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1. Full Text FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
by Darnell, Robert B and Darnell, Jennifer C and Van Driesche, Sarah J and Zhang, Chaolin and Hung, Ka Ying Sharon and Mele, Aldo and Fraser, Claire E and Stone, Elizabeth F and Chen, Cynthia and Fak, John J and Chi, Sung Wook and Licatalosi, Donny D and Richter, Joel D
Cell, ISSN 0092-8674, 07/2011, Volume 146, Issue 2, pp. 247 - 261
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it... 
LOCAL PROTEIN-SYNTHESIS | MEMORY | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | DEPENDENT TRANSLATION | INHIBITS TRANSLATION | KNOCKOUT MICE | POLYRIBOSOMES | X MENTAL-RETARDATION | PLASTICITY | CELL BIOLOGY | Protein Biosynthesis | Autistic Disorder - physiopathology | Autistic Disorder - metabolism | Fragile X Syndrome - physiopathology | Humans | Fragile X Syndrome - metabolism | Ribosomes - metabolism | Fragile X Mental Retardation Protein - metabolism | RNA-Binding Proteins | Mice, Knockout | Brain - metabolism | Animals | Sequence Analysis, RNA | Synapses - metabolism | Polyribosomes - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Proteins | Autism | Medical colleges | Crosslinked polymers | Messenger RNA | Neurons | Protein binding | Translocation | Brain | RNA-binding protein | Translation | Immunoprecipitation | RNA | Coding | Cognitive ability | Ribosomes | Fragile X syndrome
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2. Full Text Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons
by Ricardos Tabet and Enora Moutin and Jérôme A. J. Becker and Dimitri Heintz and Laetitia Fouillen and Eric Flatter and Wojciech Krężel and Violaine Alunni and Pascale Koebel and Doulaye Dembélé and Flora Tassone and Barbara Bardoni and Jean-Louis Mandel and Nicolas Vitale and Dominique Muller and Julie Le Merrer and Hervé Moine
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. E3619 - E3628
Fragile X syndrome (FXS) is caused by the absence of the Fragile X Mental Retardation Protein (FMRP) in neurons. In the mouse, the lack of FMRP is associated... 
Fragile X syndrome | Diacylglycerol kinase | FMRP | Translation control | CLIP | MULTIDISCIPLINARY SCIENCES | fragile X syndrome | diacylglycerol kinase | translation control | TRANSLATION | SYNAPTIC PLASTICITY | DENDRITIC SPINES | SOCIAL-BEHAVIOR | MESSENGER-RNA | OPIOID RECEPTOR | MOUSE MODEL | IN-VIVO | NULL MICE | DEFICITS | Fragile X Syndrome - genetics | Signal Transduction | Diacylglycerol Kinase - metabolism | Dendritic Spines - enzymology | Humans | Mice, Inbred C57BL | Middle Aged | Fragile X Syndrome - metabolism | Male | Dendritic Spines - metabolism | Fragile X Mental Retardation Protein - metabolism | Diacylglycerol Kinase - genetics | Mice, Knockout | Animals | Fragile X Syndrome - enzymology | Diglycerides - metabolism | Neurons - enzymology | Aged | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Neurons | Development and progression | Diglycerides | Genetic aspects | Genetic regulation | Health aspects | Life Sciences | Molecular biology | Biochemistry, Molecular Biology | Biological Sciences | PNAS Plus
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3. Full Text Fragile X mental retardation protein controls synaptic vesicle exocytosis by modulating N-type calcium channel density
by Ferron, Laurent and Nieto-Rostro, Manuela and Cassidy, John S and Dolphin, Annette C
Nature Communications, ISSN 2041-1723, 04/2014, Volume 5, Issue 1, p. 3628
Fragile X syndrome (FXS), the most common heritable form of mental retardation, is characterized by synaptic dysfunction. Synaptic transmission depends... 
MESSENGER-RNAS | INTERACTION SITE | TRANSMISSION | NEUROTRANSMITTER RELEASE | MULTIDISCIPLINARY SCIENCES | CA2+ CHANNELS | MOUSE MODEL | SYMPATHETIC NEURONS | FMRP PHOSPHORYLATION | BINDING PROTEIN | CA(V)2.2 | Cell Line | Synaptic Vesicles - metabolism | Synaptic Transmission - physiology | Calcium - metabolism | Humans | Rats | Fragile X Mental Retardation Protein - metabolism | Calcium Channels, N-Type - metabolism | Exocytosis - physiology | Patch-Clamp Techniques | Animals | Neurons - physiology | Mice | Neurons - metabolism
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4. Full Text The Fragile X Syndrome Protein Represses Activity-Dependent Translation through CYFIP1, a New 4E-BP
by Napoli, Ilaria and Mercaldo, Valentina and Boyl, Pietro Pilo and Eleuteri, Boris and Zalfa, Francesca and De Rubeis, Silvia and Di Marino, Daniele and Mohr, Evita and Massimi, Marzia and Falconi, Mattia and Witke, Walter and Costa-Mattioli, Mauro and Sonenberg, Nahum and Achsel, Tilmann and Bagni, Claudia
Cell, ISSN 0092-8674, 2008, Volume 134, Issue 6, pp. 1042 - 1054
Strong evidence indicates that regulated mRNA translation in neuronal dendrites underlies synaptic plasticity and brain development. The fragile X mental... 
