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2003, ISBN 0306478315, [xi], 267
Book
Cell Cycle, ISSN 1538-4101, 11/2015, Volume 14, Issue 21, pp. 3434 - 3440
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 113 - 117
Eukaryotic DNA replication uses kinase regulatory pathways to facilitate coordination with other processes during cell division cycles and response to... 
COMPLEX | CHROMATIN | BUDDING YEAST | INITIATION | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC DNA-REPLICATION | CELL-CYCLE | CHECKPOINT | CDC7-DBF4 | CDK-DEPENDENT PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | Hydroxyurea - pharmacology | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Substrate Specificity | G1 Phase - drug effects | Minichromosome Maintenance Complex Component 4 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | DNA-Binding Proteins - antagonists & inhibitors | Microbial Viability - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Genes, Essential | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae Proteins - metabolism | S Phase - physiology | Saccharomyces cerevisiae - enzymology | Cell Proliferation - drug effects | S Phase - drug effects | DNA Damage | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | DNA replication | Interphase | Analysis | Physiological aspects | Genetic aspects | Research | Biological control systems | Protein kinases | Proteins | Cell division | Kinases | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2005, Volume 7, Issue 8, pp. 831 - 836
The cyclin-dependent kinase inhibitor p27Kip1 is known as a negative regulator of cell-cycle progression and as a tumour suppressor. Cdk2 is the main target of... 
CYCLIN-E | ENTRY | CDK2 | GROWTH | MOUSE | DEPENDENT-KINASE INHIBITOR | HYPERPLASIA | MAMMALIAN-CELLS | MICE LACKING | P27(KIP1) | CELL BIOLOGY | Cell Proliferation | Cyclin-Dependent Kinases - metabolism | Ovarian Neoplasms - pathology | Gonads - pathology | Male | Mitosis - genetics | Body Weight - genetics | CDC2 Protein Kinase - metabolism | Ovarian Neoplasms - genetics | Cyclin-Dependent Kinase 2 | Cyclins - metabolism | 2-Aminopurine - analogs & derivatives | Cyclin-Dependent Kinases - antagonists & inhibitors | Thymus Gland - metabolism | Fibroblasts - metabolism | Tumor Suppressor Proteins - metabolism | Pituitary Neoplasms - genetics | Cell Cycle Proteins - metabolism | Enzyme Inhibitors - pharmacology | CDC2-CDC28 Kinases - metabolism | Mice, Knockout | Fibroblasts - drug effects | Fibroblasts - cytology | Mice | Interphase - genetics | Interphase - physiology | Infertility - genetics | Transfection | Tumor Suppressor Proteins - genetics | Thymus Gland - pathology | Cell Cycle Proteins - genetics | Female | G1 Phase - genetics | CDC2 Protein Kinase - genetics | Mice, Inbred C57BL | Pituitary Neoplasms - pathology | 2-Aminopurine - pharmacology | G1 Phase - physiology | S Phase - genetics | Cyclin-Dependent Kinase Inhibitor p27 | Animals | Spleen - metabolism | RNA, Double-Stranded - genetics | Sex Factors | Protein Binding | S Phase - physiology | S Phase - drug effects | Cyclin E - metabolism | CDC2-CDC28 Kinases - genetics | Interphase - drug effects | Crosses, Genetic | Physiological aspects | Tumor suppressor genes | Control | Cellular signal transduction | Research | Cell cycle | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2011, Volume 54, Issue 14, pp. 5013 - 5030
On the basis of structures of known topoisomerase H catalytic inhibitors and initial molecular docking studies, bicyclic N-fused aminoimidazoles were predicted... 
DNA TOPOISOMERASE | CELLS | MOLECULAR-DYNAMICS | ETOPOSIDE | DOMAIN | CHEMISTRY, MEDICINAL | MECHANISM | ICRF-187 | ATP-BINDING-SITE | CANCER | FLEXIBLE DOCKING | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Imidazoles - chemistry | Cercopithecus aethiops | Structure-Activity Relationship | Topoisomerase II Inhibitors - chemistry | S Phase | HEK293 Cells | Antineoplastic Agents - pharmacology | Topoisomerase II Inhibitors - chemical synthesis | Imidazoles - chemical synthesis | Intercalating Agents - chemical synthesis | Binding Sites | Vero Cells | Cell Survival - drug effects | Antigens, Neoplasm | DNA-Binding Proteins - antagonists & inhibitors | Heterocyclic Compounds, 2-Ring - chemistry | Etoposide - pharmacology | Models, Molecular | Imidazoles - pharmacology | Intercalating Agents - pharmacology | Topoisomerase II Inhibitors - pharmacology | Antineoplastic Agents - chemistry | Intercalating Agents - chemistry | Molecular Dynamics Simulation | Heterocyclic Compounds, 2-Ring - pharmacology | Cell Movement - drug effects | G1 Phase | Animals | Cell Line, Tumor | Adenosine Triphosphatases - chemistry | DNA Topoisomerases, Type II | Fluorouracil - pharmacology | Adenosine Triphosphate - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Drug Screening Assays, Antitumor | Index Medicus
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 02/2016, Volume 7, Issue 1, pp. 10660 - 10660
Embryonic stem cells (ESCs) represent a transient biological state, where pluripotency is coupled with fast proliferation. ESCs display a constitutively active... 
GENOMIC INSTABILITY | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | IN-VIVO | SELF-RENEWAL | PLURIPOTENCY | HOMOLOGOUS RECOMBINATION | DARK SIDE | CYCLE | REVERSAL | Index Medicus
Journal Article
Journal Article
Science, ISSN 0036-8075, 04/2016, Volume 352, Issue 6284, pp. 453 - 459