X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (41) 41
animals (39) 39
fumarate hydratase - antagonists & inhibitors (38) 38
humans (38) 38
fumarate hydratase - metabolism (35) 35
biochemistry & molecular biology (27) 27
fumarate hydratase (17) 17
fumarate hydratase - genetics (17) 17
kinetics (17) 17
fumarates - metabolism (16) 16
metabolism (15) 15
physiological aspects (15) 15
research (15) 15
enzyme inhibitors - pharmacology (14) 14
oncology (14) 14
enzymes (13) 13
mutation (13) 13
cancer (12) 12
cell biology (12) 12
swine (12) 12
fumarate-hydratase (11) 11
kidney neoplasms - genetics (11) 11
carcinoma, renal cell - genetics (10) 10
fumarase (10) 10
rats (10) 10
biophysics (9) 9
female (9) 9
genetic aspects (9) 9
hydro-lyases - antagonists & inhibitors (9) 9
kidney neoplasms - metabolism (9) 9
male (9) 9
mice (9) 9
proteins (9) 9
article (8) 8
carcinoma, renal cell - pathology (8) 8
kidney neoplasms - pathology (8) 8
malates - metabolism (8) 8
mitochondria - enzymology (8) 8
myocardium - enzymology (8) 8
aconitate hydratase - metabolism (7) 7
binding sites (7) 7
carcinoma, renal cell - metabolism (7) 7
cell line, tumor (7) 7
fumarate hydratase - chemistry (7) 7
hereditary leiomyomatosis (7) 7
hydrogen-ion concentration (7) 7
inhibition (7) 7
kidney cancer (7) 7
mitochondria (7) 7
mitochondria - metabolism (7) 7
protein binding (7) 7
renal-cell carcinoma (7) 7
succinate-dehydrogenase (7) 7
antineoplastic agents - pharmacology (6) 6
carcinoma, renal cell - therapy (6) 6
care and treatment (6) 6
cells (6) 6
citric acid cycle - drug effects (6) 6
escherichia-coli (6) 6
fumarates (6) 6
genes (6) 6
kidney neoplasms - therapy (6) 6
leiomyomatosis - genetics (6) 6
models, biological (6) 6
oxidative stress (6) 6
pharmacology & pharmacy (6) 6
reactive oxygen species - metabolism (6) 6
signal transduction (6) 6
tumors (6) 6
cell line (5) 5
fumarate hydratase - deficiency (5) 5
fumarates - pharmacology (5) 5
glutamine (5) 5
glycolysis (5) 5
hypoxia-inducible factor 1, alpha subunit - metabolism (5) 5
in vitro techniques (5) 5
kidney neoplasms - drug therapy (5) 5
l-lactate dehydrogenase - metabolism (5) 5
liver - enzymology (5) 5
microbiology (5) 5
multidisciplinary sciences (5) 5
neoplasms - genetics (5) 5
renal cell carcinoma (5) 5
research article (5) 5
succinate dehydrogenase - genetics (5) 5
aconitate hydratase - antagonists & inhibitors (4) 4
bacterial proteins - genetics (4) 4
binding, competitive (4) 4
carcinoma, renal cell - drug therapy (4) 4
cells, cultured (4) 4
citrate-synthase - antagonists & inhibitors (4) 4
citric acid cycle (4) 4
computer simulation (4) 4
cytosol - enzymology (4) 4
dna methylation (4) 4
dose-response relationship, drug (4) 4
expression (4) 4
gene (4) 4
germline mutations (4) 4
glucose - metabolism (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Molecular Cell, ISSN 1097-2765, 07/2013, Volume 51, Issue 2, pp. 236 - 248
The tricarboxylic acid cycle enzyme fumarate hydratase (FH) has been identified as a tumor suppressor in a subset of human renal cell carcinomas. Human... 
ACTIVATION | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | HYDRATASE | CHEMICAL-MODIFICATION | MUTATIONS | HYPOXIA | CANCER | RENAL-CELL CARCINOMA | CELL BIOLOGY | Antioxidants | Enzymes | Medical colleges | Thiols | Metabolites | Histones | Citric acid | Glutamine
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 8, Issue 2, pp. 143 - 153
Individuals with hemizygous germline fumarate hydratase (FH) mutations are predisposed to renal cancer. These tumors predominantly exhibit functional... 
