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fructosediphosphates - metabolism (214) 214
biochemistry & molecular biology (152) 152
index medicus (135) 135
animals (126) 126
kinetics (112) 112
humans (86) 86
glycolysis (85) 85
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research (80) 80
fructosediphosphates - pharmacology (78) 78
enzymes (70) 70
amino acid sequence (68) 68
escherichia-coli (67) 67
fructosediphosphate aldolase (64) 64
binding sites (61) 61
fructose (61) 61
models, molecular (61) 61
allosteric regulation (57) 57
mutation (52) 52
glucose - metabolism (51) 51
metabolism (51) 51
mutagenesis, site-directed (51) 51
physiological aspects (51) 51
rats (50) 50
fructose 2,6-bisphosphate (49) 49
escherichia coli - genetics (48) 48
microbiology (48) 48
male (45) 45
genetic aspects (44) 44
cell biology (43) 43
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phosphorylation (40) 40
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fructose-bisphosphate aldolase - metabolism (38) 38
gene (38) 38
expression (36) 36
protein conformation (36) 36
recombinant proteins - metabolism (34) 34
biotechnology & applied microbiology (33) 33
escherichia coli - enzymology (33) 33
mice (33) 33
catalysis (32) 32
fructosediphosphates - chemistry (32) 32
pyruvate kinase - genetics (32) 32
proteins (31) 31
cloning, molecular (30) 30
crystallography, x-ray (30) 30
enzyme (30) 30
enzyme activation (30) 30
fructose-bisphosphate aldolase - chemistry (30) 30
fructose-bisphosphate aldolase - genetics (30) 30
isoenzymes - genetics (30) 30
pyruvate kinase - metabolism (30) 30
gene expression (29) 29
glucose (29) 29
phosphofructokinase-2 (29) 29
chemical properties (28) 28
life sciences (28) 28
liver - enzymology (28) 28
adenosine triphosphate - metabolism (27) 27
fructose-1,6-bisphosphate (27) 27
mechanism (27) 27
phosphofructokinase-1 - metabolism (27) 27
phosphates (26) 26
phosphofructokinase (26) 26
protein binding (26) 26
sequence alignment (26) 26
bacterial proteins - genetics (25) 25
phosphotransferases - metabolism (25) 25
bacterial proteins - metabolism (24) 24
binding (24) 24
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liver (24) 24
recombinant proteins - chemistry (24) 24
isoenzymes - metabolism (23) 23
phosphotransferases - genetics (23) 23
saccharomyces cerevisiae - genetics (23) 23
sequence homology, amino acid (23) 23
fructosephosphates - metabolism (22) 22
glucose metabolism (22) 22
multidisciplinary sciences (22) 22
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escherichia coli - metabolism (21) 21
fructose-1,6-diphosphate (21) 21
plant sciences (21) 21
recombinant proteins - genetics (21) 21
structure-activity relationship (21) 21
aldehyde-lyases - metabolism (20) 20
hydrogen-ion concentration (20) 20
phosphofructokinase-2 - genetics (20) 20
purification (20) 20
structure (20) 20
aldehyde-lyases - genetics (19) 19
fructosediphosphates - genetics (19) 19
l-lactate dehydrogenase - metabolism (19) 19
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Cell, ISSN 0092-8674, 2006, Volume 126, Issue 1, pp. 107 - 120
The p53 tumor-suppressor protein prevents cancer development through various mechanisms, including the induction of cell-cycle arrest, apoptosis, and the... 
CANCER-CELLS | GLUCOSE-6-PHOSPHATE-DEHYDROGENASE | ARREST | OXIDATIVE STRESS | ACTIVATION | PENTOSE-PHOSPHATE PATHWAY | GENE | GLUCOSE-METABOLISM | FRUCTOSE-2,6-BISPHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | P53 | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Humans | DNA Repair - physiology | Cell Survival - genetics | Genomic Instability - physiology | Molecular Sequence Data | Apoptosis - genetics | Fructose-Bisphosphatase - isolation & purification | Proteins - isolation & purification | Tumor Suppressor Protein p53 - genetics | Phosphoric Monoester Hydrolases - isolation & purification | Fructosediphosphates - metabolism | Glycolysis - genetics | DNA Damage - physiology | Cell Transformation, Neoplastic - genetics | Base Sequence | Energy Metabolism - genetics | Chromosomes, Human, Pair 12 - genetics | Amino Acid Sequence | Phosphoric Monoester Hydrolases - genetics | Oxidative Stress - genetics | Tumor Suppressor Protein p53 - metabolism | Gene Expression Regulation - physiology | Intracellular Signaling Peptides and Proteins | Cell Transformation, Neoplastic - metabolism | Down-Regulation - physiology | Proteins - genetics | Fructose-Bisphosphatase - metabolism | Proteins - metabolism | Cell Line, Tumor | Signal Transduction - physiology | Fructose-Bisphosphatase - genetics | Phosphoric Monoester Hydrolases - metabolism | Glycolysis | Genetic research | Tumor suppressor genes | Research | Apoptosis | Prevention | Oncology, Experimental | Tumor proteins | Fructose | Cancer
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2009, Volume 284, Issue 36, pp. 24223 - 24232
Journal Article
Plant and Cell Physiology, ISSN 0032-0781, 06/2012, Volume 53, Issue 6, pp. 1017 - 1032
Rhizoctonia solani Kuhn causes sheath blight disease in rice, and genetic resistance against it is the most desirable characteristic. Current improvement... 
