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FASEB JOURNAL, ISSN 0892-6638, 07/2014, Volume 28, Issue 7, pp. 2995 - 3006
The alpha 7 nicotinic receptor (alpha 7) plays an important role in neuronal growth and structural plasticity in the developing brain. We have recently... 
PROTEIN-KINASE-C | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | calcium stores | SUBUNITS | KNOCKOUT MICE | ACETYLCHOLINE-RECEPTOR | INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR | CELL BIOLOGY | choline | EB3 | CALCIUM | BIOLOGY | NEURONS | BINDING | PIP2 | MODULATION | heterotrimeric G protein
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 09/2010, Volume 334, Issue 3, pp. 809 - 819
Lipid rafts, formed by sphingolipids and cholesterol within the membrane bilayer, are believed to have a critical role in signal transduction. P2Y(2) receptors... 
ACTIVATION | CHOLESTEROL | NG108-15 CELLS | ADENYLYL-CYCLASE | MEMBRANE | LIM-KINASE | SURFACE | PHARMACOLOGY & PHARMACY | CAVEOLAE | RECEPTORS | G-PROTEIN
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 10/2007, Volume 204, Issue 11, pp. 2705 - 2718
CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than... 
CALCIUM INFLUX | MEDICINE, RESEARCH & EXPERIMENTAL | CYCLIC ADP-RIBOSE | HETEROTRIMERIC G-PROTEINS | CHEMOATTRACTANT RECEPTORS | INTRACELLULAR CALCIUM | IMMUNE-RESPONSES | FORMYL PEPTIDE RECEPTOR | PHOSPHOLIPASE-C | IMMUNOLOGY | NF-KAPPA-B | PERTUSSIS-TOXIN
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 19144 - 19149
Central nervous system responses to cannabis are primarily mediated by CB1 receptors, which couple preferentially to G(i/o) G proteins. Here, we used calcium... 
phospholipase C | ACTIVATION | MULTIDISCIPLINARY SCIENCES | PHOSPHOLIPASE-C | RELEASE | aminoalkylindole | neurons | inositol phosphate | SIGNAL-TRANSDUCTION | RESPONSES | CA2 | NG108-15 CELLS | G(Q) | DELTA-TETRAHYDROCANNABINOL
Journal Article
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, ISSN 0892-6638, 07/2014, Volume 28, Issue 7, pp. 2995 - 3006
Journal Article
JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN 0730-2312, 05/2017, Volume 118, Issue 5, pp. 979 - 993
Recent evidences show that activation of serotonin 2A receptors (5-HT2AR) by agonists is significant in improving therapeutic activity of disease conditions,... 
G(q/11) | AQUEOUS EXTRACT | ACTIVATION | BEHAVIOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5-HT2A RECEPTOR | HALLUCINOGENS | PREFRONTAL CORTEX | OBSESSIVE-COMPULSIVE DISORDER | HETEROMERIZATION | CELL BIOLOGY | SIGNALING PATHWAY | AUSTRALIAN CANE TOAD SKIN | DOPAMINE-D-2 RECEPTORS | ORBITOFRONTAL CORTEX | CLU213 CELLS
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 08/2009, Volume 34, Issue 9, pp. 2156 - 2166
Alterations in muscarinic acetylcholine receptor (CHRM) populations have been implicated in the pathology of schizophrenia. Here we have assessed whether the... 
[H-3]-pirenzepine binding | SUBTYPE | Muscarinic acetylcholine receptor (CHRM) | PSYCHIATRY | MEMBRANES | schizophrenia | human brain tissue | NEUROSCIENCES | PREFRONTAL CORTEX | MUTANT MICE | AVAILABILITY | [S-35]-GTP gamma S immunocapture | PHARMACOLOGY & PHARMACY | DYSFUNCTION | G alpha(q/11) protein | BINDING | EXPRESSION | BRAIN | AGONIST
Journal Article
JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, ISSN 1079-9893, 01/2019, Volume 39, Issue 1, pp. 9 - 17
Although multiple roles of dopamine through D-1-like (D-1 and D-5) and D-2-like (D-2, D-3, and D-4) receptors are initiated primarily through stimulation or... 
SCINTILLATION PROXIMITY | ANTAGONIST | dopamine D-1-like receptor | AGONISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | 5-HT2 | CELL BIOLOGY | 5-HT2A receptor | SCH-23390 | GAMMA-S BINDING | SEROTONIN | pergolide | PROTEINS | dopamine | SELECTIVITY | BRAIN | G protein
Journal Article
JOURNAL OF NEUROCHEMISTRY, ISSN 0022-3042, 10/2015, Volume 135, Issue 1, pp. 88 - 100
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 02/2007, Volume 320, Issue 2, pp. 607 - 614
Muscarinic M-2 receptors preferentially couple with the G(i/o) class of G- proteins to inhibit cAMP synthesis. However, they can also stimulate net synthesis... 
