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1. Full Text Sorting Nexin 27 Regulation of G Protein-Gated Inwardly Rectifying K+ Channels Attenuates In Vivo Cocaine Response
by Munoz, Michaelanne B and Slesinger, Paul A
Neuron (Cambridge, Mass.), ISSN 0896-6273, 05/2014, Volume 82, Issue 3, pp. 659 - 669
Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Protein Binding - genetics | Sorting Nexins - deficiency | Ventral Tegmental Area - drug effects | Mice, Inbred C57BL | Neuronal Plasticity - drug effects | Male | Signal Transduction - genetics | Ventral Tegmental Area - cytology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Sorting Nexins - physiology | Mice, Knockout | Neuronal Plasticity - genetics | Animals | Cocaine - toxicity | Ventral Tegmental Area - metabolism | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Female | Mice | G Protein-Coupled Inwardly-Rectifying Potassium Channels - biosynthesis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Organ Culture Techniques | Proteins | Neurons | Rodents | Cocaine | Addictions | Experiments | Defects | Index Medicus
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2. Full Text Calcium-sensing receptor decreases cell surface expression of the inwardly rectifying K+ channel Kir4.1
by Cha, Seung-Kuy and Huang, Chunfa and Ding, Yaxian and Qi, Xiaoping and Huang, Chou-Long and Miller, R. Tyler
The Journal of biological chemistry, ISSN 0021-9258, 01/2011, Volume 286, Issue 3, pp. 1828 - 1835
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Potassium - metabolism | Humans | Receptors, Calcium-Sensing - metabolism | Clathrin-Coated Vesicles - metabolism | Gene Knockdown Techniques | Potassium Channels, Inwardly Rectifying - biosynthesis | Clathrin Heavy Chains - metabolism | HEK293 Cells | Biological Transport - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Sodium Chloride - metabolism | Water-Electrolyte Imbalance - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Clathrin-Coated Vesicles - genetics | Signal Transduction | Gene Expression Regulation | Caveolin 1 - genetics | Rats | Potassium Channels, Inwardly Rectifying - genetics | Caveolin 1 - metabolism | Water-Electrolyte Imbalance - metabolism | Animals | Clathrin Heavy Chains - genetics | Receptors, Calcium-Sensing - genetics | Nephrons - metabolism | Index Medicus | Potassium Channels | G Protein-coupled Receptors (GPCR) | Heterotrimeric G Proteins | Kidney | Cell Biology
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3. Full Text Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology
by Devalla, Harsha D and Schwach, Verena and Ford, John W and Milnes, James T and El-Haou, Said and Jackson, Claire and Gkatzis, Konstantinos and Elliott, David A and Chuva de Sousa Lopes, Susana M and Mummery, Christine L and Verkerk, Arie O and Passier, Robert
EMBO molecular medicine, ISSN 1757-4684, 2015, Volume 7, Issue 4, pp. 394 - 410
atrial cardiomyocytes | COUP‐TF | atrial fibrillation | arrhythmias | ion channels | Ion channels | COUP-TF | Atrial fibrillation | Arrhythmias | Atrial cardiomyocytes | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Atrial Fibrillation - pathology | Drug Evaluation, Preclinical - methods | Gene Expression | Heart Atria - pathology | Atrial Fibrillation - drug therapy | Humans | Heart Atria - metabolism | Pluripotent Stem Cells - metabolism | Pluripotent Stem Cells - pathology | Atrial Fibrillation - metabolism | Myocytes, Cardiac - pathology | Models, Biological | Myocytes, Cardiac - metabolism | Kv1.5 Potassium Channel - antagonists & inhibitors | Kv1.5 Potassium Channel - biosynthesis | Drug Delivery Systems - methods | G Protein-Coupled Inwardly-Rectifying Potassium Channels - biosynthesis | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Potassium Channel Blockers - pharmacology | Embryonic stem cells | Analysis | Anti-arrhythmia drugs | Heart cells | Tretinoin | Drugs | Heart | Cell culture | Flow cytometry | Cardiac arrhythmia | Animal models | Transcription factors | Arrhythmia | Genes | Stem cell transplantation | Action potential | Drug delivery | Experiments | Fibrillation | Physiology | Potassium channels (voltage-gated) | Pharmaceutical industry | Data analysis | Potassium channels (inwardly-rectifying) | Research & development--R&D | Cardiomyocytes | Pharmacology | Cell lines | Stem cells | Ventricle | Retinoic acid | Pluripotency | Index Medicus | s
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4. Full Text Crystal structure of a Kir3.1-prokaryotic Kir channel chimera
by Cadene, Martine and MacKinnon, Roderick and Chait, Brian T and Nishida, Motohiko and Brookhaven National Laboratory (BNL) National Synchrotron Light Source
The EMBO journal, ISSN 0261-4189, 09/2007, Volume 26, Issue 17, pp. 4005 - 4015
crystal structure | gating | G‐protein‐gated inward rectifier | selectivity filter | potassium channel | G-protein-gated inward rectifier | Selectivity filter | Gating | Potassium channel | Crystal structure | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Recombinant Fusion Proteins - biosynthesis | Amino Acid Sequence | Bacterial Proteins - genetics | G Protein-Coupled Inwardly-Rectifying Potassium Channels - chemistry | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Recombinant Fusion Proteins - chemistry | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Burkholderia - metabolism | Escherichia coli - metabolism | Recombinant Fusion Proteins - genetics | Protein Conformation | Binding Sites | G Protein-Coupled Inwardly-Rectifying Potassium Channels - biosynthesis | Ion Channel Gating | Cellular biology | Molecular biology | Potassium | Index Medicus | Cristallography | Chemical Sciences | GTP-ASES | ORIGIN | ESCHERICHIA COLI | STREPTOMYCES | CHIMERAS | MEMBRANES | CRYSTAL STRUCTURE | national synchrotron light source | MATERIALS SCIENCE | RESIDUES | LIPIDS
