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Neuron, ISSN 0896-6273, 2008, Volume 59, Issue 1, pp. 70 - 83
Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is... 
PROTEINS | MOLNEURO | SIGNALING | MESSENGER-RNAS | RIBOSOMAL-PROTEINS | IMMEDIATE-EARLY GENE | GLUTAMATE RECEPTORS | POSTSYNAPTIC SITES | AMPA RECEPTORS | FACTOR-II | LONG-TERM DEPRESSION | MOUSE MODEL | SYNAPTIC PLASTICITY | NEUROSCIENCES | Excitatory Postsynaptic Potentials - radiation effects | Protein Biosynthesis - physiology | Fragile X Mental Retardation Protein - physiology | Male | Protein Transport - physiology | Protein Transport - drug effects | Excitatory Postsynaptic Potentials - drug effects | Excitatory Postsynaptic Potentials - physiology | Excitatory Amino Acid Agents - pharmacology | Neurons - physiology | Long-Term Potentiation - physiology | Cytoskeletal Proteins - metabolism | Protein Biosynthesis - radiation effects | Protein Synthesis Inhibitors - pharmacology | Electric Stimulation - methods | Animals, Newborn | Receptors, AMPA - physiology | Cells, Cultured | Hippocampus - cytology | Cycloheximide - pharmacology | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Patch-Clamp Techniques | Animals | Peptide Elongation Factor 2 - physiology | Models, Biological | Gene Expression Regulation - radiation effects | Protein Biosynthesis - drug effects | Fragile X Mental Retardation Protein - genetics | Mice | In Vitro Techniques | Dose-Response Relationship, Radiation | Proteins | Studies | Cell culture | Kinases | Protein synthesis | Neurons | Index Medicus
Journal Article
PLoS Genetics, ISSN 1553-7390, 04/2010, Volume 6, Issue 4, pp. e1000898 - e1000898
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2016, Volume 113, Issue 26, pp. E3619 - E3628
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 35, pp. 15601 - 15606
Fragile X syndrome is caused by the absence of functional fragile X mental retardation protein (FMRP), an RNA binding protein. The molecular mechanism of... 
Dendritic spines | Receptors | Messenger RNA | Intellectual disability | Neurons | Protein synthesis | Imaging | Dendrites | Gene expression regulation | Fragile X syndrome | Local translation | Dendritic mRNA targeting | ACTIVATION | FMRP | MULTIDISCIPLINARY SCIENCES | fragile X syndrome | IDENTIFICATION | local translation | SYNAPTIC PLASTICITY | HIPPOCAMPAL-NEURONS | GRANULES | DENDRITIC SPINES | dendritic mRNA targeting | MYOSIN-VA | LONG-TERM DEPRESSION | MOUSE MODEL | Protein Biosynthesis | Neurons - cytology | Fragile X Mental Retardation Protein - metabolism | Green Fluorescent Proteins - genetics | Receptors, Metabotropic Glutamate - metabolism | RNA, Messenger - metabolism | Receptors, Metabotropic Glutamate - genetics | Time Factors | Receptor, Metabotropic Glutamate 5 | Neurons - metabolism | Neurons - drug effects | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism | Dendrites - metabolism | Green Fluorescent Proteins - metabolism | RNA Transport | Mice, Inbred C57BL | RNA, Messenger - genetics | Cells, Cultured | In Situ Hybridization, Fluorescence | Hippocampus - cytology | Mice, Knockout | Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Protein Binding | Fragile X Mental Retardation Protein - genetics | Mice | Kinetics | Microscopy, Fluorescence | Protein biosynthesis | Genetic aspects | Chemical properties | Research | Binding proteins | Health aspects | Proteins | Ribonucleic acid--RNA | Intellectual disabilities | Rodents | Binding sites | Index Medicus | Translation | Data processing | mRNA | RNA-binding protein | Molecular modelling | RNA transport | fragile X mental retardation protein | Ca super(2+)/calmodulin-dependent protein kinase II | Protein transport | Glutamic acid receptors (metabotropic) | FMR1 protein | Biological Sciences
Journal Article
CELL, ISSN 0092-8674, 11/2001, Volume 107, Issue 4, pp. 489 - 499
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2007, Volume 104, Issue 39, pp. 15537 - 15542
Fragile X syndrome (FXS), a common inherited form of mental retardation, is caused by the functional absence of the fragile X mental retardation protein... 
