Insect Biochemistry and Molecular Biology, ISSN 0965-1748, 04/2013, Volume 43, Issue 4, pp. 366 - 375
The RDL GABA receptor is an attractive target of insecticides. Here we demonstrate that meta-diamides [3-benzamido-...
A2′ mutation | Meta-diamide | RDL GABA receptor | Insecticide | A2' mutation | DIELDRIN RESISTANCE | POINT MUTATION | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIPRONIL RESISTANCE | IDENTIFICATION | ENTOMOLOGY | DROSOPHILA | A2 ' mutation | MOLECULAR-CLONING | GAMMA-AMINOBUTYRIC-ACID | BINDING | SUBUNIT | Drosophila - drug effects | Insecticides - chemistry | Drosophila - chemistry | Molecular Sequence Data | Diamide - pharmacology | Diamide - metabolism | Spodoptera - drug effects | Binding Sites | Insect Proteins - metabolism | GABA Antagonists - chemistry | Drosophila - genetics | GABA Antagonists - metabolism | Insecticides - pharmacology | Amino Acid Sequence | Receptors, GABA - genetics | Spodoptera - chemistry | Insect Proteins - genetics | Insect Proteins - antagonists & inhibitors | GABA Antagonists - pharmacology | Sequence Alignment | Animals | Insecticides - metabolism | Receptors, GABA - chemistry | Spodoptera - metabolism | Insect Proteins - chemistry | Diamide - chemistry | Receptors, GABA - metabolism | Protein Binding | Drosophila - metabolism | Spodoptera - genetics | GABA | Insecticides | Analysis
A2′ mutation | Meta-diamide | RDL GABA receptor | Insecticide | A2' mutation | DIELDRIN RESISTANCE | POINT MUTATION | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | FIPRONIL RESISTANCE | IDENTIFICATION | ENTOMOLOGY | DROSOPHILA | A2 ' mutation | MOLECULAR-CLONING | GAMMA-AMINOBUTYRIC-ACID | BINDING | SUBUNIT | Drosophila - drug effects | Insecticides - chemistry | Drosophila - chemistry | Molecular Sequence Data | Diamide - pharmacology | Diamide - metabolism | Spodoptera - drug effects | Binding Sites | Insect Proteins - metabolism | GABA Antagonists - chemistry | Drosophila - genetics | GABA Antagonists - metabolism | Insecticides - pharmacology | Amino Acid Sequence | Receptors, GABA - genetics | Spodoptera - chemistry | Insect Proteins - genetics | Insect Proteins - antagonists & inhibitors | GABA Antagonists - pharmacology | Sequence Alignment | Animals | Insecticides - metabolism | Receptors, GABA - chemistry | Spodoptera - metabolism | Insect Proteins - chemistry | Diamide - chemistry | Receptors, GABA - metabolism | Protein Binding | Drosophila - metabolism | Spodoptera - genetics | GABA | Insecticides | Analysis
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2015, Volume 764, pp. 497 - 507
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds...
Benzothiophene | Nootropic agents | GABA | GABA A antagonist | Isoquinoline | Extrasynaptic receptors | 2,3-Benzodiazepine | Object recognition test | SUBTYPES | GARA | SUBUNIT COMPOSITION | A RECEPTORS | PYRAMIDAL NEURONS | GABA(A) antagonist | PHARMACOLOGY | ANIMAL-MODELS | ION-CHANNEL | PHARMACOLOGY & PHARMACY | RAT-BRAIN | ANTAGONISTS | TONIC INHIBITION | Capillary Permeability | Seizures - prevention & control | Benzodiazepines - chemical synthesis | Nootropic Agents - metabolism | Humans | Motor Activity - drug effects | Male | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Anticonvulsants - pharmacology | Seizures - chemically induced | Dose-Response Relationship, Drug | HEK293 Cells | Receptors, GABA-A - drug effects | Behavior, Animal - drug effects | Molecular Structure | Benzodiazepines - metabolism | Disease Models, Animal | GABA-A Receptor Antagonists - pharmacology | Benzodiazepines - pharmacology | Anticonvulsants - chemical synthesis | Xenopus laevis | Anticonvulsants - metabolism | Nootropic Agents - chemical synthesis | Rats, Sprague-Dawley | Anticonvulsants - toxicity | Blood-Brain Barrier - metabolism | GABA-A Receptor Antagonists - chemical synthesis | Nootropic Agents - toxicity | Animals | Recognition (Psychology) - drug effects | Benzodiazepines - toxicity | Receptors, GABA-A - genetics | Mice | Pentylenetetrazole | Receptors, GABA-A - metabolism | GABA-A Receptor Antagonists - toxicity | Nootropic Agents - pharmacology
