X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (3051) 3051
science & technology (2821) 2821
life sciences & biomedicine (2534) 2534
cell line, tumor (1606) 1606
apoptosis - drug effects (1455) 1455
apoptosis (1420) 1420
cell cycle (1392) 1392
g2 phase cell cycle checkpoints - drug effects (1267) 1267
oncology (1130) 1130
animals (1103) 1103
cell proliferation - drug effects (994) 994
antineoplastic agents - pharmacology (832) 832
cell biology (780) 780
cancer (758) 758
g2 phase - drug effects (746) 746
mice (655) 655
dna damage (649) 649
biochemistry & molecular biology (620) 620
female (599) 599
hep g2 cells (568) 568
proteins (566) 566
cell survival - drug effects (517) 517
phosphorylation (487) 487
flow cytometry (479) 479
dose-response relationship, drug (451) 451
kinases (445) 445
signal transduction - drug effects (430) 430
analysis (419) 419
cell cycle checkpoints - drug effects (414) 414
pharmacology & pharmacy (410) 410
g2 phase (409) 409
male (388) 388
m phase cell cycle checkpoints - drug effects (381) 381
signal transduction (378) 378
cell cycle proteins - metabolism (371) 371
cell proliferation (371) 371
cell cycle - drug effects (370) 370
gene expression (360) 360
tumor suppressor protein p53 - metabolism (353) 353
research (349) 349
cell division - drug effects (346) 346
cell growth (336) 336
deoxyribonucleic acid--dna (329) 329
mice, nude (313) 313
reactive oxygen species - metabolism (300) 300
research article (299) 299
hela cells (296) 296
chemotherapy (293) 293
mitosis - drug effects (291) 291
tumors (291) 291
cytotoxicity (288) 288
cancer therapies (287) 287
antineoplastic agents, phytogenic - pharmacology (284) 284
time factors (282) 282
xenograft model antitumor assays (280) 280
science & technology - other topics (279) 279
care and treatment (271) 271
cell line (271) 271
dna repair (260) 260
biology (259) 259
multidisciplinary sciences (259) 259
cell division (258) 258
dna (250) 250
cell death (244) 244
protein-serine-threonine kinases - metabolism (240) 240
health aspects (239) 239
medicine (236) 236
genetic aspects (233) 233
rna interference (231) 231
mitosis (230) 230
blotting, western (229) 229
breast cancer (228) 228
antineoplastic agents - chemistry (224) 224
caspase 3 - metabolism (224) 224
liver neoplasms - pathology (222) 222
liver cancer (218) 218
tumor cells, cultured (211) 211
science (203) 203
cell cycle arrest (200) 200
gene expression regulation, neoplastic - drug effects (200) 200
mice, inbred balb c (198) 198
phosphorylation - drug effects (197) 197
carcinoma, hepatocellular - pathology (196) 196
chemistry (196) 196
g2 phase cell cycle checkpoints (190) 190
genetics & heredity (189) 189
tumor suppressor protein p53 - genetics (189) 189
drug screening assays, antitumor (188) 188
medicine, research & experimental (187) 187
research & experimental medicine (186) 186
physical sciences (185) 185
studies (184) 184
tumor proteins (184) 184
cdc2 protein kinase - metabolism (183) 183
checkpoint kinase 1 (182) 182
protein kinases - metabolism (182) 182
g2/m arrest (181) 181
gene expression regulation, neoplastic (181) 181
membrane potential, mitochondrial - drug effects (181) 181
proto-oncogene proteins c-akt - metabolism (181) 181
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (3523) 3523
Japanese (20) 20
Chinese (12) 12
German (8) 8
Portuguese (4) 4
Russian (2) 2
Czech (1) 1
Dutch (1) 1
French (1) 1
Norwegian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


PloS one, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, pp. e107142 - e107142
