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The EMBO Journal, ISSN 0261-4189, 11/2017, Volume 36, Issue 21, pp. 3120 - 3138
The cause of protein accumulation in neurodegenerative disease is incompletely understood. In Alzheimer's disease ( AD ), the axonally enriched protein Tau... 
amyloid‐β | protein synthesis | microtubule‐associated protein Tau | Src kinase Fyn | proximity ligation assay | amyloid-β | microtubule-associated protein Tau | S6 PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CEREBROSPINAL-FLUID | SYNAPTIC PLASTICITY | MOUSE MODELS | CELL BIOLOGY | amyloid-beta | COGNITIVE IMPAIRMENTS | PRION PROTEIN | MESSENGER-RNA | T-CELLS | AMYLOID-BETA OLIGOMERS | TRANSGENIC MICE | Neurons - pathology | Protein Biosynthesis | Ribosomal Protein S6 Kinases - metabolism | Embryo, Mammalian | Humans | Injections, Intraventricular | tau Proteins - metabolism | Male | Alzheimer Disease - pathology | MAP Kinase Signaling System | Proto-Oncogene Proteins c-fyn - genetics | Neurons - ultrastructure | tau Proteins - genetics | Amyloid beta-Protein Precursor - metabolism | HEK293 Cells | Puromycin - pharmacology | Neurons - metabolism | Amyloid beta-Peptides - administration & dosage | Mice, Inbred C57BL | Peptide Fragments - administration & dosage | Gene Expression Regulation | Hippocampus - pathology | Mice, Knockout | Stereotaxic Techniques | Hippocampus - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Ribosomal Protein S6 Kinases - genetics | Phosphorylation | Translation | Neurodegenerative diseases | Extracellular signal-regulated kinase | Protein biosynthesis | Activation | Pharmacology | Agglomeration | Kinases | Accumulation | Proteins | Signal transduction | Signaling | Detachment | Clonal deletion | Tau protein | Protein synthesis | Microtubules | Deletion | β-Amyloid | Transduction | Alzheimers disease | Alzheimer's disease | Fyn protein | Index Medicus | Neuroscience | Protein Biosynthesis & Quality Control
Journal Article
Biochemical Journal, ISSN 0264-6021, 12/2017, Volume 474, Issue 23, pp. 3963 - 3984
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 02/2013, Volume 288, Issue 6, pp. 4056 - 4065
The mechanisms underlying Tau-related synaptic and cognitive deficits and the interrelationships between Tau species, their clearance pathways, and synaptic... 
DOMAIN | PROTEIN | PHOSPHORYLATION | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCIBLE MOUSE MODELS | PATHOLOGY | PLAQUES | DETERMINES AGGREGATION | RECEPTORS | OLIGOMERS | Disks Large Homolog 4 Protein | Solubility - drug effects | Tauopathies - genetics | Humans | Receptors, N-Methyl-D-Aspartate - metabolism | Tauopathies - pathology | tau Proteins - metabolism | Male | Intracellular Signaling Peptides and Proteins - metabolism | Synapses - genetics | Synapses - pathology | Proto-Oncogene Proteins c-akt - genetics | Receptors, N-Methyl-D-Aspartate - genetics | Proto-Oncogene Proteins c-fyn - genetics | Heat-Shock Proteins - genetics | Proteolysis - drug effects | Synapses - metabolism | tau Proteins - genetics | Protein Multimerization - genetics | Aged, 80 and over | Behavior, Animal - drug effects | Female | Membrane Proteins - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Membrane Proteins - genetics | Heat-Shock Proteins - metabolism | Curcumin - pharmacology | Mice, Transgenic | Hippocampus - pathology | Hippocampus - metabolism | Tauopathies - metabolism | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics | Aged | Mice | Tauopathies - drug therapy | Protein Multimerization - drug effects | Index Medicus | Hsp90 | Molecular Bases of Disease | Neurodegenerative Diseases | Human Tau Transgenic Mice | Heat Shock Proteins | Tau | Curcumin | Tau Oligomers | Alzheimer Disease | Neurological Diseases
Journal Article
Proteins: Structure, Function, and Bioinformatics, ISSN 0887-3585, 07/2017, Volume 85, Issue 7, pp. 1336 - 1350
The molecular details of the association between the human Fyn‐SH3 domain, and the fragment of 18.5‐kDa myelin basic protein (MBP) spanning residues S38–S107... 
