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1. Full Text Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway
by Ducker, Gregory S and Chen, Li and Morscher, Raphael J and Ghergurovich, Jonathan M and Esposito, Mark and Teng, Xin and Kang, Yibin and Rabinowitz, Joshua D
Cell metabolism, ISSN 1550-4131, 06/2016, Volume 23, Issue 6, pp. 1140 - 1153
Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Leucovorin - metabolism | Methylenetetrahydrofolate Dehydrogenase (NADP) - deficiency | Humans | Cytosol - drug effects | HEK293 Cells | NADP - metabolism | Aminoimidazole Carboxamide - metabolism | Formates - metabolism | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Carbon - metabolism | Ribonucleotides - metabolism | Gene Library | HCT116 Cells | Leucovorin - analogs & derivatives | Mitochondria - metabolism | Mitochondria - drug effects | Gene Knockout Techniques | Glycine Hydroxymethyltransferase - metabolism | Mutation - genetics | CRISPR-Cas Systems - genetics | Xenograft Model Antitumor Assays | Aminoimidazole Carboxamide - analogs & derivatives | Glycine - pharmacology | Serine - pharmacology | Colonic Neoplasms - pathology | Cell Compartmentation - drug effects | Folic Acid - metabolism | Cytosol - metabolism | Cell Proliferation - drug effects | Metabolic Networks and Pathways - drug effects | Medical colleges | Colon cancer | Metabolites | Medical genetics | Physiological aspects | Glycine | Cells | Folic acid | Index Medicus
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2. Full Text EWS‐FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine‐glycine biosynthesis
by Sen, Nirmalya and Cross, Allison M and Lorenzi, Philip L and Khan, Javed and Gryder, Berkley E and Kim, Suntae and Caplen, Natasha J
Molecular carcinogenesis, ISSN 0899-1987, 10/2018, Volume 57, Issue 10, pp. 1342 - 1357
de novo serine‐glycine biosynthesis | Ewing sarcoma | metabolism | glutamine | ROS | de novo serine-glycine biosynthesis | Biochemistry & Molecular Biology | Oncology | Life Sciences & Biomedicine | Science & Technology | Multifunctional Enzymes - genetics | Oncogene Proteins, Fusion - metabolism | Humans | Gene Expression Regulation, Neoplastic | Sarcoma, Ewing - pathology | Cell Survival - genetics | Glutamine - metabolism | Multienzyme Complexes - metabolism | Apoptosis - genetics | Serine - biosynthesis | Aminohydrolases - genetics | Multifunctional Enzymes - metabolism | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Proto-Oncogene Protein c-fli-1 - metabolism | HEK293 Cells | Minor Histocompatibility Antigens - genetics | Bone Neoplasms - genetics | Amino Acid Transport System ASC - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Sarcoma, Ewing - metabolism | Phosphoglycerate Dehydrogenase - metabolism | Proto-Oncogene Protein c-fli-1 - genetics | HCT116 Cells | RNA-Binding Protein EWS - genetics | Glycine - biosynthesis | Amino Acid Transport System ASC - metabolism | Multienzyme Complexes - genetics | RNA-Binding Protein EWS - metabolism | Phosphoglycerate Dehydrogenase - genetics | Formate-Tetrahydrofolate Ligase - metabolism | Minor Histocompatibility Antigens - metabolism | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Formate-Tetrahydrofolate Ligase - genetics | Aminohydrolases - metabolism | Sarcoma, Ewing - genetics | Glucose metabolism | International trade | Enzymes | Sarcoma | Analysis | Amino acids | Carbon cycle (Biogeochemistry) | Reactive oxygen species | Serine | DNA damage | Biosynthesis | Bone tumors | Glycine | Ewing's sarcoma | Ewings sarcoma | Proteins | Transcription activation | Adolescents | Redox properties | Damage accumulation | Deoxyribonucleic acid--DNA | Cell survival | Young adults | Risk groups | Metabolism | Nutrient uptake | Gene expression | Survival | Carbon cycle | Gene silencing | Adults | Transporter | Tumors | Apoptosis | Glutamine | Index Medicus
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3. Full Text The nexus of syntrophy‐associated microbiota in anaerobic digestion revealed by long‐term enrichment and community survey
by Narihiro, Takashi and Nobu, Masaru K and Kim, Na‐Kyung and Kamagata, Yoichi and Liu, Wen‐Tso
