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1. Full Text Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation
by Rao, Rajesh R and Li, Qingsheng and Bupp, Melanie R. Gubbels and Shrikant, Protul A
Immunity (Cambridge, Mass.), ISSN 1074-7613, 03/2012, Volume 36, Issue 3, pp. 374 - 387
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | CD8-Positive T-Lymphocytes - cytology | Multiprotein Complexes | T-Box Domain Proteins - immunology | Mechanistic Target of Rapamycin Complex 1 | CD8-Positive T-Lymphocytes - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-12 - pharmacology | Mice, Inbred C57BL | Mice, Transgenic | Forkhead Transcription Factors - genetics | Sirolimus - pharmacology | Mice, Knockout | Cell Differentiation - immunology | Animals | Proteins - metabolism | CD8-Positive T-Lymphocytes - drug effects | Immunologic Memory | Trans-Activators - metabolism | Forkhead Box Protein O1 | Mice | TOR Serine-Threonine Kinases | Transcription Factors | CD8-Positive T-Lymphocytes - immunology | Proteins - antagonists & inhibitors | Proteins | Flow cytometry | Genotype & phenotype | Phosphorylation | Transcription factors | Statistical analysis | Kinases | Mammals | Index Medicus | IFN-γ | Akt | Eomesodermin | mTORC2 | IL-12 | CD8+ T cell | mTORC1 | T-bet | effector and memory differentiation | instructional programming | Foxo1
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2. Full Text Zebrafish microRNA miR-210-5p inhibits primitive myelopoiesis by silencing foxj1b and slc3a2a mRNAs downstream of gata4/5/6 transcription factor genes
by Jia, Wenshuang and Liang, Dong and Li, Nan and Liu, Meijing and Dong, Zhangji and Li, Jingyun and Dong, Xiaohua and Yue, Yunyun and Hu, Ping and Yao, Jihua and Zhao, Qingshun
The Journal of biological chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 8, pp. 2732 - 2743
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Embryo, Nonmammalian - cytology | Fusion Regulatory Protein 1, Heavy Chain - antagonists & inhibitors | Embryo, Nonmammalian - metabolism | GATA5 Transcription Factor - antagonists & inhibitors | GATA5 Transcription Factor - metabolism | Gene Regulatory Networks | RNA, Messenger - metabolism | Zebrafish - embryology | GATA Transcription Factors - antagonists & inhibitors | GATA5 Transcription Factor - genetics | GATA Transcription Factors - metabolism | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | RNA, Messenger - antagonists & inhibitors | Fusion Regulatory Protein 1, Heavy Chain - genetics | Forkhead Transcription Factors - antagonists & inhibitors | Myelopoiesis | Zebrafish Proteins - metabolism | RNA, Messenger - genetics | Zebrafish Proteins - antagonists & inhibitors | Gene Silencing | Forkhead Transcription Factors - genetics | GATA Transcription Factors - genetics | Zebrafish - genetics | Animals | Zebrafish - metabolism | MicroRNAs - genetics | Zebrafish Proteins - genetics | Fusion Regulatory Protein 1, Heavy Chain - metabolism | Index Medicus | transcription factor | microRNA (miRNA) | gata4 | miR-210-5p | slc3a2a | microRNA mechanism | post-transcriptional regulation | zebrafish | primitive myelopoiesis | Developmental Biology | foxj1b
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3. Full Text The SKN‐1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms
by Tullet, Jennifer M.A and Green, James W and Au, Catherine and Benedetto, Alexandre and Thompson, Maximillian A and Clark, Emily and Gilliat, Ann F and Young, Adelaide and Schmeisser, Kathrin and Gems, David
Aging cell, ISSN 1474-9718, 10/2017, Volume 16, Issue 5, pp. 1191 - 1194
transcription regulation | C. elegans | aging | oxidative stress | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Caenorhabditis elegans - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Caenorhabditis elegans - growth & development | Oxidative Stress | Signal Transduction | Caenorhabditis elegans - genetics | Caenorhabditis elegans Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Longevity - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Forkhead Transcription Factors - genetics | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Animals | Caenorhabditis elegans Proteins - antagonists & inhibitors | RNA Interference | Forkhead Transcription Factors - metabolism | Gene Expression Regulation, Developmental | Caenorhabditis elegans Proteins - genetics | Physiological aspects | Oxidative stress | Index Medicus | Short Takes | Short Take
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4. Full Text Redox regulation of FoxO transcription factors
by Klotz, Lars-Oliver and Sánchez-Ramos, Cristina and Prieto-Arroyo, Ignacio and Urbánek, Pavel and Steinbrenner, Holger and Monsalve, Maria
