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Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
PLoS Pathogens, ISSN 1553-7366, 05/2009, Volume 5, Issue 5, p. e1000459
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 395 - 402
Inflammasomes regulate the activity of caspase-1 and the maturation of interleukin 1. (IL-1.) and IL-18. AIM2 has been shown to bind DNA and engage the... 
RECOGNITION | TOLL-LIKE RECEPTOR | INDUCIBLE GENES | INNATE IMMUNE-RESPONSE | INFECTION | VACCINIA VIRUS | IMMUNOLOGY | MURINE CYTOMEGALOVIRUS | FRANCISELLA-TULARENSIS | CASPASE-1 ACTIVATION | FAMILY | Tularemia - metabolism | Cytoskeletal Proteins - genetics | Humans | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Multiprotein Complexes - metabolism | Lymphocyte Activation - genetics | Transcription Factors - immunology | Cytokines - genetics | Macrophages - microbiology | DNA-Binding Proteins | DNA Viruses - pathogenicity | Macrophages - pathology | Killer Cells, Natural - virology | Listeriosis - genetics | Signal Transduction - genetics | DNA Virus Infections - genetics | Viral Load - immunology | Mice, Knockout | Macrophages - metabolism | DNA Virus Infections - immunology | Mice | Killer Cells, Natural - metabolism | Multiprotein Complexes - immunology | DNA Virus Infections - metabolism | Caspase 1 - immunology | Killer Cells, Natural - pathology | Signal Transduction - immunology | Macrophages - virology | Listeriosis - immunology | Tularemia - immunology | Killer Cells, Natural - immunology | Nuclear Proteins - genetics | Macrophages - immunology | Cytokines - immunology | Killer Cells, Natural - microbiology | Cell Line | Francisella tularensis - immunology | Listeriosis - metabolism | Cytokines - metabolism | DNA - immunology | Mice, Inbred C57BL | Nuclear Proteins - metabolism | Transcription Factors - genetics | Immunity, Innate | Nuclear Proteins - immunology | Viral Load - genetics | DNA Viruses - immunology | Transcription Factors - metabolism | Animals | Apoptosis Regulatory Proteins | Caspase 1 - genetics | DNA Viruses - growth & development | CARD Signaling Adaptor Proteins | Francisella tularensis - pathogenicity | Bacterial infections | Immune response | Cytomegalovirus infections | Research | DNA viruses | Health aspects | Risk factors
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 12, pp. 7562 - 7572
An inadequate innate immune response appears to contribute to the virulence of Francisella tularensis following pulmonary infection. Studies in mice suggest... 
TUMOR-NECROSIS-FACTOR | SIGNALING PATHWAYS | INNATE IMMUNE-RESPONSES | INFLAMMATORY RESPONSES | PROTEIN-KINASE PHOSPHATASE-1 | NEGATIVE REGULATION | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | IMMUNOLOGY | PHOSPHOINOSITIDE 3-KINASE | FACTOR-ALPHA | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Bacterial Vaccines - genetics | Tumor Necrosis Factor-alpha - genetics | Immunity, Innate - genetics | Tularemia - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - immunology | Inflammation - metabolism | Phosphorylation - genetics | Francisella tularensis - metabolism | Bone Marrow Cells - immunology | Tumor Necrosis Factor-alpha - immunology | Phosphorylation - immunology | p38 Mitogen-Activated Protein Kinases - metabolism | Phosphorylation - drug effects | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Dual Specificity Phosphatase 1 - genetics | Interleukin-6 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Enzyme Inhibitors - pharmacology | Myeloid Differentiation Factor 88 - genetics | Signal Transduction - genetics | p38 Mitogen-Activated Protein Kinases - immunology | Toll-Like Receptor 2 - metabolism | Macrophages - metabolism | Proto-Oncogene Proteins c-akt - immunology | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Interleukin-6 - immunology | Toll-Like Receptor 2 - immunology | Mice | Tumor Necrosis Factor-alpha - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Tularemia - prevention & control | Phosphatidylinositol 3-Kinases - metabolism | Vaccines, Attenuated - metabolism | Proto-Oncogene Proteins c-akt - genetics | Signal Transduction - immunology | Mice, Mutant Strains | Myeloid Differentiation Factor 88 - immunology | Tularemia - immunology | Bacterial Vaccines - metabolism | Macrophages - immunology | Francisella tularensis - immunology | Mitogen-Activated Protein Kinase 3 - immunology | Immunity, Innate - drug effects | Morpholines - pharmacology | p38 Mitogen-Activated Protein Kinases - genetics | Dual Specificity Phosphatase 1 - immunology | Inflammation - immunology | Phosphatidylinositol 3-Kinases - genetics | Immunity, Innate - immunology | Vaccines, Attenuated - immunology | Animals | Androstadienes - pharmacology | Bacterial Vaccines - immunology | Inflammation - genetics | Dual Specificity Phosphatase 1 - metabolism | Myeloid Differentiation Factor 88 - metabolism | Bone Marrow Cells - metabolism | Vaccines, Attenuated - genetics
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2017, Volume 66, Issue 2, pp. 221 - 233.e4
The CRISPR-associated protein Cas12a (Cpf1), which has been repurposed for genome editing, possesses two distinct nuclease activities: endoribonuclease... 