Benzothiophene | Nootropic agents | GABA | GABA A antagonist | Isoquinoline | Extrasynaptic receptors | 2,3-Benzodiazepine | Object recognition test | SUBTYPES | GARA | SUBUNIT COMPOSITION | A RECEPTORS | PYRAMIDAL NEURONS | GABA(A) antagonist | PHARMACOLOGY | ANIMAL-MODELS | ION-CHANNEL | PHARMACOLOGY & PHARMACY | RAT-BRAIN | ANTAGONISTS | TONIC INHIBITION | Capillary Permeability | Seizures - prevention & control | Benzodiazepines - chemical synthesis | Nootropic Agents - metabolism | Humans | Motor Activity - drug effects | Male | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Anticonvulsants - pharmacology | Seizures - chemically induced | Dose-Response Relationship, Drug | HEK293 Cells | Receptors, GABA-A - drug effects | Behavior, Animal - drug effects | Molecular Structure | Benzodiazepines - metabolism | Disease Models, Animal | GABA-A Receptor Antagonists - pharmacology | Benzodiazepines - pharmacology | Anticonvulsants - chemical synthesis | Xenopus laevis | Anticonvulsants - metabolism | Nootropic Agents - chemical synthesis | Rats, Sprague-Dawley | Anticonvulsants - toxicity | Blood-Brain Barrier - metabolism | GABA-A Receptor Antagonists - chemical synthesis | Nootropic Agents - toxicity | Animals | Recognition (Psychology) - drug effects | Benzodiazepines - toxicity | Receptors, GABA-A - genetics | Mice | Pentylenetetrazole | Receptors, GABA-A - metabolism | GABA-A Receptor Antagonists - toxicity | Nootropic Agents - pharmacology
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 08/2005, Volume 25, Issue 34, pp. 7724 - 7733
During status epilepticus ( SE), GABAergic mechanisms fail and seizures become self-sustaining and pharmacoresistant. During lithium-pilocarpine-induced SE,...
epilepsy | math model | hippocampus | GABAERGIC INHIBITION | synaptic inhibition | GABA(A) receptor trafficking | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | status epilepticus | A RECEPTORS | ELECTRICAL-STIMULATION | SUSTAINING STATUS EPILEPTICUS | KINASE-C ACTIVITY | CALCINEURIN ACTIVITY | GAMMA-AMINOBUTYRIC-ACID | GABA Antagonists - metabolism | Synaptic Transmission - physiology | GABA-A Receptor Antagonists | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Rats | Status Epilepticus - drug therapy | gamma-Aminobutyric Acid - pharmacology | Male | Protein Transport - physiology | Protein Transport - drug effects | GABA Antagonists - therapeutic use | GABA Antagonists - pharmacology | GABA-A Receptor Agonists | Neural Inhibition - physiology | Animals | Drug Resistance - physiology | Synaptic Transmission - drug effects | Receptors, GABA-A - metabolism | Status Epilepticus - metabolism | Neural Inhibition - drug effects
epilepsy | math model | hippocampus | GABAERGIC INHIBITION | synaptic inhibition | GABA(A) receptor trafficking | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | status epilepticus | A RECEPTORS | ELECTRICAL-STIMULATION | SUSTAINING STATUS EPILEPTICUS | KINASE-C ACTIVITY | CALCINEURIN ACTIVITY | GAMMA-AMINOBUTYRIC-ACID | GABA Antagonists - metabolism | Synaptic Transmission - physiology | GABA-A Receptor Antagonists | Rats, Wistar | gamma-Aminobutyric Acid - metabolism | Rats | Status Epilepticus - drug therapy | gamma-Aminobutyric Acid - pharmacology | Male | Protein Transport - physiology | Protein Transport - drug effects | GABA Antagonists - therapeutic use | GABA Antagonists - pharmacology | GABA-A Receptor Agonists | Neural Inhibition - physiology | Animals | Drug Resistance - physiology | Synaptic Transmission - drug effects | Receptors, GABA-A - metabolism | Status Epilepticus - metabolism | Neural Inhibition - drug effects
Journal Article
Neuron, ISSN 0896-6273, 03/2014, Volume 81, Issue 5, pp. 1084 - 1096
NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and GluN3 subunits. Two different GluN2 subunits have been identified in...