Rice (Oryza sativa L.) | R. solani-resistant rice line | Rhizoctonia solani | Phenylpropanoid pathway | Coarse and fine metabolic controls | Glycolytic pathway | DEPENDENT PHOSPHOFRUCTOKINASE | DEFENSE | LEAVES | CARBON METABOLISM | DEVELOPING ENDOSPERM | PLANT SCIENCES | CELL BIOLOGY | SHEATH BLIGHT | RICINUS-COMMUNIS | solani-resistant rice line | RESISTANCE | PENTOSE-PHOSPHATE | Rice (Oryza sativa L | SUSPENSION CELLS | Dihydroxyacetone Phosphate - genetics | Dihydroxyacetone Phosphate - metabolism | Plant Diseases - immunology | Phosphofructokinase-1 - genetics | Plant Diseases - microbiology | Glucose-6-Phosphate Isomerase - genetics | Fructosediphosphates - metabolism | Cytosol - enzymology | Fructosephosphates - metabolism | Oryza - genetics | Time Factors | Isoenzymes - metabolism | Oryza - microbiology | Gene Expression Regulation, Plant | Pyruvic Acid - metabolism | Plant Proteins - metabolism | Rhizoctonia - pathogenicity | Plant Leaves - enzymology | Oryza - immunology | Phosphoglucomutase - metabolism | Glyceraldehyde 3-Phosphate - metabolism | Disease Resistance | Isoenzymes - genetics | Glyceraldehyde 3-Phosphate - genetics | Oryza - enzymology | Fructosediphosphates - genetics | Fructosephosphates - genetics | Hydrogen Peroxide - metabolism | Gene Expression Regulation, Enzymologic | Glucose-6-Phosphate Isomerase - metabolism | Host-Pathogen Interactions | Phosphoenolpyruvate - metabolism | Plant Proteins - genetics | Plant Leaves - genetics | Plant Leaves - metabolism | Glycolysis | Cytosol - metabolism | Rhizoctonia - immunology | Enzyme Activation | Phosphofructokinase-1 - metabolism | Quantitative Trait Loci | Phosphoglucomutase - genetics
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2011, Volume 286, Issue 46, pp. 40219 - 40231
Journal Article
The FEBS Journal, ISSN 1742-464X, 09/2017, Volume 284, Issue 18, pp. 2955 - 2980
Changes in allosteric regulation of glycolytic enzymes have been linked to metabolic reprogramming involved in cancer. Remarkably, allosteric mechanisms... 