Synapsins | Neurons | Internalization | Small interfering RNA | Agonists | Dendrites | Long term depression | Physiological regulation | Behavioral neuroscience | Synapses | Autism | Fragile X syndrome | FMR1 | MULTIDISCIPLINARY SCIENCES | fragile X syndrome | TRAFFICKING | ENDOCYTOSIS | SYNAPTIC PLASTICITY | autism | MGLUR | IONOTROPIC GLUTAMATE RECEPTORS | LONG-TERM DEPRESSION | MOUSE MODEL | EXPRESSION | LTD | Fragile X Syndrome - genetics | Gene Expression Regulation | Rats | Receptors, Metabotropic Glutamate - physiology | Fragile X Mental Retardation Protein - physiology | Receptors, Metabotropic Glutamate - metabolism | RNA, Messenger - metabolism | Intellectual Disability - genetics | Hippocampus - metabolism | Microscopy, Confocal | Animals | Receptor, Metabotropic Glutamate 5 | Fragile X Mental Retardation Protein - genetics | Neurons - metabolism | Receptors, AMPA - metabolism | Receptors, Metabotropic Glutamate - antagonists & inhibitors | Disease Models, Animal | RNA, Small Interfering - metabolism | Neuroplasticity | Evaluation | Complications and side effects | Physiological aspects | Protein biosynthesis | Chemical properties | Protein deficiency | Binding proteins | Health aspects | Signal transduction | Amino acids | Ribonucleic acid--RNA | Protein synthesis | Mental retardation | Index Medicus | Biological Sciences
Journal Article
Neuron, ISSN 0896-6273, 2006, Volume 51, Issue 4, pp. 441 - 454
Genetic deletion of fragile X mental retardation protein (FMRP) has been shown to enhance mGluR-dependent long-term depression (LTD). Herein, we demonstrate... 
HUMDISEASE | MOLNEURO | SYSTEM | MESSENGER-RNAS | SYNAPSES | UBIQUITIN | FMR1 | MOUSE MODEL | DEGRADATION | GLUTAMATE-RECEPTOR ACTIVATION | HIPPOCAMPAL AREA CA1 | SYNAPTIC PLASTICITY | NEUROSCIENCES | Glycine - analogs & derivatives | Microtubule-Associated Proteins - metabolism | Protein Biosynthesis - physiology | Receptors, Metabotropic Glutamate - physiology | Male | Fragile X Mental Retardation Protein - metabolism | Long-Term Synaptic Depression - drug effects | RNA, Messenger - metabolism | Dose-Response Relationship, Drug | Drug Interactions | Protein Synthesis Inhibitors - pharmacology | Animals, Newborn | Long-Term Synaptic Depression - physiology | Blotting, Western - methods | Fluorescent Antibody Technique - methods | Excitatory Amino Acid Antagonists - pharmacology | Mice, Knockout | Leupeptins - pharmacology | Methoxyhydroxyphenylglycol - analogs & derivatives | Methoxyhydroxyphenylglycol - pharmacology | Animals | Glycine - pharmacology | Signal Transduction - drug effects | Models, Biological | Cysteine Proteinase Inhibitors - pharmacology | Benzoates - pharmacology | Anisomycin - pharmacology | Protein Biosynthesis - drug effects | Fragile X Mental Retardation Protein - genetics | Mice | Pyridines - pharmacology | Proteasome Endopeptidase Complex - metabolism | In Vitro Techniques | Ubiquitin | Physiological aspects | Neurosciences | Proteolysis | Mental retardation | Depression, Mental | Proteins | Studies | Software | Protein synthesis | Experiments | Index Medicus
Journal Article