.... A stable shRNA knockdown model for ALDH1A1 was utilized to determine its effect on cancer stem cell-like properties, cell cycle checkpoints, and DNA repair mediators. Results... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | DNA Repair - drug effects | Platinum - therapeutic use | Neoplastic Stem Cells - drug effects | Humans | Ovarian Neoplasms - pathology | Down-Regulation - drug effects | Gene Knockdown Techniques | Disease-Free Survival | Phenotype | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Isoenzymes - metabolism | Kruppel-Like Transcription Factors - metabolism | Cell Line, Tumor | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Neoplastic Stem Cells - pathology | Female | Aldehyde Dehydrogenase - metabolism | Neoplastic Stem Cells - enzymology | Ovarian Neoplasms - drug therapy | Platinum - pharmacology | Drug Resistance, Neoplasm - drug effects | Flow cytometry | GTP-binding protein | Dehydrogenases | Ovarian carcinoma | Bax protein | DNA damage | G2 phase | Genomes | Kinases | DNA repair | Aldehyde dehydrogenase | Cancer therapies | Ovarian cancer | Proteins | Genotype & phenotype | KLF4 protein | Platinum | Cell cycle | PARP-1 protein | Repair | Deoxyribonucleic acid--DNA | Cell survival | BRCA1 protein | Anemia | CHK1 protein | Poly(ADP-ribose) polymerase | Breast cancer | Tumor cell lines | Gene expression | Fanconi syndrome | Patients | Survival | Cytometry | Signaling | Poly(ADP-ribose) Polymerase 1 | Properties (attributes) | Chemotherapy | Medical prognosis | Stem cells | Response rates | Replication | Head & neck cancer | Ascites | Apoptosis | Cancer | Index Medicus | Deoxyribonucleic acid | DNA
Journal Article
PloS one, ISSN 1932-6203, 04/2013, Volume 8, Issue 4, pp. e62087 - e62087
.... However, the underlying toxic effect mechanisms of silica nanoparticles on endothelial cells are still poorly understood... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Protein Kinases - metabolism | Reactive Oxygen Species - metabolism | Nanoparticles - chemistry | Apoptosis - drug effects | Humans | Membrane Potential, Mitochondrial - drug effects | Necrosis | Flow Cytometry | G2 Phase Cell Cycle Checkpoints - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Intracellular Space - drug effects | Subcellular Fractions - drug effects | Endocytosis - drug effects | Nanoparticles - ultrastructure | Hydrodynamics | Static Electricity | Comet Assay | Nanoparticles - toxicity | Subcellular Fractions - metabolism | Particle Size | Human Umbilical Vein Endothelial Cells - enzymology | Silicon Dioxide - toxicity | Intracellular Space - metabolism | Checkpoint Kinase 1 | Human Umbilical Vein Endothelial Cells - pathology | DNA Damage | Oxidative Stress - drug effects | Drugs | Nanoparticles | Drug delivery systems | DNA | DNA damage | Superoxide | Radiation, Background | DNA repair | Silica | Vehicles | Endothelium | Cdc2 protein | Reactive oxygen species | Intravenous administration | Toxicity | Cytology | Cytotoxicity | Superoxide dismutase | Drug delivery | Kinases | Cyclin B1 | Silicon dioxide | Signal transduction | Mitochondria | Peroxidase | Membrane potential | Damage | Heart diseases | Deoxyribonucleic acid--DNA | Glutathione | Glutathione peroxidase | Outdoor air quality | Oxygen | CHK1 protein | Lactate dehydrogenase | Exposure | Hazards | Malondialdehyde | L-Lactate dehydrogenase | Endothelial cells | Signaling | Lactic acid | Mutation | Gene therapy | Cardiovascular diseases | Apoptosis | Index Medicus | Deoxyribonucleic acid
Journal Article
EMBO reports, ISSN 1469-3178, 06/2019, Volume 20, Issue 8, pp. e47026 - n/a
Checkpoint kinase 1 (CHK1) is critical for S‐phase fidelity and preventing premature mitotic entry in the presence of DNA damage... 
