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PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, p. e29817
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2014, Volume 124, Issue 7, pp. 2877 - 2890
About half of all melanomas harbor a mutation that results in a constitutively active BRAF kinase mutant (BRAF(V6005E/K)) that can be selectively inhibited by... 
BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | SIGNALING PATHWAY | COLORECTAL-CANCER | CUTANEOUS MELANOMA | THERAPEUTIC TARGET | ACQUIRED-RESISTANCE | MALIGNANT-MELANOMA | WNT/BETA-CATENIN PATHWAY | MEDIATES RESISTANCE | Frizzled Receptors - antagonists & inhibitors | Humans | Cell Survival - genetics | Wnt-5a Protein | Wnt Proteins - metabolism | Wnt Proteins - genetics | RNA Interference | Melanoma - genetics | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Indoles - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Cell Survival - drug effects | Proto-Oncogene Proteins - antagonists & inhibitors | Signal Transduction | Frizzled Receptors - metabolism | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | beta Catenin - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Frizzled Receptors - genetics | Wnt Signaling Pathway - drug effects | Receptor Protein-Tyrosine Kinases - genetics | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Wnt Proteins - antagonists & inhibitors | Care and treatment | Oncology, Experimental | Melanoma | Genetic aspects | Research | Drug resistance | Cancer | Proteins | Studies | Medical research | Kinases | Gene expression | Experiments | Drug dosages | Patients | Tumors
Journal Article
Oncogene, ISSN 0950-9232, 06/2009, Volume 28, Issue 23, pp. 2245 - 2256
Journal Article
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 10/2017, Volume 136, Issue 17, pp. 1629 - 1642
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 139, Issue 2, pp. 285 - 298
Disorders of vascular structure and function play a central role in a wide variety of CNS diseases. Mutations in the Frizzled-4 (Fz4) receptor, Lrp5... 
HUMDISEASE | DEVBIO | SIGNALING | ANGIOGENESIS | SOX17 | VENOUS INSUFFICIENCY | VASCULATURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE | MUTATIONS | MODEL | FAMILIAL EXUDATIVE VITREORETINOPATHY | DISEASE MICE | REDUNDANT ROLES | CELL BIOLOGY | Genetic research | Medical colleges | Neurosciences | Ophthalmology | Neurons | Endothelium
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2013, Volume 110, Issue 31, pp. 12649 - 12654
Journal Article
Nature Reviews Genetics, ISSN 1471-0056, 02/2007, Volume 8, Issue 2, pp. 126 - 138
Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in... 
XENOPUS-GASTRULATION | OMMATIDIAL ROTATION |