metabolism | LOV2 | molecular dynamics | PKM2 | optogenetics | ALLOSTERIC REGULATION | BINDING DOMAINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | J-ALPHA HELIX | MASS-SPECTROMETRY | LOV2 DOMAIN | CONFORMATIONAL-CHANGE | M2 ISOFORM | BLUE-LIGHT RECEPTOR | CELL SURVIVAL | CANCER METABOLISM | Apoproteins - chemistry | Allosteric Regulation | Humans | Substrate Specificity | Crystallography, X-Ray | Recombinant Fusion Proteins - metabolism | Thyroid Hormones - chemistry | Avena - chemistry | DNA-Binding Proteins - metabolism | Fructosediphosphates - metabolism | Fructosediphosphates - chemistry | Thermodynamics | Avena - genetics | Plant Proteins - chemistry | Light | Escherichia coli - metabolism | Protein Engineering | Carrier Proteins - chemistry | Membrane Proteins - metabolism | Plant Proteins - metabolism | Protein Interaction Domains and Motifs | Binding Sites | Apoproteins - metabolism | Gene Expression | Protein Structure, Secondary | Membrane Proteins - genetics | Models, Molecular | Recombinant Fusion Proteins - chemistry | Thyroid Hormones - genetics | DNA-Binding Proteins - genetics | Static Electricity | DNA-Binding Proteins - chemistry | Amino Acid Motifs | Carrier Proteins - genetics | Plant Proteins - genetics | Carrier Proteins - metabolism | Membrane Proteins - chemistry | Escherichia coli - genetics | Thyroid Hormones - metabolism | Allosteric Site | Apoproteins - genetics | Protein Binding | Recombinant Fusion Proteins - genetics | Kinetics | Glucose metabolism | Enzymes | Usage | Molecular dynamics | Physiological aspects | Light-emitting diodes | Cells | Fructose | Cell proliferation | Pyruvate kinase | Pyruvic acid | Labelling | Glucose | Mammals | Secondary structure | Metabolism | Kinases | Mammalian cells | Control | Cell growth | Allosteric properties | Enzymatic activity | Glycolysis | Protein structure | Cancer | Long-term effects | Editor's Choice
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2011, Volume 286, Issue 22, pp. 19247 - 19258
Macrophages activated through Toll receptor triggering increase the expression of the A(2A) and A(2B) adenosine receptors. In this study, we show that... 
MEDIATED INFLAMMATION | TUMOR-NECROSIS-FACTOR | ACTIVATED PROTEIN-KINASE | A(2A) RECEPTORS | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRUCTOSE 2,6-BISPHOSPHATE | MOUSE MACROPHAGES | NF-KAPPA-B | UP-REGULATION | TRANSCRIPTION FACTOR | Gene Expression Regulation, Enzymologic - drug effects | Sequence Deletion | Adenosine Triphosphate - genetics | Sp1 Transcription Factor - metabolism | Gene Expression Regulation, Enzymologic - physiology | Adenosine Triphosphate - biosynthesis | Glycolysis - drug effects | Macrophages, Peritoneal - cytology | Adenosine - genetics | Fructosediphosphates - metabolism | Glycolysis - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Toll-Like Receptor 4 - agonists | Receptor, Adenosine A2A - genetics | Macrophage Activation - physiology | Amino Acid Sequence | Cell Line | Mutagenesis, Site-Directed | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Isoenzymes - genetics | Macrophages, Peritoneal - enzymology | Toll-Like Receptor 4 - genetics | Receptor, Adenosine A2A - metabolism | Toll-Like Receptor 4 - metabolism | Fructosediphosphates - genetics | Mice, Knockout | Receptor, Adenosine A2B | Animals | Phosphofructokinase-2 - biosynthesis | Sp1 Transcription Factor - genetics | Phosphofructokinase-2 - genetics | Lipopolysaccharides - pharmacology | Adenosine - metabolism | Mice | Isoenzymes - biosynthesis | Macrophage Activation - drug effects | Index Medicus | Gene Expression | Immunology | Toll-like Receptors | Phosphofructokinase | Adenosine Receptor | Lipopolysaccharide (LPS) | Macrophage
Journal Article
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 11/2007, Volume 34, Issue 11, pp. 1131 - 1137
SUMMARY • Male hypogonadism is a major problem that starts to affect middle-aged men and has adversely effects on human sexual life. The aim of the present... 