molecular recognition fragment (MoRF) | poly‐proline type II (PPII) | Fyn‐SH3 | amphipathic α‐helix | myelin basic protein (MBP) | intrinsically disordered protein (IDP) | molecular dynamics (MD) simulations | GROMACS | amphipathic α-helix | poly-proline type II (PPII) | Fyn-SH3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | IMMUNODOMINANT EPITOPE | POSTTRANSLATIONAL MODIFICATIONS | amphipathic -helix | AZE AZETIDINE-2-CARBOXYLIC ACID | INTRINSICALLY DISORDERED PROTEINS | FYN TYROSINE KINASE | BIOPHYSICS | MULTIPLE-SCLEROSIS | CRK N-SH3 DOMAIN | STATE NMR-SPECTROSCOPY | CENTRAL-NERVOUS-SYSTEM | MESSENGER-RNA TRANSPORT | Protein Structure, Tertiary | Amino Acid Sequence | Protein Conformation, alpha-Helical | Peptides - chemistry | Humans | Phosphorylcholine - analogs & derivatives | Molecular Dynamics Simulation | Proline - chemistry | src Homology Domains | Thermodynamics | Animals | Protein Conformation, beta-Strand | Myelin Basic Protein - chemistry | Water - chemistry | Phosphorylcholine - chemistry | Protein Binding | Mice | Molecular Docking Simulation | Proto-Oncogene Proteins c-fyn - chemistry | Lipid Bilayers - chemistry | Binding Sites | Dimyristoylphosphatidylcholine - chemistry | Unithiol - chemistry | Molecular dynamics | Proline | Phospholipids | Myelin proteins | Proteins | Peptides | Myelin | Docking | Fuzzy | Myelin basic protein | Sheets | Fyn protein | Index Medicus
Journal Article
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 2011, Volume 411, Issue 2, pp. 486 - 498
Journal Article
Nature Cell Biology, ISSN 1465-7392, 02/2003, Volume 5, Issue 2, pp. 155 - 160
SAP (SLAM-associated protein) is a small lymphocyte-specific signalling molecule that is defective or absent in patients with X-linked lymphoproliferative... 
HEMATOPOIETIC-CELLS | GENE-PRODUCT SAP | ACTIVATION | CRYSTAL-STRUCTURE | SURFACE | ENCODING GENE | HUMAN B-LYMPHOCYTES | MUTATIONS | LINKED LYMPHOPROLIFERATIVE-DISEASE | SH3 DOMAIN | CELL BIOLOGY | Receptors, Virus - metabolism | Humans | Glycoproteins - metabolism | Proto-Oncogene Proteins c-fyn | Molecular Sequence Data | Crystallography, X-Ray | Receptors, Cell Surface | Lymphoproliferative Disorders - immunology | Proto-Oncogene Proteins - chemistry | Immunoglobulins - genetics | Recombinant Fusion Proteins - metabolism | Antigens, CD - metabolism | Lymphoproliferative Disorders - metabolism | Immunoglobulins - metabolism | Signaling Lymphocytic Activation Molecule Family Member 1 | Protein Structure, Quaternary | Carrier Proteins - chemistry | Glycoproteins - chemistry | Thymus Gland - metabolism | Binding Sites | Genes, Reporter | Glycoproteins - genetics | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cells, Cultured | Thymus Gland - cytology | Intracellular Signaling Peptides and Proteins | Models, Molecular | Proto-Oncogene Proteins - genetics | Macromolecular Substances | Mice, Knockout | src Homology Domains | Carrier Proteins - genetics | Two-Hybrid System Techniques | Immunoglobulins - chemistry | Sequence Alignment | Animals | Carrier Proteins - metabolism | Models, Biological | Signaling Lymphocytic Activation Molecule Associated Protein | Protein Binding | Signal Transduction - physiology | Mice | Proteins | Physiological aspects | Cell receptors | Genetic aspects | Research | Protein kinases | immune receptors | SLAM protein | X-linked lymphoproliferative syndrome | adaptor proteins | Fyn protein | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2012, Volume 7, Issue 8, pp. e42610 - e42610
The B lymphotrophic γ-herpesvirus EBV is associated with a variety of lymphoid- and epithelial-derived malignancies, including B cell lymphomas in... 
