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The Journal of Trauma: Injury, Infection, and Critical Care, ISSN 0022-5282, 10/2007, Volume 63, Issue 4, pp. 849 - 854
Journal Article
Vestnik Rossiiskoi akademii meditsinskikh nauk, ISSN 0869-6047, 2000, Issue 2, p. 14
After both thermal and mechanical injuries, mice are shown to have depressed functions of phagocytes (primarily neutrophils), suppressed ability of an immune... 
Fractures, Bone - immunology | Mice, Inbred C57BL | Neutrophils - physiology | Phagocytosis - immunology | Wound Healing - immunology | Fracture Healing - immunology | Animals | Hindlimb - injuries | Immunity, Cellular - physiology | Mice, Inbred CBA | Mice | Burns - immunology | Disease Models, Animal
Journal Article
Clinical Orthopaedics and Related Research, ISSN 0009-921X, 1991, Issue 264, pp. 270 - 277
Journal Article
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, ISSN 0301-620X, 08/2002, Volume 84B, Issue 6, pp. 802 - 806
Journal Article
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), ISSN 2522-9028, 2008, Volume 54, Issue 4, p. 30
Journal Article
Biomaterials, ISSN 0142-9612, 2013, Volume 34, Issue 27, pp. 6412 - 6421
Abstract Endochondral ossification plays a key role in the bone healing process, which requires normal cartilage callus formation. Progranulin (PGRN) growth... 
Advanced Basic Science | Dentistry | Bone resorption | Bone repair | Progranulin | TNF-α | BMP-2 | Endochondral ossification | MATERIALS SCIENCE, BIOMATERIALS | TNF-alpha | ENGINEERING, BIOMEDICAL | DEFECT MODEL | GRANULIN-EPITHELIN PRECURSOR | OLIGOMERIC MATRIX PROTEIN | DEFICIENT MICE | TUMOR-NECROSIS-FACTOR | FRACTURE REPAIR | HOST-DEFENSE | GROWTH-FACTOR | TRANSCRIPTION FACTOR | Recombinant Proteins - therapeutic use | Femur - pathology | Tumor Necrosis Factor-alpha - genetics | Male | Femoral Fractures - pathology | Intercellular Signaling Peptides and Proteins - metabolism | Fracture Healing - drug effects | Gene Deletion | Tumor Necrosis Factor-alpha - immunology | Femur - injuries | Recombinant Proteins - metabolism | Cell Line | Femoral Fractures - immunology | Signal Transduction | Osteogenesis - drug effects | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Femur - drug effects | Mice, Transgenic | Recombinant Proteins - genetics | Femoral Fractures - metabolism | Animals | Recombinant Proteins - immunology | Femoral Fractures - drug therapy | Intercellular Signaling Peptides and Proteins - therapeutic use | Mice | Receptors, Tumor Necrosis Factor - immunology | Intercellular Signaling Peptides and Proteins - immunology | Genetically modified animals | Immunohistochemistry | Genetic engineering | Analysis | Cells | Regeneration | Biomedical materials | Healing | Biocompatibility | Bones | Formations | Recombinant | progranulin | endochondral ossification | bone resorption | bone repair
Journal Article
Cell and Tissue Research, ISSN 0302-766X, 3/2012, Volume 347, Issue 3, pp. 567 - 573
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 05/2011, Volume 89, Issue 5, pp. 669 - 673
Review discusses a mechanism by which systemic inflammation evoked by severe injury can impair fracture healing. Apart from their pivotal role in the host... 
priming | repair | bone | neutrophil | leukocytosis | Priming | Leukocytosis | Bone | Neutrophil | Repair | HEMATOMA | BETA-GLUCAN | ANGIOGENESIS | DELTA-T-CELLS | IMMUNOLOGY | MOLECULAR ASPECTS | CELL BIOLOGY | RESPONSE SYNDROME | IN-VIVO | HEMATOLOGY | SKELETAL DEVELOPMENT | TRAUMA PATIENTS | Fracture Healing - physiology | Inflammation - pathology | Animals | Leukocytes - metabolism | Humans
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 06/2014, Volume 29, Issue 6, pp. 1478 - 1491
Journal Article
Gene Therapy, ISSN 0969-7128, 09/2006, Volume 13, Issue 17, pp. 1290 - 1299
Critical size defects of bone and delayed fracture healing due to metabolic disorders are still problems in orthopaedic surgery. Adenoviral vectors encoding... 
