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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2008, Volume 105, Issue 12, pp. 4826 - 4831
To enhance therapeutic efficacy and reduce adverse effects, practitioners of traditional Chinese medicine (TCM) prescribe a combination of plant... 
Up regulation | Acute promyelocytic leukemia | Arsenic | Medical treatment | Leukemia | Cell cycle | Cell lines | Mice | Cellular differentiation | Blood | Traditional Chinese medicine | Active ingredient | Systems biology | Synergism | Tetraarsenic tetrasulfide | systems biology | NB4 | APOPTOSIS | PHOSPHORYLATION | active ingredient | MULTIDISCIPLINARY SCIENCES | tetraarsenic tetrasulfide | traditional chinese medicine | ARSENIC TRIOXIDE AS2O3 | IN-VITRO | RETINOIC ACID | THERAPY | GENE | synergism | CELL-CYCLE | EXPRESSION | Transcription, Genetic - drug effects | Oncogene Proteins, Fusion - metabolism | Leukemia, Promyelocytic, Acute - pathology | Humans | Drugs, Chinese Herbal - pharmacology | G1 Phase - drug effects | Aquaporins - genetics | Arsenicals - therapeutic use | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Drugs, Chinese Herbal - therapeutic use | Disease Models, Animal | Sulfides - pharmacology | Medicine, Chinese Traditional | Arsenicals - pharmacology | Aquaporins - metabolism | Sulfides - therapeutic use | Drug Synergism | Up-Regulation - drug effects | Animals | Cell Differentiation - drug effects | Cell Line, Tumor | Resting Phase, Cell Cycle - drug effects | Leukemia, Promyelocytic, Acute - genetics | Leukemia, Promyelocytic, Acute - drug therapy | Evaluation | Medicine, Chinese | Research | Drug synergism | Chinese medicine | Flowers & plants | Cells | Effectiveness studies | Index Medicus | Biological Sciences
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 19127 - 19137
Trastuzumab resistance emerges to be a major issue in anti-human epidermal growth factor receptor 2 (HER2) therapy for breast cancers. Here, we demonstrated... 
INVASION | CARCINOMA CELLS | POOR-PROGNOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | GROWTH | TUMOR-SUPPRESSOR GENE | DOWN-REGULATION | PTEN | MICRORNA-21 TARGETS | EXPRESSION | Carcinoma, Ductal, Breast - genetics | Gene Silencing - drug effects | Oligodeoxyribonucleotides, Antisense - pharmacology | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Antineoplastic Agents - therapeutic use | G1 Phase - drug effects | Breast Neoplasms - metabolism | Antibodies, Monoclonal, Humanized | Carcinoma, Ductal, Breast - drug therapy | Female | Antineoplastic Agents - pharmacology | Receptor, ErbB-2 - antagonists & inhibitors | G1 Phase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Tumor Cells, Cultured | Carcinoma, Ductal, Breast - metabolism | PTEN Phosphohydrolase - genetics | Antibodies, Monoclonal - pharmacology | PTEN Phosphohydrolase - biosynthesis | MicroRNAs - biosynthesis | Up-Regulation - genetics | Breast Neoplasms - drug therapy | S Phase - genetics | Gene Expression Regulation, Enzymologic | Up-Regulation - drug effects | Breast Neoplasms - genetics | RNA, Neoplasm - biosynthesis | RNA, Neoplasm - genetics | MicroRNAs - genetics | S Phase - drug effects | Trastuzumab | Drug Resistance, Neoplasm - drug effects | Index Medicus | Gene Regulation | RNA Silencing | MicroRNA | Gene Therapy | Tumor Therapy | Breast Cancer
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 04/2017, Volume 24, Issue 4, pp. 353 - 361
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7277, pp. 113 - 117
Eukaryotic DNA replication uses kinase regulatory pathways to facilitate coordination with other processes during cell division cycles and response to... 
COMPLEX | CHROMATIN | BUDDING YEAST | INITIATION | MULTIDISCIPLINARY SCIENCES | EUKARYOTIC DNA-REPLICATION | CELL-CYCLE | CHECKPOINT | CDC7-DBF4 | CDK-DEPENDENT PHOSPHORYLATION | SACCHAROMYCES-CEREVISIAE | Hydroxyurea - pharmacology | Protein-Serine-Threonine Kinases - deficiency | Sequence Deletion | Phosphorylation | Substrate Specificity | G1 Phase - drug effects | Minichromosome Maintenance Complex Component 4 | Cell Cycle Proteins - antagonists & inhibitors | Cell Cycle Proteins - chemistry | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Cell Cycle Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Protein Structure, Tertiary | DNA-Binding Proteins - antagonists & inhibitors | Microbial Viability - drug effects | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Saccharomyces cerevisiae Proteins - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - chemistry | Genes, Essential | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae Proteins - metabolism | S Phase - physiology | Saccharomyces cerevisiae - enzymology | Cell Proliferation - drug effects | S Phase - drug effects | DNA Damage | Saccharomyces cerevisiae - growth & development | Saccharomyces cerevisiae Proteins - chemistry | DNA replication | Interphase | Analysis | Physiological aspects | Genetic aspects | Research | Biological control systems | Protein kinases | Proteins | Cell division | Kinases | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, pp. e70627 - e70627
Resveratrol, a naturally occurring polyphenolic compound, has been reported to exert anticancer activity by affecting diverse molecular targets. In this study,... 
