Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (2812) 2812
Publication (743) 743
Book Chapter (51) 51
Book Review (48) 48
Newsletter (41) 41
Conference Proceeding (28) 28
Book / eBook (13) 13
Newspaper Article (4) 4
Magazine Article (2) 2
Dissertation (1) 1
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (1818) 1818
index medicus (1605) 1605
animals (1571) 1571
fragile-x-syndrome (1012) 1012
neurosciences (896) 896
fragile x syndrome (861) 861
fragile x syndrome - genetics (849) 849
male (846) 846
mice (828) 828
fragile x mental retardation protein - genetics (748) 748
biochemistry & molecular biology (649) 649
female (600) 600
fragile x mental retardation protein - metabolism (558) 558
mental-retardation protein (514) 514
genetics & heredity (511) 511
mouse model (494) 494
article (487) 487
fragile x syndrome - metabolism (485) 485
autism (462) 462
fragile x mental retardation protein (446) 446
cell biology (438) 438
congenital, hereditary, and neonatal diseases and abnormalities (422) 422
mutation (419) 419
mice, knockout (408) 408
proteins (401) 401
disease models, animal (393) 393
research (386) 386
mental retardation (373) 373
messenger-rna (355) 355
rna, messenger - metabolism (340) 340
synaptic plasticity (336) 336
nerve tissue proteins - genetics (317) 317
nervous system diseases (311) 311
genetic aspects (303) 303
analysis (297) 297
neurons - metabolism (287) 287
expression (282) 282
fmrp (279) 279
neurons (279) 279
gene expression (272) 272
gene (269) 269
brain (266) 266
molecular sequence data (261) 261
mice, inbred c57bl (259) 259
protein binding (243) 243
rna-binding proteins - metabolism (242) 242
fragile x syndrome - physiopathology (238) 238
rna (238) 238
translation (233) 233
mental-retardation (231) 231
fragile x syndrome - pathology (225) 225
mental illness (222) 222
brain - metabolism (221) 221
rna-binding proteins - genetics (221) 221
base sequence (217) 217
nerve tissue proteins - metabolism (214) 214
adult (212) 212
genetics (208) 208
physiological aspects (208) 208
rna-binding proteins (207) 207
cells, cultured (203) 203
phenotype (203) 203
protein biosynthesis (201) 201
fmr1 (200) 200
child (196) 196
multidisciplinary sciences (194) 194
dendritic spines (193) 193
long-term potentiation (192) 192
neurology (185) 185
dna methylation (181) 181
methylation (180) 180
rna, messenger - genetics (175) 175
research article (173) 173
long-term depression (169) 169
biology (167) 167
synapses - metabolism (163) 163
genes (161) 161
nervous system (159) 159
neuroscience (158) 158
amino acid sequence (157) 157
gene expression regulation (154) 154
identification (154) 154
psychiatry (154) 154
signal transduction (153) 153
dna (151) 151
rodents (148) 148
fmr1 protein (143) 143
review (142) 142
clinical neurology (141) 141
drosophila (140) 140
adolescent (136) 136
cgg repeat (134) 134
medicine (134) 134
mental disorders (133) 133
fragile x (132) 132
cell line (131) 131
intellectual disabilities (129) 129
rats (129) 129
middle aged (128) 128
phosphorylation (128) 128
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (9) 9
Collection Dvlpm't (Acquisitions) - Closed Orders (1) 1
Collection Dvlpm't (Acquisitions) - Vendor file (1) 1
Holland Bloorview Kids Rehabilitation - Stacks (1) 1
Lakeridge Health Sciences - Oshawa (1) 1
OISE - Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
UTL at Downsview - May be requested (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (2846) 2846
Spanish (12) 12
French (8) 8
Japanese (5) 5
Chinese (3) 3
Russian (3) 3
Portuguese (2) 2
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome
by Todd, Peter K and Oh, Seok Yoon and Krans, Amy and He, Fang and Sellier, Chantal and Frazer, Michelle and Renoux, Abigail J and Chen, Kai-chun and Scaglione, K. Matthew and Basrur, Venkatesha and Elenitoba-Johnson, Kojo and Vonsattel, Jean P and Louis, Elan D and Sutton, Michael A and Taylor, J. Paul and Mills, Ryan E and Charlet-Berguerand, Nicholas and Paulson, Henry L
Neuron, ISSN 0896-6273, 05/2013, Volume 78, Issue 3, pp. 440 - 455
Fragile X-associated tremor ataxia syndrome (FXTAS) results from a CGG repeat expansion in the 5′ UTR of . This repeat is thought to elicit toxicity as RNA,... 