GLUTAMATE BINDING-SITE | TERMINAL DOMAIN | D-ASPARTATE RECEPTORS | RAT CORTICAL-NEURONS | ZINC INHIBITION | MOLECULAR DETERMINANTS | SYNAPTIC CURRENTS | NR2A SUBUNIT | GABA(B) RECEPTOR | NEUROSCIENCES | HIPPOCAMPAL SYNAPSES | Excitatory Amino Acid Antagonists - metabolism | Piperidines - metabolism | Humans | Xenopus laevis | Glutamic Acid - physiology | Rats | Recombinant Proteins - chemistry | Excitatory Amino Acid Antagonists - pharmacology | Recombinant Proteins - genetics | Trace Elements - pharmacology | Sulfonamides - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Oocytes - cytology | Patch-Clamp Techniques | Animals | Piperidines - pharmacology | Receptors, N-Methyl-D-Aspartate - chemistry | HEK293 Cells | Zinc - pharmacology | Dimerization | Protein Binding - physiology | Zinc compounds | Methyl aspartate | Glutamate | Analysis | Medical colleges | Yuan (China) | Peptides | Retention | Endoplasmic reticulum | Rodents
GLUTAMATE BINDING-SITE | TERMINAL DOMAIN | D-ASPARTATE RECEPTORS | RAT CORTICAL-NEURONS | ZINC INHIBITION | MOLECULAR DETERMINANTS | SYNAPTIC CURRENTS | NR2A SUBUNIT | GABA(B) RECEPTOR | NEUROSCIENCES | HIPPOCAMPAL SYNAPSES | Excitatory Amino Acid Antagonists - metabolism | Piperidines - metabolism | Humans | Xenopus laevis | Glutamic Acid - physiology | Rats | Recombinant Proteins - chemistry | Excitatory Amino Acid Antagonists - pharmacology | Recombinant Proteins - genetics | Trace Elements - pharmacology | Sulfonamides - pharmacology | Receptors, N-Methyl-D-Aspartate - physiology | Receptors, N-Methyl-D-Aspartate - genetics | Oocytes - cytology | Patch-Clamp Techniques | Animals | Piperidines - pharmacology | Receptors, N-Methyl-D-Aspartate - chemistry | HEK293 Cells | Zinc - pharmacology | Dimerization | Protein Binding - physiology | Zinc compounds | Methyl aspartate | Glutamate | Analysis | Medical colleges | Yuan (China) | Peptides | Retention | Endoplasmic reticulum | Rodents
Journal Article
Neuroscience Letters, ISSN 0304-3940, 01/2012, Volume 506, Issue 2, pp. 322 - 326
The bile steroids (BS) cholic acid and chenodeoxycholic acid are produced in hepatocytes and in the brain. Nothing is known about neuronal actions of BS....
Histamine | AMPA | GABA | NMDA | Hypothalamus | Patch-clamp | Bile salts | ACIDS | NEURONS | PREGNENOLONE SULFATE | NEUROSCIENCES | BRAIN | Animals, Newborn | Excitatory Amino Acid Antagonists - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, N-Methyl-D-Aspartate - metabolism | Excitatory Amino Acid Antagonists - pharmacology | GABA-A Receptor Antagonists - metabolism | Patch-Clamp Techniques | Animals | Hypothalamus - metabolism | Chenodeoxycholic Acid - metabolism | Chenodeoxycholic Acid - pharmacology | Mice | Neurons - metabolism | Receptors, GABA-A - metabolism | Hypothalamus - drug effects | Neurons - drug effects | GABA-A Receptor Antagonists - pharmacology
Histamine | AMPA | GABA | NMDA | Hypothalamus | Patch-clamp | Bile salts | ACIDS | NEURONS | PREGNENOLONE SULFATE | NEUROSCIENCES | BRAIN | Animals, Newborn | Excitatory Amino Acid Antagonists - metabolism | Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors | Receptors, N-Methyl-D-Aspartate - metabolism | Excitatory Amino Acid Antagonists - pharmacology | GABA-A Receptor Antagonists - metabolism | Patch-Clamp Techniques | Animals | Hypothalamus - metabolism | Chenodeoxycholic Acid - metabolism | Chenodeoxycholic Acid - pharmacology | Mice | Neurons - metabolism | Receptors, GABA-A - metabolism | Hypothalamus - drug effects | Neurons - drug effects | GABA-A Receptor Antagonists - pharmacology
Journal Article
Journal of Agricultural and Food Chemistry, ISSN 0021-8561, 02/2014, Volume 62, Issue 5, pp. 1019 - 1024
Isoxazoline insecticides, such as fluralaner (formerly A1443), are noncompetitive γ-aminobutyric acid (GABA) receptor (GABA-R) antagonists with selective...
