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Neuron, ISSN 0896-6273, 03/2012, Volume 73, Issue 6, pp. 1116 - 1126
The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are... 
SYNAPTIC SPECIFICITY | ADULT BRAIN | SIGNALING PATHWAY | IN-VIVO | BOC | GROWTH | MECHANISMS | AXON-GUIDANCE | MEMBRANE-PROTEINS | NEUROSCIENCES | CEREBRAL-CORTEX | Silver Staining - methods | RNA, Small Interfering - genetics | Furans - metabolism | Electric Stimulation | gamma-Aminobutyric Acid - metabolism | Channelrhodopsins | Hedgehog Proteins - metabolism | Dendritic Spines - metabolism | Functional Laterality - genetics | Nerve Net - cytology | Synaptophysin - genetics | Neurons - ultrastructure | Neurons - metabolism | Repressor Proteins - metabolism | Gene Expression Regulation, Developmental - physiology | Synaptophysin - metabolism | Animals, Newborn | Fluorobenzenes - metabolism | Tumor Suppressor Proteins - metabolism | Matrix Attachment Region Binding Proteins - metabolism | Dendritic Spines - physiology | Mice, Transgenic | Synapses - ultrastructure | Electroporation - methods | Mutation - genetics | Corpus Callosum - cytology | Patch-Clamp Techniques | Immunoglobulin G - genetics | Cerebral Cortex - growth & development | Luminescent Proteins - genetics | Corpus Callosum - growth & development | Mice | Immunoglobulin G - metabolism | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Membrane Potentials - genetics | Age Factors | Gene Expression Regulation, Developmental - genetics | Phosphopyruvate Hydratase - metabolism | Cerebral Cortex - cytology | DNA-Binding Proteins - metabolism | Synapses - metabolism | Hedgehog Proteins - genetics | Pyramidal Tracts - physiology | Stilbamidines - metabolism | Receptors, Cell Surface - metabolism | Nuclear Proteins - metabolism | Transcription Factors - metabolism | Animals | Nerve Net - metabolism | In Vitro Techniques | Luminescent Proteins - metabolism | Stem cell research | Neurosciences | Nervous system diseases | Neurons | Stem cells | Collateralized debt obligations | Physiological aspects | Cells | Proteins | Transcription factors | Software | Sucrose | Synaptogenesis | Circuits | Hedgehog protein | Neural networks | Pyramidal cells | Cortex | Synapses | Index Medicus
Journal Article
Science, ISSN 0036-8075, 10/2003, Volume 302, Issue 5642, pp. 84 - 88
Abnormally high spiking activity can damage neurons. Signaling systems to protect neurons from the consequences of abnormal discharge activity have been... 
Brain | Receptors | Neuroscience | Messenger RNA | Neurons | Forebrain | Research Articles | Endocannabinoids | Genotypes | Hippocampus | Seizures | NERVOUS-SYSTEM | ENDOCANNABINOIDS | GLUTAMATE | MULTIDISCIPLINARY SCIENCES | ANANDAMIDE | SEIZURE | ACUTE NEURONAL INJURY | MICE | RAT-BRAIN | NEUROPROTECTION | N-ACYLETHANOLAMINE PHOSPHOLIPIDS | Brain-Derived Neurotrophic Factor - genetics | Receptors, Drug - genetics | gamma-Aminobutyric Acid - metabolism | Furans - pharmacology | Epilepsy - metabolism | Male | Epilepsy - physiopathology | Hippocampus - drug effects | Neuroprotective Agents - metabolism | Prosencephalon - drug effects | Brain - metabolism | Polyunsaturated Alkamides | Arachidonic Acids - metabolism | Piperidines - pharmacology | Excitatory Postsynaptic Potentials | Neurons - physiology | Brain-Derived Neurotrophic Factor - metabolism | Neurons - metabolism | Prosencephalon - metabolism | Neurons - drug effects | Cannabinoids - metabolism | Pyrazoles - pharmacology | Signal Transduction | Kainic Acid - pharmacology | Mice, Inbred C57BL | Mice, Transgenic | Excitatory Amino Acid Agonists - pharmacology | Glycerides - metabolism | Arachidonic Acids - pharmacology | Receptors, Drug - metabolism | Mice, Knockout | Brain - drug effects | Gene Expression Regulation - drug effects | Hippocampus - metabolism | Animals | Receptors, Cannabinoid | Glutamic Acid - metabolism | Mice | Genes, Immediate-Early | Mutation | In Vitro Techniques | Receptors, Drug - antagonists & inhibitors | Mitogen-Activated Protein Kinases - metabolism | Physiological aspects | Nervous system | Cannabinoids | Research | Convulsions & seizures | Index Medicus
Journal Article
Nutrition Research, ISSN 0271-5317, 04/2018, Volume 52, pp. 87 - 97
Arctigenin (ATG), a lignin extracted from (L.), exerts antioxidant and anti-inflammatory effects. We hypothesized that ATG exerts a protective effect on... 