TREMOR/ATAXIA-SYNDROME | PREMUTATION CARRIERS | MESSENGER-RNA | DROSOPHILA MODEL | MOUSE MODEL | IN-VIVO | INTRANUCLEAR INCLUSIONS | RCGG REPEATS | HEXANUCLEOTIDE REPEAT | MAMMALIAN-CELLS | NEUROSCIENCES | Neurons - pathology | Protein Biosynthesis | Tremor - pathology | Humans | Nerve Degeneration - genetics | Fragile X Syndrome - pathology | Fragile X Mental Retardation Protein - metabolism | Nerve Degeneration - metabolism | Brain - metabolism | Neurons - metabolism | Ataxia - genetics | Ataxia - metabolism | Ataxia - pathology | Disease Models, Animal | Fragile X Syndrome - genetics | Animals, Genetically Modified | Drosophila | Cells, Cultured | Fragile X Syndrome - metabolism | Nerve Degeneration - pathology | Animals | Tremor - genetics | Brain - pathology | Trinucleotide Repeat Expansion - genetics | Tremor - metabolism | Fragile X Mental Retardation Protein - genetics | Ubiquitin | Ataxia | Universities and colleges | Tremor | RNA | Analysis | Proteins | Confidence intervals | Insects | Neurodegeneration | Rodents | Alzheimers disease | Mental retardation | Patients
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Dysregulation of mTOR Signaling in Fragile X Syndrome
by Sharma, Ali and Hoeffer, Charles A and Takayasu, Yukihiro and Miyawaki, Takahiro and McBride, Sean M and Klann, Eric and Zukin, R. Suzanne
Journal of Neuroscience, ISSN 0270-6474, 01/2010, Volume 30, Issue 2, pp. 694 - 702
Fragile X syndrome, the most common form of inherited mental retardation and leading genetic cause of autism, is caused by transcriptional silencing of the... 
COWDEN-SYNDROME | PTEN MUTATION | COMPLEX | PATHWAY | LONG-TERM DEPRESSION | MOUSE MODEL | KINASE | METABOTROPIC GLUTAMATE RECEPTORS | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | Long-Term Synaptic Depression - genetics | Fragile X Syndrome - pathology | Phosphatidylinositol 3-Kinases - metabolism | Receptors, Metabotropic Glutamate - metabolism | Long-Term Synaptic Depression - drug effects | Phosphoproteins - metabolism | Excitatory Postsynaptic Potentials - drug effects | Phosphorylation - genetics | Cognition Disorders - etiology | CA1 Region, Hippocampal - metabolism | Oncogene Protein v-akt - metabolism | Eukaryotic Initiation Factor-4A - genetics | Excitatory Postsynaptic Potentials - genetics | Disease Models, Animal | Fragile X Syndrome - genetics | Immunoprecipitation - methods | Gene Expression Regulation - genetics | Fragile X Syndrome - metabolism | Signal Transduction - genetics | Phosphoproteins - genetics | Sirolimus - metabolism | Serine - metabolism | Fragile X Syndrome - complications | Mice, Knockout | Gene Expression Regulation - drug effects | Carrier Proteins - genetics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Carrier Proteins - metabolism | Signal Transduction - physiology | Fragile X Mental Retardation Protein - genetics | Mice | Eukaryotic Initiation Factor-4A - metabolism | In Vitro Techniques
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Differential Modeling of Fragile X Syndrome by Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
by Urbach, Achia and Bar-Nur, Ori and Daley, George Q and Benvenisty, Nissim
Cell Stem Cell, ISSN 1934-5909, 2010, Volume 6, Issue 5, pp. 407 - 411
STEMCELL | ALLELE | METHYLATION | INSTABILITY | DISEASE | LENGTH | GENERATION | FMR1 GENE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cell Line | Embryonic Stem Cells - metabolism | Gene Expression Regulation, Developmental | Models, Biological | Epigenesis, Genetic | Humans | Fragile X Syndrome - metabolism | Fragile X Syndrome - pathology | Fragile X Mental Retardation Protein - genetics | Fragile X Mental Retardation Protein - metabolism | Induced Pluripotent Stem Cells - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Altered Neuronal and Circuit Excitability in Fragile X Syndrome
by Contractor, Anis and Klyachko, Vitaly A and Portera-Cailliau, Carlos
Neuron, ISSN 0896-6273, 08/2015, Volume 87, Issue 4, pp. 699 - 715
Fragile X syndrome (FXS) results from a genetic mutation in a single gene yet produces a phenotypically complex disorder with a range of neurological and... 
