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Cancer Biology & Therapy, ISSN 1538-4047, 05/2019, Volume 20, Issue 5, pp. 700 - 710
There is no efficacious standard of care therapy for uveal melanoma. Unlike cutaneous disease, uveal melanoma does not exhibit RAS mutations but instead... 
neratinib | autophagy | RAS | HDAC inhibitor | G alpha
Journal Article
SCIENCE SIGNALING, ISSN 1945-0877, 06/2017, Volume 10, Issue 484
The beta(2)-adrenergic receptor (beta(2)AR) has provided a paradigm to elucidate how G protein-coupled receptors (GPCRs) control intracellular signaling,... 
CELLS | DYNAMIC PROCESS | ACTIVATION | G-ALPHA | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TRAFFICKING | PROTEIN-COUPLED RECEPTORS | TRANSDUCTION | ADRENERGIC-RECEPTOR | CELL BIOLOGY
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 08/2014, Volume 16, Issue 8, pp. 758 - U231
Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During embryogenesis, murine epidermis expands rapidly from a single... 
PLANAR DIVISIONS | NEURAL STEM-CELLS | HETEROTRIMERIC G-PROTEINS | G-ALPHA | ASYMMETRIC DIVISIONS | DEVELOPING NEOCORTEX | CAENORHABDITIS-ELEGANS EMBRYOS | DROSOPHILA NEUROBLASTS | POLARITY PROTEIN | MITOTIC SPINDLE ORIENTATION | CELL BIOLOGY
Journal Article
PLANT PHYSIOLOGY, ISSN 0032-0889, 03/2015, Volume 167, Issue 3, pp. 1004 - 1004
In animals, heterotrimeric G proteins, comprising G alpha, G beta, and G gamma subunits, are molecular switches whose function tightly depends on G alpha and G... 
G-ALPHA | NECROTROPHIC PATHOGENS | RECEPTOR-LIKE KINASES | PSEUDOMONAS-SYRINGAE | CELL-PROLIFERATION | GUARD-CELLS | PLASMA-MEMBRANE | BLUE-LIGHT | INNATE IMMUNITY | CHANNEL REGULATION | PLANT SCIENCES
Journal Article
by Tang, XL and Jin, RR and Qu, GJ and Wang, X and Li, ZX and Yuan, ZJ and Zhao, C and Siwko, S and Shi, TL and Wang, P and Xiao, JR and Liu, MY and Luo, J
CANCER RESEARCH, ISSN 0008-5472, 10/2013, Volume 73, Issue 20, pp. 6206 - 6218
Adhesion G-protein-coupled receptors (GPCR), which contain adhesion domains in their extracellular region, have been found to play important roles in cell... 
IG-HEPTA | NUCLEOTIDE-EXCHANGE-FACTOR | G-ALPHA-Q | ACTIVATION | GPR56 | ONCOLOGY | RAC1 | RHO-GTPASES | CELL-SHAPE | PROGRESSION | FAMILY
Journal Article
Science Signaling, ISSN 1945-0877, 09/2018, Volume 11, Issue 546
Constitutively active G protein a subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition... 
ACTIVATION | G-ALPHA | UVEAL MELANOMA | MECHANISM | GNAQ | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | SOMATIC MUTATION | OPTIONS | BINDING | INSIGHTS | CELL BIOLOGY
Journal Article
CELL, ISSN 0092-8674, 09/2009, Volume 138, Issue 6, pp. 1150 - 1163
Asymmetric cell division is intensely studied because it can generate cellular diversity as well as maintain stem cell populations. Asymmetric cell division... 
NEURAL STEM-CELLS | CAENORHABDITIS-ELEGANS | ASYMMETRIC DIVISIONS | DROSOPHILA AURORA-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | TUMOR-SUPPRESSOR | G-ALPHA-I | NEUROBLASTS | CORTICAL POLARITY | PROTEIN COMPLEX | CELL BIOLOGY
Journal Article
BONE, ISSN 8756-3282, 10/2019, Volume 127, pp. 592 - 601
The human disease fibrodysplasia ossificans progressiva (FOP) is a rare and highly disabling disorder of extensive heterotopic bone growth that is caused by a... 
Activin A | BMP | HETEROTRIMERIC G-PROTEINS | FOP | ENDOCRINOLOGY & METABOLISM | Smad | DIFFERENTIATION | G-ALPHA(Q) | Alk2 | Osteoblast differentiation
Journal Article
Journal Article
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 12/2019, Volume 218, Issue 12, pp. 4112 - 4126
In animal cells, faithful chromosome segregation depends on the assembly of a bipolar spindle driven by the timely separation of the two centrosomes. Here we... 
ASYMMETRY | KINESIN | PROTEIN | G-ALPHA | FUNCTIONAL-ANALYSIS | NUCLEAR-ENVELOPE BREAKDOWN | CHROMOSOME SEGREGATION | CORTICAL DYNEIN | POLO-LIKE KINASE | MITOTIC SPINDLE ORIENTATION | CELL BIOLOGY
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 05/2018, Volume 365, Issue 2, pp. 219 - 225
Ser54 of G(s)alpha binds guanine nucleotide and Mg2+ as part of a conserved sequence motif in GTP binding proteins. Mutating the homologous residue in small... 
ALPHA-SUBUNITS | TRANSDUCIN | ACTIVATION | G-ALPHA(S) | STRUCTURAL BASIS | MG-2+-BINDING SITE | SIGNALS | AURICULOCONDYLAR SYNDROME | RECEPTOR | PHARMACOLOGY & PHARMACY | MUTATIONS
Journal Article