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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2008, Volume 51, Issue 11, pp. 3061 - 3064
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 11/2015, Volume 76, Issue 5, pp. 1051 - 1061
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 12/2012, Volume 70, Issue 6, pp. 823 - 832
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2013, Volume 23, Issue 16, pp. 4511 - 4516
Journal Article
The Lancet Oncology, ISSN 1470-2045, 06/2018, Volume 19, Issue 6, pp. 812 - 824
Journal Article
Journal Article
Cancer Chemotherapy and Pharmacology, ISSN 0344-5704, 11/2015, Volume 76, Issue 5, pp. 897 - 907
The California Cancer Consortium completed a phase I trial of E7389 (eribulin mesylate), an analog of the marine natural product halichondrin B. This trial was... 
Pharmacodynamics | Eribulin | Medicine & Public Health | Phase I trial | Oncology | Cancer Research | Halichondrin B analog | Pharmacology/Toxicology | Pharmacokinetics | VINCA DOMAIN | MESYLATE E7389 | PACLITAXEL RESISTANCE | HOMOHALICHONDRIN-B | SENSITIVITY | MARINE NATURAL-PRODUCTS | CELL LUNG-CANCER | BREAST-CANCER | ONCOLOGY | DRUGS | PHARMACOLOGY & PHARMACY | TUBULIN MUTATIONS | Melanoma - blood | Lung Neoplasms - drug therapy | Injections, Intravenous | Febrile Neutropenia - chemically induced | Tubulin Modulators - pharmacology | Furans - pharmacology | Humans | Middle Aged | Salvage Therapy | Male | Antineoplastic Agents - therapeutic use | Furans - adverse effects | Furans - therapeutic use | Dose-Response Relationship, Drug | Furans - pharmacokinetics | Urologic Neoplasms - drug therapy | Antineoplastic Agents - adverse effects | Ketones - blood | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Ketones - therapeutic use | Ovarian Neoplasms - drug therapy | Ketones - adverse effects | Tubulin Modulators - blood | Carcinoma - drug therapy | Ketones - pharmacology | Carcinoma - blood | Tubulin Modulators - adverse effects | Tubulin Modulators - pharmacokinetics | Ovarian Neoplasms - blood | Breast Neoplasms - drug therapy | Furans - blood | Tubulin Modulators - therapeutic use | Urologic Neoplasms - blood | Ketones - pharmacokinetics | Melanoma - drug therapy | Antineoplastic Agents - blood | Breast Neoplasms - blood | Aged | Lung Neoplasms - blood | Drug Monitoring | Lymphopenia - chemically induced | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2011, Volume 54, Issue 6, pp. 1927 - 1942
We present the first report of the application of the dipeptidyl peptidase IV (DPPIV/CD26) based prodrug approach to hydroxy-containing drug derivatives. In... 
SELECTIVE-INHIBITION | POTENT | ACTIVATION | ACYCLOVIR | DESIGN |