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furin (273) 273
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Journal Article
PLoS One, ISSN 1932-6203, 2013, Volume 8, Issue 12, p. e83110
Journal Article
FASEB Journal, ISSN 0892-6638, 2014, Volume 28, Issue 8, pp. 3703 - 3719
Exosomes are extracellular vesicles that mediate intercellular communication and are involved in several biological processes. The objective of our study was... 
HERV | Fusogenic protein | Microvesicles biomarker | Villous cytotrophoblasts | TROPHOBLAST CELLS | FAS LIGAND | HERV-W | VESICLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | FUNCTIONAL-CHARACTERIZATION | microvesicles | biomarker | PREGNANCY | CELL BIOLOGY | fusogenic protein | ENDOGENOUS RETROVIRAL ENVELOPE | BIOLOGY | HUMAN BLOOD | villous cytotrophoblasts | EXPRESSION | Exosomes - metabolism | Endogenous Retroviruses - physiology | Pregnancy Proteins - deficiency | Tumor Suppressor Proteins - antagonists & inhibitors | Minor Histocompatibility Antigens | Uterine Neoplasms - pathology | Humans | Endogenous Retroviruses - genetics | Gene Products, env - blood | Endosomes - metabolism | Cell Fusion | Pregnancy Proteins - blood | Endocytosis | RNA Interference | Tumor Suppressor Proteins - genetics | Amino Acid Transport System ASC - physiology | Gene Products, env - physiology | Pregnancy Proteins - physiology | Adult | Female | Amino Acid Transport System ASC - genetics | Trophoblasts - metabolism | Furin - physiology | RNA, Small Interfering - pharmacology | Amino Acid Transport System ASC - antagonists & inhibitors | Cell Communication | Pregnancy | Microscopy, Confocal | Tumor Suppressor Proteins - physiology | Choriocarcinoma - pathology | Pre-Eclampsia - blood | Furin - antagonists & inhibitors | Cell Line, Tumor
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 09/2017, Volume 140, pp. 8 - 15
Proprotein convertases are serine proteases responsible for the cleavage and subsequent activation of protein substrates, many of them relevant for the... 
Proprotein convertases | Tumor progression | Molecular therapy | CANCER-CELLS | ALPHA-1-ANTITRYPSIN PORTLAND | HEPATOMA-CELLS | OVARIAN-CANCER | FURIN INHIBITORS | POTENT INHIBITORS | PACE4 INHIBITORS | PCSK9 INHIBITION | PHARMACOLOGY & PHARMACY | TUMORICIDAL ACTIVITY | GROWTH-FACTOR | Proprotein Convertases - antagonists & inhibitors | Activation, Metabolic | Drugs, Investigational - pharmacology | Humans | Drugs, Investigational - pharmacokinetics | Drugs, Investigational - therapeutic use | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Isoenzymes - chemistry | Prodrugs - chemistry | Molecular Targeted Therapy | Neoplasm Proteins - metabolism | Drugs, Investigational - chemistry | Enzyme Inhibitors - pharmacokinetics | Isoenzymes - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Binding Sites | Binding, Competitive | Catalytic Domain | Proprotein Convertases - metabolism | Enzyme Inhibitors - pharmacology | Neoplasms - enzymology | Neoplasm Proteins - chemistry | Proprotein Convertases - chemistry | Antineoplastic Agents - chemistry | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Animals | Prodrugs - pharmacokinetics | Tumor Burden - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Prodrugs - therapeutic use | Neoplasms - pathology | Prodrugs - pharmacology | Isoenzymes - antagonists & inhibitors | Medical research | Proteases | Communicable diseases | Low density lipoproteins | Medicine, Experimental | Development and progression | Amino acids | Ovarian cancer | Index Medicus
Journal Article
Journal of Enzyme Inhibition and Medicinal Chemistry, ISSN 1475-6366, 01/2017, Volume 32, Issue 1, pp. 712 - 721
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 09/2007, Volume 18, Issue 9, pp. 3607 - 3619
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 05/2017, Volume 12, Issue 5, pp. 1211 - 1216
Proprotein convertases (PCs) represent highly selective serine proteases that activate their substrates upon proteolytic cleavage. Their inhibition is a... 
PROPROTEIN CONVERTASES | POTENT | CRYSTALLOGRAPHY | TUMOR PROGRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Proprotein Convertases - antagonists & inhibitors | Catalytic Domain | Enzyme Inhibitors - chemistry | Humans | Furin - antagonists & inhibitors | Furin - chemistry | Crystallography, X-Ray | Binding Sites
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e78603
The ATPase 6 accessory protein 2 (ATP6AP2)/(pro)renin receptor (PRR) is essential for the biogenesis of active vacuolar H+-ATPase (V-ATPase). Genetic deletion... 
V-ATPASE | MEMBRANE SECTOR | PRORENIN RECEPTOR | NONPROTEOLYTIC ACTIVATION | MULTIDISCIPLINARY SCIENCES | PRO RENIN RECEPTOR | ENDOPLASMIC-RETICULUM | ANGIOTENSIN-II | (PRO)RENIN RECEPTOR | OSTEOCLAST DIFFERENTIATION | SACCHAROMYCES-CEREVISIAE | RNA, Small Interfering - genetics | Vacuolar Proton-Translocating ATPases - genetics | Embryo, Mammalian | Humans | Receptors, Cell Surface - antagonists & inhibitors | Vacuolar Proton-Translocating ATPases - metabolism | Proton-Translocating ATPases - metabolism | trans-Golgi Network - metabolism | Protein Isoforms - metabolism | Proton-Translocating ATPases - genetics | Transfection | Protein Isoforms - chemistry | Adenoviridae - genetics | Receptors, Cell Surface - chemistry | Autophagy - genetics | Proton-Translocating ATPases - antagonists & inhibitors | Fibroblasts - metabolism | Furin - metabolism | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Gene Expression | Receptors, Cell Surface - metabolism | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Proton-Translocating ATPases - chemistry | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Vacuolar Proton-Translocating ATPases - chemistry | Fibroblasts - cytology | Mice | Adenoviridae - metabolism | Mutation | Primary Cell Culture | Genetic Vectors | Protein Isoforms - genetics | RNA, Small Interfering - metabolism | Receptors, Cell Surface - genetics | Shedding | Basal ganglia | Nephrology | Hydrogen | Acidification | Amino acids | Biosynthesis | Kinases | Deletion mutant | Proteins | Renin | Clonal deletion | Deletion | Furin | Cleavage | Cardiology | Movement disorders | H+-transporting ATPase | Hypertension | Internal medicine | Spasticity | Central nervous system diseases | Metabolism | Golgi apparatus | Medicine | Endoplasmic reticulum | Adenosine triphosphatase | Endocrinology
Journal Article
Journal Article
Journal Article