Arctigenin | Inflammation | Nonalcoholic fatty liver disease | Lipotoxicity | Steatosis | OXIDATIVE STRESS | FATTY-ACID-METABOLISM | PALMITIC ACID | LIVER-DISEASE | LIPID-ACCUMULATION | NUTRITION & DIETETICS | LIPOGENESIS | STEATOHEPATITIS | HEPATIC STEATOSIS | EXPRESSION | AMP-Activated Protein Kinases - metabolism | Liver - pathology | Plant Extracts - pharmacology | Furans - pharmacology | Humans | Phosphatidylinositol 3-Kinases - metabolism | Hepatocytes - metabolism | Lignans - pharmacology | Furans - therapeutic use | Interleukins - metabolism | Lignans - therapeutic use | Inflammation - metabolism | Arctium - chemistry | Liver - drug effects | Carnitine O-Palmitoyltransferase - metabolism | Phytotherapy | Proto-Oncogene Proteins c-akt - metabolism | Phosphatidylinositol 3-Kinase - metabolism | Hepatocytes - drug effects | Sterol Regulatory Element Binding Protein 1 - metabolism | Oleic Acid - metabolism | Fatty Liver - metabolism | Signal Transduction | Liver - metabolism | Fatty Liver - prevention & control | Non-alcoholic Fatty Liver Disease - metabolism | Hep G2 Cells | Intercellular Adhesion Molecule-1 - metabolism | Non-alcoholic Fatty Liver Disease - prevention & control | Inflammation - prevention & control | Liver - cytology | Oxidative Stress - drug effects | PPAR alpha - metabolism | Plant Extracts - therapeutic use | Acetyl-CoA Carboxylase - metabolism | Oxidases | Viral antibodies | Antioxidants | Lignin | Monounsaturated fatty acids | Synthesis | Lymphocytes | Liver | Antibodies | Fatty acids | Protein kinases | Protein binding | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7448, pp. 217 - 223
The mammalian target of rapamycin (mTOR), a phosphoinositide 3-kinase-related protein kinase, controls cell growth in response to nutrients and growth factors... 
MAMMALIAN TARGET | RAPTOR | BINDING PARTNER | RAG GTPASES | TOS MOTIF | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PIK-RELATED KINASES | CELL-GROWTH | P70 S6 KINASE | RAPAMYCIN COMPLEX-1 | Adaptor Proteins, Signal Transducing - chemistry | Catalytic Domain - drug effects | TOR Serine-Threonine Kinases - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Structure-Activity Relationship | Pyrimidines - chemistry | TOR Serine-Threonine Kinases - antagonists & inhibitors | Indoles - metabolism | Furans - chemistry | Adenosine Triphosphate - metabolism | Indoles - pharmacology | Tacrolimus Binding Protein 1A - pharmacology | Naphthyridines - chemistry | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Purines - metabolism | Purines - pharmacology | MTOR Associated Protein, LST8 Homolog | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Magnesium - metabolism | Pyrimidines - pharmacology | Sirolimus - metabolism | Sirolimus - pharmacology | Magnesium - chemistry | Purines - chemistry | TOR Serine-Threonine Kinases - chemistry | Tacrolimus Binding Protein 1A - metabolism | Pyridines - pharmacology | Sirolimus - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Adenosine Triphosphate - chemistry | Indoles - chemistry | Naphthyridines - pharmacology | Naphthyridines - metabolism | Protein Structure, Tertiary - drug effects | Proteins | Enzymes | Kinases | Crystal structure | Index Medicus
Journal Article
Life Sciences, ISSN 0024-3205, 08/2019, Volume 230, pp. 68 - 75
The aim of the present study was to investigate the protective effects of AGK2 as a selective SIRT2 inhibitor on thioacetamide (TAA)-induced acute liver... 
