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by Lat, PK and Sen, D
PLOS ONE, ISSN 1932-6203, 06/2018, Volume 13, Issue 6
Massive expansion of a DNA hexanucleotide sequence repeat (C(2)G(4)) within the human C9orf72 gene has been linked to a number of neurodegenerative diseases.... 
CIRCULAR-DICHROISM | ANTISENSE TRANSCRIPTS | MULTIDISCIPLINARY SCIENCES | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | INTRAMOLECULAR TRIPLEX | PROTEINS | HEXANUCLEOTIDE REPEAT | G-QUADRUPLEX | BRAID-LIKE | RNA FOCI
Journal Article
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 3/2014, Volume 127, Issue 3, pp. 377 - 389
GGGGCC (G4C2) hexanucleotide repeat expansion in chromosome 9 open reading frame 72 (C9ORF72) has been identified as the most common genetic abnormality in... 
RBP | Neurosciences | GGGGCC (G 4 C 2 ) hexanucleotide repeat expansion | hnRNP | Amyotrophic lateral sclerosis (ALS) | Drosophila | Chromosome 9 open reading frame 72 ( C9ORF72 ) | Zebrafish | RNA foci | Frontotemporal dementia (FTD) | Induced pluripotent stem cells (iPSCs) | Repeat-associated neurodegenerative disease | Pathology | RNA toxicity | Medicine & Public Health | Frontotemporal lobar degeneration (FTLD) | Mouse | TDP-43 | Sequestration | Repeat associated non-ATG (RAN) translation | Dipeptide-repeat protein (DPR) | GGGGCC (G | Chromosome 9 open reading frame 72 (C9ORF72) | hexanucleotide repeat expansion | LOBAR DEGENERATION | ALS | PATHOLOGY | TRANSLATION | CLINICAL NEUROLOGY | ANTISENSE TRANSCRIPTS | Chromosome 9 open reading frame 72 C9ORF72 | GGGGCC (GC) hexanucleotide repeat expansion | TOXICITY | NEUROSCIENCES | MEDIATED NEURODEGENERATION | PROTEINS | GGGGCC REPEAT | Frontotemporal Dementia - genetics | Frontotemporal Dementia - physiopathology | Amyotrophic Lateral Sclerosis - physiopathology | Amyotrophic Lateral Sclerosis - genetics | Humans | Open Reading Frames | Cells, Cultured | Apoptosis - genetics | Proteins - genetics | DNA Repeat Expansion | Animals | Proteins - metabolism | C9orf72 Protein | Apoptosis - physiology | Disease Models, Animal | RNA - metabolism | Nervous system diseases | Analysis | Genetically modified organisms | Stem cells | Amyotrophic lateral sclerosis | Antisense RNA | Genetic engineering | Binding proteins | Protein binding | Dementia | Index Medicus
Journal Article
Acta Neuropathologica, ISSN 0001-6322, 5/2015, Volume 129, Issue 5, pp. 715 - 727
Journal Article
NEUROBIOLOGY OF AGING, ISSN 0197-4580, 02/2015, Volume 36, Issue 2, pp. 1091 - 1096
The G(4)C(2) hexanucleotide repeat expansion, located in the first intron of the C9ORF72 gene, represents a major genetic hallmark of amyotrophic lateral... 
DEMENTIA | G-quadruplex | Amyotrophic lateral sclerosis | Frontotemporal lobar degeneration | Expanded hexanucleotide repeats | TRANSLATION | NEUROSCIENCES | FOCI | GERIATRICS & GERONTOLOGY | MESSENGER-RNA | GENE | ANTISENSE TRANSCRIPTS | EXPANSION | DISEASE | Chromosome 9 open reading frame 72 | PROTEINS | HEXANUCLEOTIDE REPEAT
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7567, pp. 56 - 61
Journal Article
Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2018, Volume 141, Issue 5, pp. 1831 - 1843.e10
Journal Article
Journal Article
CELL CHEMICAL BIOLOGY, ISSN 2451-9448, 02/2019, Volume 26, Issue 2, pp. 179 - 179
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is an expanded G(4)C(2) repeat [(G(4)C(2))(exp)] in... 
IN-VITRO | ANTISENSE TRANSCRIPTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | FRONTOTEMPORAL DEMENTIA | G-QUADRUPLEX STABILIZER | HUMAN TELOMERE | HEXANUCLEOTIDE REPEAT | NEURODEGENERATIVE DISEASES | PATHOLOGICAL FEATURES | K+ SOLUTION | RNA FOCI
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 12/2015, Volume 5
The G(4)C(2) hexanucleotide repeat expansion mutation (HREM) in C9ORF72, represents the most common mutation associated with amyotrophic lateral sclerosis... 
G-QUADRUPLEX STRUCTURES | CIRCULAR-DICHROISM | GENE | STABILITY | MULTIDISCIPLINARY SCIENCES | DISEASE | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | PROTEINS | HEXANUCLEOTIDE REPEAT | DEGENERATION
Journal Article
JOURNAL OF MOLECULAR BIOLOGY, ISSN 0022-2836, 01/1999, Volume 285, Issue 4, pp. 1623 - 1632
Gel retardation studies and other experiments indicate that DNA sequences containing the d(GA(4)T(4)C)(n) motif are curved, whereas those of identical... 
KINETOPLAST DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIRECTED CURVATURE | DNA curvature | molecular dynamics | CRYSTALLIZING AGENT 2-METHYL-2,4-PENTANEDIOL | INCLUDING INTERNAL-ROTATION | NUCLEIC-ACIDS | ADENINE TRACT | TA step | INTERMOLECULAR POTENTIAL FUNCTIONS | CURVED DNA | B-DNA | AT step | T-G-G | A-tract
Journal Article