human β | chloride channel | house fly | GABA receptor | homopentamer | isoxazoline | avermectin | honeybee | TARGET | HEAD | RADIOLIGAND | FOOD SCIENCE & TECHNOLOGY | human beta homopentamer | GATED CHLORIDE CHANNEL | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | BRAIN | GABA Antagonists - metabolism | Insecticides - chemistry | GABA Antagonists - toxicity | Houseflies - genetics | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Houseflies - drug effects | Androstenols - toxicity | Insect Proteins - antagonists & inhibitors | Animals | Bridged Bicyclo Compounds, Heterocyclic - toxicity | Houseflies - metabolism | Androstenols - chemistry | Receptors, GABA - metabolism | Binding Sites | Insect Proteins - metabolism | Insecticides - toxicity | GABA Antagonists - chemistry | Index Medicus
human β | chloride channel | house fly | GABA receptor | homopentamer | isoxazoline | avermectin | honeybee | TARGET | HEAD | RADIOLIGAND | FOOD SCIENCE & TECHNOLOGY | human beta homopentamer | GATED CHLORIDE CHANNEL | AGRICULTURE, MULTIDISCIPLINARY | CHEMISTRY, APPLIED | BRAIN | GABA Antagonists - metabolism | Insecticides - chemistry | GABA Antagonists - toxicity | Houseflies - genetics | Bridged Bicyclo Compounds, Heterocyclic - chemistry | Houseflies - drug effects | Androstenols - toxicity | Insect Proteins - antagonists & inhibitors | Animals | Bridged Bicyclo Compounds, Heterocyclic - toxicity | Houseflies - metabolism | Androstenols - chemistry | Receptors, GABA - metabolism | Binding Sites | Insect Proteins - metabolism | Insecticides - toxicity | GABA Antagonists - chemistry | Index Medicus
Journal Article
Molecular and Cellular Neuroscience, ISSN 1044-7431, 2010, Volume 43, Issue 1, pp. 146 - 156
Activity-regulated gene expression is believed to play a key role in the development and refinement of neuronal circuitry. Nevertheless, the transcriptional...
RHO-FAMILY GTPASES | MORPHOGENESIS | PYRAMIDAL NEURONS | RETT-SYNDROME | SYNAPSES | GTPASE-ACTIVATING-PROTEIN | NUCLEOTIDE EXCHANGE FACTOR | BINDING-PROTEIN | RECEPTOR | NEUROSCIENCES | TERM SYNAPTIC PLASTICITY | GABA Antagonists - metabolism | Guanine Nucleotide Exchange Factors - genetics | p21-Activated Kinases - genetics | Synapses - physiology | Cells, Cultured | Dendritic Spines - physiology | Rats | MicroRNAs - metabolism | Neurons - cytology | Hippocampus - cytology | p21-Activated Kinases - metabolism | Rats, Sprague-Dawley | Bicuculline - metabolism | Animals | Guanine Nucleotide Exchange Factors - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | MicroRNAs - genetics | Neurons - metabolism | rac1 GTP-Binding Protein - metabolism | Dendritic Spines - ultrastructure | rac1 GTP-Binding Protein - genetics | Gene expression | Muscle proteins | Developmental biology | Actin | Stem cells
RHO-FAMILY GTPASES | MORPHOGENESIS | PYRAMIDAL NEURONS | RETT-SYNDROME | SYNAPSES | GTPASE-ACTIVATING-PROTEIN | NUCLEOTIDE EXCHANGE FACTOR | BINDING-PROTEIN | RECEPTOR | NEUROSCIENCES | TERM SYNAPTIC PLASTICITY | GABA Antagonists - metabolism | Guanine Nucleotide Exchange Factors - genetics | p21-Activated Kinases - genetics | Synapses - physiology | Cells, Cultured | Dendritic Spines - physiology | Rats | MicroRNAs - metabolism | Neurons - cytology | Hippocampus - cytology | p21-Activated Kinases - metabolism | Rats, Sprague-Dawley | Bicuculline - metabolism | Animals | Guanine Nucleotide Exchange Factors - metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Signal Transduction - physiology | MicroRNAs - genetics | Neurons - metabolism | rac1 GTP-Binding Protein - metabolism | Dendritic Spines - ultrastructure | rac1 GTP-Binding Protein - genetics | Gene expression | Muscle proteins | Developmental biology | Actin | Stem cells
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10800 - 10806
1,4-Benzodiazepines are used in the treatment of anxiety disorders but have limited long-term use due to adverse effects. HZ-166 (2) has been shown to have...
