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Cell (Cambridge), ISSN 0092-8674, 2006, Volume 125, Issue 5, pp. 873 - 886
.... This silencing depends on a functional RNAi pathway, requires the heterochromatin proteins, Swi6/HP1, Clr4/Suv39h, and Sir2, and is accompanied by the generation of ura4... 
H3 LYSINE-9 METHYLATION | DOUBLE-STRANDED-RNA | FISSION YEAST | EPIGENETIC CONTROL | HISTONE H3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INTERFERENCE | MECHANISMS | CHROMOSOME SEGREGATION | POLYMERASE-II | SCHIZOSACCHAROMYCES-POMBE | CELL BIOLOGY | RNA, Small Interfering - genetics | RNA-Binding Proteins - genetics | Exoribonucleases - genetics | Methyltransferases - metabolism | RNA-Induced Silencing Complex - genetics | Methyltransferases - genetics | Schizosaccharomyces - genetics | DNA Methylation | Schizosaccharomyces pombe Proteins - metabolism | Cell Cycle Proteins - genetics | Gene Expression Regulation, Fungal - genetics | RNA Interference - physiology | Sirtuins - genetics | Schizosaccharomyces pombe Proteins - genetics | Chromosomal Proteins, Non-Histone - metabolism | Cell Cycle Proteins - metabolism | RNA Precursors - genetics | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Heterochromatin - genetics | Histones - metabolism | Sirtuins - metabolism | Exoribonucleases - metabolism | Regulatory Elements, Transcriptional - genetics | Histones | Genetic research | Gene silencing | Research | Chromatin | Genetic engineering | RNA | Methylation | Lysine | Analysis | Sirtuins | Gene Expression Regulation, Fungal | RNA Precursors | Exoribonucleases | Schizosaccharomyces pombe Proteins | Chromosomal Proteins, Non-Histone | RNA-Binding Proteins | Life Sciences | Heterochromatin | Methyltransferases | RNA Interference | Regulatory Elements, Transcriptional | Genetics | RNA, Small Interfering | Cell Cycle Proteins | RNA-Induced Silencing Complex | Schizosaccharomyces | Carrier Proteins
Journal Article
BMC Evolutionary Biology, ISSN 1471-2148, 2007, Volume 7, Issue 1, pp. 103 - 103
Background: Septins are cytoskeletal GTPase proteins first discovered in the fungus Saccharomyces cerevisiae where they organize the septum and link nuclear division with cell division... 
P-LOOP | ORGANIZATION | PHYLOGENY | EVOLUTIONARY BIOLOGY | YEAST SEPTINS | GENE | SEQUENCE | GENETICS & HEREDITY | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | BINDING | COILED COILS | Consensus Sequence | Fungal Proteins - chemistry | Gene Duplication | Multigene Family | Species Specificity | Cytoskeletal Proteins - genetics | Caenorhabditis elegans Proteins - chemistry | Humans | Cell Cycle Proteins - classification | Phylogeny | Protozoan Proteins - genetics | Fungi - genetics | Cell Cycle Proteins - chemistry | GTP Phosphohydrolases - chemistry | Profilins - genetics | Protein Isoforms - chemistry | Cell Cycle Proteins - genetics | Conserved Sequence | Microsporidia - genetics | Protozoan Proteins - chemistry | Microsporidia - enzymology | Protein Structure, Tertiary | Zebrafish Proteins - chemistry | Fungi - enzymology | Insect Proteins - genetics | Rats | Terminology as Topic | Cytoskeletal Proteins - chemistry | Cytoskeletal Proteins - classification | Drosophila Proteins - chemistry | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Fungal Proteins - classification | Sequence Homology, Amino Acid | Sequence Alignment | Animals | GTP Phosphohydrolases - genetics | Profilins - chemistry | GTP Phosphohydrolases - classification | Insect Proteins - chemistry | Mice | Drosophila Proteins - genetics | Zebrafish Proteins - genetics | Amino Acid Motifs - genetics | Caenorhabditis elegans Proteins - genetics | Evolution, Molecular | Protein Isoforms - genetics | Saccharomyces cerevisiae Proteins - chemistry | Amino acid sequence | Genetic aspects | Yeast fungi | Guanosine triphosphatase | Analysis
Journal Article
Developmental Cell, ISSN 1534-5807, 03/2010, Volume 18, Issue 3, pp. 397 - 409
.... The discovery that centromeric Rec8 is protected from separase during meiosis I by shugoshin/MEI-S332 proteins that bind PP2A phosphatase suggests that phosphorylation either of separase or cohesin... 