Thioacetamide | Acute liver failure | AGK2 | SIRT2 | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | ACETYLATION | INJURY | MODEL | INHIBITION | METABOLISM | INFLAMMATION | PHARMACOLOGY & PHARMACY | BRAIN | SIRTUIN 2 | KINASES | Tumor Necrosis Factor-alpha - metabolism | Thioacetamide - pharmacology | Furans - metabolism | Liver - pathology | Apoptosis - drug effects | Furans - pharmacology | Male | NF-kappa B - metabolism | Quinolines - pharmacology | Interleukin-1beta - metabolism | Inflammation Mediators - metabolism | Sirtuin 2 - antagonists & inhibitors | Liver Failure, Acute - drug therapy | Cytokines - metabolism | Signal Transduction | Liver - metabolism | Mice, Inbred C57BL | Liver Failure, Acute - chemically induced | Aspartate Aminotransferases - metabolism | Quinolines - metabolism | Animals | Transcription Factor RelA - metabolism | Lipopolysaccharides - pharmacology | Mice | Alanine Transaminase - metabolism | Mitogen-Activated Protein Kinases - metabolism | Liver failure | Protein kinases | Mitogens | Phosphorylation | Liver | Staining | Kinases | Western blotting | Pathways | Inhibition | Pretreatment | NF-κB protein | Damage assessment | Alanine | Liver diseases | Cell survival | Cytokines | MAP kinase | Pharmacology | Inflammation | Tumor necrosis factor-α | IL-1β | Survival | Nitric-oxide synthase | Polymerase chain reaction | DNA nucleotidylexotransferase | Hepatocytes | Protein kinase | Alanine transaminase | Aspartate aminotransferase | Index Medicus
Journal Article
中国药理学报:英文版, ISSN 1671-4083, 2014, Volume 35, Issue 10, pp. 1274 - 1284
Aim: Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan found in traditional Chinese herbs, has been determined to exhibit a variety of pharmacological... 
SD大鼠 | 谷胱甘肽过氧化物酶 | 氧化途径 | Western印迹 | physical endurance | antioxidant | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | INJURY | PPAR alpha | weight-loaded forced swimming test | CHEMISTRY, MULTIDISCIPLINARY | EXERCISE | SKELETAL-MUSCLE | arctigenin | fatigue | RAW264.7 CELLS | Nrf2 | ROS | AMPK | PHARMACOLOGY & PHARMACY | UNCOUPLING PROTEIN-2 | INDUCED NEUROTOXICITY | skeletal muscle | UP-REGULATION | AMP-Activated Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Glutathione Reductase - metabolism | Antioxidants - metabolism | Fatigue - metabolism | Furans - pharmacology | Male | Muscle, Skeletal - metabolism | PPAR gamma - metabolism | Lignans - pharmacology | Mitochondrial Proteins - metabolism | Muscle, Skeletal - drug effects | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Thioredoxins - metabolism | Superoxide Dismutase - metabolism | Cell Line | Glutathione Peroxidase - metabolism | Fatigue - drug therapy | Hydrogen Peroxide - pharmacology | Tumor Suppressor Protein p53 - metabolism | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Physical Conditioning, Animal - physiology | Swimming - physiology | Transcription Factors - metabolism | Animals | Ion Channels - metabolism | Signal Transduction - drug effects | Uncoupling Protein 2 | Physical Endurance - drug effects | GA-Binding Protein Transcription Factor - metabolism | Index Medicus | PPARα | Original
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2010, Volume 327, Issue 5973, pp. 1638 - 1642
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases with diverse roles in health and disease. The primordial PI3K, Vps34, is present in all eukaryotes and has... 
Proteins | Yeasts | Enzymes | Adenosine triphosphatases | Crystals | Lipids | Reports | Catalytic activity | Catalysis | Inhibitory concentration 50 | Phosphatidylinositols | UVRAG | ACTIVATION | BECLIN 1 | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | REGULATES AUTOPHAGY | ENDOSOME | HVPS34 | PHOSPHOINOSITIDE 3-KINASE | SACCHAROMYCES-CEREVISIAE | Furans - metabolism | Pyridines - chemistry | Furans - pharmacology | Humans | Crystallography, X-Ray | Phosphatidylinositol 3-Kinases - metabolism | Drosophila Proteins - metabolism | Enzyme Inhibitors - chemical synthesis | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Autophagy - drug effects | Pyrimidines - chemistry | Pyrimidines - metabolism | Furans - chemistry | Enzyme Inhibitors - chemistry | Phosphatidylinositols - metabolism | Cell Membrane - metabolism | Binding Sites | Drosophila Proteins - antagonists & inhibitors | Protein Structure, Tertiary | Catalytic Domain | Adenine - analogs & derivatives | Enzyme Inhibitors - metabolism | Protein Structure, Secondary | Enzyme Inhibitors - pharmacology | Phosphatidylinositol 3-Kinases - chemistry | Adenosine Triphosphatases - metabolism | Models, Molecular | Adenine - pharmacology | Drosophila Proteins - chemistry | Pyrimidines - pharmacology | Phosphatidylinositol 3-Kinases - genetics | Point Mutation | Animals | Pyridines - metabolism | Hydrophobic and Hydrophilic Interactions | Protein Conformation | Adenine - metabolism | Pyridines - pharmacology | Drosophila Proteins - genetics | Drosophila melanogaster | Physiological aspects | Autophagy (Cytology) | Research | Chemical properties | Phosphotransferases | Membranes | Cellular biology | Kinases | Crystal structure | Index Medicus
Journal Article
Journal Article