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Journal of Cancer, ISSN 1837-9664, 2019, Volume 10, Issue 11, pp. 2488 - 2500
The BCR-ABL fusion protein with strong tyrosine kinase activity is one of the molecular biological bases of leukemia. Imatinib (Gleevec), a specific targeted... 
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 356, Issue 2, pp. 597 - 605
Journal Article
Cancer Science, ISSN 1347-9032, 08/2017, Volume 108, Issue 8, pp. 1657 - 1666
Chromosomal translocation occurs in some cancer cells, which results in the expression of aberrant oncogenic fusion proteins that include BCR‐ABL in chronic... 
protein knockdown | E3 ubiquitin ligase | dasatinib | BCR‐ABL | LCL161 | BCR-ABL | CHRONIC MYELOGENOUS LEUKEMIA | RNA INTERFERENCE | CANCER-CELLS | UBIQUITIN LIGASE | TYROSINE KINASE | HYBRID SMALL MOLECULES | CHRONIC MYELOID-LEUKEMIA | SMALL-MOLECULE PROTACS | ONCOLOGY | PHILADELPHIA-CHROMOSOME | TARGETED DEGRADATION | Cell Survival - drug effects | Down-Regulation | Humans | Dasatinib - chemistry | Dasatinib - pharmacology | Protein Kinase Inhibitors - chemistry | Ubiquitination - drug effects | Proteolysis | K562 Cells | Cell Line, Tumor | Protein Binding | Ligands | Thiazoles - chemistry | Cell Proliferation - drug effects | Inhibitor of Apoptosis Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Fusion Proteins, bcr-abl - metabolism | Ubiquitin | Tyrosine | Snipers | Ligases | Analysis | Leukemia | Drug resistance | Polyols | BCR protein | Phosphorylation | Transcription | XIAP protein | Kinases | Proteins | Cell growth | Polyethylene glycol | Protein-tyrosine kinase | Medical research | Polyethylene | IAP protein | Imatinib | Research & development--R&D | Myeloid leukemia | Abl protein | Stat5 protein | Chronic myeloid leukemia | Proteasomes | Mutation | Binding sites | Apoptosis | Pharmaceuticals | Original
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2016, Volume 55, Issue 2, pp. 807 - 810
Journal Article
Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 401 - 412
Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain... 
CHEMBIO | HUMDISEASE | CHRONIC MYELOGENOUS LEUKEMIA | DASATINIB BMS-354825 | MESYLATE | CML | ONCOLOGY | KINASE DOMAIN MUTATIONS | AMN107 | IMATINIB RESISTANCE | NILOTINIB | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Pyridazines - pharmacology | Protein Kinase Inhibitors - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Antineoplastic Agents - pharmacology | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proto-Oncogene Proteins c-abl - genetics | Cell Growth Processes - drug effects | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-abl - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Fusion Proteins, bcr-abl - metabolism | Chronic myeloid leukemia | BCR protein | Imatinib | Mutagenesis | Abl protein | Mutation | Fusion protein | Tumors | Index Medicus | imatinib resistance | dasatinib | nilotinib | compound mutation
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 09/2011, Volume 286, Issue 37, pp. 32313 - 32323
Chronic myelogenous leukemia (CML) is a myeloproliferative disorder characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with... 
TRANSFORMATION | CELLS | MOLECULAR-BIOLOGY | SRC | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | HUMAN BREAST-CANCER | EXPRESSION | FIBROBLASTS | CHRONIC MYELOID-LEUKEMIA | KINASES | Gene Expression Regulation, Enzymologic - drug effects | RNA, Small Interfering - genetics | Reactive Oxygen Species - metabolism | Humans | Lysosomes - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Gene Expression Regulation, Leukemic - genetics | Lysosomes - metabolism | Ubiquitination - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - genetics | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | RNA, Small Interfering - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Gene Expression Regulation, Leukemic - drug effects | Pyrimidines - pharmacology | Imatinib Mesylate | Piperazines - pharmacology | Fusion Proteins, bcr-abl - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - metabolism | Gene Expression Regulation, Enzymologic - genetics | Protein Stability - drug effects | K562 Cells | Protein Kinase Inhibitors - pharmacology | Benzamides | Fusion Proteins, bcr-abl - metabolism | Ubiquitination - genetics | Molecular Bases of Disease | Ubiquitination | CML | PTP1B | Leukemia | Tyrosine Protein Kinase (Tyrosine Kinase) | Bcr-Abl | Protein Phosphorylation | Tyrosine Protein Phosphatase (Tyrosine Phosphatase)
Journal Article
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 5, pp. 7777 - 7790
Chronic myeloid leukemia (CML) is a clonal malignant disease caused by the expression of BCR/ABL. MDM2 (human homolog of the murine double minute-2) inhibitors... 
T315I mutation | Chronic myeloid leukemia | BCR/ABL | JNJ-26854165 | CHRONIC MYELOGENOUS LEUKEMIA | STEM-CELLS | CHRONIC-PHASE | BCR-ABL | CANCER-THERAPY | CELL BIOLOGY | IN-VITRO | PHILADELPHIA-CHROMOSOME | IMATINIB | chronic myeloid leukemia | TYROSINE KINASE INHIBITOR | BLAST CRISIS CELLS | Humans | Gene Expression Regulation, Neoplastic | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Drug Resistance, Neoplasm | Tumor Suppressor Protein p53 - genetics | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Dose-Response Relationship, Drug | Time Factors | Tryptamines - pharmacology | Proteolysis | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Biomarkers, Tumor - metabolism | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Tumor Cells, Cultured | Biomarkers, Tumor - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Imatinib Mesylate - pharmacology | Enzyme Inhibitors - pharmacology | Tumor Suppressor Protein p53 - metabolism | Mice, SCID | Drug Synergism | Xenograft Model Antitumor Assays | Fusion Proteins, bcr-abl - genetics | Animals | Fusion Proteins, bcr-abl - antagonists & inhibitors | K562 Cells | Biomarkers, Tumor - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Mutation | Proteasome Endopeptidase Complex - metabolism | Fusion Proteins, bcr-abl - metabolism
Journal Article
Blood, ISSN 0006-4971, 02/2012, Volume 119, Issue 6, pp. 1501 - 1510
Journal Article
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2012, Volume 8, Issue 3, pp. 285 - 293
Journal Article