SUBTYPE | CHEMISTRY, MEDICINAL | PAIN | BENZODIAZEPINE SITE LIGANDS | L-838417 | ANXIETY | PHARMACOLOGY | SELECTIVE PARTIAL AGONIST | NS11394 | MICE | Anti-Anxiety Agents - metabolism | Humans | Imidazoles - chemistry | GABA-A Receptor Antagonists - chemistry | Male | Anxiety - drug therapy | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Oxazoles - chemistry | Dose-Response Relationship, Drug | Pain - drug therapy | HEK293 Cells | Anti-Anxiety Agents - chemistry | Molecular Structure | Benzodiazepines - metabolism | GABA-A Receptor Antagonists - pharmacology | Imidazoles - metabolism | Oxazoles - metabolism | Benzodiazepines - pharmacology | Anti-Anxiety Agents - pharmacology | Rats | Imidazoles - pharmacology | Mice, Inbred Strains | Rats, Sprague-Dawley | Animals | Benzodiazepines - chemistry | Epilepsy - drug therapy | Ligands | Mice | Oxazoles - pharmacology | Receptors, GABA-A - metabolism
SUBTYPE | CHEMISTRY, MEDICINAL | PAIN | BENZODIAZEPINE SITE LIGANDS | L-838417 | ANXIETY | PHARMACOLOGY | SELECTIVE PARTIAL AGONIST | NS11394 | MICE | Anti-Anxiety Agents - metabolism | Humans | Imidazoles - chemistry | GABA-A Receptor Antagonists - chemistry | Male | Anxiety - drug therapy | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Oxazoles - chemistry | Dose-Response Relationship, Drug | Pain - drug therapy | HEK293 Cells | Anti-Anxiety Agents - chemistry | Molecular Structure | Benzodiazepines - metabolism | GABA-A Receptor Antagonists - pharmacology | Imidazoles - metabolism | Oxazoles - metabolism | Benzodiazepines - pharmacology | Anti-Anxiety Agents - pharmacology | Rats | Imidazoles - pharmacology | Mice, Inbred Strains | Rats, Sprague-Dawley | Animals | Benzodiazepines - chemistry | Epilepsy - drug therapy | Ligands | Mice | Oxazoles - pharmacology | Receptors, GABA-A - metabolism
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2006, Volume 103, Issue 13, pp. 5185 - 5190
Several major insecticides, including α-endosulfan, lindane, and fipronil, and the botanical picrotoxinin are noncompetitive antagonists (NCAs) for the GABA...
Hydroxyls | Receptors | Oxygen | Mutagenesis | GABA receptors | Disulfides | Insecticides | Ligands | Insect control | Binding sites | CONSERVED M2 LEUCINE | PICROTOXIN | MECHANISM | MEMBRANE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | insecticide | transmembrane 2 | GATED CHLORIDE CHANNEL | receptor model | GABA(A) RECEPTORS | disulfide trapping | CYSTEINE MUTANTS | beta 3 homopentamer | BRAIN | SUBUNIT | Nitriles - pharmacology | Humans | Molecular Sequence Data | Structure-Activity Relationship | Protein Subunits - metabolism | Protein Structure, Quaternary | Binding Sites | Bridged Bicyclo Compounds, Heterocyclic - metabolism | GABA Antagonists - chemistry | GABA Antagonists - metabolism | Amino Acid Sequence | Cell Line | Nitriles - metabolism | Gene Expression | Bridged Bicyclo Compounds - pharmacology | Receptors, GABA - genetics | Drosophila | Models, Molecular | Rats | Mutation - genetics | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Sequence Alignment | Animals | Receptors, GABA - chemistry | Bridged Bicyclo Compounds - metabolism | Receptors, GABA - metabolism | Protein Binding | Protein Subunits - chemistry | Biological Sciences | β3 homopentamer
Hydroxyls | Receptors | Oxygen | Mutagenesis | GABA receptors | Disulfides | Insecticides | Ligands | Insect control | Binding sites | CONSERVED M2 LEUCINE | PICROTOXIN | MECHANISM | MEMBRANE | MULTIDISCIPLINARY SCIENCES | HIGH-AFFINITY | insecticide | transmembrane 2 | GATED CHLORIDE CHANNEL | receptor model | GABA(A) RECEPTORS | disulfide trapping | CYSTEINE MUTANTS | beta 3 homopentamer | BRAIN | SUBUNIT | Nitriles - pharmacology | Humans | Molecular Sequence Data | Structure-Activity Relationship | Protein Subunits - metabolism | Protein Structure, Quaternary | Binding Sites | Bridged Bicyclo Compounds, Heterocyclic - metabolism | GABA Antagonists - chemistry | GABA Antagonists - metabolism | Amino Acid Sequence | Cell Line | Nitriles - metabolism | Gene Expression | Bridged Bicyclo Compounds - pharmacology | Receptors, GABA - genetics | Drosophila | Models, Molecular | Rats | Mutation - genetics | Bridged Bicyclo Compounds, Heterocyclic - pharmacology | Sequence Alignment | Animals | Receptors, GABA - chemistry | Bridged Bicyclo Compounds - metabolism | Receptors, GABA - metabolism | Protein Binding | Protein Subunits - chemistry | Biological Sciences | β3 homopentamer
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2011, Volume 589, Issue 14, pp. 3641 - 3658
Non‐technical summary Shivering is an involuntary somatic motor response that occurs in skeletal muscles to produce heat during exposure to cold environments...