INTELLECTUAL DISABILITY | MESSENGER-RNAS | GABA(A) RECEPTOR | POTASSIUM CHANNELS | MOUSE MODEL | LONG-TERM POTENTIATION | MENTAL-RETARDATION PROTEIN | SYNAPTIC PLASTICITY | NEUROSCIENCES | CA1 PYRAMIDAL NEURONS | FMR1 KNOCKOUT MICE | Fragile X Syndrome - genetics | Synapses - physiology | Brain - physiopathology | Fragile X Syndrome - physiopathology | Humans | Fragile X Syndrome - metabolism | Fragile X Mental Retardation Protein - metabolism | Brain - metabolism | Animals | Nerve Net - metabolism | Neurons - physiology | Fragile X Mental Retardation Protein - genetics | Nerve Net - physiopathology | Fragile X syndrome | Gene mutations | Neurons | Analysis | Neurophysiology | Proteins | Studies | Autism | Genotype & phenotype | Behavior | Neural networks | audiogenic seizures | FMRP | tactile defensiveness | Fmr1 | GABA | intrinsic excitability | hyperarousal | autism | ion channels
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Molecular mechanisms of fragile X syndrome: A twenty-year perspective
by Santoro, Michael R and Bray, Steven M and Warren, Stephen T
Annual Review of Pathology: Mechanisms of Disease, ISSN 1553-4006, 2012, Volume 7, Issue 1, pp. 219 - 245
Fragile X syndrome (FXS) is a common form of inherited intellectual disability and is one of the leading known causes of autism. The mutation responsible for... 
Autism | Intellectual disability | Trinucleotide repeat expansion | FMRP | FMR1 | Synaptic plasticity | PREMUTATION CARRIERS | YEAST 3-HYBRID SYSTEM | METABOTROPIC GLUTAMATE RECEPTORS | PREMATURE OVARIAN FAILURE | PATHOLOGY | autism | trinucleotide repeat expansion | LONG-TERM DEPRESSION | EMBRYONIC STEM-CELLS | MOUSE MODEL | synaptic plasticity | DENDRITIC MESSENGER-RNA | MENTAL-RETARDATION PROTEIN | intellectual disability | FMR1 KNOCKOUT MICE | Fragile X Syndrome - genetics | Trinucleotide Repeats | Dendrites - metabolism | Phosphorylation | Fragile X Syndrome - physiopathology | Humans | RNA, Messenger - genetics | Fragile X Syndrome - metabolism | Receptors, Metabotropic Glutamate - physiology | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Animals | Neuronal Plasticity | Fragile X Mental Retardation Protein - genetics | Complications and side effects | Care and treatment | Gene mutations | Causes of | Research | Fragile X syndrome | Risk factors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Fragile X Syndrome: Loss of Local mRNA Regulation Alters Synaptic Development and Function
by Bassell, Gary J and Warren, Stephen T
Neuron, ISSN 0896-6273, 2008, Volume 60, Issue 2, pp. 201 - 214
Fragile X syndrome is the most common inherited form of cognitive deficiency in humans and perhaps the best-understood single cause of autism. A trinucleotide... 
DENDRITIC SPINES | ACTIVITY-DEPENDENT TRAFFICKING | TREMOR/ATAXIA SYNDROME | AMPA RECEPTORS | LONG-TERM DEPRESSION | MOUSE MODEL | SPINE MORPHOGENESIS | METABOTROPIC GLUTAMATE RECEPTORS | MENTAL-RETARDATION PROTEIN | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | Fragile X Syndrome - genetics | Synaptic Transmission - genetics | Brain - physiopathology | Fragile X Syndrome - physiopathology | Humans | Fragile X Syndrome - metabolism | Fragile X Mental Retardation Protein - metabolism | Neurites - metabolism | Receptors, Metabotropic Glutamate - biosynthesis | Brain - abnormalities | Biological Transport, Active - genetics | RNA, Messenger - metabolism | Brain - metabolism | Neuronal Plasticity - genetics | Animals | Receptors, Metabotropic Glutamate - genetics | Fragile X Mental Retardation Protein - genetics | Messenger RNA | Fragile X syndrome | Glutamate | Human genetics | Proteins | Autism | Insects | Ligands | Mutation | Mammals | Males | Mental retardation | Methods
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
by Darnell, Robert B and Darnell, Jennifer C and Van Driesche, Sarah J and Zhang, Chaolin and Hung, Ka Ying Sharon and Mele, Aldo and Fraser, Claire E and Stone, Elizabeth F and Chen, Cynthia and Fak, John J and Chi, Sung Wook and Licatalosi, Donny D and Richter, Joel D
Cell, ISSN 0092-8674, 07/2011, Volume 146, Issue 2, pp. 247 - 261
FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it... 
