2010, 1. Aufl., ISBN 9780470749142, xiv, 296
G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents....
Cell receptors | Ion channels
Cell receptors | Ion channels
Book
2014, Advances in experimental medicine and biology, ISBN 9789400774223, Volume 796, viii, 228
"This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the...
Receptors | Receptors, G-Protein-Coupled | G proteins | Cell receptors | Membrane proteins
Receptors | Receptors, G-Protein-Coupled | G proteins | Cell receptors | Membrane proteins
Book
2011, ISBN 0521112087, xvi, 430
Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first...
Cell receptors | Signal Transduction | Receptors, G-Protein-Coupled | physiology | Cellular signal transduction | G proteins | Drug Delivery Systems
Cell receptors | Signal Transduction | Receptors, G-Protein-Coupled | physiology | Cellular signal transduction | G proteins | Drug Delivery Systems
Book
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 1/2016, Volume 56, Issue 1, pp. 403 - 425
G protein-coupled receptors (GPCRs) compose one of the largest families of membrane proteins involved in intracellular signaling. They are involved in numerous...
oligomers | proximity-based assays | heterodimerization | dimerization | bivalent ligands | biochemical fingerprint | allosterism | Oligomers | Bivalent ligands | Allosterism | Biochemical fingerprint | Heterodimerization | Dimerization | Proximity-based assays | BIVALENT LIGAND | ULTRASTRUCTURAL-LOCALIZATION | CB1 CANNABINOID RECEPTOR | TIME-RESOLVED FRET | HUMAN NEUROBLASTOMA | DELTA-OPIOID RECEPTORS | ADENOSINE A(2A) RECEPTORS | DOPAMINE D2 RECEPTORS | RAT UTERINE ARTERY | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Drug Discovery - methods | Signal Transduction - physiology | Membrane Proteins - metabolism | Animals | Receptors, G-Protein-Coupled - metabolism | Humans | Life Sciences | Other
oligomers | proximity-based assays | heterodimerization | dimerization | bivalent ligands | biochemical fingerprint | allosterism | Oligomers | Bivalent ligands | Allosterism | Biochemical fingerprint | Heterodimerization | Dimerization | Proximity-based assays | BIVALENT LIGAND | ULTRASTRUCTURAL-LOCALIZATION | CB1 CANNABINOID RECEPTOR | TIME-RESOLVED FRET | HUMAN NEUROBLASTOMA | DELTA-OPIOID RECEPTORS | ADENOSINE A(2A) RECEPTORS | DOPAMINE D2 RECEPTORS | RAT UTERINE ARTERY | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Drug Discovery - methods | Signal Transduction - physiology | Membrane Proteins - metabolism | Animals | Receptors, G-Protein-Coupled - metabolism | Humans | Life Sciences | Other
Journal Article
Nature, ISSN 0028-0836, 02/2013, Volume 494, Issue 7436, pp. 185 - 194
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and...
DISTINCT CONFORMATIONS | STRUCTURAL INSIGHTS | BETA ADRENERGIC-RECEPTOR | RESOLUTION CRYSTAL-STRUCTURE | ALLOSTERIC COMMUNICATION | MULTIDISCIPLINARY SCIENCES | ADENOSINE A(2A) RECEPTOR | MEMBRANE-PROTEINS | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Animals | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Receptors, G-Protein-Coupled - antagonists & inhibitors | Crystallography, X-Ray | Ligands | Protein Conformation | Receptors, G-Protein-Coupled - agonists | Binding Sites | Protein Folding | Receptors, G-Protein-Coupled - chemistry | Proteins | Studies | Signal transduction | Nanocrystals | Disease | Peptides | Biology | Genomes | Comparative analysis | Crystallography | Chemokines
DISTINCT CONFORMATIONS | STRUCTURAL INSIGHTS | BETA ADRENERGIC-RECEPTOR | RESOLUTION CRYSTAL-STRUCTURE | ALLOSTERIC COMMUNICATION | MULTIDISCIPLINARY SCIENCES | ADENOSINE A(2A) RECEPTOR | MEMBRANE-PROTEINS | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Animals | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Humans | Receptors, G-Protein-Coupled - antagonists & inhibitors | Crystallography, X-Ray | Ligands | Protein Conformation | Receptors, G-Protein-Coupled - agonists | Binding Sites | Protein Folding | Receptors, G-Protein-Coupled - chemistry | Proteins | Studies | Signal transduction | Nanocrystals | Disease | Peptides | Biology | Genomes | Comparative analysis | Crystallography | Chemokines
Journal Article
2011, RSC drug discovery, ISBN 1849731837, Volume no. 8, xxxv, 511
This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design..
Cell receptors | Receptors | genetics | Receptors, G-Protein-Coupled | physiology | drug effects | Structure-Activity Relationship | G proteins | Structure-activity relationships | Drug Discovery | Pharmacology | Cellular signal transduction
Cell receptors | Receptors | genetics | Receptors, G-Protein-Coupled | physiology | drug effects | Structure-Activity Relationship | G proteins | Structure-activity relationships | Drug Discovery | Pharmacology | Cellular signal transduction
Book
2000, Methods in signal transduction., ISBN 0849333849, 398 p., [8] p. of plates
Book
Trends in Pharmacological Sciences, ISSN 0165-6147, 2011, Volume 33, Issue 1, pp. 17 - 27
G protein-coupled receptors (GPCRs) comprise the most ‘prolific’ family of cell membrane proteins, which share a general mechanism of signal transduction, but...
Advanced Basic Science | SUBTYPE-SELECTIVITY | LIGAND-BINDING | STRUCTURE-BASED DISCOVERY | CRYSTAL-STRUCTURE | X-RAY-STRUCTURE | DRUG DISCOVERY | PHARMACOLOGY & PHARMACY | ADENOSINE A(2A) RECEPTOR | ALLOSTERIC MODULATION | BETA ADRENOCEPTOR | BETA-ADRENERGIC RECEPTOR | Ligands | Protein Conformation | Animals | Humans | Receptors, G-Protein-Coupled - chemistry | Histamine receptors | Histamine | Structure | Analysis | Crystals | Membrane proteins | adenosine | rhodopsin | G protein-coupled receptor | chemokine | histamine | adrenergic | dopamine
Advanced Basic Science | SUBTYPE-SELECTIVITY | LIGAND-BINDING | STRUCTURE-BASED DISCOVERY | CRYSTAL-STRUCTURE | X-RAY-STRUCTURE | DRUG DISCOVERY | PHARMACOLOGY & PHARMACY | ADENOSINE A(2A) RECEPTOR | ALLOSTERIC MODULATION | BETA ADRENOCEPTOR | BETA-ADRENERGIC RECEPTOR | Ligands | Protein Conformation | Animals | Humans | Receptors, G-Protein-Coupled - chemistry | Histamine receptors | Histamine | Structure | Analysis | Crystals | Membrane proteins | adenosine | rhodopsin | G protein-coupled receptor | chemokine | histamine | adrenergic | dopamine
Journal Article