PHYSIOLOGY | NONSHIVERING THERMOGENESIS | 5-HT1A RECEPTORS | SYMPATHETIC PREMOTOR NEURONS | SPINAL-CORD | DORSOMEDIAL HYPOTHALAMUS | BROWN ADIPOSE-TISSUE | EXPRESSING PREOPTIC NEURONS | BODY-TEMPERATURE | NEUROSCIENCES | PROSTAGLANDIN EP3 RECEPTOR | RAPHE PALLIDUS | Skin Temperature - physiology | Neural Pathways - drug effects | Efferent Pathways - physiology | Fever - metabolism | Male | Preoptic Area - metabolism | Neural Pathways - physiology | Fever - physiopathology | N-Methylaspartate - pharmacology | Neurons - metabolism | Medulla Oblongata - physiology | Preoptic Area - physiology | Dinoprostone - pharmacology | Body Temperature Regulation - physiology | Shivering - physiology | Rats | Mediodorsal Thalamic Nucleus - drug effects | Tachycardia - metabolism | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Neural Pathways - metabolism | Adipose Tissue, Brown - drug effects | Receptors, GABA-A - metabolism | Muscimol - pharmacology | Rats, Wistar | Preoptic Area - drug effects | Sympathetic Nervous System - drug effects | GABA-A Receptor Antagonists - metabolism | Sympathetic Nervous System - metabolism | Raphe Nuclei - metabolism | Thermogenesis - physiology | Heart Rate - drug effects | Mediodorsal Thalamic Nucleus - metabolism | Sympathetic Nervous System - physiology | Shivering - drug effects | Neurons - physiology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Tachycardia - pathology | Mediodorsal Thalamic Nucleus - physiology | Neurons - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Cold Temperature | Medulla Oblongata - drug effects | Medulla Oblongata - metabolism | Adipose Tissue, Brown - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Efferent Pathways - metabolism | Animals | Thermogenesis - drug effects | GABA | Heart beat | Neurons | Analysis | Prostaglandins E | Heart rate | Skin | Cooling | Thermogenesis | Cold | Rodents | Integrative
PHYSIOLOGY | NONSHIVERING THERMOGENESIS | 5-HT1A RECEPTORS | SYMPATHETIC PREMOTOR NEURONS | SPINAL-CORD | DORSOMEDIAL HYPOTHALAMUS | BROWN ADIPOSE-TISSUE | EXPRESSING PREOPTIC NEURONS | BODY-TEMPERATURE | NEUROSCIENCES | PROSTAGLANDIN EP3 RECEPTOR | RAPHE PALLIDUS | Skin Temperature - physiology | Neural Pathways - drug effects | Efferent Pathways - physiology | Fever - metabolism | Male | Preoptic Area - metabolism | Neural Pathways - physiology | Fever - physiopathology | N-Methylaspartate - pharmacology | Neurons - metabolism | Medulla Oblongata - physiology | Preoptic Area - physiology | Dinoprostone - pharmacology | Body Temperature Regulation - physiology | Shivering - physiology | Rats | Mediodorsal Thalamic Nucleus - drug effects | Tachycardia - metabolism | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Neural Pathways - metabolism | Adipose Tissue, Brown - drug effects | Receptors, GABA-A - metabolism | Muscimol - pharmacology | Rats, Wistar | Preoptic Area - drug effects | Sympathetic Nervous System - drug effects | GABA-A Receptor Antagonists - metabolism | Sympathetic Nervous System - metabolism | Raphe Nuclei - metabolism | Thermogenesis - physiology | Heart Rate - drug effects | Mediodorsal Thalamic Nucleus - metabolism | Sympathetic Nervous System - physiology | Shivering - drug effects | Neurons - physiology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Tachycardia - pathology | Mediodorsal Thalamic Nucleus - physiology | Neurons - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Cold Temperature | Medulla Oblongata - drug effects | Medulla Oblongata - metabolism | Adipose Tissue, Brown - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Efferent Pathways - metabolism | Animals | Thermogenesis - drug effects | GABA | Heart beat | Neurons | Analysis | Prostaglandins E | Heart rate | Skin | Cooling | Thermogenesis | Cold | Rodents | Integrative
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2016, Volume 6, Issue 1, p. 26181
The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease...