Recombinant Proteins - metabolism | Amino Acid Sequence | Signal Transduction | Protein-Tyrosine Kinases - metabolism | Herpesvirus 4, Human - physiology | Humans | Molecular Sequence Data | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-fyn - metabolism | Viral Matrix Proteins - chemistry | Lymphoma, B-Cell - enzymology | src-Family Kinases - metabolism | Cell Line, Tumor | Interleukin-10 - metabolism | Protein Binding | Lymphoma, B-Cell - virology | Viral Matrix Proteins - metabolism | Receptor, Nerve Growth Factor - metabolism | Syk Kinase | Nerve growth factor | Lymphomas | Epstein-Barr virus | B cells | Phosphorylation | Transplants & implants | Downstream effects | LMP1 protein | Viruses | AKT protein | Activation | Antagonists | Kinases | Proteins | Signal transduction | Cell activation | Immunology | Surgery | Tumor necrosis factor-TNF | Autocrine signalling | Fyn protein | Cbl protein | Immunoglobulins | Cloning | T cell receptors | siRNA | Src protein | 1-Phosphatidylinositol 3-kinase | Abdomen | Membrane proteins | Medicine | BLNK protein | Nerve growth factor receptors | Lymphocytes B | Cell lines | Interleukin 10 | Syk protein | Binding sites | Latent membrane protein 1 | B-cell lymphoma | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2014, Volume 111, Issue 34, pp. 12420 - 12425
The Src kinase family comprises nine homologous members whose distinct expression patterns and cellular distributions indicate that they have unique roles.... 
COS cells | T lymphocytes | Protein isoforms | Proteins | Phenotypes | Cell membranes | Focal adhesions | Kinetics | Cells | Endothelial cells | Protein engineering | Image analysis | Rapamycin | Motion classification | Live cell imaging | PALMITOYLATION | SPECIFICITY | YES | MULTIDISCIPLINARY SCIENCES | SH3 DOMAINS | live cell imaging | PROTEIN-TYROSINE KINASE | image analysis | PLASMA-MEMBRANE | CANCER | motion classification | protein engineering | FYN | rapamycin | C-SRC | LIVING CELLS | Cercopithecus aethiops | Molecular Sequence Data | Isoenzymes - chemistry | Recombinant Fusion Proteins - metabolism | Proto-Oncogene Proteins c-fyn - genetics | Isoenzymes - metabolism | Protein Engineering | src-Family Kinases - metabolism | Proto-Oncogene Proteins c-fyn - chemistry | Tacrolimus Binding Protein 1A - genetics | Acylation | Amino Acid Sequence | Biophysical Phenomena | Mutagenesis, Site-Directed | Isoenzymes - genetics | Tacrolimus Binding Protein 1A - chemistry | Models, Molecular | Recombinant Fusion Proteins - chemistry | src Homology Domains | Sequence Homology, Amino Acid | Phenotype | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Tacrolimus Binding Protein 1A - metabolism | Recombinant Fusion Proteins - genetics | Enzyme Activation | src-Family Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Amino Acid Substitution | Morphogenesis | Protein research | Physiological aspects | Cellular signal transduction | Research | Phosphotransferases | Genotype & phenotype | Membranes | Correlation analysis | Morphology | Binding sites | Index Medicus | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, pp. e70546 - e70546
Background: Scaffolding proteins of the intersectin (ITSN) family, ITSN1 and ITSN2, are crucial for the initiation stage of clathrin-mediated endocytosis.... 
