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science & technology (228) 228
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1. Full Text XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
by Kim, Jimi and McMillan, Elizabeth and Kim, Hyun Seok and Venkateswaran, Niranjan and Makkar, Gurbani and Rodriguez-Canales, Aime and Villalobos, Pamela and Neggers, Jasper Edgar and Mendiratta, Saurabh and Wei, Shuguang and Landesman, Yosef and Senapedis, William and Baloglu, Erkan and Chow, Chi-Wan B and Frink, Robin E and Gao, Boning and Roth, Michael and Minna, John D and Daelemans, Dirk and Wistuba, Ignacio I and Posner, Bruce A and Scaglioni, Pier Paolo and White, Michael A
Nature (London), ISSN 0028-0836, 09/2016, Volume 538, Issue 7623, pp. 114 - 117
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Lung Neoplasms - drug therapy | Proto-Oncogene Proteins p21(ras) - genetics | Humans | Lung Neoplasms - metabolism | Cell Survival - genetics | Lung Neoplasms - pathology | NF-kappa B - metabolism | Phosphoproteins - antagonists & inhibitors | Phosphoproteins - metabolism | DNA-Binding Proteins - metabolism | Cell Nucleus - metabolism | RNA Interference | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Female | Verteporfin | Protein-Serine-Threonine Kinases - metabolism | Carcinoma, Non-Small-Cell Lung - pathology | Follistatin-Related Proteins - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | NF-kappa B - antagonists & inhibitors | DNA-Binding Proteins - antagonists & inhibitors | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Carcinoma, Non-Small-Cell Lung - metabolism | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Porphyrins - pharmacology | Transcription Factors - metabolism | Xenograft Model Antitumor Assays | Animals | Karyopherins - metabolism | Active Transport, Cell Nucleus - drug effects | Genes, Lethal - genetics | NF-KappaB Inhibitor alpha - metabolism | Nuclear Proteins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | RNA, Small Interfering | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Cell Nucleus - drug effects | Karyopherins - antagonists & inhibitors | Receptors, Cytoplasmic and Nuclear - metabolism | Care and treatment | Genetic aspects | Gene mutations | Health aspects | Guanosine triphosphatase | Lung cancer | Genomics | Genomes | Kinases | Drug resistance | Gene expression | Drug dosages | Index Medicus
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2. Full Text Blocking follistatin-like 1 attenuates bleomycin-induced pulmonary fibrosis in mice
by Dong, Yingying and Geng, Yan and Li, Lian and Li, Xiaohe and Yan, Xiaohua and Fang, Yinshan and Li, Xinxin and Dong, Siyuan and Liu, Xue and Li, Xue and Yang, Xiuhong and Zheng, Xiaohong and Xie, Ting and Liang, Jiurong and Dai, Huaping and Liu, Xinqi and Yin, Zhinan and Noble, Paul W and Jiang, Dianhua and Ning, Wen
The Journal of experimental medicine, ISSN 0022-1007, 2015, Volume 212, Issue 2, pp. 235 - 252
Immunology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Inflammation - pathology | Lung Injury - pathology | Myofibroblasts - immunology | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Antibiotics, Antineoplastic - adverse effects | Follistatin-Related Proteins - antagonists & inhibitors | Male | Pulmonary Fibrosis - genetics | Bone Morphogenetic Protein 4 - metabolism | Myofibroblasts - metabolism | Respiratory Mucosa - pathology | Inflammation - metabolism | Respiratory Mucosa - immunology | Lung Injury - metabolism | Female | Pulmonary Fibrosis - metabolism | Disease Models, Animal | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Cell Line | Gene Expression | Signal Transduction | Antibodies, Monoclonal - pharmacology | Cell Communication | Mesenchymal Stromal Cells - metabolism | Antibodies, Neutralizing - pharmacology | Inflammation - immunology | Bleomycin - adverse effects | Follistatin-Related Proteins - deficiency | Mice, Knockout | Lung Injury - genetics | Phenotype | Animals | Inflammation - genetics | Protein Binding | Pulmonary Fibrosis - chemically induced | Aged | Mice | Pulmonary Fibrosis - drug therapy | Respiratory Mucosa - metabolism | Lung Injury - chemically induced | Smad Proteins - metabolism | Index Medicus