Environmental microbiology, ISSN 1462-2912, 05/2015, Volume 17, Issue 5, pp. 1707 - 1720
Life Sciences & Biomedicine | Microbiology | Science & Technology | Anaerobiosis | Propionates - metabolism | Butyrates - metabolism | Carbon Dioxide - metabolism | Methane - metabolism | Acetates - metabolism | Benzoates - metabolism | Chloroflexi - genetics | Euryarchaeota - metabolism | Bacteroidetes - metabolism | Base Sequence | Actinobacteria - genetics | Actinobacteria - metabolism | RNA, Ribosomal, 16S - genetics | Microbial Consortia - genetics | Chloroflexi - metabolism | Bacteroidetes - genetics | Water Purification - methods | Sewage - microbiology | Formates - metabolism | Methane | Surveys | Esters | Microbiota (Symbiotic organisms) | Index Medicus
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4. Full Text Increased formate overflow is a hallmark of oxidative cancer
by Meiser, Johannes and Schuster, Anne and Pietzke, Matthias and Voorde, Johan Vande and Athineos, Dimitris and Oizel, Kristell and Burgos-Barragan, Guillermo and Wit, Niek and Dhayade, Sandeep and Morton, Jennifer P and Dornier, Emmanuel and Sumpton, David and Mackay, Gillian M and Blyth, Karen and Patel, Ketan J and Niclou, Simone P and Vazquez, Alexei
Nature communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1368 - 12
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Methotrexate - pharmacology | Intestinal Mucosa - metabolism | Adenoma - genetics | Gene Expression Regulation, Neoplastic | Mammary Glands, Animal - virology | Male | Mammary Neoplasms, Experimental - metabolism | Mammary Neoplasms, Experimental - genetics | Adenoma - metabolism | Isoenzymes - metabolism | Antimetabolites, Antineoplastic - pharmacology | Female | Mammary Tumor Virus, Mouse - pathogenicity | Intestinal Neoplasms - genetics | Formates - metabolism | Mammary Neoplasms, Experimental - drug therapy | Tumor Microenvironment - drug effects | Glycine Hydroxymethyltransferase - genetics | Intestines - pathology | Oxidation-Reduction | Isoenzymes - genetics | Mammary Glands, Animal - pathology | Intestinal Neoplasms - metabolism | Mice, Inbred C57BL | Mitochondria - metabolism | Mitochondria - drug effects | Glycine Hydroxymethyltransferase - metabolism | Serine - metabolism | Intestinal Neoplasms - pathology | Animals | Mammary Glands, Animal - metabolism | Formates - pharmacology | Adenoma - pathology | Cell Line, Tumor | Mice | Mammary Neoplasms, Experimental - virology | Phenotypes | Mitochondria | Animal models | Intestine | Oxidative metabolism | Serine | Catabolism | Mammary gland | Tumor cell lines | Metabolism | Overflow | Cancer | Index Medicus
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5. Full Text Peat: Home to novel syntrophic species that feed acetate- and hydrogen-scavenging methanogens
by Schmidt, Oliver and Hink, Linda and Horn, Marcus A and Drake, Harold L
The ISME Journal, ISSN 1751-7362, 08/2016, Volume 10, Issue 8, pp. 1954 - 1966
Environmental Sciences & Ecology | Ecology | Life Sciences & Biomedicine | Microbiology | Science & Technology | Deltaproteobacteria - metabolism | Carbon - metabolism | Propionates - metabolism | Butyrates - metabolism | Carbon Dioxide - metabolism | Ethanol - metabolism | Methane - metabolism | Soil Microbiology | Acetates - metabolism | Methanosarcina - classification | Deltaproteobacteria - classification | Bacteria, Anaerobic - genetics | Phylogeny | Fermentation | Bacteria, Anaerobic - classification | Models, Biological | Deltaproteobacteria - genetics | Methanosarcina - genetics | Soil | Methanosarcina - metabolism | Bacteria, Anaerobic - metabolism | Hydrogen - metabolism | Formates - metabolism | Index Medicus | Original
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6. Full Text Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos
by Bryant, Joshua D and Sweeney, Shannon R and Sentandreu, Enrique and Shin, Minhye and Ipas, Hélène and Xhemalce, Blerta and Momb, Jessica and Tiziani, Stefano and Appling, Dean R
The Journal of biological chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 16, pp. 5821 - 5833
