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Scientific Reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 46056 - 46056
Three new oxoaporphine Co(II), Ni(II) and Zn(II) complexes 1-3 have been synthesized and fully characterized. 1-3 have similar mononuclear structures with the... 
COPPER(II) COMPLEXES | TUMOR-CELL APOPTOSIS | DAMAGE CHECKPOINT | OXIDATIVE STRESS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TELOMERASE ACTIVITY | CYCLE ARREST | CRYSTAL-STRUCTURES | VIVO ANTICANCER ACTIVITY | G-QUADRUPLEX DNA | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Calcium - metabolism | Antineoplastic Agents - chemical synthesis | Humans | Membrane Potential, Mitochondrial - drug effects | Aporphines - chemical synthesis | Caspases - metabolism | Coordination Complexes - pharmacology | Antineoplastic Agents - pharmacology | Aporphines - chemistry | DNA Topoisomerases, Type II - metabolism | Cytochromes c - metabolism | Tumor Suppressor Protein p53 - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Antineoplastic Agents - chemistry | Down-Regulation - drug effects | Coordination Complexes - chemistry | Aporphines - pharmacology | Hep G2 Cells | Cell Shape - drug effects | Up-Regulation - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Coordination Complexes - chemical synthesis | Ligands | Mice | S Phase - drug effects | DNA Damage | Metals - pharmacology | GTP-binding protein | Reactive oxygen species | Bax protein | Bcl-2 protein | p53 Protein | CHK1 protein | Caspase | Poly(ADP-ribose) polymerase | Cytotoxicity | Cisplatin | Cyclin-dependent kinase 2 | Cytochrome c | Mitochondria | Cyclin A | Proliferating cell nuclear antigen | Xenografts | Bcl protein | Antitumor activity | Apoptosis | Index Medicus
Journal Article
Cell Cycle, ISSN 1538-4101, 11/2015, Volume 14, Issue 21, pp. 3434 - 3440
Journal Article
Journal Article
by Xu, B and Kim, ST and Kastan, MB
MOLECULAR AND CELLULAR BIOLOGY, ISSN 0270-7306, 05/2001, Volume 21, Issue 10, pp. 3445 - 3450
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 07/2010, Volume 102, Issue 14, pp. 1052 - 1068
Patients with glioblastoma multiforme, the most aggressive form of glioma, have a median survival of approximately 12 months. Calcium (Ca2+) signaling plays an... 
DNA-DAMAGE CHECKPOINTS | BREAST-CANCER CELLS | PROTEIN-KINASE-C | RECEPTOR POTENTIAL CHANNELS | OPERATED CALCIUM-ENTRY | ONCOLOGY | GROWTH-FACTOR PDGF | IN-VIVO | CENTRAL-NERVOUS-SYSTEM | CELL-CYCLE PROGRESSION | HUMAN-MALIGNANT GLIOMAS | Immunohistochemistry | Up-Regulation | Adenoviridae | Humans | Brain Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Molecular Sequence Data | Immunoblotting | Transplantation, Heterologous | RNA, Messenger - metabolism | Brain Neoplasms - metabolism | Glioma - metabolism | Glioma - genetics | Flow Cytometry | In Situ Hybridization | Cell Transformation, Neoplastic - genetics | Base Sequence | Cell Division | Glioma - pathology | G2 Phase | TRPC Cation Channels - genetics | Fluorescent Antibody Technique, Indirect | Disease Models, Animal | TRPC Cation Channels - immunology | TRPC6 Cation Channel | Brain Neoplasms - genetics | Reverse Transcriptase Polymerase Chain Reaction | Cell Transformation, Neoplastic - metabolism | Lentivirus | TRPC Cation Channels - antagonists & inhibitors | Cell Transformation, Neoplastic - immunology | Phenotype | Animals | TRPC Cation Channels - metabolism | Cell Line, Tumor | Mice | RNA, Small Interfering | Genetic Vectors | Calcium channels | Care and treatment | Gliomas | Cell cycle | Physiological aspects | Research | Risk factors | Proteins | Oncology | Genes | Tumors | Index Medicus
Journal Article
Journal Article
Genes and Development, ISSN 0890-9369, 12/2002, Volume 16, Issue 24, pp. 3236 - 3252
The intra-S-phase checkpoint in yeast responds to stalled replication forks by activating the ATM-like kinase Mec1 and the CHK2-related kinase Rad53, which in... 
ORC | Rad53 | Yeast | Replication checkpoint | S phase | DNA damage | PATHWAYS | DNA-REPLICATION CHECKPOINT | PROTEIN | CHROMATIN | BUDDING YEAST | DEVELOPMENTAL BIOLOGY | SACCHAROMYCES-CEREVISIAE | yeast | DAMAGE CHECKPOINTS | CELL BIOLOGY | G2/M ARREST | replication checkpoint | ORIGIN RECOGNITION COMPLEX | GENETICS & HEREDITY | FORK PROGRESSION | Chromosomes, Fungal | Hydroxyurea - pharmacology | Phosphorylation | Origin Recognition Complex | Ubiquitin - metabolism | Dose-Response Relationship, Drug | DNA, Fungal - biosynthesis | Genes, cdc - physiology | Protein Synthesis Inhibitors - pharmacology | Nucleic Acid Conformation | Protein-Serine-Threonine Kinases - metabolism | Gene Expression Regulation, Fungal | Cell Survival - drug effects | DNA-Binding Proteins - physiology | Saccharomyces cerevisiae - physiology | Protein-Serine-Threonine Kinases - genetics | DNA Replication | Fungal Proteins - genetics | Cycloheximide - pharmacology | Replication Origin | Saccharomyces cerevisiae Proteins | Checkpoint Kinase 2 | S Phase - physiology | DNA Damage | Mutation | Methyl Methanesulfonate - pharmacology | Cell Cycle Proteins | Fungal Proteins - metabolism | Cell proliferation | Yeast fungi | Physiological aspects | Metabolic regulation | Genetic aspects | Research | Index Medicus | Research Paper | yeast, DNA damage
Journal Article