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3. Full Text ‘See-saw’ expression of microrna-198 and fstl1 from a single transcript in wound healing
by Sundaram, Gopinath M and Sundaram, Gopinath M and Common, John E. A and Common, John E. A and Gopal, Felicia E and Gopal, Felicia E and Srikanta, Satyanarayana and Srikanta, Satyanarayana and Lakshman, Krishnaswamy and Lunny, Declan P and Lunny, Declan P and Lim, Thiam C and Tanavde, Vivek and Tanavde, Vivek and Lane, E. Birgitte and Lane, E. Birgitte and Sampath, Prabha and Sampath, Prabha
Nature (London), ISSN 0028-0836, 2013, Volume 495, Issue 7439, pp. 103 - 106
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | RNA-Binding Proteins - genetics | Urokinase-Type Plasminogen Activator - antagonists & inhibitors | Skin - cytology | Skin - metabolism | Humans | Transforming Growth Factor beta1 - metabolism | Laminin - antagonists & inhibitors | Skin - injuries | Time Factors | Adaptor Proteins, Signal Transducing - antagonists & inhibitors | Trans-Activators - genetics | Wound Healing - genetics | Skin - pathology | Follistatin-Related Proteins - genetics | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Diabetic Foot - pathology | Exons - genetics | Keratinocytes - cytology | Open Reading Frames - genetics | Follistatin-Related Proteins - biosynthesis | Diabetic Foot - genetics | Diabetic Foot - metabolism | Urokinase-Type Plasminogen Activator - metabolism | Keratinocytes - metabolism | Trans-Activators - metabolism | MicroRNAs - genetics | Laminin - metabolism | Transcription, Genetic - genetics | Adaptor Proteins, Signal Transducing - metabolism | In Vitro Techniques | RNA-Binding Proteins - metabolism | Cell Movement | Wound healing | MicroRNA | Messenger RNA | Research | Genetic transcription | Properties | Binding proteins | Gene expression | Proteins | Skin | Diabetes | Binding sites | Cell adhesion & migration | Index Medicus
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4. Full Text Molecular Biomarkers for Weight Control in Obese Individuals Subjected to a Multiphase Dietary Intervention
by Bolton, Jennifer and Montastier, Emilie and Carayol, Jerome and Bonnel, Sophie and Mir, Lucile and Marques, Marie-Adeline and Astrup, Arne and Saris, Wim and Iacovoni, Jason and Villa-Vialaneix, Nathalie and Valsesia, Armand and Langin, Dominique and Viguerie, Nathalie
The journal of clinical endocrinology and metabolism, ISSN 0021-972X, 08/2017, Volume 102, Issue 8, pp. 2751 - 2761
SKELETAL-MUSCLE | WOMEN | TGF-BETA | MACROPHAGES | TISSUE GENE-EXPRESSION | FAT | ADIPOCYTE DIFFERENTIATION | BINDING PROTEIN-3 | RESTRICTION | ADIPOSE-TISSUE | Life Sciences & Biomedicine | Endocrinology & Metabolism | Science & Technology | Insulin-Like Growth Factor Binding Protein 3 - genetics | Obesity - diet therapy | alpha-Crystallin B Chain - genetics | Ubiquitin-Specific Proteases - genetics | Membrane Glycoproteins - metabolism | Caloric Restriction | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | alpha-Crystallin B Chain - metabolism | Gene Expression Profiling | Gene Regulatory Networks | RNA, Messenger - metabolism | Obesity - genetics | Subcutaneous Fat - metabolism | Osteonectin - genetics | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Microarray Analysis | Adult | Female | Membrane Proteins - metabolism | Ubiquitin-Specific Proteases - metabolism | Real-Time Polymerase Chain Reaction | Extracellular Matrix Proteins - metabolism | Biomarkers - metabolism | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Enzyme-Linked Immunosorbent Assay | Membrane Proteins - genetics | Down-Regulation | Extracellular Matrix Proteins - genetics | Osteonectin - metabolism | Membrane Glycoproteins - genetics | Obesity - metabolism | Polymorphism, Genetic | Quantitative Trait Loci | Intervention | Controllers | Nutrient deficiency | Adipose tissue | Transforming growth factor | Genes | Weight loss | Reverse transcription | Gene expression | Ribonucleic acid--RNA | Quantitative trait loci | Polymerase chain reaction | Proteins | Weight control | Diet | Osteonectin | Biomarkers | Insulin-like growth factor-binding protein 3 | Enzyme-linked immunosorbent assay | Index Medicus | Abridged Index Medicus | Life Sciences