SODIUM | VOLTAGE | PHENYTOIN | MULTIDISCIPLINARY SCIENCES | PATTERNS | MECHANISMS | INDUCTION | MULTIELECTRODE ARRAY | MICROELECTRODE ARRAYS | CEREBRAL-CORTEX | PLASTICITY | Excitatory Amino Acid Antagonists - metabolism | GABA Antagonists - metabolism | Excitatory Amino Acid Agonists - metabolism | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Cells, Cultured | GABA Agonists - metabolism | Action Potentials | Animals | Time Factors | Nerve Net | Lepidoptera | Neurons - physiology | Cell Differentiation | Electrophysiological Phenomena | Neurons - drug effects | Organ Culture Techniques | Cell culture | γ-Aminobutyric acid | Developmental stages | Neural networks | Epilepsy | Cortex | Standardization | Stem cells | Neural stem cells | Glutamatergic transmission | Drug screening | Pluripotency
SODIUM | VOLTAGE | PHENYTOIN | MULTIDISCIPLINARY SCIENCES | PATTERNS | MECHANISMS | INDUCTION | MULTIELECTRODE ARRAY | MICROELECTRODE ARRAYS | CEREBRAL-CORTEX | PLASTICITY | Excitatory Amino Acid Antagonists - metabolism | GABA Antagonists - metabolism | Excitatory Amino Acid Agonists - metabolism | Induced Pluripotent Stem Cells - drug effects | Induced Pluripotent Stem Cells - physiology | Cells, Cultured | GABA Agonists - metabolism | Action Potentials | Animals | Time Factors | Nerve Net | Lepidoptera | Neurons - physiology | Cell Differentiation | Electrophysiological Phenomena | Neurons - drug effects | Organ Culture Techniques | Cell culture | γ-Aminobutyric acid | Developmental stages | Neural networks | Epilepsy | Cortex | Standardization | Stem cells | Neural stem cells | Glutamatergic transmission | Drug screening | Pluripotency
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2017, Volume 56, Issue 1, pp. 193 - 197
Caged neurotransmitters, in combination with focused light beams, enable precise interrogation of neuronal function, even at the level of single synapses....
two-photon photolysis | GABA-A receptors | biologically inert | optical methods | caged compounds | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | DENDRITIC SPINES | VISIBLE-LIGHT | INHIBITION | GLUTAMATE | CALCIUM | GABA | GAMMA-AMINOBUTYRIC-ACID | PHOTOLYSIS | RECEPTORS | Dendrimers - metabolism | gamma-Aminobutyric Acid - metabolism | Cells, Cultured | GABA-A Receptor Antagonists - chemistry | gamma-Aminobutyric Acid - pharmacology | Male | Neurons - cytology | Photons | GABA-A Receptor Antagonists - metabolism | Animals | Microscopy, Fluorescence - methods | Photolysis | Dendrimers - chemistry | Female | Mice | Neurons - metabolism | Dendrimers - pharmacology | Neurons - drug effects | gamma-Aminobutyric Acid - analogs & derivatives | Optical Imaging - methods | GABA-A Receptor Antagonists - pharmacology | Investigations | Neurophysiology | Cage compounds | Photon beams | Antagonists | Signaling | Antagonism | Receptors | γ-Aminobutyric acid | Neurotransmitters | Transmitters | Light beams | Microscopy | Interrogation | Conjugation | Synapses | two-photon
two-photon photolysis | GABA-A receptors | biologically inert | optical methods | caged compounds | MICROSCOPY | CHEMISTRY, MULTIDISCIPLINARY | DENDRITIC SPINES | VISIBLE-LIGHT | INHIBITION | GLUTAMATE | CALCIUM | GABA | GAMMA-AMINOBUTYRIC-ACID | PHOTOLYSIS | RECEPTORS | Dendrimers - metabolism | gamma-Aminobutyric Acid - metabolism | Cells, Cultured | GABA-A Receptor Antagonists - chemistry | gamma-Aminobutyric Acid - pharmacology | Male | Neurons - cytology | Photons | GABA-A Receptor Antagonists - metabolism | Animals | Microscopy, Fluorescence - methods | Photolysis | Dendrimers - chemistry | Female | Mice | Neurons - metabolism | Dendrimers - pharmacology | Neurons - drug effects | gamma-Aminobutyric Acid - analogs & derivatives | Optical Imaging - methods | GABA-A Receptor Antagonists - pharmacology | Investigations | Neurophysiology | Cage compounds | Photon beams | Antagonists | Signaling | Antagonism | Receptors | γ-Aminobutyric acid | Neurotransmitters | Transmitters | Light beams | Microscopy | Interrogation | Conjugation | Synapses | two-photon
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 03/2017, Volume 798, pp. 129 - 136
The neurotransmitter gamma-amino butyric acid (GABA) has a fundamental role in CNS function and ionotropic (GABA(A)) receptors that mediate many of the actions...
