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JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2666 - 2689
Since the discovery of compound BIX01294 over 10 years ago, only a very limited number of nonquinazoline inhibitors of H3K9-specific methyltransferases G9a and... 
CHEMISTRY, MEDICINAL | H3K9 METHYLATION | G9A INHIBITOR | ASSAY | DNA METHYLATION | SMALL-MOLECULE INHIBITORS | SELECTIVE INHIBITORS | CHEMICAL PROBE | GLP | HISTONE/PROTEIN METHYLTRANSFERASE | G9A-LIKE PROTEIN
Journal Article
CEREBRAL CORTEX, ISSN 1047-3211, 07/2019, Volume 29, Issue 7, pp. 2932 - 2946
Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) is conventionally considered to be solely dependent on local protein synthesis.... 
METHYLTRANSFERASE G9A | MEMORY FORMATION | LTP | mGluR-LTD | PKM-ZETA | SYNAPTIC PLASTICITY | PROTEIN-SYNTHESIS | HISTONE ACETYLATION | NEUROSCIENCES | G9a | PKMzeta | LONG-TERM DEPRESSION | EPIGENETIC REGULATION | GENE-EXPRESSION | DENTATE GYRUS | metaplasticity
Journal Article
Neuron, ISSN 0896-6273, 08/2011, Volume 71, Issue 4, pp. 656 - 670
Journal Article
Cancer Research, ISSN 0008-5472, 10/2018, Volume 78, Issue 20, pp. 5754 - 5760
Ovarian cancer ranks as the most deadly gynecologic cancer, and there is an urgent need to develop more effective therapies. Previous studies have shown that... 
ENDOGENOUS RETROVIRUSES | EPIGENETIC THERAPY | LUNG-CANCER | METHYLATION | START SITES | ONCOLOGY | EMBRYONIC STEM-CELLS | PHASE-III | GENE-EXPRESSION | EPIGENOME | G9A | endogenous retrovirus (ERVs) | Epigenetic therapy | DNA methyltransferase inhibitor (DNMTi) | G9A histone methyltransferase inhibitor (G9Ai) | ovarian cancer
Journal Article
Journal Article
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 07/2019, Volume 37, Issue 10, pp. 2581 - 2592
Mono- and di-methylation of the H3K9 residue in the histone tail by G9a lysine methyltransferase is associated with transcriptional suppression of genes. Here,... 
Histone methylation | G9a lysine methyltransferase | epigenetics | molecular dynamics simulation | G9a inhibitors | LANGUAGE | METHYLATION | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | COMPLEXES | DISCOVERY | SOLVENT | BIOPHYSICS | HISTONE H3 | DNA | TARGETS | GENERATION
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 03/2017, Volume 60, Issue 5, pp. 1876 - 1891
G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic... 
REFINEMENT | CHEMISTRY, MEDICINAL | H3K9 METHYLATION | DISRUPTION | DNA METHYLATION | CHROMATIN | TRANSCRIPTION | ESTABLISHMENT | EUCHROMATIN | HISTONE METHYLTRANSFERASE | G9A
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 09/2019, Volume 431, Issue 19, pp. 3606 - 3625
Differentiation toward CD4 regulatory T (Treg) cells is essentially dependent on an epigenetic program at Treg signature genes, which involves remodeling of... 
ascorbate | mass spectrometry | vitamin C | epigenetics | T helper cell | DNA-pull down | CIS-ELEMENT | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENHANCER | G9A | G9A/GLP COMPLEX | NOVO DNA METHYLATION | LYSINE METHYLTRANSFERASE | DEMETHYLATION | GENE-EXPRESSION | BINDING | Epigenetic inheritance | Methyltransferases | Analysis | Genetic research | Histones | DNA binding proteins | T cells | Mass spectrometry | Cells
Journal Article
Journal Article