APOPTOSIS | IN-VITRO | DEACETYLASE | MULTIDISCIPLINARY SCIENCES | HUMANS | RATS | CELL-CYCLE ARREST | STRESS | SIRT1 | SMALL-MOLECULE ACTIVATORS | P53 | Immunohistochemistry | Sirtuin 1 - metabolism | Cell Cycle - genetics | RNA, Small Interfering - genetics | Stilbenes - therapeutic use | Apoptosis - drug effects | Humans | Cell Survival - genetics | Cellular Senescence - drug effects | Stomach Neoplasms - metabolism | Apoptosis - genetics | G1 Phase - drug effects | Stilbenes - pharmacology | Sirtuin 1 - genetics | Female | G1 Phase - genetics | Stomach Neoplasms - genetics | Cell Survival - drug effects | Cellular Senescence - genetics | Stomach Neoplasms - drug therapy | Blotting, Western | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Cell Line, Tumor | Mice | Mice, Inbred BALB C | Cell Cycle - drug effects | Prevention | Care and treatment | Health aspects | Stomach cancer | Resveratrol | Cancer | Cell proliferation | Regulators | Senescence | Biochemistry | Biology | Cyclin D1 | Cancer therapies | Cyclin-dependent kinase 4 | Anticancer properties | Cyclin-dependent kinase | Ethics | Cell growth | Pathways | Cell cycle | Xenografts | Inhibition | Gastric cancer | G1 phase | Pathogens | Breast cancer | SIRT1 protein | Medicine | Antitumor activity | Diabetes | Viability | Apoptosis | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 2002, Volume 109, Issue 4, pp. 459 - 472
Fanconi anemia (FA) and ataxia telangiectasia (AT) are clinically distinct autosomal recessive disorders characterized by spontaneous chromosome breakage and... 
TARGETED DISRUPTION | CHECKPOINT PATHWAY | DNA-DAMAGE RESPONSE | BIOCHEMISTRY & MOLECULAR BIOLOGY | S-PHASE | ATM-DEPENDENT PHOSPHORYLATION | NUCLEAR-COMPLEX | NIJMEGEN-BREAKAGE-SYNDROME | IONIZING-RADIATION | X-IRRADIATION | MAMMALIAN-CELLS | CELL BIOLOGY | Nucleic Acid Synthesis Inhibitors - pharmacology | Fanconi Anemia - metabolism | Humans | Ubiquitin - metabolism | Phosphoserine - antagonists & inhibitors | G1 Phase - drug effects | G2 Phase - drug effects | Genes, cdc - radiation effects | Cell Nucleus - metabolism | Cell Nucleus - radiation effects | Nuclear Proteins - deficiency | Fanconi Anemia - genetics | Signal Transduction - radiation effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins | Radiation, Ionizing | Ataxia Telangiectasia - physiopathology | Fanconi Anemia Complementation Group D2 Protein | G2 Phase - radiation effects | Mutation - radiation effects | Protein-Serine-Threonine Kinases - genetics | Genes, cdc - drug effects | Ataxia Telangiectasia - metabolism | Signal Transduction - genetics | Ubiquitin - genetics | Ataxia Telangiectasia Mutated Proteins | Phosphoserine - metabolism | S Phase - genetics | Mitomycin - pharmacology | Phosphorylation - radiation effects | S Phase - radiation effects | Mutation - drug effects | G1 Phase - radiation effects | Signal Transduction - drug effects | Fanconi Anemia - physiopathology | Ataxia Telangiectasia - genetics | S Phase - drug effects | HeLa Cells | Cell Nucleus - drug effects | Cell Cycle Proteins | Cell Line, Transformed | Tumor Suppressor Proteins | Cell research | Ionizing radiation | Mitomycin | Analysis | Causes of | Physiological aspects | Ataxia telangiectasia | Genetic aspects | Gene expression | Chromosomes | Cells | Fanconi's anemia | Index Medicus
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2010, Volume 107, Issue 46, pp. 20003 - 20008
Histone deacetylase 6 (HDAC6) is structurally and functionally unique among the 11 human zinc-dependent histone deacetylases. Here we show that chemical... 
Cell culture techniques | Histone deacetylase inhibitors | Cell death | DNA damage | DNA | Cell lines | Histones | Cultured cells | Viability | Apoptosis | DDIT3/CHOP/GADD153 | Chk2 | γH2AX | PROTEIN | CANCER CELLS | ACETYLATION | MULTIDISCIPLINARY SCIENCES | apoptosis | CHAPERONE FUNCTION | VORINOSTAT | histones | PHARMACOKINETICS | gamma H2AX | PERSPECTIVES | PROTEASOME | LYMPHOMA | STRESS | DNA Replication - drug effects | Humans | G1 Phase - drug effects | Neoplasm Proteins - metabolism | Caspases - metabolism | Cell Transformation, Neoplastic - genetics | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Hydroxamic Acids - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Histone Deacetylase 6 | Etoposide - pharmacology | Histone Deacetylases - metabolism | Topoisomerase II Inhibitors - pharmacology | Down-Regulation - drug effects | Drug Synergism | Up-Regulation - drug effects | Anilides - pharmacology | Cell Line, Tumor | Checkpoint Kinase 2 | Histone Deacetylase Inhibitors - pharmacology | Cell Transformation, Neoplastic - drug effects | DNA Damage | Histones - metabolism | Cell Transformation, Neoplastic - pathology | Doxorubicin - pharmacology | Drug Screening Assays, Antitumor | Antimitotic agents | Genetic aspects | Research | Properties | Antineoplastic agents | RecA protein | Physiology | Gene expression | Kinases | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Biological Sciences | DDIT3 | GADD153 | CHOP
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 4180 - 17
Journal Article