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fumarate hydratase - metabolism (252) 252
animals (247) 247
index medicus (169) 169
biochemistry & molecular biology (165) 165
humans (163) 163
fumarate hydratase (133) 133
fumarate hydratase - genetics (114) 114
kinetics (105) 105
rats (96) 96
male (73) 73
mutation (71) 71
metabolism (68) 68
cancer (62) 62
mitochondria - metabolism (59) 59
enzymes (58) 58
mitochondria (56) 56
mitochondria - enzymology (51) 51
female (50) 50
cell biology (49) 49
citric acid cycle (48) 48
research (48) 48
physiological aspects (47) 47
amino acid sequence (46) 46
malate dehydrogenase - metabolism (46) 46
fumarates - metabolism (45) 45
swine (45) 45
fumarase (43) 43
fumarate hydratase - analysis (42) 42
myocardium - enzymology (42) 42
malates - metabolism (40) 40
succinate dehydrogenase - metabolism (40) 40
oxidative stress (39) 39
expression (37) 37
oncology (37) 37
gene (36) 36
genetic aspects (36) 36
molecular sequence data (36) 36
citrate-synthase - metabolism (35) 35
biophysics (34) 34
escherichia coli - enzymology (34) 34
escherichia-coli (34) 34
mice (34) 34
aconitate hydratase - metabolism (33) 33
article (33) 33
hydrogen-ion concentration (33) 33
fumarate hydratase - chemistry (32) 32
fumarate-hydratase (32) 32
genes (32) 32
analysis (31) 31
fumarate hydratase - deficiency (31) 31
l-lactate dehydrogenase - metabolism (31) 31
proteins (31) 31
cytosol - enzymology (30) 30
liver - enzymology (30) 30
fumarate hydratase - isolation & purification (29) 29
isocitrate dehydrogenase - metabolism (29) 29
models, biological (28) 28
mutations (28) 28
base sequence (27) 27
energy metabolism (27) 27
neoplasms - metabolism (27) 27
escherichia coli - genetics (26) 26
research article (26) 26
succinate dehydrogenase - genetics (26) 26
binding sites (25) 25
genetics & heredity (25) 25
succinate-dehydrogenase (25) 25
gene expression (24) 24
hereditary leiomyomatosis (24) 24
oxidation-reduction (24) 24
tumors (24) 24
metabolites (23) 23
hydro-lyases (22) 22
hypoxia (22) 22
kidney neoplasms - genetics (22) 22
neoplasms - genetics (22) 22
physiology (22) 22
purification (22) 22
rats, inbred strains (22) 22
time factors (22) 22
citric acid cycle - physiology (21) 21
mitochondrial (21) 21
dehydrogenase (20) 20
fumarate hydratase - antagonists & inhibitors (20) 20
glucose - metabolism (20) 20
hydro-lyases - metabolism (20) 20
microbiology (20) 20
protein binding (20) 20
signal transduction (20) 20
succinate dehydrogenase (20) 20
cell line, tumor (19) 19
cells, cultured (19) 19
mitochondria, liver - enzymology (19) 19
saccharomyces cerevisiae - enzymology (19) 19
saccharomyces-cerevisiae (19) 19
tricarboxylic acid cycle (19) 19
fumarate (18) 18
gene-expression (18) 18
renal-cell cancer (18) 18
centrifugation, density gradient (17) 17
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Cancer Cell, ISSN 1535-6108, 10/2011, Volume 20, Issue 4, pp. 524 - 537
Journal Article
The Journal of experimental medicine, ISSN 0022-1007, 03/2017, Volume 214, Issue 3, pp. 719 - 735
Journal Article
Journal of the American Society of Nephrology, ISSN 1046-6673, 02/2016, Volume 27, Issue 2, pp. 466 - 481
Journal Article
Journal Article
Malaria Journal, ISSN 1475-2875, 06/2017, Volume 16, Issue 1, pp. 247 - 11
Background: Aspartate, which is converted from oxaloacetate (OAA) by aspartate aminotransferase, is considered an important precursor for purine salvage and... 
Fumarate hydratase (FH) | Plasmodium berghei | Luciferase-luciferin system | Malate:quinone oxidoreductase (MQO) | HIGH-EFFICIENCY TRANSFECTION | INFECTIOUS DISEASES | RODENT MALARIA | FUMARASE | BLOOD STAGES | BERGHEI | Malate: quinone oxidoreductase (MQO) | ATOVAQUONE | TROPICAL MEDICINE | METABOLISM | YOELII-YOELII | PARASITE PLASMODIUM-FALCIPARUM | SELECTION | PARASITOLOGY | Oxidoreductases - antagonists & inhibitors | Mitochondria - enzymology | Specific Pathogen-Free Organisms | Fumarate Hydratase - physiology | Mice, Inbred C57BL | Oxaloacetic Acid - metabolism | Plasmodium berghei - genetics | Male | Oxidoreductases - physiology | Fumarate Hydratase - deficiency | Malaria, Cerebral - prevention & control | Blood-Brain Barrier - metabolism | Animals | Plasmodium berghei - enzymology | Malates - metabolism | Membrane Potential, Mitochondrial | Fumarates - metabolism | Plasmodium berghei - growth & development | Female | Fumarate Hydratase - antagonists & inhibitors | Mice | Erythrocytes - parasitology | Mitochondria - physiology | Oxidoreductases - deficiency | Physiological aspects | Plasmodium falciparum | Research | Virulence (Microbiology) | Malaria | Risk factors | Quinone oxidoreductase | Salvaging | Growth | Oxidoreductase | Virulence | Genes | Erythrocytes | Genomes | Biosynthesis | Parasites | Cytosol | Blood | Purines | Mitochondria | Pyrimidines | Dynamics | Extracellular matrix | Dihydrofolate reductase | Public health | Phosphoenolpyruvate carboxylase | Vector-borne diseases | Pathogens | Enzymes | Phenotypes | Human diseases | Quinone | Metabolism | Strain | Pathogenicity | Fumarate hydratase | Mosquitoes | Aspartate aminotransferase | Oxidoreductases | Luciferase–luciferin system
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 03/2003, Volume 3, Issue 3, pp. 193 - 202
Mitochondrial defects have been associated with neurological disorders, as well as cancers. Two ubiquitously expressed mitochondrial enzymes - succinate... 
