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Cancer Cell, ISSN 1535-6108, 2009, Volume 16, Issue 5, pp. 401 - 412
Inhibition of BCR-ABL by imatinib induces durable responses in many patients with chronic myeloid leukemia (CML), but resistance attributable to kinase domain... 
CHEMBIO | HUMDISEASE | CHRONIC MYELOGENOUS LEUKEMIA | DASATINIB BMS-354825 | MESYLATE | CML | ONCOLOGY | KINASE DOMAIN MUTATIONS | AMN107 | IMATINIB RESISTANCE | NILOTINIB | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Pyridazines - pharmacology | Protein Kinase Inhibitors - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | Antineoplastic Agents - pharmacology | Fusion Proteins, bcr-abl - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - enzymology | Proto-Oncogene Proteins c-abl - genetics | Cell Growth Processes - drug effects | Proto-Oncogene Proteins c-abl - chemistry | Models, Molecular | Imidazoles - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Pyridazines - chemistry | Fusion Proteins, bcr-abl - genetics | Animals | Signal Transduction - drug effects | Fusion Proteins, bcr-abl - antagonists & inhibitors | Cell Line, Tumor | Proto-Oncogene Proteins c-abl - metabolism | Mice | Protein Kinase Inhibitors - pharmacology | Fusion Proteins, bcr-abl - metabolism | Chronic myeloid leukemia | BCR protein | Imatinib | Mutagenesis | Abl protein | Mutation | Fusion protein | Tumors | Index Medicus | imatinib resistance | dasatinib | nilotinib | compound mutation
Journal Article
Blood, ISSN 0006-4971, 02/2012, Volume 119, Issue 6, pp. 1501 - 1510
Recent evidence suggests chronic myeloid leukemia (CML) stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated... 
CHRONIC MYELOGENOUS LEUKEMIA | SELECTIVE INHIBITOR | POSITIVE CELLS | COLONY-STIMULATING FACTOR | TYROSINE KINASE | PHILADELPHIA-CHROMOSOME | ACUTE LYMPHOBLASTIC-LEUKEMIA | RESIDUAL DISEASE | HEMATOLOGY | HEMATOPOIETIC PROGENITORS | IMATINIB MESYLATE | Antigens, CD34 - metabolism | Apoptosis - drug effects | Humans | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Dose-Response Relationship, Drug | STAT5 Transcription Factor - metabolism | Flow Cytometry | Neoplastic Stem Cells - metabolism | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology | HEK293 Cells | Neoplastic Stem Cells - pathology | Cell Survival - drug effects | Dasatinib | Mice, Transgenic | Nuclear Proteins - metabolism | Gene Expression Regulation, Leukemic | Pyrimidines - pharmacology | Gene Knockout Techniques | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Fusion Proteins, bcr-abl - genetics | Animals | Fusion Proteins, bcr-abl - antagonists & inhibitors | K562 Cells | Cell Line, Tumor | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Thiazoles - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Fusion Proteins, bcr-abl - metabolism | Index Medicus | Abridged Index Medicus | Myeloid Neoplasia
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 03/2012, Volume 8, Issue 3, pp. 285 - 293
Journal Article
Cell, ISSN 0092-8674, 10/2011, Volume 147, Issue 2, pp. 306 - 319
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 01/2011, Volume 121, Issue 1, pp. 396 - 409
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 09/2009, Volume 27, Issue 25, pp. 4204 - 4210
Journal Article
by Guo, G and Kang, Q and Zhu, X and Chen, Q and Wang, X and Chen, Y and Ouyang, J and Zhang, L and Tan, H and Chen, R and Huang, S and Chen, J.-L
Oncogene, ISSN 0950-9232, 04/2015, Volume 34, Issue 14, pp. 1768 - 1779
Journal Article
Journal Article
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 2, pp. 129 - 141
Journal Article
Journal Article