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JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 11/2004, Volume 279, Issue 46, pp. 47438 - 47445
YM-254890, which was isolated from the culture broth of Chromobacterium sp., inhibits ADP-induced platelet aggregation and has antithrombotic and thrombolytic... 
ALPHA-SUBUNITS | G(Q/11) INHIBITOR | ADP RECEPTORS | CELLS | ACTIVATION | YM-254890 | BIOCHEMISTRY & MOLECULAR BIOLOGY | PHOSPHOLIPASE-C | IN-VIVO | G-PROTEIN ANTAGONISTS | GTP HYDROLYSIS
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 08/2012, Volume 14, Issue 8, pp. 850 - U168
Activation of the TRPM8 ion channel in sensory nerve endings produces a sensation of pleasant coolness. Here we show that inflammatory mediators such as... 
ALPHA-SUBUNITS | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | PHOSPHORYLATION | MEMBRANE | G-PROTEINS | PHOSPHOLIPASE-C | RECEPTOR | MICE | TRPV1 | LIVING CELLS | CELL BIOLOGY
Journal Article
Arthritis Research & Therapy, ISSN 1478-6354, 08/2018, Volume 20, Issue 1
Recent studies have shown a crucial role of G[alpha]q in immune regulation, but how G[alpha]q modulates regulatory B-cell (Breg) function is still unclear. We... 
Care and treatment | Immune response | Rheumatoid arthritis | Physiological aspects | Development and progression | B cells | Research | G proteins | Health aspects | Immunological research
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 04/2019, Volume 17, Issue 4, pp. 963 - 973
Uveal melanoma is the most common intraocular tumor in adults and often metastasizes to the liver, leaving patients with few options. Recurrent activating... 
BRAF GENE | ACTIVATION | COUNTER-CURRENT CHROMATOGRAPHY | ERBB3 | ONCOLOGY | HIPPO SIGNALING PATHWAY | LANDSCAPE | GNAQ | MUTATIONS | MEK INHIBITORS | G-PROTEIN | CELL BIOLOGY
Journal Article
by Wu, F and Qiu, J and Fan, Y and Zhang, QL and Cheng, BH and Wu, YL and Bai, B
EXPERIMENTAL NEUROLOGY, ISSN 0014-4886, 04/2018, Volume 302, pp. 136 - 144
Cerebral ischemia/reperfusion (I/R) injury-induced neuronal apoptosis contributes to the death and disability in patients with ischemic stroke. However,... 
NADPH OXIDASE | ISCHEMIA/REPERFUSION INJURY | Ischemic strok | Apelin-13 | CK2 | SUPPRESSION | NEUROSCIENCES | Unfolded protein response | CELL-DEATH | INHIBITION | G alpha(i)/G alpha(q) | KINASE CK2 | NF-KAPPA-B | CEREBRAL-ISCHEMIA | MODULATION | Apoptosis
Journal Article
TRENDS IN PHARMACOLOGICAL SCIENCES, ISSN 0165-6147, 01/2014, Volume 35, Issue 1, pp. 23 - 30
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, ISSN 0363-6143, 05/2019, Volume 316, Issue 5, pp. C741 - C752
Endothelial cell (EC) mechanochemical transduction is the process by which mechanical stimuli are sensed by ECs and transduced into biochemical signals and... 
VASCULAR DEVELOPMENT | PECAM-1 | ION-CHANNEL PIEZO1 | endothelial cells | PHYSIOLOGY | PLA | MECHANISM | FLUID SHEAR-STRESS | MEMBRANE | G-PROTEINS | Piezo1 | G alpha(q/11) | BLOOD-PRESSURE | CELL BIOLOGY | shear stress | ENDOTHELIAL-CELLS | GAMMA-SUBUNIT | ATP
Journal Article
NEURON, ISSN 0896-6273, 05/2018, Volume 98, Issue 3, pp. 562 - 562
Perhaps the most devastating decline with age is the loss of memory. Therefore, identifying mechanisms to restore memory function with age is critical. Using... 
LIFE-SPAN | PROTEIN-KINASE-C | LONG-TERM-MEMORY | CAENORHABDITIS-ELEGANS | CREB | G(Q)ALPHA | GENE-EXPRESSION | MICE | BINDING | NEUROSCIENCES | BETA
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 07/2019, Volume 39, Issue 31, pp. 6067 - 6080
The cold- and menthol-sensitive transient receptor potential melastatin 8 (TRPM8) channel is important for both physiological temperature detection and cold... 
COLD SENSOR TRPM8 | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE | POTENTIAL MELASTATIN-8 | PHOSPHORYLATION | PHOSPHOLIPASE-C | TRPV1 | NEUROSCIENCES | PHOSPHOINOSITIDES | PAIN | ION-CHANNEL | NEURONS | DRG neuron | G-protein | GPCR | TRPM8 | PIP2
Journal Article
SCIENCE, ISSN 0036-8075, 12/2005, Volume 310, Issue 5754, pp. 1686 - 1690
G protein-coupled receptor kinase 2 (GRK2) plays a key role in the desensitization of G protein-coupled receptor signaling by phosphorylating activated... 