Sheep | Fracture healing | Inflammation | Bone formation | BMP-2 | Adenoviral gene transfer | MEDICINE, RESEARCH & EXPERIMENTAL | HUMORAL IMMUNE-RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RABBIT MODEL | fracture healing | VIRAL-ANTIGENS | INTERBODY FUSION | THERAPY | inflammation | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | GENETICS & HEREDITY | adenoviral gene transfer | RECOMBINANT ADENOVIRUSES | bone formation | ANIMAL-MODEL | SPINE FUSION | sheep | MORPHOGENETIC PROTEIN-2 | Genetic Vectors - administration & dosage | Osteotomy | Bony Callus | Luciferases - genetics | Time Factors | Antibodies, Viral - analysis | Adenoviridae - genetics | Female | Models, Animal | Adenoviridae - immunology | Bone Morphogenetic Proteins - genetics | Transduction, Genetic - methods | Tibial Fractures - therapy | Hip Fractures - immunology | Gene Expression | Genetic Vectors - immunology | Bone Morphogenetic Protein 2 | Fractures, Bone - immunology | Hip Fractures - pathology | Genetic Vectors - genetics | Animals | Fracture Healing | Hip Fractures - therapy | Transforming Growth Factor beta - genetics | Fractures, Bone - pathology | Fractures, Bone - therapy | Tibial Fractures - pathology | Transgenes - immunology | Tibial Fractures - immunology | Osteogenesis | Genetic Therapy - methods | Care and treatment | Fractures | Growth | Physiological aspects | Bones | Genetic aspects | Research | Gene therapy | Health aspects | Proteins | Adenoviruses
Journal Article
BMC Musculoskeletal Disorders, ISSN 1471-2474, 06/2017, Volume 18, Issue 1, pp. 253 - 10
Background: Heightened local inflammation due to muscle trauma or disease is associated with impaired bone regeneration. Methods: We hypothesized that FK506,... 
Composite injury | Open fracture | Orthopaedic trauma | Tacrolimus | Immunomodulation | Adaptive immune response | Inflammation | Volumetric muscle loss | Musculoskeletal | Skeletal muscle injury | DOSE-DEPENDENCE | AXONAL REGENERATION | INDUCTION | MODEL | RHEUMATOLOGY | CYCLOSPORINE-A | IMMUNE-SYSTEM | IMMUNOSUPPRESSION | BONE REGENERATION | ORTHOPEDICS | T-CELLS | Bony Callus - immunology | Bony Callus - drug effects | Torque | Bone Nails | Osteotomy | Humans | Immunosuppressive Agents - therapeutic use | Soft Tissue Injuries - immunology | Rats, Inbred Lew | Soft Tissue Injuries - drug therapy | Male | Bony Callus - pathology | Muscle, Skeletal - injuries | Tibial Fractures - surgery | Tibial Fractures - drug therapy | Fracture Healing - drug effects | Soft Tissue Injuries - complications | Tibial Fractures - physiopathology | T-Lymphocytes - drug effects | Muscle, Skeletal - drug effects | Muscular Diseases - drug therapy | Tacrolimus - pharmacology | Fracture Fixation, Intramedullary - instrumentation | Immunosuppressive Agents - pharmacology | Macrophages - immunology | Disease Models, Animal | Bone Regeneration - drug effects | Immunity, Innate - drug effects | Rats | Muscular Diseases - pathology | Soft Tissue Injuries - pathology | Tacrolimus - therapeutic use | Fracture Fixation, Intramedullary - methods | Muscular Diseases - immunology | Adaptive Immunity - drug effects | Animals | Biopsy | Muscular Diseases - complications | Macrophages - drug effects | T-Lymphocytes - immunology | Muscle, Skeletal - pathology | Callus | Cytokines | Mechanical properties | Arthritis | Lymphocytes T | Bone healing | Gene expression | Macrophages | Trauma | Muscle contraction | Skeletal muscle | Regeneration | Bone growth | Fractures | Tibia | Lymphocytes | Stem cells | Laboratory animals | Growth factors
Journal Article
Journal of Bone and Mineral Research, ISSN 0884-0431, 11/2010, Volume 25, Issue 11, pp. 2412 - 2418
Journal Article
Journal Article