Redox biology, ISSN 2213-2317, 12/2015, Volume 6, pp. 51 - 72
Oxidative stress | C. elegans | Stress signaling | DAF-16 | Forkhead box proteins | Akt | Antioxidant proteins | Insulin signaling | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neoplasms - metabolism | Reactive Oxygen Species - metabolism | Oxidative Stress | Diabetes Mellitus, Type 2 - genetics | Humans | Molecular Sequence Data | Mitochondrial Proteins - genetics | Diabetes Mellitus, Type 2 - metabolism | Blood Proteins - metabolism | Obesity - genetics | Protein Isoforms - metabolism | Neoplasms - genetics | Blood Proteins - genetics | Forkhead Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Protein Isoforms - chemistry | Forkhead Transcription Factors - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Oxidation-Reduction | Signal Transduction | Gene Expression Regulation | Forkhead Transcription Factors - genetics | Obesity - metabolism | Obesity - pathology | Forkhead Box Protein O1 | Diabetes Mellitus, Type 2 - pathology | Neoplasms - pathology | Protein Isoforms - genetics | Index Medicus
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5. Full Text ROS inhibitor N-acetyl-L-cysteine antagonizes the activity of proteasome inhibitors
by Halasi, Marianna and Wang, Ming and Chavan, Tanmay S and Gaponenko, Vadim and Hay, Nissim and Gartel, Andrei L
Biochemical journal, ISSN 0264-6021, 09/2013, Volume 454, Issue 2, pp. 201 - 208
Catalase | N-acetyl-L-cysteine (NAC) | Proteasome inhibitor | Reactive oxygen species (ROS) | Forkhead box protein M1 (FOXM1) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Free Radical Scavengers - pharmacology | Oxidants - pharmacology | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Acetylcysteine - metabolism | Proteasome Inhibitors - chemistry | Proteasome Inhibitors - metabolism | Viral Proteins - metabolism | Antineoplastic Agents, Phytogenic - antagonists & inhibitors | Chromans - metabolism | Proteasome Endopeptidase Complex - drug effects | Chromans - pharmacology | Dioxolanes - pharmacology | Forkhead Transcription Factors - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Ubiquitinated Proteins - metabolism | Recombinant Proteins - metabolism | Recombinant Proteins - antagonists & inhibitors | Free Radical Scavengers - metabolism | Proteasome Inhibitors - pharmacology | Catalase - genetics | Chromans - antagonists & inhibitors | Hydrogen Peroxide - pharmacology | Viral Proteins - genetics | Oxidants - antagonists & inhibitors | Dioxolanes - antagonists & inhibitors | Forkhead Transcription Factors - genetics | Catalase - metabolism | Reactive Oxygen Species - antagonists & inhibitors | Protein Stability - drug effects | Acetylcysteine - pharmacology | Cell Line, Tumor | Cytomegalovirus - enzymology | Proteasome Endopeptidase Complex - metabolism | Antineoplastic Agents, Phytogenic - pharmacology | Forkhead Box Protein M1 | Hydrogen Peroxide - antagonists & inhibitors | Index Medicus | N-acetyl-l-cysteine (NAC) | proteasome inhibitor | reactive oxygen species (ROS) | catalase
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6. Full Text The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
by Staron, Matthew M and Gray, Simon M and Marshall, Heather D and Parish, Ian A and Chen, Jonathan H and Perry, Curtis J and Cui, Guoliang and Li, Ming O and Kaech, Susan M
Immunity (Cambridge, Mass.), ISSN 1074-7613, 11/2014, Volume 41, Issue 5, pp. 802 - 814
Life Sciences & Biomedicine | Immunology | Science & Technology | Forkhead Transcription Factors - immunology | Lymphocytic choriomeningitis virus - immunology | Humans | Antibodies, Blocking - pharmacology | Lymphocytic Choriomeningitis - immunology | TOR Serine-Threonine Kinases - antagonists & inhibitors | Lymphocyte Activation - immunology | Programmed Cell Death 1 Receptor - biosynthesis | Receptors, Antigen, T-Cell - immunology | Granzymes - biosynthesis | TOR Serine-Threonine Kinases - biosynthesis | T-Lymphocytes, Cytotoxic - immunology | Forkhead Transcription Factors - biosynthesis | Lymphocytic Choriomeningitis - virology | Jurkat Cells | Antibodies, Monoclonal - pharmacology | Mice, Inbred C57BL | Mice, Transgenic | CD28 Antigens - immunology | Forkhead Transcription Factors - genetics | Sirolimus - pharmacology | Proto-Oncogene Proteins c-akt - biosynthesis | Cell Differentiation - immunology | Animals | Cell Line, Tumor | Forkhead Box Protein O1 | Mice | Programmed Cell Death 1 Receptor - immunology | CD8-Positive T-Lymphocytes - immunology | Chronic Disease | T-Lymphocytes, Cytotoxic - cytology | Interferon-gamma - biosynthesis | T cell receptors | Kinases | Plasmids | Viral infections | Immune system | Index Medicus