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5. Full Text Altered Expression of Bone Morphogenetic Protein Accessory Proteins in Murine and Human Pulmonary Fibrosis
by Murphy, Noelle and Gaynor, Katherine U and Rowan, Simon C and Walsh, Sinead M and Fabre, Aurelie and Boylan, John and Keane, Michael P and McLoughlin, Paul
The American journal of pathology, ISSN 0002-9440, 2016, Volume 186, Issue 3, pp. 600 - 615
Pathology | Life Sciences & Biomedicine | Science & Technology | Epithelial Cells - metabolism | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Idiopathic Pulmonary Fibrosis - chemically induced | RNA, Messenger - metabolism | Idiopathic Pulmonary Fibrosis - metabolism | Bone Morphogenetic Proteins - metabolism | Adult | Lung - metabolism | Membrane Proteins - metabolism | Bone Morphogenetic Proteins - genetics | Disease Models, Animal | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Specific Pathogen-Free Organisms | Signal Transduction | Membrane Proteins - genetics | Mice, Inbred C57BL | Gene Expression Regulation | Transforming Growth Factor beta1 - genetics | Bleomycin - adverse effects | Random Allocation | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Idiopathic Pulmonary Fibrosis - pathology | Aged | Mice | Index Medicus | Abridged Index Medicus
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6. Full Text Fstl1 Promotes Glioma Growth Through the BMP4/Smad1/5/8 Signaling Pathway
by Jin, Xin and Nie, Er and Zhou, Xu and Zeng, Ailiang and Yu, Tianfu and Zhi, Tongle and Jiang, Kuan and Wang, Yingyi and Zhang, Junxia and You, Yongping
Cellular physiology and biochemistry, ISSN 1015-8987, 12/2017, Volume 44, Issue 4, pp. 1616 - 1628
Original Paper | BMP4 | Smad1/5/8 signaling pathway | Proliferation | Fstl1 | Glioblastoma | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Phosphorylation | Immunoprecipitation | Humans | Brain Neoplasms - pathology | Follistatin-Related Proteins - antagonists & inhibitors | Transplantation, Heterologous | Bone Morphogenetic Protein 4 - metabolism | Brain Neoplasms - metabolism | Glioma - metabolism | S Phase Cell Cycle Checkpoints | RNA Interference | Smad5 Protein - metabolism | Glioma - pathology | Brain Neoplasms - mortality | Follistatin-Related Proteins - genetics | Follistatin-Related Proteins - metabolism | Glioma - mortality | Signal Transduction | Kaplan-Meier Estimate | Bone Morphogenetic Protein Receptors, Type II - metabolism | Animals | Cell Line, Tumor | Protein Binding | Smad1 Protein - metabolism | Mice | Smad8 Protein - metabolism | RNA, Small Interfering - metabolism | Medical research | Review boards | Pathogenesis | Brain cancer | Multiple myeloma | Gene expression | Patients | Autophagy | Proteins | Cell growth | Brain research | Medical prognosis | Stem cells | Growth factors | Tumors | Index Medicus
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7. Full Text Adipo-Myokines: Two Sides of the Same Coin- Mediators of Inflammation and Mediators of Exercise
by Silja Raschke and Jürgen Eckel
Mediators of inflammation, ISSN 0962-9351, 12/2013, Volume 2013, pp. 320724 - 16
Immunology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Follistatin-Related Proteins - metabolism | Angiopoietins - metabolism | Humans | Leptin - metabolism | Gene Expression Regulation | Muscle, Skeletal - metabolism | Adipokines - metabolism | RNA, Messenger - metabolism | Endocrine System | Adipose Tissue - metabolism | Fibroblast Growth Factors - metabolism | Angiopoietin-like 4 Protein | Inflammation - metabolism | Animals | Exercise | Interleukin-15 - metabolism | Brain-Derived Neurotrophic Factor - metabolism | Chemokine CCL2 - metabolism | Interleukin-6 - metabolism | Physiological aspects | Inflammation | Cytokines | Health aspects | Index Medicus | Review
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