CELLBIO | RECOMBINATION | MAINTENANCE | KINETOCHORES | CENTROMERIC COHESION | HOMOLOGOUS CHROMOSOMES | REQUIRES | DEVELOPMENTAL BIOLOGY | SISTER-CHROMATID SEPARATION | PROTEIN PHOSPHATASE 2A | SEGREGATION | SHUGOSHIN | CELL BIOLOGY | Protein Kinases - metabolism | Casein Kinase Idelta - metabolism | Chromatin - metabolism | Meiosis - physiology | Phosphorylation | Protein Kinases - genetics | Casein Kinase I - genetics | Saccharomyces cerevisiae - genetics | Green Fluorescent Proteins - genetics | Centromere - metabolism | Recombinant Fusion Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Casein Kinase Iepsilon - metabolism | Cell Cycle Proteins - genetics | Genes, Fungal | Casein Kinase Iepsilon - genetics | Nuclear Proteins - genetics | Binding Sites | Casein Kinase Idelta - genetics | Protein-Serine-Threonine Kinases - metabolism | Endopeptidases - metabolism | Green Fluorescent Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Separase | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Saccharomyces cerevisiae Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Saccharomyces cerevisiae - cytology | Meiosis - genetics | Endopeptidases - genetics | Models, Biological | Protein Phosphatase 2 - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Recombinant Fusion Proteins - genetics | Casein Kinase I - metabolism | Mutation | Chromosomal Proteins, Non-Histone - chemistry | Saccharomyces cerevisiae Proteins - chemistry | DNA replication | Phosphatases | Casein | Phosphotransferases | Protein binding
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e85212
.... In the budding yeast Saccharomyces cerevisiae the RNA binding protein Ssd1 helps control cell wall remodeling by repressing translation of proteins involved in wall expansion... 
LOCALIZATION | GREEN FLUORESCENT PROTEIN | WALL | MESSENGER-RNA | SACCHAROMYCES-CEREVISIAE W303-1A | MULTIDISCIPLINARY SCIENCES | KINASE | MITOTIC EXIT | YEAST CBK1 | GENETIC INTERACTIONS | RNA-BINDING PROTEIN | Protein Biosynthesis | Saccharomyces cerevisiae - genetics | 3' Untranslated Regions - genetics | 5' Untranslated Regions - genetics | Chitinases - metabolism | Green Fluorescent Proteins - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mitochondrial Proteins - genetics | Chitinases - genetics | Saccharomyces cerevisiae - metabolism | Heat-Shock Proteins - genetics | Basic Helix-Loop-Helix Transcription Factors - metabolism | Mitochondrial Proteins - metabolism | Membrane Proteins - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Genes, Reporter | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Fungal | Green Fluorescent Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Morphogenesis - genetics | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Cell Wall - genetics | Repressor Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Proteins | Messenger RNA | Protein kinases | Protein binding | Repressing | Translation | Protein kinase C | Baking yeast | Yeast | Immunoprecipitation | Transcription | Cell walls | RNA polymerase | Remodeling | Kinases | Gene expression | Ribonucleic acid--RNA | Morphogenesis | RNA-binding protein | Cell growth | Protein kinase | Genetics | Viability | RNA | Ribonucleic acid
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2001, Volume 294, Issue 5550, pp. 2364 - 2368
In Saccharomyces cerevisiae, more than 80% of the ∼6200 predicted genes are nonessential, implying that the genome is buffered from the phenotypic consequences of genetic perturbation... 
Yeasts | Microbial genetics | Cell growth | Diploidy | Molecular genetics | Cell walls | DNA | Actins | Reports | Genetic mutation | Genetic screening | MORPHOGENESIS | SCREEN | BUDDING YEAST | SYNTHETIC LETHAL | MULTIDISCIPLINARY SCIENCES | ACTIN CYTOSKELETON | MUTATIONS | SACCHAROMYCES-CEREVISIAE | Cytoskeletal Proteins | Cell Polarity | Mitosis | Saccharomyces cerevisiae - genetics | Microtubule Proteins - physiology | Databases, Genetic | Endodeoxyribonucleases - physiology | Robotics | DNA, Fungal - biosynthesis | Genome, Fungal | RecQ Helicases | Recombination, Genetic | Gene Deletion | Cell Cycle Proteins - genetics | Microtubule Proteins - genetics | DNA Helicases - genetics | Genes, Fungal - physiology | Carrier Proteins - physiology | Saccharomyces cerevisiae - physiology | Computational Biology | Fungal Proteins - genetics | Genetic Markers | Saccharomyces cerevisiae Proteins - genetics | Genetic Techniques | Genes, Essential | Carrier Proteins - genetics | Endodeoxyribonucleases - genetics | Fungal Proteins - physiology | Microfilament Proteins | DNA Repair | Flap Endonucleases | Cytoskeleton - physiology | Saccharomyces cerevisiae Proteins - physiology | Cell Cycle Proteins - physiology | Saccharomyces cerevisiae - growth & development | Crosses, Genetic | DNA Helicases - physiology | Yeast | Gene mutations | Analysis | Genetic research | Genetic aspects | Research | Genetics | Mutation
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2004, Volume 116, Issue 1, pp. 75 - 86
.... Here we report the identification of a protein, Sus1, which functions in both transcription and mRNA export... 