strontium fructose 1,6-diphosphate | endothelin | hypogonadism | testosterone | steroidogenic acute regulatory protein | adenine | strontium fructose 1,6‐diphosphate | Adenine | Strontium fructose 1,6-diphosphate | Testosterone | Endothelin | Steroidogenic acute regulatory protein | Hypogonadism | STEROIDOGENESIS | PHYSIOLOGY | LEYDIG-CELLS | RAT | FRUCTOSE-1,6-BISPHOSPHATE | ELEMENT-BINDING-PROTEIN | 6-diphosphate | SMOOTH-MUSCLE | CONTRACTION | GENE | TESTIS | PHARMACOLOGY & PHARMACY | EXPRESSION | strontium fructose 1 | Metalloendopeptidases - genetics | Sperm Count | Cholesterol Side-Chain Cleavage Enzyme - metabolism | Testis - metabolism | Fructosediphosphates - pharmacology | Male | Metalloendopeptidases - metabolism | Aspartic Acid Endopeptidases - genetics | Phosphoproteins - metabolism | RNA, Messenger - metabolism | Endothelin-Converting Enzymes | Testis - drug effects | Cholesterol Side-Chain Cleavage Enzyme - genetics | Dose-Response Relationship, Drug | Hypogonadism - prevention & control | Strontium | Hypogonadism - metabolism | Testis - enzymology | 3-Hydroxysteroid Dehydrogenases - metabolism | Testosterone - blood | Sexual Behavior, Animal - drug effects | Disease Models, Animal | Spermatogenesis - drug effects | Endothelin-1 - genetics | Endothelin-1 - metabolism | Rats | Signal Transduction - genetics | Phosphoproteins - genetics | Receptor, Endothelin A - genetics | Gene Expression Regulation - drug effects | Sperm Motility - drug effects | Hypogonadism - chemically induced | Organ Size - drug effects | Animals | Testis - pathology | Signal Transduction - drug effects | Aspartic Acid Endopeptidases - metabolism | Fructosediphosphates - therapeutic use | Receptor, Endothelin A - metabolism | 3-Hydroxysteroid Dehydrogenases - genetics | Fructosediphosphates, therapeutic use | Phosphoproteins, metabolism | Receptor, Endothelin A, genetics | Metalloendopeptidases, metabolism | Spermatogenesis, drug effects | Organ Size, drug effects | Metalloendopeptidases, genetics | Signal Transduction, drug effects | 3-Hydroxysteroid Dehydrogenases, genetics | Hypogonadism, chemically induced | Hypogonadism, metabolism | Cholesterol Side-Chain Cleavage Enzyme, metabolism | Endothelin-1, genetics | Gene Expression Regulation, drug effects | Sexual Behavior, Animal, drug effects | Testis, enzymology | 3-Hydroxysteroid Dehydrogenases, metabolism | Aspartic Endopeptidases, genetics | Phosphoproteins, genetics | Signal Transduction, genetics | RNA, Messenger, metabolism | Sperm Motility, drug effects | Receptor, Endothelin A, metabolism | Testosterone, blood | Testis, metabolism | Cholesterol Side-Chain Cleavage Enzyme, genetics | Hypogonadism, prevention and control | Fructosediphosphates, pharmacology | Testis, drug effects | Testis, pathology | Aspartic Endopeptidases, metabolism | Endothelin-1, metabolism | Messenger RNA | Fructose
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 15, pp. 10640 - 10651
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2009, Volume 284, Issue 3, pp. 1748 - 1754
Activation of the p53 tumor suppressor by cellular stress leads to variable responses ranging from growth inhibition to apoptosis. TIGAR is a novel... 
PROTEIN | METABOLISM | BROAD-SPECIFICITY PHOSPHATASE | CRYSTAL-STRUCTURE | FRUCTOSE-2,6-BISPHOSPHATASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE | BIFUNCTIONAL ENZYME | BACILLUS-STEAROTHERMOPHILUS | FRUCTOSE 2,6-BISPHOSPHATE | PHOSPHOGLYCERATE MUTASE HOMOLOG | Porins - metabolism | Substrate Specificity - physiology | Intracellular Signaling Peptides and Proteins - metabolism | Fructosediphosphates - metabolism | Fructosediphosphates - chemistry | Apoptosis Regulatory Proteins - genetics | Porins - chemistry | Intracellular Signaling Peptides and Proteins - genetics | Recombinant Proteins - metabolism | Phosphofructokinase-2 - chemistry | Porins - genetics | Zebrafish Proteins - chemistry | Zebrafish Proteins - metabolism | Apoptosis Regulatory Proteins - chemistry | Recombinant Proteins - chemistry | Escherichia coli Proteins - metabolism | Recombinant Proteins - genetics | Catalytic Domain - physiology | Protein Folding | Zebrafish - genetics | Apoptosis Regulatory Proteins - metabolism | Hydrolysis | Animals | Phosphofructokinase-2 - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Phosphofructokinase-2 - genetics | Zebrafish - metabolism | Escherichia coli Proteins - genetics | Structural Homology, Protein | Zebrafish Proteins - genetics | Escherichia coli Proteins - chemistry | Protein Structure, Tertiary - physiology | HUMAN POPULATIONS | APOPTOSIS | NEOPLASMS | SPECIFICITY | BASIC BIOLOGICAL SCIENCES | national synchrotron light source | LEVELS | FUNCTIONS | MOLECULES | WELLS | GLYCOLYSIS | FRUCTOSE | INHIBITION | HISTIDINE | ENZYMES | IN VITRO | GENES | GROWTH | GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE | PHOSPHATES | RESIDUES | PHOSPHATASES
Journal Article