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Immunity, ISSN 1074-7613, 09/2015, Volume 43, Issue 3, pp. 475 - 487
Interleukin-17 (IL-17) induces pathology in autoimmunity and infections; therefore, constraint of this pathway is an essential component of its regulation. We... 
negative regulation | Regnase-1 | fungal immunity | autoimmunity | signal transduction | IL-17 | Autoimmunity | Signal transduction | Fungal immunity | Negative regulation | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | IL-17 RECEPTOR | TARGET GENES | CANDIDA-ALBICANS | C/EBP-BETA | GENE-EXPRESSION | HOST-DEFENSE | NECROSIS-FACTOR-ALPHA | MESSENGER-RNA STABILITY | T-CELL | IMMUNOLOGY | Candidiasis - genetics | Oncogene Proteins - genetics | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Male | Receptors, Interleukin-17 - genetics | Ribonucleases - metabolism | Host-Pathogen Interactions - immunology | Inflammation - metabolism | Lipocalins - genetics | Adaptor Proteins, Signal Transducing - immunology | Pneumonia - immunology | Candida albicans - physiology | Encephalomyelitis, Autoimmune, Experimental - genetics | Receptors, Interleukin-17 - metabolism | Interleukin-6 - metabolism | Pneumonia - genetics | Interleukin-6 - genetics | Oncogene Proteins - metabolism | Signal Transduction - genetics | Candida albicans - immunology | Reverse Transcriptase Polymerase Chain Reaction | Mice, Knockout | Interleukin-17 - metabolism | Lipocalin-2 | Lipocalins - immunology | Interleukin-6 - immunology | Pneumonia - metabolism | Ribonucleases - genetics | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, Interleukin-17 - immunology | Interleukin-17 - immunology | Acute-Phase Proteins - genetics | Candidiasis - microbiology | Signal Transduction - immunology | HEK293 Cells | Female | Candidiasis - immunology | Nuclear Proteins - genetics | Oncogene Proteins - immunology | Lipocalins - metabolism | Cell Line | Acute-Phase Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Nuclear Proteins - metabolism | Inflammation - immunology | Nuclear Proteins - immunology | Animals | Ribonucleases - immunology | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Adaptor Proteins, Signal Transducing - metabolism | Acute-Phase Proteins - immunology | Medical colleges | Nucleases | Interleukins | RNA | Cellular signal transduction | Inflammation | Proteins | Cytokines | Rodents | Fibroblasts | Infections | Kinases | Laboratory animals | Gene expression | Experiments | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 41, pp. 34149 - 34156
Dectin-1 is a pattern recognition receptor that is important for innate immune responses against fungi in humans and mice. Dectin-1 binds to beta-glucans in... 
YEAST | CELLS | RESPONSES | PHAGOCYTOSIS | ACTIVATION | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-GLUCAN RECOGNITION | RECEPTOR | AUTOPHAGY | DECTIN-1 | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Lectins, C-Type - immunology | NADPH Oxidases - immunology | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Lectins, C-Type - genetics | Enzyme Activation - immunology | Protein-Tyrosine Kinases - immunology | CD4-Positive T-Lymphocytes - immunology | Lectins, C-Type - metabolism | Phagosomes - immunology | Protein-Tyrosine Kinases - genetics | Bone Marrow Cells - immunology | NADPH Oxidases - genetics | Histocompatibility Antigens Class II - metabolism | beta-Glucans - immunology | Intracellular Signaling Peptides and Proteins - genetics | Syk Kinase | Macrophages - immunology | Cell Line | Bone Marrow Cells - cytology | Antigens, Fungal - metabolism | CD4-Positive T-Lymphocytes - cytology | Phagosomes - metabolism | CD4-Positive T-Lymphocytes - metabolism | Antigens, Fungal - immunology | Macrophages - cytology | Mice, Knockout | Microtubule-Associated Proteins - immunology | beta-Glucans - metabolism | Animals | Histocompatibility Antigens Class II - immunology | Autophagy-Related Protein 5 | Protein Binding | Dendritic Cells - cytology | Mice | Histocompatibility Antigens Class II - genetics | Enzyme Activation - genetics | Antigen Presentation - physiology | Phagosomes - genetics | Index Medicus | Lectin | Dectin-1 | Immunology | Dendritic Cells | Innate Immunity | Macrophages | Phagocytosis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 17, pp. 5533 - 5538
Oligogalacturonides (OGs) are fragments of pectin that activate plant innate immunity by functioning as damage-associated molecular patterns (DAMPs). We set... 