HNRNP-LIKE PROTEINS | YEAST | COACTIVATOR | POLY(A)(+) RNA | INTERACTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | COUPLING TRANSCRIPTION | YRA1P | SACCHAROMYCES-CEREVISIAE | NUCLEOCYTOPLASMIC TRANSPORT | CELL BIOLOGY | Nucleocytoplasmic Transport Proteins | RNA-Binding Proteins - genetics | Yeasts | Acetyltransferases - metabolism | Transcriptional Activation - genetics | Histone Acetyltransferases | Nuclear Proteins - isolation & purification | Active Transport, Cell Nucleus - physiology | DNA, Complementary - genetics | Molecular Sequence Data | Amino Acid Sequence - genetics | RNA, Messenger - metabolism | RNA-Binding Proteins - isolation & purification | Acetyltransferases - genetics | Promoter Regions, Genetic - genetics | Porins | Genes, Regulator - genetics | Cell Nucleus - metabolism | Nuclear Proteins - deficiency | Ribonucleoproteins - genetics | Saccharomyces cerevisiae Proteins - isolation & purification | Gene Expression Regulation, Fungal - genetics | Fungal Proteins - isolation & purification | Nuclear Proteins - genetics | DNA, Complementary - analysis | Base Sequence - genetics | RNA, Messenger - genetics | Nuclear Pore - genetics | Nuclear Proteins - metabolism | Ribonucleoproteins - metabolism | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Pore - metabolism | Genes, Lethal - genetics | Saccharomyces cerevisiae Proteins - metabolism | RNA-Binding Proteins - metabolism | Fungal Proteins - metabolism | Histones | Genetic research | Messenger RNA | Genetic transcription | Research
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 118, Issue 6, pp. 699 - 713
.... The Mre11 nuclease and the ATM-related Tel1 kinase are the first proteins detected at DSBs... 
MRE11 COMPLEX | TELOMERE MAINTENANCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOUBLE-STRAND BREAKS | S-PHASE | NUCLEAR FOCI | STALLED REPLICATION FORKS | HOMOLOGOUS RECOMBINATION | SENSITIVE MUTANTS | SACCHAROMYCES-CEREVISIAE | RAD52 PROTEIN | CELL BIOLOGY | Gamma Rays | Hydroxyurea - pharmacology | G2 Phase - genetics | Saccharomyces cerevisiae - genetics | Protein-Serine-Threonine Kinases | DNA Repair - genetics | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Time Factors | Endodeoxyribonucleases - metabolism | Cell Cycle Proteins - genetics | DNA Damage - genetics | Recombination, Genetic - genetics | Genes, cdc - physiology | Gene Expression Regulation, Fungal - genetics | Exodeoxyribonucleases - genetics | Replication Protein A | Saccharomyces cerevisiae - radiation effects | Oxidative Stress - genetics | Intracellular Signaling Peptides and Proteins | DNA - metabolism | Fungal Proteins - genetics | Reaction Time - genetics | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | S Phase - genetics | DNA - genetics | Transcription Factors - metabolism | Endodeoxyribonucleases - genetics | Endonucleases | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Fungal Proteins - metabolism | Genetic research | DNA replication | Genomes | Research | DNA repair
Journal Article
Cell, ISSN 0092-8674, 2004, Volume 116, Issue 3, pp. 405 - 415
The FLO gene family of Saccharomyces cerevisiae includes an expressed gene, FLO11, and a set of silent, telomere-adjacent FLO genes. This gene family encodes... 