RESPIRATORY-CHAIN | GERM-LINE MUTATIONS | ONCOLOGY | LEIGH-SYNDROME | C-OXIDASE DEFICIENCY | HEREDITARY PARAGANGLIOMA | SACCHAROMYCES-CEREVISIAE | RENAL-CELL CANCER | DNA MUTATIONS | RET PROTOONCOGENE | COMPLEX-I DEFICIENCY | Mitochondria - enzymology | Protein Subunits | Kidney Neoplasms - genetics | Humans | Mitochondrial Encephalomyopathies - enzymology | Carcinoma, Renal Cell - genetics | Pheochromocytoma - enzymology | Apoptosis - genetics | Oxidoreductases - physiology | Fumarate Hydratase - deficiency | Electron Transport Complex II | Multienzyme Complexes - deficiency | Carcinoma, Renal Cell - enzymology | Neoplastic Syndromes, Hereditary - genetics | Oxidoreductases - deficiency | Paraganglioma - enzymology | Free Radicals | Neovascularization, Physiologic - genetics | Oxidoreductases - genetics | Paraganglioma - genetics | Fumarate Hydratase - physiology | Mitochondrial Encephalomyopathies - genetics | Multienzyme Complexes - genetics | Fumarate Hydratase - genetics | Forecasting | Succinate Dehydrogenase - deficiency | Homozygote | Neovascularization, Physiologic - physiology | Citric Acid Cycle - genetics | Succinate Dehydrogenase - genetics | Energy Metabolism | Kidney Neoplasms - enzymology | Multienzyme Complexes - physiology | Neoplastic Syndromes, Hereditary - enzymology | Heterozygote | Pheochromocytoma - genetics | Apoptosis - physiology | Mutation | Succinate Dehydrogenase - physiology | Leiomyomatosis - enzymology | Leiomyomatosis - genetics | Enzymes | Mitochondria | Gene mutations | Physiological aspects | Genetic aspects | Research | Health aspects | Cancer
Journal Article
Expert Opinion on Biological Therapy, ISSN 1471-2598, 06/2008, Volume 8, Issue 6, pp. 779 - 790
Background: Kidney cancer is not a homogenous entity; it is comprised of many different tumor types, with different biologies and molecular mechanisms leading... 
hereditary leiomyomatosis renal cell carcinoma | kidney cancer | renal cell carcinoma | fumarate hydratase | Birt-Hogg-Dubé | Von Hippel-Lindau | Met | hereditary papillary renal cancer | Fumarate hydratase | Hereditary leiomyomatosis renal cell carcinoma | Renal cell carcinoma | Hereditary papillary renal cancer | Kidney cancer | Kidney Neoplasms - genetics | Humans | Neoplasm Proteins - physiology | Carcinoma, Renal Cell - genetics | Receptors, Growth Factor - antagonists & inhibitors | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Fumarate Hydratase - deficiency | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Proto-Oncogenes | Receptors, Growth Factor - genetics | Neoplasms, Multiple Primary - therapy | Leiomyomatosis - therapy | Tumor Suppressor Proteins - deficiency | Tumor Suppressor Proteins - genetics | Drug Design | Antineoplastic Agents - pharmacology | Neoplastic Syndromes, Hereditary - genetics | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Neoplasm Proteins - genetics | Genes, Tumor Suppressor | Kidney Neoplasms - therapy | Proto-Oncogene Proteins - antagonists & inhibitors | Genetic Predisposition to Disease | von Hippel-Lindau Disease - therapy | Neoplasms, Multiple Primary - genetics | Fumarate Hydratase - physiology | Proto-Oncogene Proteins c-met | Von Hippel-Lindau Tumor Suppressor Protein - physiology | Proto-Oncogene Proteins - genetics | Fumarate Hydratase - genetics | Proto-Oncogene Proteins - deficiency | von Hippel-Lindau Disease - genetics | Tumor Suppressor Proteins - physiology | Receptors, Growth Factor - physiology | Receptors, Growth Factor - deficiency | Proto-Oncogene Proteins - physiology | Carcinoma, Renal Cell - therapy | Neoplastic Syndromes, Hereditary - therapy | Leiomyomatosis - genetics | Hereditary Leiomyomatosis Renal Cell Carcinoma | Hereditary Papillary Renal Cancer
Journal Article