G-ALPHA-SUBUNITS | 2.0 ANGSTROM | SELECTIVE REGULATION | CRYSTAL-STRUCTURE | ADENYLYL-CYCLASE | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | BETA-GAMMA-SUBUNITS | COUPLED RECEPTOR KINASE-2 | MUSCARINIC ACETYLCHOLINE-RECEPTORS | STRUCTURAL DETERMINANTS
Journal Article
Neuron, ISSN 0896-6273, 12/2017, Volume 96, Issue 5, pp. 1070 - 1083.e5
Journal Article
STRUCTURE, ISSN 0969-2126, 03/2013, Volume 21, Issue 3, pp. 438 - 448
The heterotrimeric G protein G alpha(q) is a key regulator of blood pressure, and excess G alpha(q) signaling leads to hypertension. A specific inhibitor of G... 
ALPHA-SUBUNITS | POINT MUTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | MEMBRANE ANCHOR | PHOSPHOLIPASE C-BETA | G-ALPHA(Q) | CELL BIOLOGY | RGS2 | BIOPHYSICS | ACTIVATING PROTEINS | GTPASE ACCELERATING PROTEIN | BINDING
Journal Article
Cellular Signalling, ISSN 0898-6568, 06/2019, Volume 58, p. 34
G protein [alpha]q-coupled receptors (Gq-GPCRs) primarily signal through G[alpha]qGTP mediated phospholipase C[beta] (PLC[beta]) stimulation and the subsequent... 
Proteins | Analysis | Cellular signal transduction | G proteins
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9
G alpha(q) is a ubiquitous molecular switch that activates the effectors phospholipase-C-beta 3 (PLC-beta 3) and Rho guanine-nucleotide exchange factors. G... 
SIGNAL-TRANSDUCTION | SELECTIVE REGULATION | HETEROTRIMERIC G-PROTEINS | DETERMINANTS | GTPASE-ACTIVATING PROTEINS | RGS DOMAIN | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | PHOSPHOLIPASE-C-BETA | MECHANISMS | COUPLED RECEPTOR KINASE
Journal Article
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, ISSN 0305-1870, 06/2019, Volume 46, Issue 6, pp. 567 - 574
Although it is recognized that alpha(1)-adrenoceptors are coupled to diverse intracellular signalling pathways, its primary transduction mechanisms are evoked... 
PHYSIOLOGY | STIMULATION | MODULATES ALPHA(1B)-ADRENOCEPTOR PHOSPHORYLATION | PHARMACOLOGICAL CHARACTERIZATION | ALPHA | oxymetazoline | alpha-Adrenoceptor | BINDING ASSAY | 5-HT2A receptor | NOMENCLATURE | INTERNATIONAL UNION | adrenaline | CONTRACTION | G-protein | PHARMACOLOGY & PHARMACY | RECEPTORS
Journal Article
BIOCHEMICAL PHARMACOLOGY, ISSN 0006-2952, 05/2016, Volume 107, pp. 59 - 66
G alpha(q) inhibitor UBO-QIC (FR900359) is becoming an important pharmacological tool, but its selectivity against other G proteins and their subunits,... 
UBO-QIC | MIGRATION | CELLS | ACTIVATION | STIMULATION | HETEROTRIMERIC G-PROTEINS | PHOSPHORYLATION | GB gamma subunits | PHOSPHOLIPASE-C | G alpha(q) inhibitor | ADENOSINE RECEPTOR | GPCR | PHARMACOLOGY & PHARMACY | FR900359 | BETA-GAMMA-SUBUNITS | G protein | ARRESTINS
Journal Article
EMBO JOURNAL, ISSN 0261-4189, 06/2012, Volume 31, Issue 13, pp. 2869 - 2881
Membrane trafficking involves large fluxes of cargo and membrane across separate compartments. These fluxes must be regulated by control systems to maintain... 
HETEROTRIMERIC G-PROTEIN | COMPLEX | MECHANISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | endomembrane signalling | G-protein-coupled receptor | COMPARTMENTS | FAMILY | CELL BIOLOGY | EPITHELIAL-CELLS | Golgi complex | VESICULAR TRANSPORT | KDEL receptor | BINDING | APPARATUS | LIVING CELLS
Journal Article
SCIENCE, ISSN 0036-8075, 12/2007, Volume 318, Issue 5858, pp. 1923 - 1927
The guanine nucleotide exchange factor p63RhoGEF is an effector of the heterotrimeric guanine nucleotide- binding protein ( G protein) G alpha(q) and thereby... 
PLURIPOTENT STEM-CELLS | G-BETA-GAMMA | DEFINED FACTORS | TRIO | GTPASES | MULTIDISCIPLINARY SCIENCES | G-PROTEINS | NUCLEOTIDE EXCHANGE FACTOR | PLECKSTRIN HOMOLOGY DOMAIN | GENE-THERAPY | PH DOMAINS
Journal Article
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