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by Zheng, Hou‐Feng and Forgetta, Vincenzo and Hsu, Yi‐Hsiang and Estrada, Karol and Rosello‐Diez, Alberto and Leo, Paul J and Dahia, Chitra L and Park‐Min, Kyung Hyun and Tobias, Jonathan H and Kooperberg, Charles and Kleinman, Aaron and Styrkarsdottir, Unnur and Liu, Ching‐Ti and Uggla, Charlotta and Evans, Daniel S and Nielson, Carrie M and Walter, Klaudia and Pettersson‐Kymmer, Ulrika and McCarthy, Shane and Eriksson, Joel and Kwan, Tony and Jhamai, Mila and Trajanoska, Katerina and Memari, Yasin and Min, Josine and Huang, Jie and Danecek, Petr and Wilmot, Beth and Li, Rui and Chou, Wen‐Chi and Mokry, Lauren E and Moayyeri, Alireza and Claussnitzer, Melina and Cheng, Chia‐Ho and Cheung, Warren and Medina‐Gómez, Carolina and Ge, Bing and Chen, Shu‐Huang and Choi, Kwangbom and Oei, Ling and Fraser, James and Kraaij, Robert and Hibbs, Matthew A and Gregson, Celia L and Paquette, Denis and Hofman, Albert and Wibom, Carl and Tranah, Gregory J and Marshall, Mhairi and Gardiner, Brooke B and Cremin, Katie and Auer, Paul and Hsu, Li and Ring, Sue and Tung, Joyce Y and Thorleifsson, Gudmar and Enneman, Anke W and van Schoor, Natasja M and de Groot, Lisette C. P. G. M and van der Velde, Nathalie and Melin, Beatrice and Kemp, John P and Christiansen, Claus and Sayers, Adrian and Zhou, Yanhua and Calderari, Sophie and van Rooij, Jeroen and Carlson, Chris and Peters, Ulrike and Berlivet, Soizik and Dostie, Josée and Uitterlinden, Andre G and Williams, Stephen R and Farber, Charles and Grinberg, Daniel and LaCroix, Andrea Z and Haessler, Jeff and Chasman, Daniel I and Giulianini, Franco and Rose, Lynda M and Ridker, Paul M and Eisman, John A and Nguyen, Tuan V and Center, Jacqueline R and Nogues, Xavier and Garcia‐Giralt, Natalia and Launer, Lenore L and Gudnason, Vilmunder and Mellström, Dan and Vandenput, Liesbeth and Amin, Najaf and van Duijn, Cornelia M and Karlsson, Magnus K and Ljunggren, Östen and Svensson, Olle and Hallmans, Göran and Rousseau, François and Giroux, Sylvie and Bussière, Johanne and Arp, Pascal P and ... and AOGC Consortium and UK10K Consortium and Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa and Göteborgs universitet and Gothenburg University and Institute of Medicine, School of Public Health and Community Medicine and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Nature (London), ISSN 1476-4687, 2015, Volume 526, Issue 7571, pp. 112 - 117
Journal Article
by Estrada, Karol and Styrkarsdottir, Unnur and Evangelou, Evangelos and Hsu, Yi-Hsiang and Duncan, Emma L and Ntzani, Evangelia E and Oei, Ling and Albagha, Omar M E and Amin, Najaf and Kemp, John P and Koller, Daniel L and Li, Guo and Liu, Ching-Ti and Minster, Ryan L and Moayyeri, Alireza and Vandenput, Liesbeth and Willner, Dana and Xiao, Su-Mei and Yerges-Armstrong, Laura M and Zheng, Hou-Feng and Alonso, Nerea and Eriksson, Joel and Kammerer, Candace M and Kaptoge, Stephen K and Leo, Paul J and Thorleifsson, Gudmar and Wilson, Scott G and Wilson, James F and Aalto, Ville and Alen, Markku and Aragaki, Aaron K and Aspelund, Thor and Center, Jacqueline R and Dailiana, Zoe and Duggan, David J and Garcia, Melissa and Garcia-Giralt, Natàlia and Giroux, Sylvie and Hallmans, Göran and Hocking, Lynne J and Husted, Lise Bjerre and Jameson, Karen A and Khusainova, Rita and Kim, Ghi Su and Kooperberg, Charles and Koromila, Theodora and Kruk, Marcin and Laaksonen, Marika and Lacroix, Andrea Z and Lee, Seung Hun and Leung, Ping C and Lewis, Joshua R and Masi, Laura and Mencej-Bedrac, Simona and Nguyen, Tuan V and Nogues, Xavier and Patel, Millan S and Prezelj, Janez and Rose, Lynda M and Scollen, Serena and Siggeirsdottir, Kristin and Smith, Albert V and Svensson, Olle and Trompet, Stella and Trummer, Olivia and van Schoor, Natasja M and Woo, Jean and Zhu, Kun and Balcells, Susana and Brandi, Maria Luisa and Buckley, Brendan M and Cheng, Sulin and Christiansen, Claus and Cooper, Cyrus and Dedoussis, George and Ford, Ian and Frost, Morten and Goltzman, David and González-Macías, Jesús and Kähönen, Mika and Karlsson, Magnus and Khusnutdinova, Elza and Koh, Jung-Min and Kollia, Panagoula and Langdahl, Bente Lomholt and Leslie, William D and Lips, Paul and Ljunggren, Östen and Lorenc, Roman S and Marc, Janja and Mellström, Dan and Obermayer-Pietsch, Barbara and Olmos, José M and Pettersson-Kymmer, Ulrika and Reid, David M and Riancho, José A and Ridker, Paul M and Rousseau, François and lagboom, P Eline S and Tang, Nelson L S and ... and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy
Nature genetics, ISSN 1546-1718, 2012, Volume 44, Issue 5, pp. 491 - 501
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed the largest meta-analysis to date on lumbar spine and femoral neck... 