R-loop | nuclease | CRISPR RNA | target DNA cleavage | CRISPR-Cas | Cpf1 | Cas12a | Cas9 | seed sequence | crRNA processing | CRISPR-CAS SYSTEMS | IMMUNITY | COMPLEX | ENDONUCLEASE | RECOGNITION | HUMAN-CELLS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEQUENCE | CLEAVAGE | CPF1 NUCLEASES | CELL BIOLOGY | RNA Precursors - chemistry | CRISPR-Associated Proteins - chemistry | Endonucleases - genetics | DNA, Bacterial - metabolism | RNA, Guide - genetics | RNA, Guide - metabolism | Bacterial Proteins - chemistry | DNA, Bacterial - chemistry | Structure-Activity Relationship | Endonucleases - metabolism | RNA, Guide - chemistry | Francisella - enzymology | Clustered Regularly Interspaced Short Palindromic Repeats | RNA, Bacterial - genetics | RNA Precursors - metabolism | Catalysis | Nucleic Acid Conformation | RNA, Bacterial - metabolism | Escherichia coli - enzymology | CRISPR-Associated Proteins - genetics | Bacterial Proteins - genetics | Models, Molecular | RNA Precursors - genetics | Endonucleases - chemistry | DNA, Bacterial - genetics | Escherichia coli - genetics | CRISPR-Associated Proteins - metabolism | RNA, Bacterial - chemistry | CRISPR-Cas Systems | Bacterial Proteins - metabolism | Protein Conformation | Gene Editing - methods | Francisella - genetics | Enzymes | Nucleases | RNA | Genomics | DNA | Crystals | Structure | Phosphates
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 385 - 393
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1... 
PHAGOSOMAL ESCAPE | ACTIVATION | CASPASE-1 | ASC PYROPTOSOME | IMMUNOLOGY | NF-KAPPA-B | PATHOGEN RECOGNITION | NALP3 INFLAMMASOME | CYTOPLASMIC DNA | CELL-DEATH | PYRIN | L-Lactate Dehydrogenase - metabolism | Tularemia - metabolism | Humans | Protein Multimerization | Tularemia - genetics | Caspase 1 - metabolism | Multiprotein Complexes - genetics | Caspase 1 - immunology | Interleukin-1beta - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Multiprotein Complexes - metabolism | L-Lactate Dehydrogenase - immunology | Tularemia - immunology | Calcium Signaling - immunology | Interleukin-1beta - biosynthesis | Nuclear Proteins - genetics | Macrophages - immunology | DNA-Binding Proteins | Interferon Regulatory Factor-3 - immunology | Francisella tularensis - immunology | Macrophages - pathology | Cells, Cultured | Interleukin-1beta - immunology | Nuclear Proteins - metabolism | Immunity, Innate | Nuclear Proteins - immunology | Mice, Knockout | Macrophages - metabolism | Animals | L-Lactate Dehydrogenase - genetics | Caspase 1 - genetics | Interferon Regulatory Factor-3 - metabolism | Francisella tularensis - pathogenicity | Mice | Multiprotein Complexes - immunology | Interleukins | Bacterial proteins | Tularemia | Physiological aspects | Causes of | Genetic aspects | Research | Health aspects | Francisella tularensis
Journal Article
Microbiology (United Kingdom), ISSN 1350-0872, 11/2017, Volume 163, Issue 11, pp. 1664 - 1679
Journal Article
Nature Immunology, ISSN 1529-2908, 2014, Volume 15, Issue 4, pp. 343 - 353
Journal Article
PLoS ONE, ISSN 1932-6203, 2009, Volume 4, Issue 12, pp. e8360 - e8360
A robust, rapid and flexible real-time PCR assay for hierarchical genetic typing of clinical and environmental isolates of Francisella is presented. Typing... 
TULARENSIS SUBSPECIES TULARENSIS | UNITED-STATES | STRAINS | CHALLENGE | POLYMERASE-CHAIN-REACTION | EVOLUTION | MULTIDISCIPLINARY SCIENCES | HOLARCTICA | SAMPLES | TULAREMIA VACCINE | MOLECULAR ANALYSIS | Geography | Genes, Bacterial - genetics | Humans | Genetic Loci - genetics | Genotype | INDEL Mutation - genetics | Genetic Markers | Phylogeny | Polymerase Chain Reaction - methods | Sweden | Francisella - isolation & purification | Time Factors | Bacterial Typing Techniques | Francisella - classification | Minisatellite Repeats - genetics | Polymorphism, Single Nucleotide - genetics | Cluster Analysis | DNA, Ribosomal - genetics | Francisella - genetics | Medical colleges | Analysis | Genomics | Genomes | Single nucleotide polymorphisms | Chromosomes | Laboratories | Insertion | Infections | Single-nucleotide polymorphism | Gene deletion | Assaying | Epidemiology | Proteins | Clonal deletion | Deletion | Population | Deoxyribonucleic acid--DNA | Geographical distribution | Origins | Typing | Markers | Tularemia | Genetic diversity | Real time | Patients | Bacteriology | Polymerase chain reaction | Infectious diseases | Ulcers | Mutation | Medical and Health Sciences | Medicin och hälsovetenskap | polymerase chain-reaction | Infektionsmedicin | united states | evolution | Klinisk medicin | strains | samples | holarctica | Clinical Medicine | tularemia vaccine | Infectious Medicine | challenge | tularensis subspecies tularensis | molecular analysis | Deoxyribonucleic acid | DNA
Journal Article