PROTEINS | HUMDISEASE | MOLNEURO | DROSOPHILA CUP | MESSENGER-RNA | FMRP | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BC1 RNA | BINDING-PROTEIN | INITIATION-FACTOR 4E | MICE | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | CELL BIOLOGY | Amino Acid Sequence | Brain - embryology | Protein Biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Eukaryotic Initiation Factor-4E - metabolism | Models, Molecular | Molecular Sequence Data | Fragile X Mental Retardation Protein - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Brain - metabolism | Nerve Tissue Proteins - metabolism | Sequence Alignment | Animals | Fragile X Mental Retardation Protein - chemistry | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | Eukaryotic Initiation Factor-4E - genetics | Synapses | Proteins | Protein biosynthesis
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5. Full Text S6K1 Phosphorylates and Regulates Fragile X Mental Retardation Protein (FMRP) with the Neuronal Protein Synthesis-dependent Mammalian Target of Rapamycin (mTOR) Signaling Cascade
by Usha Narayanan and Vijayalaxmi Nalavadi and Mika Nakamoto and George Thomas and Stephanie Ceman and Gary J. Bassell and Stephen T. Warren
Journal of Biological Chemistry, ISSN 0021-9258, 07/2008, Volume 283, Issue 27, pp. 18478 - 18482
Fragile X syndrome is a common form of cognitive deficit caused by the functional absence of fragile X mental retardation protein (FMRP), a dendritic... 
INACTIVATION | KINASE-ACTIVITY | LOCALIZATION | MESSENGER-RNA TRANSLATION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LONG-TERM DEPRESSION | MOUSE MODEL | RECEPTOR ACTIVATION | MICE | IDENTIFICATION | Protein Kinases - metabolism | Neurons - pathology | Phosphorylation | Protein Kinases - genetics | Humans | Fragile X Mental Retardation Protein - metabolism | Receptors, Metabotropic Glutamate - metabolism | RNA, Messenger - metabolism | Neuronal Plasticity - genetics | Receptors, Metabotropic Glutamate - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Neurons - metabolism | Protein Biosynthesis - genetics | Fragile X Syndrome - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | RNA, Messenger - genetics | Cells, Cultured | Protein Phosphatase 2 - genetics | Fragile X Syndrome - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Hippocampus - pathology | Signal Transduction - genetics | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Hippocampus - metabolism | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Protein Phosphatase 2 - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | TOR Serine-Threonine Kinases | Mitogen-Activated Protein Kinase 1 - metabolism
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6. Full Text FMRP targets distinct mRNA sequence elements to regulate protein expression
by Ascano, Manuel and Mukherjee, Neelanjan and Bandaru, Pradeep and Miller, Jason B and Nusbaum, Jeffrey D and Corcoran, David L and Langlois, Christine and Munschauer, Mathias and Dewell, Scott and Hafner, Markus and Williams, Zev and Ohler, Uwe and Tuschl, Thomas
Nature, ISSN 0028-0836, 12/2012, Volume 492, Issue 7429, pp. 382 - 386
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature ovarian insufficiency in female... 
SYNAPTIC FUNCTION | AUTISM | GENE | PAR-CLIP | MULTIDISCIPLINARY SCIENCES | MUTATION | FRAGILE-X-SYNDROME | CGG-REPEAT | BINDING PROTEIN | IDENTIFICATION | MENTAL-RETARDATION PROTEIN | Child Development Disorders, Pervasive - metabolism | Multigene Family | Immunoprecipitation | Humans | Molecular Sequence Data | Substrate Specificity | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Brain - metabolism | Base Sequence | HEK293 Cells | Female | Protein Biosynthesis - genetics | Response Elements - genetics | Binding Sites | Child | Regulatory Sequences, Ribonucleic Acid - genetics | Ovary - metabolism | Cross-Linking Reagents | Ovary - pathology | Signal Transduction | Gene Expression Regulation - genetics | RNA, Messenger - genetics | Animals | Child Development Disorders, Pervasive - genetics | Fragile X Mental Retardation Protein - genetics | Mice | Mutation | Usage | Messenger RNA | DNA microarrays | Physiological aspects | Research | Gene expression | Binding proteins | Proteins | Cell culture | Protein synthesis | Binding sites | Methods
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7. Full Text Translational Control of Long-Lasting Synaptic Plasticity and Memory
by Costa-Mattioli, Mauro and Sossin, Wayne S and Klann, Eric and Sonenberg, Nahum
Neuron, ISSN 0896-6273, 2009, Volume 61, Issue 1, pp. 10 - 26
Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological,... 