WOMEN | GENE | VARIANTS | DISEASE | GENETICS & HEREDITY | OSTEOPOROTIC FRACTURES | LRP5 | PATTERNS | EXPRESSION | BURDEN | HIP | Glycoproteins - genetics | Genetic Predisposition to Disease | Genome-Wide Association Study | Low Density Lipoprotein Receptor-Related Protein-5 - genetics | Extracellular Matrix Proteins - genetics | Humans | Risk Factors | Computational Biology | Intercellular Signaling Peptides and Proteins - genetics | European Continental Ancestry Group | Genotype | Male | Bone Density - genetics | Gene Expression Profiling | Phosphoproteins - genetics | Fractures, Bone - genetics | Mitochondrial Membrane Transport Proteins - genetics | Polymorphism, Single Nucleotide - genetics | Female | Femur Neck - physiopathology | Osteoporosis - genetics | Spectrin - genetics | Quantitative Trait Loci | Lumbar Vertebrae - physiopathology | Quantitative trait loci | Measurement | Fractures | Bones | Genetic aspects | Identification and classification | Density | Risk factors | Medical research | Osteoporosis | Genomics | Bone density | Gene loci | Vèrtebres lumbars | Gens | Femur | Genes | Bone densitometry | Densitometria òssia | Fèmur | Lumbar vertebrae | Spectrin | Klinisk medicin | Single Nucleotide | Mitochondrial Membrane Transport Proteins | genetics | Endokrinologi och diabetes | Extracellular Matrix Proteins | Phosphoproteins | Endocrinology and Diabetes | Bone Density | Low Density Lipoprotein Receptor-Related Protein-5 | Intercellular Signaling Peptides and Proteins | Femur Neck | Glycoproteins | Clinical Medicine | physiopathology | Bone | Lumbar Vertebrae | Polymorphism
Journal Article
by Zheng, Hou-Feng and Tobias, Jon H and Duncan, Emma and Evans, David M and Eriksson, Joel and Paternoster, Lavinia and Yerges-Armstrong, Laura M and Lehtimäki, Terho and Bergström, Ulrica and Kähönen, Mika and Leo, Paul J and Raitakari, Olli and Laaksonen, Marika and Nicholson, Geoffrey C and Viikari, Jorma and Ladouceur, Martin and Lyytikäinen, Leo-Pekka and Medina-Gomez, Carolina and Rivadeneira, Fernando and Prince, Richard L and Sievanen, Harri and Leslie, William D and Mellström, Dan and Eisman, John A and Movérare-Skrtic, Sofia and Goltzman, David and Hanley, David A and Jones, Graeme and St. Pourcain, Beate and Xiao, Yongjun and Timpson, Nicholas J and Smith, George Davey and Reid, Ian R and Ring, Susan M and Sambrook, Philip N and Karlsson, Magnus and Dennison, Elaine M and Kemp, John P and Danoy, Patrick and Sayers, Adrian and Wilson, Scott G and Nethander, Maria and McCloskey, Eugene and Vandenput, Liesbeth and Eastell, Richard and Liu, Jeff and Spector, Tim and Mitchell, Braxton D and Streeten, Elizabeth A and Brommage, Robert and Pettersson-Kymmer, Ulrika and Brown, Matthew A and Ohlsson, Claes and Richards, J. Brent and Lorentzon, Mattias and Institutionen för biomedicin, avdelningen för medicinsk genetik och klinisk genetik and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin and Institute of Biomedicine, Department of Medical and Clinical Genetics and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine
PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 7, p. e1002745
Journal Article
BioMed research international, ISSN 2314-6141, 2015, Volume 2015, pp. 1 - 10
.... Nowadays, the incidence of hip fractures due to osteoporosis is increasing worldwide. Ovariectomized (OVX) rats have fragile bone due to estrogen deficiency and mimic the menopausal conditions in women... 
