
International Journal of Developmental Neuroscience, ISSN 0736-5748, 02/2019, Volume 72, pp. 6 - 12
Embryonic development is a critical period wherein brain neurons are generated and organized. Maternal dietary folate, a cofactor in one-carbon metabolism,... 
Bcl-2 | Maternal | miR-34a | Folate deficiency | Apoptosis | DOMAIN | STABILITY | DEVELOPMENTAL BIOLOGY | DECREASES | NEUROSCIENCES | DIFFERENTIATION | MICRORNA-34A | CONTRIBUTES | BINDING | Neurons - pathology | Brain - embryology | Embryo, Mammalian | Caspase 3 - metabolism | Male | MicroRNAs - metabolism | Brain - growth & development | Proto-Oncogene Proteins c-bcl-2 - metabolism | Female | Neurons - metabolism | bcl-2-Associated X Protein - genetics | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | In Situ Nick-End Labeling | bcl-2-Associated X Protein - metabolism | Rats | Rats, Sprague-Dawley | Pregnancy | Animals | Folic Acid Deficiency - complications | Maternal-Fetal Relations | Folic Acid - blood | Brain - pathology | Apoptosis - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Brain | Parturition | Bax protein | Bcl-2 protein | Central nervous system | Caspase-3 | Neurogenesis | Folic acid | Signal transduction | Embryogenesis | Vitamin B | Rodents | Nutrient deficiency | Neurons | MiRNA | Caspase | Vitamin deficiency | Metabolism | Embryonic growth stage | Progeny | Offspring | Acids | Diet | Ribonucleic acids | MicroRNAs | Critical period
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12. Full Text Understanding pluripotency under folic acid deficiency using embryonic stem cells as an in vitro model
by Kasulanati, Sowmya and Venkatesan, Vijayalakshmi
Medical Hypotheses, ISSN 0306-9877, 02/2018, Volume 111, pp. 24 - 26
Innumerable studies have been carried out by people to trace out those elements, find out the mechanisms that are vital to the maintenance of stemness. Amongst... 
MEDICINE, RESEARCH & EXPERIMENTAL | EPIGENETIC REGULATION | ADENOSYLMETHIONINE | METABOLISM | S-ADENOSYLHOMOCYSTEINE | Models, Theoretical | Embryonic Stem Cells - cytology | Histones - chemistry | Epigenesis, Genetic | Humans | DNA - metabolism | Embryonic Development | Folic Acid Deficiency - physiopathology | Pregnancy | DNA Methylation | Micronutrients - chemistry | Teratoma - pathology | Folic Acid - metabolism | Female | In Vitro Techniques | Methylation
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13. Full Text Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression
by Liu, Huan and Tian, Tian and Qin, Shanchun and Li, Wen and Zhang, Xumei and Wang, Xuan and Gao, Yuxia and Huang, Guowei
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 12/2015, Volume 26, Issue 12, pp. 1502 - 1508
Recent efforts have revealed the microRNA (miRNA) pathways in the pathogenesis of Alzheimer's disease (AD). Epidemiological studies have revealed an... 
MicroRNA | APP/PS1 mice | Alzheimer's disease | Folic acid | Amyloid β-peptide | BETA-SECRETASE | HOMOCYSTEINE | METHYLATION | FOLATE-DEFICIENCY | PROTEIN | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MILD COGNITIVE IMPAIRMENT | BACE1 | BIOMARKERS | Amyloid beta-peptide | NUTRITION & DIETETICS | VITAMIN-B-12 | Folic Acid Deficiency - metabolism | Cognition Disorders - metabolism | Male | MicroRNAs - metabolism | Cognition | Gene Expression Profiling | Brain - metabolism | Amyloid - metabolism | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Real-Time Polymerase Chain Reaction | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Folic Acid - chemistry | Gene Expression Regulation | Mice, Transgenic | Amyloid Precursor Protein Secretases - metabolism | Animals | Maze Learning | Aspartic Acid Endopeptidases - metabolism | Presenilin-1 - metabolism | Alzheimer Disease - metabolism | Folic Acid - blood | Cell Line, Tumor | Mice | Enzymes | Analysis | Genetic research | Folic acid deficiency | Gene expression | Enzyme-linked immunosorbent assay
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14. Full Text Life-threatening Folic Acid Deficiency: Diogenes Syndrome in a Young Woman?
by Sheridan, Mia, MB ChB and Jamieson, Andrew, MB ChB(Hons), BSc(Hons), PhD
American Journal of Medicine, The, ISSN 0002-9343, 2015, Volume 128, Issue 8, pp. e7 - e8
Internal Medicine | MEDICINE, GENERAL & INTERNAL | Humans | Anemia, Macrocytic - etiology | Adult | Female | Folic Acid Deficiency - diagnosis | Nutritional Status | Social Isolation | Malnutrition - diagnosis | Anemia, Macrocytic - diagnosis | Hygiene | Syndrome | Folic Acid Deficiency - psychology | Folic acid
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15. Full Text Folic acid deficiency enhanced microglial immune response via the Notch1/nuclear factor kappa B p65 pathway in hippocampus following rat brain I/R injury and BV2 cells
by Cheng, Man and Yang, Liu and Dong, Zhiping and Wang, Mengying and Sun, Yan and Liu, Huan and Wang, Xuan and Sai, Na and Huang, Guowei and Zhang, Xumei
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 07/2019, Volume 23, Issue 7, pp. 4795 - 4807
Recent studies revealed that folic acid deficiency (FD) increased the likelihood of stroke and aggravated brain injury after focal cerebral ischaemia. The... 
microglial | Notch pathway | hippocampus | ischaemia‐reperfusion | folic acid | inflammatory | Brain | Folic acid deficiency | Immune response | Injuries | Folic acid | Occlusion | Phosphorylation | Interleukin | Inflammatory response | Activation | Experiments | Carotid arteries | Proteins | Head injuries | Reperfusion | Ischemia | Cerebral blood flow | Vitamin B | Microglial cells | Tumor necrosis factor-TNF | Immune system | Translocation | Deprivation | Stroke |