PGIP | Polygalacturonase | Oligogalacturonides | Plant immunity | DAMPs | POLYGALACTURONASE-INHIBITING PROTEIN | ARABIDOPSIS-THALIANA | DEFENSE RESPONSES | BOTRYTIS-CINEREA | MULTIDISCIPLINARY SCIENCES | TRANSLATIONAL INHIBITION | oligogalacturonides | SALICYLIC-ACID | SIGNALING PATHWAY | ELICITORS | polygalacturonase | RESISTANCE | HOST-PATHOGEN INTERACTIONS | plant immunity | Recombinant Fusion Proteins - immunology | Plant Immunity | Fungal Proteins - biosynthesis | Pseudomonas syringae - growth & development | Plant Diseases - immunology | Polygalacturonase - immunology | Arabidopsis - immunology | Plant Diseases - microbiology | Fungal Proteins - immunology | Arabidopsis Proteins - biosynthesis | Hexuronic Acids - immunology | Plant Diseases - genetics | Polygalacturonase - genetics | Pectobacterium carotovorum - growth & development | Botrytis - immunology | Botrytis - growth & development | Pectobacterium carotovorum - immunology | Recombinant Fusion Proteins - biosynthesis | Arabidopsis Proteins - genetics | Pseudomonas syringae - immunology | Mice, Transgenic | Plant Proteins - immunology | Fungal Proteins - genetics | Arabidopsis Proteins - immunology | Arabidopsis - metabolism | Arabidopsis - genetics | Arabidopsis - microbiology | Plant Proteins - genetics | Polygalacturonase - biosynthesis | Animals | Recombinant Fusion Proteins - genetics | Plant Proteins - biosynthesis | Hexuronic Acids - metabolism | Enzymes | Botanical research | Pectin | Disease susceptibility | Regulation | Research | Properties | Gene expression | Observations | Molecules | Pathogens | Flowers & plants | Transgenic plants | Immune system | Index Medicus | Biological Sciences
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2009, Volume 182, Issue 8, pp. 4938 - 4946
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6763 - 6763
Asthma, a common disorder that affects 4250 million people worldwide, is defined by exaggerated bronchoconstriction to inflammatory mediators including... 
EXTRACELLULAR-MATRIX PROTEINS | ASPERGILLUS-FUMIGATUS | EPITHELIAL-CELLS | CONTRACTION | MULTIDISCIPLINARY SCIENCES | LUNG-DISEASE | SMOOTH-MUSCLE-CELLS | MECHANISMS | PEN C-13 | SERINE PROTEINASE | EXPRESSION | Histamine - biosynthesis | Calcium - metabolism | Humans | Immunoglobulin E - biosynthesis | Extracellular Matrix - immunology | Myocytes, Smooth Muscle - pathology | Calcium - immunology | Trachea - drug effects | Histamine - immunology | Bronchi - immunology | Extracellular Matrix - chemistry | Bronchi - drug effects | Allergens - administration & dosage | Allergens - immunology | Fungal Proteins - immunology | Bronchoconstriction - drug effects | Asthma - immunology | Bronchoconstriction - immunology | Female | Bacterial Proteins - immunology | rho GTP-Binding Proteins - immunology | Myocytes, Smooth Muscle - drug effects | Bronchi - pathology | Disease Models, Animal | Gene Expression | rho GTP-Binding Proteins - genetics | Extracellular Matrix - drug effects | Administration, Inhalation | Aspergillus fumigatus - chemistry | Bacterial Proteins - administration & dosage | Endopeptidases - administration & dosage | Endopeptidases - immunology | Trachea - immunology | Trachea - pathology | Animals | Aspergillus fumigatus - immunology | Myocytes, Smooth Muscle - immunology | Mice | Mice, Inbred BALB C | Primary Cell Culture | Asthma - pathology | Fungal Proteins - administration & dosage | Biodegradation | Allergens | Calcium | Lung | Serine | Medical treatment | Lung diseases | Muscles | Smooth muscle | RhoA protein | Inflammation | Asthma | Respiratory tract | Fungi | Histamine | Bronchoconstriction | Protease | Bradykinin | Extracellular matrix | Serine proteinase | Acetylcholine | Disruption | Calcium ions | Alkaline protease | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2011, Volume 7, Issue 7, pp. e1002148 - e1002148
Wounded leaves of Arabidopsis thaliana show transient immunity to Botrytis cinerea, the causal agent of grey mould. Using a fluorescent probe, histological... 
APPRESSORIUM FORMATION | ARABIDOPSIS-THALIANA | OXIDATIVE STRESS | BOTRYTIS-CINEREA | SCLEROTINIA-SCLEROTIORUM | MICROBIOLOGY | F-SP-PISI | MAGNAPORTHE-GRISEA | VIROLOGY | CUTINASE GENE | HYDROGEN-PEROXIDE | ABSCISIC-ACID | PARASITOLOGY | Coenzyme A Ligases - genetics | Membrane Lipids - genetics | Plant Diseases - immunology | Arabidopsis - immunology | Coenzyme A Ligases - immunology | Plant Diseases - microbiology | Carboxy-Lyases - genetics | Mutation - immunology | Superoxides - immunology | Plant Diseases - genetics | Botrytis - immunology | Membrane Lipids - immunology | Arabidopsis Proteins - genetics | Plants, Genetically Modified - genetics | Plants, Genetically Modified - immunology | Fungal Proteins - genetics | Plant Immunity - physiology | Arabidopsis Proteins - immunology | Plant Leaves - immunology | Arabidopsis - microbiology | Plants, Genetically Modified - microbiology | Plant Leaves - genetics | Hydrogen Peroxide - immunology | Abscisic Acid - immunology | Carboxy-Lyases - immunology | Abscisic Acid - genetics | Trametes - genetics | Plant Leaves - microbiology | Fungal Proteins - metabolism | Arabidopsis thaliana | Physiological aspects | Reactive oxygen species | Immune response | Research | Permeability | Leaves | Humidity | Abscisic acid | ABC transporters | Biosynthesis | Flowers & plants | Gene expression | Fatty acids | Experiments | Fruits | Index Medicus
Journal Article
PLoS Pathogens, ISSN 1553-7366, 12/2011, Volume 7, Issue 12, pp. e1002379 - e1002379
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 08/2011, Volume 90, Issue 2, pp. 357 - 366
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 09/2015, Volume 11, Issue 9, pp. 733 - 740
Journal Article