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Annals of Neurology, ISSN 0364-5134, 10/2014, Volume 76, Issue 4, pp. 489 - 508
Objective To investigate whether a histone deacetylase inhibitor (HDACi) would be effective in an in vitro model for the neurodegenerative disease Friedreich... 
PLURIPOTENT STEM-CELLS | THERAPEUTICS | TRIPLET-REPEAT EXPANSION | FRATAXIN | GENE | CONTRACTION | NICOTINAMIDE | TRANSCRIPTION | DIFFERENTIATION | HISTONE DEACETYLASE INHIBITORS | NEUROSCIENCES | CLINICAL NEUROLOGY | Leukocytes, Mononuclear - metabolism | Area Under Curve | Friedreich Ataxia - pathology | Humans | Middle Aged | Male | Friedreich Ataxia - genetics | Dose-Response Relationship, Drug | Young Adult | Cell Differentiation - genetics | Benzamides - therapeutic use | Pluripotent Stem Cells | Chromatin Immunoprecipitation | Adult | Female | Benzamides - pharmacology | Aminocaproates - therapeutic use | Neurons - drug effects | Membrane Potentials - drug effects | Friedreich Ataxia - drug therapy | Leukocytes, Mononuclear - drug effects | Cross-Sectional Studies | Double-Blind Method | Administration, Oral | Gene Expression Regulation - genetics | Aminocaproates - pharmacology | DNA Methylation - genetics | Membrane Potentials - physiology | Nerve Tissue Proteins - genetics | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Cell Differentiation - drug effects | Adolescent | Trinucleotide Repeat Expansion - genetics | Iron-Binding Proteins - genetics | Histone Deacetylase Inhibitors - therapeutic use | DNA Methylation - drug effects | Cell Line, Transformed | Cohort Studies | Epigenetics | Ataxia | Chromatin | Gene expression
Journal Article
PLoS Biology, ISSN 1544-9173, 03/2012, Volume 10, Issue 3, p. e1001288
An increasing number of genes required for mitochondrial biogenesis, dynamics, or function have been found to be mutated in metabolic disorders and... 
RETINAL DEGENERATION | DNA DEPLETION | DROSOPHILA-PARKIN MUTANTS | UNFOLDED PROTEIN RESPONSE | PINK1/PARKIN PATHWAY | GENE | FRIEDREICHS-ATAXIA | COPY-NUMBER | GENOMIC HYBRIDIZATION-ARRAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISEASE | BIOLOGY | Mitochondria - enzymology | Electron Transport | Electroretinography - methods | Leukoencephalopathies - genetics | Retina - metabolism | Cell Proliferation | Reactive Oxygen Species - metabolism | Humans | Middle Aged | Muscles - physiopathology | Child, Preschool | Male | Mitochondrial Proteins - genetics | Drosophila Proteins - metabolism | Drosophila - physiology | Drosophila - enzymology | Young Adult | Mitochondria - genetics | Mitochondrial Proteins - metabolism | HEK293 Cells | Adult | Female | Methionine-tRNA Ligase - metabolism | Photoreceptor Cells - pathology | Ataxia - genetics | Muscles - metabolism | Ataxia - metabolism | Child | Drosophila - genetics | Oxidative Phosphorylation | Neurodegenerative Diseases - genetics | Leukoencephalopathies - metabolism | Longevity | Neurodegenerative Diseases - metabolism | Unfolded Protein Response | Gene Expression Regulation, Enzymologic | Phenotype | Animals | Pedigree | Photoreceptor Cells - metabolism | Adolescent | Drosophila Proteins - genetics | Mutation | Methionine-tRNA Ligase - genetics | Retina - pathology | Proteins | Medical research | Genetics | Neurodegeneration | Genes
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