HYPOXIA-INDUCIBLE FACTOR | FACTOR 1-ALPHA | NUCLEAR TRANSLOCATOR ARNT | SUCCINATE-DEHYDROGENASE | ONCOLOGY | PROLYL HYDROXYLATION | TUMOR-SUPPRESSOR PROTEIN | HEREDITARY LEIOMYOMATOSIS | CELL-CANCER | HIPPEL-LINDAU PROTEIN | FAMILIAL PHEOCHROMOCYTOMA | CELL BIOLOGY | Up-Regulation | Kidney Neoplasms - genetics | Nuclear Proteins - analysis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Leiomyomatosis - metabolism | Carcinoma, Renal Cell - genetics | DNA-Binding Proteins - analysis | Male | Kidney Neoplasms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit | DNA-Binding Proteins - metabolism | Fumarate Hydratase - metabolism | Ketoglutaric Acids - pharmacology | Procollagen-Proline Dioxygenase - antagonists & inhibitors | Adult | Carcinoma, Renal Cell - enzymology | Female | Fumarate Hydratase - antagonists & inhibitors | Nuclear Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors | Hypoxia-Inducible Factor 1 | Nuclear Proteins - metabolism | Fumarate Hydratase - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Syndrome | Transcription Factors - metabolism | Carcinoma, Renal Cell - metabolism | Fumarates - pharmacology | Kidney Neoplasms - enzymology | Alleles | Fumarates - metabolism | Transcription Factors - analysis | Leiomyomatosis - enzymology | Leiomyomatosis - genetics | Medical colleges | Hydroxylation | Pharmacy | Oncology, Experimental | Physiological aspects | Research | Cancer
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 01/2015, Volume 137, Issue 2, pp. 564 - 567
Journal Article
Journal Article
Malaria Journal, ISSN 1475-2875, 06/2017, Volume 16, Issue 1, pp. 247 - 11
Background: Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and... 
Fumarate hydratase (FH) | Plasmodium berghei | Luciferase-luciferin system | Malate:quinone oxidoreductase (MQO) | HIGH-EFFICIENCY TRANSFECTION | INFECTIOUS DISEASES | RODENT MALARIA | FUMARASE | BLOOD STAGES | BERGHEI | Malate: quinone oxidoreductase (MQO) | ATOVAQUONE | TROPICAL MEDICINE | METABOLISM | YOELII-YOELII | PARASITE PLASMODIUM-FALCIPARUM | SELECTION | PARASITOLOGY | Oxidoreductases - antagonists & inhibitors | Mitochondria - enzymology | Specific Pathogen-Free Organisms | Fumarate Hydratase - physiology | Mice, Inbred C57BL | Oxaloacetic Acid - metabolism | Plasmodium berghei - genetics | Male | Oxidoreductases - physiology | Fumarate Hydratase - deficiency | Malaria, Cerebral - prevention & control | Blood-Brain Barrier - metabolism | Animals | Plasmodium berghei - enzymology | Malates - metabolism | Membrane Potential, Mitochondrial | Fumarates - metabolism | Plasmodium berghei - growth & development | Female | Fumarate Hydratase - antagonists & inhibitors | Mice | Erythrocytes - parasitology | Mitochondria - physiology | Oxidoreductases - deficiency | Physiological aspects | Plasmodium falciparum | Research | Virulence (Microbiology) | Malaria | Risk factors | Quinone oxidoreductase | Salvaging | Growth | Oxidoreductase | Virulence | Genes | Erythrocytes | Genomes | Biosynthesis | Parasites | Cytosol | Blood | Purines | Mitochondria | Pyrimidines | Dynamics | Extracellular matrix | Dihydrofolate reductase | Public health | Phosphoenolpyruvate carboxylase | Vector-borne diseases | Pathogens | Enzymes | Phenotypes | Human diseases | Quinone | Metabolism | Strain | Pathogenicity | Fumarate hydratase | Mosquitoes | Aspartate aminotransferase | Oxidoreductases | Luciferase–luciferin system
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 2001, Volume 78, Issue 4, pp. 746 - 755
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2000, Volume 97, Issue 10, pp. 5050 - 5053
β -Cyclodextrin (CD) dimers (n = 11) were synthesized and tested against eight enzymes, seven of which were dimeric or tetrameric, for inhibitor activity.... 
Aggregation | Enzymes | Pyridines | Physical Sciences | Dehydrogenases | Citrates | Esters | Dimers | Cyclodextrins | Monomers | Chromatography | DESIGN | INHIBITION | PEPTIDES | RECOGNITION | INTERFACE | MULTIDISCIPLINARY SCIENCES | COMPLEXES | DIMERIZATION | HIV-1 PROTEASE | RECEPTORS | BINDING | Proteins | Pyridine | Lactate dehydrogenase | Biochemistry | Research
Journal Article
Journal Article