MEDICINE, RESEARCH & EXPERIMENTAL | MINERAL DENSITY | RESORPTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MODULATE | MARKERS | MICROBIOTA | FEMORAL BONE | EXPRESSION | Ovariectomy - adverse effects | Osteocalcin - genetics | Osteoporosis - drug therapy | Bone Density - genetics | Bone Remodeling - drug effects | Fractures, Bone - genetics | Bone Diseases, Metabolic - drug therapy | Osteonectin - genetics | Osteoporosis - metabolism | Bone Resorption - genetics | Bifidobacterium - metabolism | Bone Resorption - metabolism | Female | Osteoporosis - genetics | Osteogenesis - genetics | Bone Morphogenetic Protein 2 - genetics | Femur - metabolism | Osteogenesis - drug effects | Bone Resorption - drug therapy | Rats | Femur - drug effects | Probiotics - pharmacology | Rats, Sprague-Dawley | Fractures, Bone - metabolism | Bone Diseases, Metabolic - metabolism | Bone Density - drug effects | Animals | Bone Diseases, Metabolic - genetics | Bone Remodeling - genetics | Fractures, Bone - drug therapy | Host-bacteria relationships | Probiotics | Complications and side effects | Bifidobacterium | Ovariectomy | Bones | Observations | Health aspects | Density | Health sciences | Nutrition | Tissue engineering | Genes | Mortality | Metabolism | Veterinary medicine | Studies | Osteoporosis | Chemotherapy | Fractures | Womens health | Rodents | Older people | Bacteria | Hormone replacement therapy | Bone density | Laboratory animals
Journal Article
The Journal of cell biology, ISSN 0021-9525, 12/2010, Volume 191, Issue 7, pp. 1271 - 1283
Runx2 is indispensable for osteoblast lineage commitment and early differentiation but also blocks osteoblast maturation, thereby causing bone loss in Runx2 transgenic mice... 
Osteomyelitis | Phenotypes | Antibodies | Bones | Mice | Repression | Bone marrow cells | Osteoblasts | Zinc | Mesenchymal stem cells | CBFA1/RUNX2 | OVEREXPRESSION | RECRUITMENT | OSTEOBLAST DIFFERENTIATION | TGF-BETA | GENE | HOMEODOMAIN PROTEINS | CBFA1 | PARATHYROID-HORMONE | EXPRESSION | CELL BIOLOGY | Osteopontin - genetics | Bone and Bones - pathology | Transcription, Genetic - drug effects | Osteogenesis - physiology | Fractures, Spontaneous - genetics | Gene Expression - genetics | Protein Interaction Domains and Motifs - physiology | Bone Development - physiology | Cell Count | Alkaline Phosphatase - metabolism | Osteocalcin - genetics | Bone Remodeling - physiology | Core Binding Factor Alpha 1 Subunit - antagonists & inhibitors | Core Binding Factor Alpha 1 Subunit - metabolism | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Mesenchymal Stromal Cells - cytology | Bone and Bones - metabolism | Osteoprotegerin - genetics | Osteoblasts - cytology | Response Elements - physiology | Animals, Newborn | Calcification, Physiologic - genetics | Histone Deacetylases - genetics | Extracellular Matrix Proteins - genetics | Rats | Histone Deacetylases - metabolism | Mice, Transgenic | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Inbred Strains | Bone Diseases, Metabolic - metabolism | RANK Ligand - genetics | Animals | Sp7 Transcription Factor | Heterozygote | Histone Deacetylase Inhibitors - pharmacology | Zinc Fingers - physiology | Bone Diseases, Metabolic - genetics | Transcription, Genetic - genetics | Bone and Bones - abnormalities | Bone and Bones - embryology | Osteoblasts - metabolism | Core Binding Factor Alpha 1 Subunit - genetics | Protein Binding - physiology | Proteins | Enzymes | Transcription factors | Research | Properties | Density
Journal Article
PLoS genetics, ISSN 1553-7404, 2011, Volume 7, Issue 4, p. e1001372
Journal Article
American journal of human genetics, ISSN 0002-9297, 2013, Volume 92, Issue 4, pp. 565 - 574
Journal Article