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5. Full Text Adrenaline-induced hyperpolarization of mouse pancreatic islet cells is mediated by G protein-gated inwardly rectifying potassium (GIRK) channels
by Iwanir, Shachar and Reuveny, Eitan
Pflügers Archiv, ISSN 0031-6768, 9/2008, Volume 456, Issue 6, pp. 1097 - 1108
Epinephrine | Biomedicine | Human Physiology | Whole-cell recordings | Patch clamp | Islets of Langerhans | Pancreatic β-cells | G protein-coupled inwardly rectifying potassium channels | Life Sciences & Biomedicine | Physiology | Science & Technology | Islets of Langerhans - drug effects | G Protein-Coupled Inwardly-Rectifying Potassium Channels - drug effects | Electrophysiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Reverse Transcriptase Polymerase Chain Reaction | RNA - genetics | RNA - biosynthesis | Patch-Clamp Techniques | Animals | Islets of Langerhans - cytology | Fluorescent Antibody Technique | Mice | Epinephrine - pharmacology | Pancreatic beta cells | Potassium channels | Analysis | Pancreas | Cells | Index Medicus
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6. Full Text Inhibition of G Protein-Activated Inwardly Rectifying K Channels by Various Antidepressant Drugs
by Kobayashi, Toru and Washiyama, Kazuo and Ikeda, Kazutaka
Neuropsychopharmacology, ISSN 0893-133X, 10/2004, Volume 29, Issue 10, pp. 1841 - 1851
Antidepressant | GIRK | Ethanol | Kir channel | Xenopus oocyte | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Biological and medical sciences | Medical sciences | Neuropharmacology | Pharmacology. Drug treatments | GTP-Binding Proteins - physiology | G Protein-Coupled Inwardly-Rectifying Potassium Channels | Oocytes - metabolism | Potassium Channels, Inwardly Rectifying - drug effects | Humans | RNA, Messenger - genetics | Xenopus laevis | Electrophysiology | RNA, Messenger - biosynthesis | Animals | Antidepressive Agents, Tricyclic - pharmacology | Myocardium - metabolism | Heart - drug effects | Female | Antidepressive Agents - pharmacology | Potassium Channels, Inwardly Rectifying - metabolism | Potassium Channel Blockers - pharmacology | Index Medicus
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7. Full Text Lactate reduces epileptiform activity through HCA1 and GIRK channel activation in rat subicular neurons in an in vitro model
by Jorwal, Pooja and Sikdar, Sujit Kumar
Epilepsia (Copenhagen), ISSN 0013-9580, 12/2019, Volume 60, Issue 12, pp. 2370 - 2385
subiculum | GIRK | HCA1 | lactate | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Rats, Wistar | Rats | Male | Receptors, G-Protein-Coupled - biosynthesis | Hippocampus - drug effects | Action Potentials - physiology | Hippocampus - metabolism | Animals | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Neurons - metabolism | Lactic Acid - pharmacology | Neurons - drug effects | Action Potentials - drug effects | G Protein-Coupled Inwardly-Rectifying Potassium Channels - antagonists & inhibitors | Organ Culture Techniques | Immunohistochemistry | Neuroprotection | Firing pattern | Potassium channels (inwardly-rectifying) | Brain slice preparation | Epilepsy | Electrophysiology | Anticonvulsants | Metabolites | Pyramidal cells | Potassium channels (voltage-gated) | Lactic acid | Hippocampus | Brain injury | Seizures | Index Medicus
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8. Full Text Macrolides selectively inhibit mutant KCNJ5 potassium channels that cause aldosterone-producing adenoma
by Scholl, Ute I and Abriola, Laura and Zhang, Chengbiao and Reimer, Esther N and Plummer, Mark and Kazmierczak, Barbara I and Zhang, Junhui and Hoyer, Denton and Merkel, Jane S and Wang, Wenhui and Lifton, Richard P
The Journal of clinical investigation, ISSN 0021-9738, 06/2017, Volume 127, Issue 7, pp. 2739 - 2750
Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Adrenal Gland Neoplasms - drug therapy | Adenoma - genetics | Aldosterone - biosynthesis | Humans | Cytochrome P-450 CYP11B2 - biosynthesis | Mutation, Missense | G Protein-Coupled Inwardly-Rectifying Potassium Channels - genetics | Neoplasm Proteins - metabolism | Adenoma - metabolism | Aldosterone - genetics | Adenoma - drug therapy | HEK293 Cells | Adenoma - pathology | Adrenal Gland Neoplasms - metabolism | Cell Line, Tumor | G Protein-Coupled Inwardly-Rectifying Potassium Channels - metabolism | Macrolides - pharmacology | Neoplasm Proteins - genetics | Adrenal Gland Neoplasms - genetics | Adrenal Gland Neoplasms - pathology | Amino Acid Substitution | Cytochrome P-450 CYP11B2 - genetics | Hypertension | Care and treatment | Gene mutations | Genetic aspects | Adenoma | Diagnosis | Research | Risk factors | Cell proliferation | Adrenal glands | Sodium conductance | Invasiveness | Benign | Macrolide antibiotics | Electrophysiology | Aldosterone synthase | Lethality | Roxithromycin | Tumor cell lines | Potassium channels | Aldosterone | Calcium influx | Depolarization | Membrane conductance | Rodents | Membrane potential | Mutation | Potassium | Tumors | Index Medicus | Abridged Index Medicus
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