TRYPANOSOMA-BRUCEI | INVASIVE GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | PILIN ANTIGENIC VARIATION | RIBOSOMAL DNA | SIR PROTEINS | ALBICANS | PATHOGEN CANDIDA-GLABRATA | SACCHAROMYCES-CEREVISIAE | PSEUDOHYPHAL DIFFERENTIATION | EXPRESSION | CELL BIOLOGY | RNA-Binding Proteins - genetics | Membrane Glycoproteins - metabolism | Saccharomyces cerevisiae - genetics | Promoter Regions, Genetic - genetics | Saccharomyces cerevisiae - metabolism | Cell Differentiation - genetics | Sirtuin 2 | Trans-Activators - genetics | Gene Expression Regulation, Fungal - genetics | Nuclear Proteins - genetics | Sirtuins - genetics | Extrachromosomal Inheritance - genetics | Repressor Proteins - metabolism | GTPase-Activating Proteins | Histone Deacetylases - genetics | Membrane Proteins - genetics | Cells, Cultured | Cell Wall - genetics | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Fungal Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Clone Cells - metabolism | Membrane Glycoproteins - genetics | Cell Wall - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Trans-Activators - metabolism | Genetic Variation - genetics | Gene Silencing - physiology | Sirtuins - metabolism | RNA-Binding Proteins - metabolism | Fungal Proteins - metabolism | Genetic code | Genetic aspects | Research | Brewer's yeast
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2014, Volume 9, Issue 5, p. e95914
Protein conformational maladies such as Huntington Disease are characterized by accumulation of intracellular and extracellular protein inclusions containing amyloid-like proteins... 
NEURONAL INTRANUCLEAR INCLUSIONS | EXPANDED POLYGLUTAMINE | UBIQUITIN-PROTEASOME SYSTEM | EXPANSION PROTEINS | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | MUTANT HUNTINGTIN | CASPASE CLEAVAGE | BODY FORMATION | SACCHAROMYCES-CEREVISIAE | TRANSCRIPTION FACTOR | Protein Aggregates | RNA-Binding Proteins - genetics | Ribonucleases - genetics | Saccharomyces cerevisiae - genetics | Humans | Huntington Disease - pathology | Molecular Sequence Data | Amyloidogenic Proteins - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Ribonucleases - metabolism | Saccharomyces cerevisiae - metabolism | Heat-Shock Proteins - genetics | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Nuclear Proteins - deficiency | Nuclear Proteins - genetics | Transgenes | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amyloidogenic Proteins - genetics | Gene Expression Regulation, Fungal | Protein Structure, Tertiary | Amino Acid Sequence | Peptides - chemistry | Signal Transduction | Heat-Shock Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | HSP70 Heat-Shock Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Nuclear Localization Signals | Huntington Disease - metabolism | Nerve Tissue Proteins - genetics | HSP70 Heat-Shock Proteins - metabolism | Protein Interaction Mapping | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Amyloidogenic Proteins - metabolism | Models, Biological | Plasmids | Saccharomyces cerevisiae Proteins - metabolism | Huntington Disease - genetics | Protein Binding | Proteins | Proline | Heat shock proteins | Huntington's chorea | Quality control | Transcription factors | Disease | Huntingtin | Toxicity | Cytotoxicity | Biology | Agglomeration | Defense mechanisms | Nuclei | Cell cycle | Physiology | Localization | RNA processing | Trinucleotide repeat diseases | Polyglutamine | Benign | Hsp70 protein | Gene expression | Ribonucleic acid--RNA | Disease control | Suppressors | Intermediates | Prions | Intracellular | Protein interaction | Cytoplasm | RNA | Ribonucleic acid
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2005, Volume 123, Issue 4, pp. 581 - 592
Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT... 
RNA-POLYMERASE-II | CHROMATIN IN-VIVO | PROTEIN IDENTIFICATION TECHNOLOGY | REGULATES H3 METHYLATION | SHOTGUN PROTEOMICS | TARGETED RECRUITMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | DNA-SYNTHESIS | YEAST PROTEOME | SACCHAROMYCES-CEREVISIAE | CELL BIOLOGY | Histone Deacetylases - analysis | Acetyltransferases - metabolism | Molecular Weight | Saccharomyces cerevisiae - genetics | Methyltransferases - metabolism | Protein Subunits - analysis | Methyltransferases - genetics | Acetyltransferases - genetics | Promoter Regions, Genetic - genetics | Repressor Proteins - analysis | Protein Subunits - metabolism | Saccharomyces cerevisiae - metabolism | Chromatin Immunoprecipitation | Acetyltransferases - analysis | Acetylation | Repressor Proteins - metabolism | Protein Subunits - genetics | Gene Expression Regulation, Fungal | Histone Deacetylases - genetics | MAP Kinase Kinase Kinases - genetics | Repressor Proteins - genetics | Histone Deacetylases - metabolism | MAP Kinase Kinase Kinases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Transcription Factors - genetics | Mutation - genetics | Open Reading Frames - genetics | Transcription Factors - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Transcription Factors - analysis | Histones - metabolism | Transcription, Genetic - genetics | Methylation | Saccharomyces cerevisiae Proteins - analysis | Histones | Research | Genetic transcription | Genetic research | Methyltransferases | RNA | Analysis
Journal Article