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1. Full Text Small-molecule-induced DNA damage identifies alternative DNA structures in human genes
by Rodriguez, Raphaël and Miller, Kyle M and Forment, Josep V and Bradshaw, Charles R and Nikan, Mehran and Britton, Sébastien and Oelschlaegel, Tobias and Xhemalce, Blerta and Balasubramanian, Shankar and Jackson, Stephen P
Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 3, pp. 301 - 310
Guanine-rich DNA sequences that can adopt non-Watson-Crick structures in vitro are prevalent in the human genome. Whether such structures normally exist in... 
TELOMERE | HUMAN GENOME | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | TRANSCRIPTION | DOUBLE-STRAND BREAKS | INHIBITOR | G-QUADRUPLEX | HELICASE | CANCER | Genetics | Oncology | Pharmacology | Molecular biology | DNA damage | DNA structure | Chromatin | Immunoprecipitation | Motility | Nucleotide sequence | Transcription | Breast cancer | Genomes | Src protein | Mammalian cells | genomics | Proto-oncogenes | Index Medicus
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2. Full Text C9orf72 nucleotide repeat structures initiate molecular cascades of disease
by Haeusler, Aaron R and Donnelly, Christopher J and Periz, Goran and Simko, Eric A. J and Shaw, Patrick G and Kim, Min-Sik and Maragakis, Nicholas J and Troncoso, Juan C and Pandey, Akhilesh and Sattler, Rita and Rothstein, Jeffrey D and Wang, Jiou
Nature, ISSN 0028-0836, 2014, Volume 507, Issue 7491, pp. 195 - 200
A hexanucleotide repeat expansion (HRE), (GGGGCC)(n), inC9orf72 is the most common genetic cause of the neurodegenerative diseases amyotrophic lateral... 
PROTEIN | DNA REPEATS | ACIDS | MULTIDISCIPLINARY SCIENCES | FRONTOTEMPORAL DEMENTIA | EXPANSION | ALS | AMYOTROPHIC-LATERAL-SCLEROSIS | RNA G-QUADRUPLEX | HEXANUCLEOTIDE REPEAT | GGGGCC REPEAT | Frontotemporal Dementia - genetics | Cell Nucleolus - pathology | Cell Nucleolus - genetics | DNA Repeat Expansion - genetics | Neurons | Amyotrophic Lateral Sclerosis - genetics | Humans | Stress, Physiological | B-Lymphocytes | Models, Molecular | Ribonucleoproteins - metabolism | DNA - metabolism | Open Reading Frames - genetics | Phosphoproteins - metabolism | RNA - chemistry | RNA - genetics | DNA - genetics | RNA - biosynthesis | Base Sequence | HEK293 Cells | G-Quadruplexes | Transcription, Genetic - genetics | RNA-Binding Proteins - metabolism | RNA - metabolism | Genetic research | Research | Nucleotide sequencing | Molecular genetics | DNA sequencing | Pathology | Amyotrophic lateral sclerosis | Plasmids | Deoxyribonucleic acid--DNA | Methods | Index Medicus | hnRNP | abortive transcription | R-loop | FTD | G-quadruplex | tandem repeats | nucleolar stress | and repeat expansions | C9orf72 | nucleolin
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3. Full Text Stabilization of i-motif structures by 2'-β-fluorination of DNA
by Assi, Hala Abou and Harkness, Robert W and Martin-Pintado, Nerea and Wilds, Christopher J and Campos-Olivas, Ramón and Mittermaier, Anthony K and González, Carlos and Damha, Masad J
Nucleic Acids Research, ISSN 0305-1048, 06/2016, Volume 44, Issue 11, pp. 4998 - 5009
i-Motifs are four-stranded DNA structures consisting of two parallel DNA duplexes held together by hemi-protonated and intercalated cytosine base pairs... 
NMR | CRYSTAL-STRUCTURE | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | O HYDROGEN-BONDS | GENE-EXPRESSION | TRANSITIONS | DUPLEX | G-QUADRUPLEX | MODULATION | NUCLEIC-ACIDS | Thermodynamics | DNA - chemistry | Base Pairing | Magnetic Resonance Spectroscopy | Nucleotide Motifs | Intercalating Agents - pharmacology | Nucleic Acid Conformation - drug effects | Cytosine - chemistry | Hydrogen-Ion Concentration | Index Medicus | Chemical Biology and Nucleic Acid Chemistry
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4. Full Text Circular Dichroism of Quadruplex Structures
by Randazzo, A and Spada, GP and da Silva, MW
2013, Topics in Current Chemistry, Volume 330, 20
Circular dichroism (CD) is a widespread technique for studying the polymorphism of G-quadruplexes. In this chapter the CD spectral features characteristic of... 