CDC42 GEF INTERSECTIN | FORMS | DENDRITIC SPINE DEVELOPMENT | COMPLEX | ABNORMALITIES | ALZHEIMERS-DISEASE | ORIENTATION | MULTIDISCIPLINARY SCIENCES | NUMB | IDENTIFICATION | REVEALS | Adaptor Proteins, Signal Transducing - chemistry | Phosphorylation | Proline - metabolism | Humans | Adaptor Proteins, Vesicular Transport - genetics | Molecular Sequence Data | Adaptor Proteins, Vesicular Transport - metabolism | Adaptor Proteins, Vesicular Transport - chemistry | Endocytosis - genetics | Protein Interaction Domains and Motifs | Binding Sites | Amino Acid Sequence | Signal Transduction | Gene Expression Regulation | Models, Molecular | Clathrin - genetics | Clathrin - metabolism | Proline - chemistry | Protein Interaction Mapping | Sequence Homology, Amino Acid | Sequence Alignment | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Protein Binding | Ligands | Epidermal Growth Factor - pharmacology | Adaptor Proteins, Signal Transducing - metabolism | Evolution, Molecular | Tyrosine | Clathrin | Evolutionary biology | Comparative analysis | Phosphotransferases | Protein-protein interactions | Protein binding | Intersectin | Genomics | Proline | Amino acids | Kinases | Proteins | Endocytosis | Epidermal growth factor | Fyn protein | Adaptor proteins | Down syndrome | 1-Phosphatidylinositol 3-kinase | Grb2 protein | Phospholipase C | Phospholipase | Vertebrates | Signaling | Cellular biology | Scaffolding | Cell lines | Isoforms | Molecular biology | Laboratory animals | Protein interaction | Binding sites | Recognition | Index Medicus | Life Sciences | Cellular Biology
Journal Article
CELL, ISSN 0092-8674, 09/1998, Volume 94, Issue 5, pp. 625 - 634
Journal Article
Journal of Neuroscience Research, ISSN 0360-4012, 01/2012, Volume 90, Issue 1, pp. 28 - 47
The developmentally regulated myelin basic proteins (MBPs), which arise from the golli (gene of oligodendrocyte lineage) complex, are highly positively... 
SH3 domain | isothermal titration calorimetry | myelination | myelin basic protein (MBP) | Fyn | oligodendrocytes | calcium imaging | Myelination | Myelin basic protein (MBP) | Oligodendrocytes | Calcium imaging | Isothermal titration calorimetry | CA2+ INFLUX | MORPHOLOGICAL-DIFFERENTIATION | POSTTRANSLATIONAL MODIFICATIONS | NEUROSCIENCES | FYN TYROSINE KINASE | MULTIPLE-SCLEROSIS | SUPRACHIASMATIC NUCLEUS | MEMBRANE IN-VITRO | CENTRAL-NERVOUS-SYSTEM | SECONDARY STRUCTURE | AZETIDINE-2-CARBOXYLIC ACID | Oligodendroglia - metabolism | Protein Binding - genetics | Calcium Channels - metabolism | Calcium - metabolism | Protein Processing, Post-Translational - genetics | Green Fluorescent Proteins - genetics | Myelin Basic Protein - genetics | Proline - genetics | Proto-Oncogene Proteins c-fyn - genetics | Transfection | Myelin Basic Protein - chemistry | Threonine - genetics | Protein Biosynthesis - genetics | Calcium Channels - genetics | Amino Acid Sequence | Myelin Basic Protein - metabolism | Cell Size | src Homology Domains - physiology | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Analysis of Variance | Calorimetry | Mice | Calcium Signaling - genetics | Cell Line, Transformed | Alternative splicing | Cell culture | Phosphorylation | Threonine | Myelin | Central nervous system | Amino acid sequence | Proline | Compaction | Src protein | Calcium influx | Myelin basic protein | Amino acid substitution | Signal transduction | Protein interaction | Elongation | Fyn protein | Index Medicus
Journal Article