BCL2 | apoptosis | CHK1 | hematopoietic stem cells | DNA damage | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Apoptosis - drug effects | Embryo, Mammalian | Humans | Hematopoietic Stem Cells - pathology | Apoptosis - genetics | Melanoma, Experimental - metabolism | Quinolines - pharmacology | Tumor Suppressor Protein p53 - genetics | Hematopoiesis - drug effects | Lymphoma - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | G2 Phase Cell Cycle Checkpoints - drug effects | Tumor Suppressor Proteins - genetics | Apoptosis Regulatory Proteins - genetics | Bone Marrow Cells - drug effects | Fetus | Lymphoma - pathology | Pyrazoles - pharmacology | Hematopoietic Stem Cells - drug effects | Tumor Suppressor Proteins - metabolism | Benzodiazepinones - pharmacology | Quinuclidines - pharmacology | Bone Marrow Cells - pathology | Checkpoint Kinase 1 - antagonists & inhibitors | Tumor Suppressor Protein p53 - metabolism | Lymphoma - genetics | Melanoma, Experimental - pathology | Hematopoiesis - genetics | Bcl-2-Like Protein 11 - genetics | Hematopoietic Stem Cells - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | G2 Phase Cell Cycle Checkpoints - genetics | Animals | Bcl-2-Like Protein 11 - metabolism | Melanoma, Experimental - genetics | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Checkpoint Kinase 1 - deficiency | Primary Cell Culture | Proto-Oncogene Proteins c-bcl-2 - genetics | Bone Marrow Cells - metabolism | Checkpoint Kinase 1 - genetics | p53 Protein | Liver | Kinases | Blood | Hematopoietic stem cells | Clonal deletion | Hematopoiesis | Rodents | Dependence | Inhibition | Damage accumulation | Deoxyribonucleic acid--DNA | Cell survival | Tumor cells | Fetuses | CHK1 protein | Blood cells | Mortality | Embryos | Survival | Progenitor cells | Hemopoiesis | Organic chemistry | Hepatocytes | Cell death | Stem cells | BIM protein | Apoptosis | Index Medicus | Stem Cells | Cell Cycle | Autophagy & Cell Death
Journal Article
Cell cycle (Georgetown, Tex.), ISSN 1538-4101, 04/2009, Volume 8, Issue 8, pp. 1196 - 1205
Journal Article
Journal Article
Molecular cancer therapeutics, ISSN 1538-8514, 09/2008, Volume 7, Issue 9, pp. 2955 - 2966
Journal Article
Molecular oncology, ISSN 1574-7891, 01/2015, Volume 9, Issue 1, pp. 192 - 203
.... We investigated radioresistance of primary GBM cells grown in stem cell conditions (CSC) compared to paired differentiated tumour cell populations and explored the radiosensitising effects of the ATM inhibitor KU-55933... 
ATM | Radiotherapy | Cancer stem cells | DNA damage response | Glioblastoma | Life Sciences & Biomedicine | Oncology | Science & Technology | M Phase Cell Cycle Checkpoints - radiation effects | Gamma Rays | Glioblastoma - enzymology | M Phase Cell Cycle Checkpoints - drug effects | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | Radiation-Sensitizing Agents - pharmacology | Morpholines - pharmacology | Male | Neoplasm Proteins - antagonists & inhibitors | Neoplasm Proteins - metabolism | Glioblastoma - radiotherapy | Pyrones - pharmacology | Radiation Tolerance - drug effects | Radiation Tolerance - radiation effects | G2 Phase Cell Cycle Checkpoints - radiation effects | G2 Phase Cell Cycle Checkpoints - drug effects | Glioblastoma - pathology | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Female | Tumor Cells, Cultured | Neoplastic Stem Cells - enzymology | Proteins | Medical colleges | Care and treatment | Nuclear radiation | DNA | Stem cells | Automated teller machines | Glioblastoma multiforme | DNA repair | Cancer | DNA damage | Radioresistance | Radiation therapy | Cell differentiation | Kinases | Cancer therapies | Studies | Hypotheses | Medical prognosis | Cell cycle | Ataxia | Deoxyribonucleic acid--DNA | Tumors | Index Medicus
Journal Article
Cancer letters, ISSN 0304-3835, 2017, Volume 392, pp. 71 - 82
...), checkpoint kinases 1 and 2, and WEE1. Inhibition or knockdown of PLK1 led to cell-cycle arrest at the G2 /M transition and apoptosis in sensitive cell lines and decreased tumor growth in an orthotopic AJUBA -mutant HNSCC mouse model... 
Hematology, Oncology and Palliative Medicine | WEE1 | Head neck squamous cell carcinoma | Polo-like kinase 1 | CHK1 | AJUBA |