LOCAL PROTEIN-SYNTHESIS | MEMORY | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | DEPENDENT TRANSLATION | INHIBITS TRANSLATION | KNOCKOUT MICE | POLYRIBOSOMES | X MENTAL-RETARDATION | PLASTICITY | CELL BIOLOGY | Protein Biosynthesis | Autistic Disorder - physiopathology | Autistic Disorder - metabolism | Fragile X Syndrome - physiopathology | Humans | Fragile X Syndrome - metabolism | Ribosomes - metabolism | Fragile X Mental Retardation Protein - metabolism | RNA-Binding Proteins | Mice, Knockout | Brain - metabolism | Animals | Sequence Analysis, RNA | Synapses - metabolism | Polyribosomes - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Proteins | Autism | Medical colleges | Crosslinked polymers | Messenger RNA | Neurons | Protein binding | Translocation | Brain | RNA-binding protein | Translation | Immunoprecipitation | RNA | Coding | Cognitive ability | Ribosomes | Fragile X syndrome
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Translation of Expanded CGG Repeats into FMRpolyG Is Pathogenic and May Contribute to Fragile X Tremor Ataxia Syndrome
by Sellier, Chantal and Buijsen, Ronald A.M and He, Fang and Natla, Sam and Jung, Laura and Tropel, Philippe and Gaucherot, Angeline and Jacobs, Hugues and Meziane, Hamid and Vincent, Alexandre and Champy, Marie-France and Sorg, Tania and Pavlovic, Guillaume and Wattenhofer-Donze, Marie and Birling, Marie-Christine and Oulad-Abdelghani, Mustapha and Eberling, Pascal and Ruffenach, Frank and Joint, Mathilde and Anheim, Mathieu and Martinez-Cerdeno, Veronica and Tassone, Flora and Willemsen, Rob and Hukema, Renate K and Viville, Stéphane and Martinat, Cecile and Todd, Peter K and Charlet-Berguerand, Nicolas
Neuron, ISSN 0896-6273, 01/2017, Volume 93, Issue 2, pp. 331 - 347
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a limited expansion of CGG repeats in the 5′ UTR of  . Two... 
neurodegeneration | microsatellite expansion | RAN translation | near-cognate codon | TREMOR/ATAXIA-SYNDROME | MEDIATED NEURODEGENERATION | PREMUTATION CARRIERS | DROSOPHILA MODEL | RAN TRANSLATION | MOUSE MODEL | MITOCHONDRIAL DYSFUNCTION | FMR1 MESSENGER-RNA | HEXANUCLEOTIDE REPEAT | NEUROSCIENCES | NUCLEOCYTOPLASMIC TRANSPORT | Protein Biosynthesis | Humans | Peptides - genetics | Male | Fragile X Mental Retardation Protein - metabolism | RNA, Messenger - metabolism | Brain - metabolism | DNA-Binding Proteins - metabolism | Peptides - metabolism | Nuclear Lamina - metabolism | Membrane Proteins - metabolism | Nuclear Lamina - pathology | Ataxia - genetics | Ataxia - metabolism | Real-Time Polymerase Chain Reaction | Fragile X Syndrome - genetics | Fragile X Syndrome - metabolism | Mice, Transgenic | Animals | Tremor - genetics | Brain - pathology | Trinucleotide Repeat Expansion - genetics | Tremor - metabolism | Fragile X Mental Retardation Protein - genetics | Mice | Proteins | Nervous system diseases | Genetic engineering | RNA | Medical genetics | Codon | Resveratrol | Protein binding | Medical research | Ataxia | Mutation | Gene expression | Colleges & universities
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text GABA system dysfunction in autism and related disorders: From synapse to symptoms
by Coghlan, Suzanne and Horder, Jamie and Inkster, Becky and Mendez, M. Andreina and Murphy, Declan G and Nutt, David J
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 10/2012, Volume 36, Issue 9, pp. 2044 - 2055
► Autism Spectrum Disorders and other neurodevelopmental disorders share symptoms. ► Impaired GABA signalling via GABA receptors is seen in all these... 
Autism spectrum disorders | Foetal Anticonvulsant Syndrome | Autism | Fragile X Syndrome | GABA | Inhibitory interneurons | GABAA receptor | Rett Syndrome | receptor | RECEPTOR SUBUNIT GENES | CEREBELLAR PURKINJE-CELLS | RETT-SYNDROME | CORTICAL INHIBITION | SPECTRUM DISORDERS | BENZODIAZEPINE-RECEPTOR | NEUROSCIENCES | DE-NOVO MUTATIONS | GABA(A) receptor | MOUSE MODEL | BEHAVIORAL SCIENCES | GAMMA-AMINOBUTYRIC-ACID | MENTAL-RETARDATION PROTEIN | Child Development Disorders, Pervasive - metabolism | gamma-Aminobutyric Acid - metabolism | Brain - physiopathology | Fragile X Syndrome - physiopathology | Humans | Fragile X Syndrome - metabolism | Child Development Disorders, Pervasive - physiopathology | GABAergic Neurons - physiology | Rett Syndrome - physiopathology | Brain - metabolism | Rett Syndrome - metabolism | Synapses - metabolism | Neurons - physiology | Child | Indexing in process | Fetal Anticonvulsant Syndrome | Rett syndrome | autism spectrum disorders | inhibitory interneurons | Fragile X syndrome | autism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights