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International Journal of Cancer, ISSN 0020-7136, 04/2014, Volume 134, Issue 8, pp. 1991 - 2002
Journal Article
Toxicology Letters, ISSN 0378-4274, 05/2013, Volume 219, Issue 1, pp. 8 - 17
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, p. e62087
Silica nanoparticles have become promising carriers for drug delivery or gene therapy. Endothelial cells could be directly exposed to silica nanoparticles by... 
PATHWAYS | MAINTENANCE | AIR-POLLUTION | OXIDATIVE STRESS | CHK1 | PARTICLES | MULTIDISCIPLINARY SCIENCES | DISEASE | MITOCHONDRIA | SIZE-DEPENDENT CYTOTOXICITY | CANCER | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Viability | Apoptosis | Deoxyribonucleic acid
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 10/2017, Volume 216, Issue 10, pp. 3097 - 3115
The mechanisms by which neoplastic cells tolerate oncogene-induced DNA replication stress are poorly understood. Cyclin-dependent kinase 2 (CDK2) is a major... 
STRUCTURED DNA | STALLED REPLICATION | CANCER DEVELOPMENT | PCNA MONOUBIQUITINATION | PIGMENTOSUM VARIANT CELLS | GENOME INTEGRITY | TRANSLESION SYNTHESIS | INDUCED SENESCENCE | S-PHASE CHECKPOINT | DAMAGE BYPASS | CELL BIOLOGY | Neoplasms - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | M Phase Cell Cycle Checkpoints - genetics | Drug Resistance, Neoplasm | DNA-Directed DNA Polymerase - genetics | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | DNA Breaks, Single-Stranded | DNA-Binding Proteins - metabolism | Protein-Tyrosine Kinases - genetics | DNA, Neoplasm - biosynthesis | G2 Phase Cell Cycle Checkpoints - drug effects | Neoplasms - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Pyrazoles - pharmacology | A549 Cells | Cyclin-Dependent Kinase 2 - metabolism | M Phase Cell Cycle Checkpoints - drug effects | Signal Transduction | Cell Cycle Proteins - metabolism | Tumor Suppressor Protein p53 - metabolism | Ubiquitin-Protein Ligases - metabolism | Cyclin-Dependent Kinase 2 - genetics | Nuclear Proteins - metabolism | Pyrimidines - pharmacology | DNA-Binding Proteins - genetics | Neoplasms - drug therapy | G2 Phase Cell Cycle Checkpoints - genetics | Animals | Nuclear Proteins - antagonists & inhibitors | Mice | DNA, Neoplasm - genetics | DNA-Directed DNA Polymerase - metabolism | Ubiquitin-Protein Ligases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Journal Article
BioMed research international, ISSN 2314-6133, 2018, Volume 2018, pp. 2548378 - 11
Colon cancer represents the third most common malignancy worldwide. New drugs with high efficaciousness and safety for the treatment of colon cancer are... 
SURVIVAL | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | THERAPY | PATHWAY | PHOSPHORYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | COLORECTAL-CANCER | KINASE | DEATH | INDUCTION | ERK | Apoptosis - drug effects | Colonic Neoplasms - drug therapy | HCT116 Cells | Humans | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | NF-kappa B - metabolism | Mitochondria - drug effects | Membrane Potential, Mitochondrial - drug effects | Colonic Neoplasms - metabolism | G2 Phase Cell Cycle Checkpoints - drug effects | MAP Kinase Signaling System - drug effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Cell Line, Tumor | Interleukin-6 - metabolism | Saponins - pharmacology | Cytochrome | Bcl-2 protein | Nuclear engineering | Biochemistry | Caspase-3 | Cancer therapies | Anticancer properties | Proteins | Toxicology | Mitochondria | Tumorigenesis | Membrane potential | NF-κB protein | Immunoglobulins | Cytokines | Gene expression | Cytochrome c | Nuclear safety | Caspase-8 | Chemotherapy | Caspase-9 | Cytochromes | Disruption | Viability | Flow cytometry | Biotechnology | Phosphorylation | Bax protein | Interleukin | Colorectal cancer | mRNA | Malignancy | Kinases | Experiments | Cyclin B1 | Interleukin 6 | Colon cancer | Cell cycle | Colon | Translocation | Tumor cells | Extracellular signal-regulated kinase | Poly(ADP-ribose) polymerase | Caspase | Inflammation | Signaling | Antitumor activity | Cytoplasm | Apoptosis | Cancer
Journal Article
Oncogene, ISSN 0950-9232, 10/2011, Volume 30, Issue 41, pp. 4261 - 4274
In the presence of sustained DNA damage occurring in S-phase or G2, normal cells arrest before mitosis and eventually become senescent. The checkpoint kinases... 
cyclin B1 | ATM | Chk2 | G2-M checkpoint | cell cycle | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | TRANSCRIPTIONAL REPRESSION | G CHECKPOINT | CELL BIOLOGY | GENOMIC INSTABILITY | RETINOBLASTOMA PROTEIN | ONCOLOGY | GENETICS & HEREDITY | P53-DEFICIENT CELLS | CELL-CYCLE EXIT | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | Protein Kinases - metabolism | G2 Phase Cell Cycle Checkpoints - physiology | Phosphorylation | Protein Kinases - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Immunoblotting | Male | Cyclin B1 - metabolism | Pyrones - pharmacology | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | HCT116 Cells | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin B1 - genetics | Morpholines - pharmacology | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Piperazines - pharmacology | G2 Phase Cell Cycle Checkpoints - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Checkpoint Kinase 2 | Bleomycin - pharmacology | Checkpoint Kinase 1 | Signal Transduction - physiology | DNA Damage | HeLa Cells | Cell division | Oxidative stress | Signal transduction | DNA damage | Cyclin-dependent kinases | Cell cycle | CHK2 protein | Epithelial cells | Mitosis | CHK1 protein | G2 phase | Genotoxicity | Osteosarcoma cells | p53 protein | Cyclin-dependent kinase | Chemotherapy | Fibroblasts | Cancer
Journal Article
Journal Article
Journal Article