TOPOLOGY | RNA | FORM | BIOCHEMISTRY & MOLECULAR BIOLOGY | G-quadruplex | CD SPECTRA | GUANOSINE | INVERSION | PURINE NUCLEOSIDES | POLARITY SITE | SPECTROSCOPY | DNA | Circular Dichroism | RESIDUES | Models, Molecular | G-Quadruplexes | DNA - chemistry | Animals | Humans | Circular Dichroism - methods | Index Medicus
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5. Full Text DNA nanotechnology based on i-motif structures
by Dong, Yuanchen and Yang, Zhongqiang and Liu, Dongsheng
Accounts of Chemical Research, ISSN 0001-4842, 06/2014, Volume 47, Issue 6, pp. 1853 - 1860
CONSPECTUS: Most biological processes happen at the nanometer scale, and understanding the energy transformations and material transportation mechanisms within... 
GOLD NANOPARTICLES | PH CHANGES | CHEMICAL OSCILLATOR | NANOMACHINE | ENTITIES | MACHINE | CIRCULAR OLIGODEOXYRIBONUCLEOTIDES | DRIVEN CONFORMATIONAL SWITCH | G-QUADRUPLEX | CHEMISTRY, MULTIDISCIPLINARY | HYDROGEL | DNA - chemistry | Base Pairing | Nucleotide Motifs | Nanotechnology - methods | Surface Properties | Nanostructures - chemistry | Cytosine - chemistry | Nanopores | Hydrogen-Ion Concentration | Research | Chemical properties | DNA | Nanotechnology | Index Medicus | Molecular structure | Deoxyribonucleic acid | Motors | Nanostructure | Biological | Devices | Assembly
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6. Full Text Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
by Dai, Jixun and Carver, Megan and Punchihewa, Chandanamali and Jones, Roger A and Yang, Danzhou
Nucleic Acids Research, ISSN 0305-1048, 8/2007, Volume 35, Issue 15, pp. 4927 - 4940
Formation of the G-quadruplex in the human telomeric sequence can inhibit the activity of telomerase, thus the intramolecular telomeric G-quadruplexes have... 
RELEVANT G-QUADRUPLEX | HUMAN-CHROMOSOMES | THERMODYNAMIC PROPERTIES | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTICANCER DRUG | TARGETS | C-MYC PROMOTER | POTASSIUM SOLUTION | CANCER | REGION | Protons | Humans | Models, Molecular | Potassium - chemistry | Telomere - chemistry | DNA - chemistry | Solutions | DNA Mutational Analysis | Base Sequence | Nuclear Magnetic Resonance, Biomolecular | G-Quadruplexes | Guanine - chemistry | Nucleic Acid Conformation | Index Medicus | Structural Biology
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7. Full Text Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells
by Biffi, Giulia and Di Antonio, Marco and Tannahill, David and Balasubramanian, Shankar
Nature Chemistry, ISSN 1755-4330, 01/2014, Volume 6, Issue 1, pp. 75 - 80
Following extensive evidence for the formation of four-stranded DNA G-quadruplex structures in vitro, DNA G-quadruplexes have been observed within human cells.... 
RESOLVING ACTIVITY | MESSENGER-RNA | DNA G-QUADRUPLEX | SMALL-MOLECULE | MAJOR SOURCE | TETRAMOLECULAR QUADRUPLEX | GENE-EXPRESSION | TRANSLATION INITIATION | REPRESSES TRANSLATION | CHEMISTRY, MULTIDISCIPLINARY | UNTRANSLATED REGION | Cytoplasm - chemistry | G-Quadruplexes | Hydrogen Bonding | RNA - chemistry | Humans | Index Medicus
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8. Full Text Induction of a Four‐Way Junction Structure in the DNA Palindromic Hexanucleotide 5′‐d(CGTACG)‐3′ by a Mononuclear Platinum Complex
by van Rixel, Vincent H. S and Busemann, Anja and Wissingh, Mathijs F and Hopkins, Samantha L and Siewert, Bianka and van de Griend, Corjan and Siegler, Maxime A and Marzo, Tiziano and Papi, Francesco and Ferraroni, Marta and Gratteri, Paola and Bazzicalupi, Carla and Messori, Luigi and Bonnet, Sylvestre
Angewandte Chemie International Edition, ISSN 1433-7851, 07/2019, Volume 58, Issue 28, pp. 9378 - 9382
Four‐way junctions (4WJs) are supramolecular DNA assemblies comprising four interacting DNA strands that in biology are involved in DNA‐damage repair. In this... 
