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Chemical Reviews, ISSN 0009-2665, 04/2017, Volume 117, Issue 8, pp. 5704 - 5783
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2016, Volume 291, Issue 5, pp. 2535 - 2546
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2011, Volume 76, Issue 21, pp. 8986 - 8998
Cinnamaldehyde derivatives were synthesized in good to excellent yields in one step by a mild and selective, base-free palladium(II)-catalyzed oxidative Heck... 
ROOM-TEMPERATURE | ISOPRENOID BIOSYNTHESIS | PHOSPHONIC ACID ANTIBIOTICS | FOSMIDOMYCIN ANALOGS | BASE-FREE | CHEMISTRY, ORGANIC | BOND FORMATION | PALLADIUM(II) CATALYSIS | 5-PHOSPHATE REDUCTOISOMERASE | ARYLBORONIC ACIDS | NONMEVALONATE PATHWAY | Oxidoreductases - antagonists & inhibitors | Acrolein - analogs & derivatives | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Humans | Mycobacterium tuberculosis - drug effects | Inhibitory Concentration 50 | Mycobacterium tuberculosis - chemistry | Catalysis | Fosfomycin - analogs & derivatives | Fosfomycin - chemical synthesis | Multienzyme Complexes - chemical synthesis | Fosfomycin - chemistry | Oxidation-Reduction | Aldose-Ketose Isomerases - chemical synthesis | Fosfomycin - pharmacology | Antitubercular Agents - pharmacology | Models, Molecular | Multienzyme Complexes - antagonists & inhibitors | Acrolein - chemical synthesis | Mycobacterium tuberculosis - enzymology | Protein Binding | Acrolein - chemistry | Aldose-Ketose Isomerases - antagonists & inhibitors | Palladium - chemistry | Oxidoreductases - chemical synthesis | Palladium catalysts | Microbial enzymes | Analysis | Oxidation-reduction reaction | Chemical properties | Aldehydes | Organic chemistry | Chemistry | Naturvetenskap | Kemi med inriktning mot organisk kemi | Kemi | Chemistry with specialization in Organic Chemistry | Natural Sciences | Organisk kemi | Pharmaceutical chemistry | Läkemedelskemi
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/2007, Volume 282, Issue 27, pp. 19905 - 19916
Isopentenyl diphosphate is the precursor of various isoprenoids that are essential to all living organisms. It is produced by the mevalonate pathway in humans... 
ENZYME | ISOPRENOID BIOSYNTHESIS | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE | FOSMIDOMYCIN | CRYSTAL-STRUCTURE | ISOPENTENYL DIPHOSPHATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NON-MEVALONATE PATHWAY | 5-PHOSPHATE REDUCTOISOMERASE | BOND | NONMEVALONATE PATHWAY | Humans | Bacterial Proteins - chemistry | Eukaryota - chemistry | Multienzyme Complexes - metabolism | Mutation, Missense | NADP - chemistry | Oxidoreductases - chemistry | Mevalonic Acid - chemistry | Terpenes - chemistry | Terpenes - metabolism | NADP - metabolism | Eukaryota - enzymology | Aldose-Ketose Isomerases - metabolism | Fosfomycin - analogs & derivatives | Hemiterpenes - biosynthesis | Hemiterpenes - chemistry | Aldose-Ketose Isomerases - chemistry | Fosfomycin - chemistry | Oxidation-Reduction | Oxidoreductases - metabolism | Oxidoreductases - genetics | Bacterial Proteins - genetics | Models, Molecular | Organophosphorus Compounds - chemistry | Multienzyme Complexes - genetics | Binding Sites - genetics | Manganese - chemistry | Mevalonic Acid - metabolism | Multienzyme Complexes - chemistry | Animals | Manganese - metabolism | Mycobacterium tuberculosis - enzymology | Bacterial Proteins - metabolism | Ligands | Protein Structure, Quaternary - genetics | Aldose-Ketose Isomerases - genetics | Amino Acid Substitution | Mycobacterium tuberculosis - genetics | Xylulose - analogs & derivatives | Biological Sciences | Biology | Biologi | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2009, Volume 52, Issue 21, pp. 6539 - 6542
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e47513
Isoprenoids are natural products that are all derived from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). These precursors are... 
ISOPENTENYL DIPHOSPHATE | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | ACCUMULATION | PRECURSOR BIOSYNTHESIS | LYCOPENE PRODUCTION | STRESS | TERPENOIDS | MASS-SPECTROMETRY | SOLID-PHASE EXTRACTION | Genetic Engineering - methods | Gas Chromatography-Mass Spectrometry - methods | Metabolic Engineering - methods | Chemistry, Pharmaceutical - methods | Erythritol - analogs & derivatives | Erythritol - chemistry | Models, Chemical | Plasmids - metabolism | Fosfomycin - metabolism | Mevalonic Acid - chemistry | Terpenes - chemistry | Escherichia coli - genetics | Models, Biological | Escherichia coli - metabolism | Carotenoids - chemistry | Mass Spectrometry - methods | Fosfomycin - analogs & derivatives | Phosphates | Enzymes | Metabolites | Escherichia coli | Genetically modified organisms | Physiological aspects | Genetic engineering | Liquid chromatography | Mass spectrometry | Lycopene | Sugars | Monosaccharides | Downstream effects | Genes | Biochemistry | Biosynthesis | Kinases | Engineering | Design engineering | Microorganisms | Mevalonic acid | E coli | Polypropylene | Xylulose | Sulfur | Efflux | D-Xylulose 5-phosphate | Mass spectroscopy | Metabolism | Chromatography | Constraining | Intermediates | Natural products | Metabolic engineering | Scientific imaging | Terpenes | Isopentenyl diphosphate | Pharmaceuticals
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 4964 - 4976
The natural antibiotic fosmidomycin acts via inhibition of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR), an essential enzyme in the non-mevalonate... 
VIVO ANTIMALARIAL ACTIVITY | CLINDAMYCIN | CHEMISTRY, MEDICINAL | ISOPRENOID BIOSYNTHESIS | ISOPENTENYL DIPHOSPHATE | ESTER PRODRUGS | TERPENOID BIOSYNTHESIS | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | PLASMODIUM-FALCIPARUM MALARIA | NONMEVALONATE PATHWAY | Oxidoreductases - antagonists & inhibitors | Antitubercular Agents - chemical synthesis | Fosfomycin - chemical synthesis | Aldose-Ketose Isomerases - chemistry | Catalytic Domain | Antitubercular Agents - chemistry | Fosfomycin - chemistry | Fosfomycin - pharmacology | Antitubercular Agents - pharmacology | Models, Molecular | Crystallography, X-Ray | Structure-Activity Relationship | Multienzyme Complexes - antagonists & inhibitors | Mycobacterium tuberculosis - drug effects | Oxidoreductases - chemistry | Multienzyme Complexes - chemistry | Mycobacterium tuberculosis - enzymology | Drug Design | Protein Binding | Protein Conformation | Aldose-Ketose Isomerases - antagonists & inhibitors | Fosfomycin - analogs & derivatives | Biological Sciences | Basic Medicine | Other Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Biology | MEDICINE | Chemistry | Naturvetenskap | Biokemi och molekylärbiologi | MEDICIN | Kemi | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Cell and molecular biology | Annan medicinsk grundvetenskap | Biochemistry and Molecular Biology | Biologi | Natural Sciences | Cell- och molekylärbiologi
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2012, Volume 55, Issue 14, pp. 6566 - 6575
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2015, Volume 58, Issue 7, pp. 2988 - 3001
Journal Article