CYTOPLASMIC POLYADENYLATION ELEMENT | MESSENGER-RNA TRANSLATION | LOCAL PROTEIN-SYNTHESIS | RAPAMYCIN-SENSITIVE MANNER | DENDRITIC BC1 RNA | KINASE M-ZETA | CAP-DEPENDENT TRANSLATION | ELONGATION-FACTOR 1-ALPHA | INITIATION-FACTOR 4E | NEUROSCIENCES | X MENTAL-RETARDATION | Protein Kinases - metabolism | Protein Biosynthesis | Protein Kinases - genetics | Ribosomal Protein S6 Kinases - metabolism | mRNA Cleavage and Polyadenylation Factors - metabolism | MicroRNAs - metabolism | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Neuronal Plasticity - physiology | Neurons - physiology | Eukaryotic Initiation Factor-2 - metabolism | Gene Expression Regulation | Activating Transcription Factor 4 - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Activating Transcription Factor 4 - metabolism | Eukaryotic Initiation Factor-2 - genetics | Signal Transduction - physiology | Fragile X Mental Retardation Protein - genetics | MicroRNAs - genetics | TOR Serine-Threonine Kinases | Ribosomal Protein S6 Kinases - genetics | Memory - physiology | Proteins | Physiological aspects | Protein biosynthesis | Phosphorylation | Polypeptides | Protein synthesis | Behavior | Kinases | Gene expression | Learning
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8. Full Text The translation of translational control by FMRP: Therapeutic targets for FXS
by Darnell, Jennifer C and Klann, Eric
Nature Neuroscience, ISSN 1097-6256, 11/2013, Volume 16, Issue 11, pp. 1530 - 1536
De novo protein synthesis is necessary for long-lasting modifications in synaptic strength and dendritic spine dynamics that underlie cognition. Fragile X... 
DENDRITIC SPINES | RNA-BINDING | DEPENDENT REGULATION | LONG-TERM DEPRESSION | MOUSE MODEL | FRAGILE-X-SYNDROME | KNOCKOUT MICE | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | P70 S6 KINASE | Fragile X Syndrome - genetics | Fragile X Syndrome - therapy | Humans | Protein Biosynthesis - physiology | Fragile X Syndrome - pathology | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Fragile X Syndrome - complications | Intellectual Disability - genetics | Receptors, Metabotropic Glutamate | Animals | Neuronal Plasticity | Fragile X Mental Retardation Protein - genetics | Intellectual Disability - etiology | Physiological aspects | Protein biosynthesis | Genetic aspects | Research | Fragile X syndrome | Binding proteins | Risk factors
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9. Full Text A Chromatin-Dependent Role of the Fragile X Mental Retardation Protein FMRP in the DNA Damage Response
by Alpatov, Roman and Lesch, Bluma J and Nakamoto-Kinoshita, Mika and Blanco, Andres and Chen, Shuzhen and Stützer, Alexandra and Armache, Karim J and Simon, Matthew D and Xu, Chao and Ali, Muzaffar and Murn, Jernej and Prisic, Sladjana and Kutateladze, Tatiana G and Vakoc, Christopher R and Min, Jinrong and Kingston, Robert E and Fischle, Wolfgang and Warren, Stephen T and Page, David C and Shi, Yang
Cell, ISSN 0092-8674, 05/2014, Volume 157, Issue 4, pp. 869 - 881
Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present... 
SPERMATOGENESIS | SURVIVAL | H3K79 METHYLATION | PERSPECTIVE | INFORMATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | DYNAMICS | TARGETS | BRCA1 | MICE LACKING | CELL BIOLOGY | Chromatin - metabolism | Spermatogenesis | Humans | Prophase | Male | Fragile X Mental Retardation Protein - metabolism | Meiosis | Hippocampus - cytology | Mice, Knockout | Animals | Embryo, Mammalian - cytology | Fibroblasts | Fragile X Mental Retardation Protein - genetics | Mice | Neurons - metabolism | DNA Damage | Histones - metabolism | Mutation | Chromosome Pairing | Receptors, AMPA - metabolism | Chromatin | DNA damage | DNA | Chromosomes | Mental illness | DNA repair | Mental retardation | Cells | Protein binding
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