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Neural Tube Defects - genetics | Multienzyme Complexes - metabolism | Neural Tube Defects - pathology | Neural Tube Defects - metabolism | Aminohydrolases - genetics | Embryo, Mammalian - metabolism | Mitochondria - genetics | Gene Expression Regulation, Developmental | Gene Deletion | Methylenetetrahydrofolate Dehydrogenase (NADP) - genetics | Formates - metabolism | Methylenetetrahydrofolate Dehydrogenase (NADP) - metabolism | Embryo, Mammalian - pathology | Mice, Inbred C57BL | Cells, Cultured | Metabolome | Mitochondria - metabolism | Multienzyme Complexes - genetics | Mitochondria - pathology | Mice, Knockout | Formate-Tetrahydrofolate Ligase - metabolism | Animals | Energy Metabolism | Metabolic Networks and Pathways | Folic Acid - metabolism | Formate-Tetrahydrofolate Ligase - genetics | Glycolysis | Aminohydrolases - metabolism | Mice | Folic Acid - genetics | Index Medicus | folate | metabolomics | embryo | Metabolism | energy metabolism | neural tube closure | mitochondrial metabolism
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7. Full Text The electric picnic: synergistic requirements for exoelectrogenic microbial communities
by Kiely, Patrick D and Regan, John M and Logan, Bruce E
Current opinion in biotechnology, ISSN 0958-1669, 2011, Volume 22, Issue 3, pp. 378 - 385
Internal Medicine | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Biochemical Research Methods | Science & Technology | Propionates - metabolism | Ethanol - metabolism | Electrochemical Techniques | Bioelectric Energy Sources | Lactic Acid - metabolism | Fermentation | Microbial Consortia | Water Pollutants - metabolism | Electrodes | Geobacter - metabolism | Biofilms | Butyric Acid - metabolism | Electricity | Glucose - metabolism | Acetic Acid - metabolism | Cellulose - metabolism | Formates - metabolism | Index Medicus
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8. Full Text Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells
by Zheng, Yuxiang and Lin, Ting-Yu and Lee, Gina and Paddock, Marcia N and Momb, Jessica and Cheng, Zhe and Li, Qian and Fei, Dennis L and Stein, Benjamin D and Ramsamooj, Shivan and Zhang, Guoan and Blenis, John and Cantley, Lewis C
Cell (Cambridge), ISSN 0092-8674, 11/2018, Volume 175, Issue 6, pp. 1546 - 1560.e17
formate | methotrexate | folate | metabolism | mitochondria | one-carbon | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Methotrexate - pharmacology | Neoplasms - metabolism | Carbon - metabolism | HCT116 Cells | Humans | Methotrexate - pharmacokinetics | Mitochondria - metabolism | Mitochondria - pathology | Neoplasm Proteins - metabolism | Neoplasms - drug therapy | Tetrahydrofolate Dehydrogenase - metabolism | Tetrahydrofolates - metabolism | MCF-7 Cells | Mitochondrial Proteins - metabolism | Cytosol - metabolism | HeLa Cells | Cytosol - pathology | Neoplasms - pathology | Formates - metabolism | Enzymes | Genomics | Physiological aspects | Methotrexate | Sapropterin dihydrochloride | Folic acid | Cells | Cancer | Index Medicus
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9. Full Text C1 Metabolism in Corynebacterium glutamicum: an Endogenous Pathway for Oxidation of Methanol to Carbon Dioxide
by Sabrina Witthoff and Alice Mühlroth and Jan Marienhagen and Michael Bott
Applied and Environmental Microbiology, ISSN 0099-2240, 11/2013, Volume 79, Issue 22, pp. 6974 - 6983
Fundamental and applied biological sciences. Psychology | Microbiology | Biological and medical sciences | Corynebacterium glutamicum - genetics | Oligonucleotide Array Sequence Analysis | Formaldehyde - metabolism | Formates - metabolism | Alcohol Dehydrogenase - metabolism | Recombinant Proteins - metabolism | Carbon - metabolism | Genes, Bacterial | Carbon Dioxide - metabolism | Ethanol - metabolism | Oxidation-Reduction | Bacterial Proteins - genetics | Corynebacterium glutamicum - enzymology | Formate Dehydrogenases - metabolism | Recombinant Proteins - genetics | Aldehyde Oxidoreductases - genetics | Formate Dehydrogenases - genetics | Sequence Analysis, DNA | Aldehyde Oxidoreductases - metabolism | Methanol - metabolism | DNA, Bacterial - genetics | Alcohol Dehydrogenase - genetics | Glucose - metabolism | Bacterial Proteins - metabolism | Gene Expression Regulation, Bacterial