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Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 8/2016, Volume 197, Issue 3, pp. 910 - 922
Nuclear segmentation is a hallmark feature of mammalian neutrophil differentiation, but the mechanisms that control this process are poorly understood. Gene... 
Lamin B receptor | transcription factor | GA-binding protein | neutrophil differentiation | PU.1 | gene expression
Journal Article
Journal Article
JOURNAL OF EXPERIMENTAL MEDICINE, ISSN 0022-1007, 04/2009, Volume 206, Issue 4, pp. 779 - 791
Notch1 activation is essential for T-lineage specification of lymphomyeloid progenitors seeding the thymus. Progression along the T cell lineage further... 
MEDICINE, RESEARCH & EXPERIMENTAL | PROGENITORS | POSITIVE SELECTION | ALPHA-CHAIN | GA-BINDING-PROTEIN | ACUTE LYMPHOBLASTIC-LEUKEMIA | PRE-TCR | DIFFERENTIATION | IMMUNOLOGY | BETA-SELECTION | CELL DEVELOPMENT | INTERLEUKIN-7 RECEPTOR
Journal Article
Journal of Natural Products, ISSN 0163-3864, 02/2016, Volume 79, Issue 2, pp. 281 - 292
Traditional herbal medicines have been reported to possess significant bioactivities. In this investigation, a combined strategy using both phytochemical and... 
DEFENSE | METABOLITES | CHEMISTRY, MEDICINAL | NATURAL-PRODUCTS | FLAVONOIDS | POTENT TYROSINASE INHIBITORS | KAPPA-B | IDENTIFICATION | PLANT SCIENCES | CHALCONES | ROOTS | PHARMACOLOGY & PHARMACY | EXTRACT | Carbon Tetrachloride - pharmacology | Humans | Drugs, Chinese Herbal - pharmacology | GA-Binding Protein Transcription Factor - antagonists & inhibitors | Monophenol Monooxygenase - antagonists & inhibitors | Structure-Activity Relationship | Acetylcholinesterase | Liver - drug effects | MCF-7 Cells | Rhizome - chemistry | Nuclear Magnetic Resonance, Biomolecular | Molecular Structure | GPI-Linked Proteins - antagonists & inhibitors | Drugs, Chinese Herbal - isolation & purification | Pyrrolizidine Alkaloids - isolation & purification | Pyrrolizidine Alkaloids - pharmacology | Nitric Oxide - biosynthesis | Glycyrrhiza uralensis - chemistry | NF-kappa B - antagonists & inhibitors | Plants, Medicinal - chemistry | Liver - metabolism | Glycyrrhiza - chemistry | Protein Tyrosine Phosphatase, Non-Receptor Type 1 - antagonists & inhibitors | Pyrrolizidine Alkaloids - chemistry | Influenza A Virus, H1N1 Subtype - drug effects | Hep G2 Cells | Animals | Drugs, Chinese Herbal - chemistry | Plant Roots - chemistry | Lipopolysaccharides - pharmacology | Macrophages - drug effects | Mice | Medicine, Traditional | Index Medicus
Journal Article
Journal of Applied Physiology, ISSN 8750-7587, 06/2018, Volume 124, Issue 6, p. 1605
Mitochondrial impairments are often noted in aged skeletal muscle. The transcriptional coactivator peroxisome proliferator-activated receptor-γ coactivator-1α... 
Cytochrome | Transcription factors | Downstream effects | Methyltransferase | Contractility | Muscles | Biosynthesis | Gene expression | Muscle contraction | Recovery | Skeletal muscle | Musculoskeletal system | Signaling | Mitochondria | GA-binding protein | DNA methylation | Aging | Cytochromes | Activating transcription factor 2 | Respiration | Methylation | PGC-1 protein | Deoxyribonucleic acid--DNA | mRNA stability
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 3919 - 11
Increasing evidence indicates that Nrf-2, named the nuclear factor-erythroid 2-related factor, may perform anticancer function. In this study, a series of... 
TARGET | DRUG LEADS | NRF2 | SMALL-MOLECULE | PATHWAY | MULTIDISCIPLINARY SCIENCES | PREVENTION | ROS HOMEOSTASIS | AUTOPHAGY | IDENTIFICATION | DISCOVERY | Oxygenase | Angiogenesis | GA-binding protein | Lung | Lung cancer | Heme | Heme oxygenase (decyclizing) | Apoptosis | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 03/2017, Volume 7, Issue 1, pp. 43601 - 43601
In C. elegans, the transcription factor skinhead-1 (SKN-1), the ortholog of human NF-E2-related factor 2 (Nrf-2), plays important roles in oxidative stress... 
TRANSCRIPTION FACTOR NRF2 | BETA-N-ACETYLGLUCOSAMINE | DYNAMIC INTERPLAY | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | GLCNAC TRANSFERASE | ANTIOXIDANT RESPONSE | HISTONE CODE | NUCLEOCYTOPLASMIC PROTEINS | C. ELEGANS | POSTTRANSLATIONAL MODIFICATION | Oxidative stress | Phosphorylation | GA-binding protein | Life span | Intestine | Genes | Nematodes | Skin | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2013, Volume 8, Issue 3, pp. e59843 - e59843
Oxidative damage plays a critical role in many diseases of the central nervous system. This study was conducted to determine the molecular mechanisms involved... 
NEURONAL SURVIVAL | CORTICAL-NEURONS | OXIDATIVE DAMAGE | NRF2 | MULTIDISCIPLINARY SCIENCES | FOCAL CEREBRAL-ISCHEMIA | MOUSE | HEME OXYGENASE-1 GENE | DIETARY ANTIOXIDANTS | GLUTATHIONE S-TRANSFERASE | EXPRESSION | Phosphorylation | Oxidative Stress | Antioxidants - metabolism | Cells, Cultured - cytology | Male | Neurons - cytology | Oxygen - metabolism | Cell Nucleus - metabolism | Neuroprotective Agents - pharmacology | Chromones - pharmacology | Proto-Oncogene Proteins c-akt - metabolism | Ischemia - pathology | Animals, Newborn | Curcumin - pharmacology | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Rats, Sprague-Dawley | Brain - drug effects | Animals | Brain Ischemia - drug therapy | Brain Ischemia - pathology | Brain - pathology | Glucose - metabolism | NAD(P)H Dehydrogenase (Quinone) - metabolism | GA-Binding Protein Transcription Factor - metabolism | Brain | Neurons | Injuries | Occlusion | Neuroprotection | Oxidative stress | Traumatic brain injury | Central nervous system | AKT protein | Kinases | Experiments | Antioxidants | Head injuries | Ischemia | Cerebral blood flow | Rodents | Curcumin | Enzymes | Deprivation | Stroke | Quinone | Cortex | Gene expression | NAD | Pathology | Injury prevention | Cell injury | Molecular modelling | Brain damage | Brain injury | Cancer | Index Medicus
Journal Article