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7. Full Text FoxO Transcription Factors Promote Autophagy in Cardiomyocytes
by Arunima Sengupta and Jeffery D. Molkentin and Katherine E. Yutzey
The Journal of biological chemistry, ISSN 0021-9258, 10/2009, Volume 284, Issue 41, pp. 28319 - 28331
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Autophagy - physiology | Forkhead Transcription Factors - metabolism | Culture Media - chemistry | Animals, Newborn | Autophagy-Related Protein 12 | Starvation | Myocytes, Cardiac - cytology | Cells, Cultured | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Rats | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Rats, Sprague-Dawley | Nerve Tissue Proteins - metabolism | Proteins - genetics | Autophagy-Related Protein 8 Family | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Myocytes, Cardiac - physiology | Mice | Forkhead Box Protein O3 | Index Medicus | Mechanisms of Signal Transduction
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8. Full Text The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanisms
by Paraiso, Kim H.T and Haarberg, H. Eirik and Wood, Elizabeth and Rebecca, Vito W and Chen, Y. Ann and Xiang, Yun and Ribas, Antoni and Lo, Roger S and Weber, Jeffrey S and Sondak, Vernon K and John, Jobin K and Sarnaik, Amod A and Koomen, John M and Smalley, Keiran S.M
Clinical cancer research, ISSN 1078-0432, 05/2012, Volume 18, Issue 9, pp. 2502 - 2514
Life Sciences & Biomedicine | Oncology | Science & Technology | Biological and medical sciences | Medical sciences | Antineoplastic agents | Pharmacology. Drug treatments | Prospective Studies | Apoptosis - drug effects | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Immunoenzyme Techniques | Forkhead Transcription Factors - metabolism | Colony-Forming Units Assay | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Phthalic Acids - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Real-Time Polymerase Chain Reaction | Proto-Oncogene Proteins B-raf - metabolism | Membrane Proteins - genetics | Melanoma - pathology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Apoptosis Regulatory Proteins - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Membrane Proteins - antagonists & inhibitors | Signal Transduction - drug effects | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Mice | Mice, Inbred BALB C | Forkhead Box Protein O3 | Azabicyclo Compounds - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Proto-Oncogene Proteins c-akt - genetics | Proto-Oncogene Proteins c-bcl-2 - metabolism | Flow Cytometry | Bcl-2-Like Protein 11 | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | Forkhead Transcription Factors - antagonists & inhibitors | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | RNA, Messenger - genetics | Proto-Oncogene Proteins - genetics | Forkhead Transcription Factors - genetics | Phosphatidylinositol 3-Kinases - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Myeloid Cell Leukemia Sequence 1 Protein | Apoptosis Regulatory Proteins - antagonists & inhibitors | Fluorescent Antibody Technique | Sulfonamides - adverse effects | Proto-Oncogene Proteins c-bcl-2 - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Resistance, Neoplasm - drug effects | Index Medicus
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9. Full Text MicroRNA-9 regulates neurogenesis in mouse telencephalon by targeting multiple transcription factors
by Shibata, Mikihito and Nakao, Hiromi and Kiyonari, Hiroshi and Abe, Takaya and Aizawa, Shinichi
The Journal of neuroscience, ISSN 0270-6474, 03/2011, Volume 31, Issue 9, pp. 3407 - 3422
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Gene Targeting - methods | Receptors, Cytoplasmic and Nuclear - deficiency | Humans | Nerve Tissue Proteins - deficiency | Transcription Factors - deficiency | Receptors, Cytoplasmic and Nuclear - biosynthesis | Neurogenesis - genetics | Neurons - physiology | Female | Forkhead Transcription Factors - antagonists & inhibitors | Forkhead Transcription Factors - deficiency | Nerve Tissue Proteins - antagonists & inhibitors | Homeodomain Proteins - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Mice, Transgenic | Up-Regulation - genetics | Receptors, Cytoplasmic and Nuclear - genetics | Telencephalon - embryology | Transcription Factors - genetics | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | Down-Regulation - genetics | Homeodomain Proteins - genetics | Pregnancy | Transcription Factors - metabolism | Telencephalon - physiology | Animals | Neurogenesis - physiology | Mice | MicroRNAs - genetics | MicroRNAs - physiology | Index Medicus
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