hydrogen bonding | platinum | metallodrugs | nucleic acids | supramolecular chemistry | VISUALIZATION | RECOGNITION | CRYSTAL-STRUCTURE | ANTICANCER DRUG | CANCER | CHEMISTRY, MULTIDISCIPLINARY | CYLINDERS | CHEMISTRY | G-QUADRUPLEX DNA | BINDING | METAL-COMPLEXES | Genetic research | Structure | Hydrogen | DNA | Crystals | DNA structure | Superstructures | Platinum | DNA damage | Crystallization | Coordination compounds | DNA repair | Bonding | Hydrogen bonding | Deoxyribonucleic acid--DNA | Crystal structure | Index Medicus | Communications | Communication
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9. Full Text Circular dichroism of quadruplex structures
by Randazzo, Antonio and Spada, Gian Piero and Da Silva, Mateus Webb
Topics in Current Chemistry, ISSN 0340-1022, 2013, Volume 330, pp. 67 - 86
RNA | DNA | G-quadruplex | Circular Dichroism
Conference Proceeding
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10. Full Text DNA secondary structures and epigenetic determinants of cancer genome evolution
by De, Subhajyoti and Michor, Franziska
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2011, Volume 18, Issue 8, pp. 950 - 955
An unstable genome is a hallmark of many cancers. It is unclear, however, whether some mutagenic features driving somatic alterations in cancer are encoded in... 
METHYLATION CHANGES | INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN-CELLS | BREAST | CELL BIOLOGY | G4 DNA | TELOMERIC DNA | FORMING SEQUENCES | BIOPHYSICS | COPY-NUMBER | GENE-EXPRESSION | G-QUADRUPLEX | Genomic Instability | DNA Methylation | Neoplasms - genetics | Epigenesis, Genetic | Humans | DNA Breaks | Models, Molecular | Nucleic Acid Conformation | DNA, Neoplasm - chemistry | DNA Copy Number Variations | Physiological aspects | Genetic aspects | Genomes | Research | DNA | Cancer | Epigenetics | Mutagenesis | Molecular biology | Index Medicus
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11. Full Text Fundamental aspects of the nucleic acid i-motif structures
by Benabou, S and Aviñó, A and Eritja, R and González, C and Gargallo, R
RSC Adv, ISSN 2046-2069, 2014, Volume 4, Issue 51, pp. 26956 - 26980
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12. Full Text G-triplex structure and formation propensity
by Cerofolini, Linda and Amato, Jussara and Giachetti, Andrea and Limongelli, Vittorio and Novellino, Ettore and Parrinello, Michele and Fragai, Marco and Randazzo, Antonio and Luchinat, Claudio
Nucleic Acids Research, ISSN 0305-1048, 2014, Volume 42, Issue 21, pp. 13393 - 13404
The occurrence of a G-triplex folding intermediate of thrombin binding aptamer (TBA) has been recently predicted by metadynamics calculations, and... 
TELOMERIC G-QUADRUPLEX | G-QUADRUPLEX STRUCTURES | XPLOR-NIH | NMR | RNA | THROMBIN | DNA APTAMER D(GGTTGGTGTGGTTGG) | BIOCHEMISTRY & MOLECULAR BIOLOGY | FORCE-FIELD | COUPLING-CONSTANTS | NUCLEIC-ACIDS | DNA - chemistry | Aptamers, Nucleotide - chemistry | Models, Molecular | G-Quadruplexes | Guanine - chemistry | Nucleic Acid Conformation | Cations, Monovalent - chemistry | Index Medicus | Structural Biology
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13. Full Text Targeting G-quadruplex DNA structures in the telomere and oncogene promoter regions by benzimidazole‒carbazole ligands
by Kaulage, Mangesh H and Maji, Basudeb and Pasadi, Sanjeev and Ali, Asfa and Bhattacharya, Santanu and Muniyappa, K
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2018, Volume 148, pp. 178 - 194
Recent studies support the idea that G-quadruplex structures in the promoter regions of oncogenes and telomere DNA can serve as potential therapeutic targets... 
G-quadruplex DNA | Thiazole orange | Benzimidazole‒carbazole conjugates | Fluorescence intercalator displacement | Transcriptional regulation | Oncogenes | Polymerase stop assay | DISPLACEMENT ASSAY | CHEMISTRY, MEDICINAL | SMALL MOLECULES | CRYSTAL-STRUCTURE | GENE PROMOTERS | K+ SOLUTION | HUMAN GENOME | FORMING REGION | Benzimidazole-carbazole conjugates | INTRAMOLECULAR G-QUADRUPLEX | MINOR-GROOVE BINDING | I-MOTIF STRUCTURES | Endothelial growth factors | Genes | Denaturation | Fluorescence | Genetic transcription | Proteins | Prevention | Telomeres | DNA | Genetic research | Genetic aspects | Nucleotide sequencing | Telomerase | DNA sequencing | Cancer | Index Medicus
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