SIGNAL-TRANSDUCTION | G ALPHA(Q) | BETA ADRENERGIC-RECEPTOR | ACETYLCHOLINE-RECEPTORS | CYCLIC-AMP | COUPLING DOMAIN | HAMSTER OVARY CELLS | ADENYLYL-CYCLASE | PHOSPHOLIPASE-C | PHARMACOLOGY & PHARMACY | CHO-K1 CELLS
Journal Article
Cellular Signalling, ISSN 0898-6568, 06/2012, Volume 24, Issue 6, pp. 1351 - 1360
Protease-activated receptor 1 (PAR1) is an unusual GPCR that interacts with multiple G protein subfamilies (G , G , and G ) and their linked signaling pathways... 
Phospholipase Cε | G | Thrombin | PAR1 astrocytes | PLCε | Protease-activated receptor | G protein
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 07/1995, Volume 270, Issue 28, pp. 16677 - 16682
The angiotensin II type 1 (AT1R) and type 2 (AT2R) receptors belong to the seven transmembrane receptor superfamily. Previous studies have suggested that the... 
SIGNAL-TRANSDUCTION PATHWAYS | WASP VENOM | PHOSPHATIDYLINOSITOL HYDROLYSIS | 2ND MESSENGERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | G-PROTEINS | SITE-DIRECTED MUTAGENESIS | EXPRESSION | SMOOTH-MUSCLE CELLS | MUSCARINIC ACETYLCHOLINE-RECEPTOR
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 2005, Volume 17, Issue 10, pp. 1218 - 1228
The G protein subunit, βγ, plays an important role in targeting α subunits to the plasma membrane and is essential for binding and activation of the... 
Cyclic AMP | Heterotrimeric G protein | Signal transduction | Inositol phosphate | Subcellular localization
Journal Article
NEUROPHARMACOLOGY, ISSN 0028-3908, 07/2017, Volume 121, pp. 247 - 260
In cerebellar cortex, mGlu(4) receptors located on parallel fibers play an essential role in normal motor function, but the molecular mechanisms involved are... 
CA2+ INFLUX | LOCALIZATION | ACTIVATION | MECHANISM | Presynaptic metabotropic glutamate receptor 4 | RELEASE | NEUROSCIENCES | PARALLEL FIBERS | NEUROTRANSMITTER | Cerebellar cortex | Molecular layer interneurons | Signaling pathway | MGLUR4 | Synaptic transmission | SYNAPSES | 2ND INTRACELLULAR LOOP | PHARMACOLOGY & PHARMACY | G protein
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2002, Volume 22, Issue 11, pp. 4346 - 4356
The nucleus accumbens (NAc) is an important cerebral area involved in reward and spatial memory (Pennartz et al., 1994), but little is known about synaptic... 
Nucleus accumbens | Metabotropic glutamate receptors | Calcium channels | mGlu2/3 | Prelimbic cortex | Presynaptic inhibition | Mice | Long-term depression | MORPHINE-WITHDRAWAL SYMPTOMS | presynaptic inhibition | prelimbic cortex | NEUROTRANSMITTER RELEASE | long-term depression | calcium channels | CA2+ CHANNELS | metabotropic glutamate receptors | nucleus accumbens | mice | NEUROSCIENCES | TRANSMITTER RELEASE | SENSITIVE G-PROTEIN | RAT AMYGDALA | CENTRAL-NERVOUS-SYSTEM | SYNAPTIC TRANSMISSION | DENTATE GYRUS | Electric Stimulation | Synaptic Transmission - physiology | Calcium Channels - metabolism | Calcium - metabolism | Nucleus Accumbens - metabolism | Calcium Channels, Q-Type - metabolism | Neuronal Plasticity - drug effects | Male | Receptors, Metabotropic Glutamate - metabolism | Excitatory Postsynaptic Potentials - drug effects | Amino Acids - pharmacology | Excitatory Postsynaptic Potentials - physiology | Calcium Channels, P-Type - metabolism | Neural Inhibition - physiology | Neuronal Plasticity - physiology | Synapses - metabolism | Nucleus Accumbens - cytology | Synaptic Transmission - drug effects | Xanthenes - pharmacology | Cyclic AMP-Dependent Protein Kinases - metabolism | Bridged Bicyclo Compounds - pharmacology | Mice, Inbred C57BL | Excitatory Amino Acid Agonists - pharmacology | Excitatory Amino Acid Antagonists - pharmacology | Calcium Channel Blockers - pharmacology | Patch-Clamp Techniques | Animals | Signal Transduction - drug effects | Presynaptic Terminals - metabolism | Signal Transduction - physiology | In Vitro Techniques | Receptors, Metabotropic Glutamate - agonists | Receptors, Metabotropic Glutamate - antagonists & inhibitors
Journal Article
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