SUBTYPES | Loop -F | Extrasynaptic receptors | AMINOBUTYRIC ACID(A) RECEPTORS | PRINCIPLES | GABA(A) antagonists | Molecular modelling | Nootropic agents | ANXIOLYTICS | CHANNEL ACTIVATION | MUTATION | GABA | PHARMACOLOGY & PHARMACY | RECOGNITION MEMORY | BINDING | MODULATION | AGONIST | Binding, Competitive | Benzodiazepines - pharmacology | gamma-Aminobutyric Acid - metabolism | Humans | GABA-A Receptor Antagonists - chemistry | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Receptors, GABA-A - chemistry | Oxazoles - chemistry | Protein Subunits - metabolism | Computer Simulation | HEK293 Cells | Benzodiazepines - chemistry | Protein Conformation | Molecular Docking Simulation | Protein Subunits - chemistry | Receptors, GABA-A - metabolism | Benzodiazepines - metabolism | GABA-A Receptor Antagonists - pharmacology
SUBTYPES | Loop -F | Extrasynaptic receptors | AMINOBUTYRIC ACID(A) RECEPTORS | PRINCIPLES | GABA(A) antagonists | Molecular modelling | Nootropic agents | ANXIOLYTICS | CHANNEL ACTIVATION | MUTATION | GABA | PHARMACOLOGY & PHARMACY | RECOGNITION MEMORY | BINDING | MODULATION | AGONIST | Binding, Competitive | Benzodiazepines - pharmacology | gamma-Aminobutyric Acid - metabolism | Humans | GABA-A Receptor Antagonists - chemistry | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Receptors, GABA-A - chemistry | Oxazoles - chemistry | Protein Subunits - metabolism | Computer Simulation | HEK293 Cells | Benzodiazepines - chemistry | Protein Conformation | Molecular Docking Simulation | Protein Subunits - chemistry | Receptors, GABA-A - metabolism | Benzodiazepines - metabolism | GABA-A Receptor Antagonists - pharmacology
Journal Article
Nature Neuroscience, ISSN 1097-6256, 05/2003, Volume 6, Issue 5, pp. 484 - 490
GABA(A) receptors can mediate both 'phasic' synaptic inhibition and a persistent 'tonic' form of signaling. We show that, in the presence of intact GABA...
SYNAPTIC INHIBITION | PERSISTENT ACTIVATION | PYRAMIDAL NEURONS | DELTA-SUBUNIT | TEMPORAL-LOBE EPILEPSY | HIGH-AFFINITY | RAT-BRAIN-SLICES | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | RECEPTOR CHANNELS | GABA Antagonists - metabolism | Pyramidal Cells - metabolism | Guinea Pigs | Synaptic Transmission - physiology | GABA-A Receptor Antagonists | gamma-Aminobutyric Acid - metabolism | Interneurons - drug effects | Hippocampus - drug effects | Hippocampus - cytology | GABA Antagonists - pharmacology | gamma-Aminobutyric Acid - physiology | GABA-A Receptor Agonists | Hippocampus - metabolism | Neural Inhibition - physiology | Animals | Interneurons - metabolism | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Receptors, GABA-A - metabolism | Neural Inhibition - drug effects | GABA | Physiological aspects | Receptors | Research | Neurons
SYNAPTIC INHIBITION | PERSISTENT ACTIVATION | PYRAMIDAL NEURONS | DELTA-SUBUNIT | TEMPORAL-LOBE EPILEPSY | HIGH-AFFINITY | RAT-BRAIN-SLICES | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | CEREBELLAR GRANULE CELLS | RECEPTOR CHANNELS | GABA Antagonists - metabolism | Pyramidal Cells - metabolism | Guinea Pigs | Synaptic Transmission - physiology | GABA-A Receptor Antagonists | gamma-Aminobutyric Acid - metabolism | Interneurons - drug effects | Hippocampus - drug effects | Hippocampus - cytology | GABA Antagonists - pharmacology | gamma-Aminobutyric Acid - physiology | GABA-A Receptor Agonists | Hippocampus - metabolism | Neural Inhibition - physiology | Animals | Interneurons - metabolism | Synaptic Transmission - drug effects | Pyramidal Cells - drug effects | Receptors, GABA-A - metabolism | Neural Inhibition - drug effects | GABA | Physiological aspects | Receptors | Research | Neurons
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 08/2017, Volume 24, Issue 27, pp. 2935 - 2945
Background: gamma-Aminobutyric acid (GABA) receptors play a central role in fast inhibitory neurotransmission in insects. Several classes of insecticides...
Resistance | Insecticide | Isoxazolines | Macrocyclic lactones | Phenylpyrazoles | Toxicity | Metadiamides | GABA receptor | Polychlorocycloalkanes | Cyclodienes | cyclodienes | isoxazolines | toxicity | FIPRONIL | CHEMISTRY, MEDICINAL | COCKROACH NEURONS | APIS-MELLIFERA | BIOCHEMISTRY & MOLECULAR BIOLOGY | insecticide | resistance | ANTENNAL LOBES | phenylpyrazoles | DROSOPHILA CELL-LINE | metadiamides | GENOME SEQUENCE | INSECTS | PHARMACOLOGY & PHARMACY | macrocyclic lactones | GAMMA-AMINOBUTYRIC-ACID | MELANOGASTER | GATED CHLORIDE CHANNELS | GABA Antagonists - metabolism | Insecticides - chemistry | Oxazoles - metabolism | GABA Antagonists - toxicity | Receptors, GABA - genetics | Humans | Recombinant Proteins - chemistry | Drug Resistance - drug effects | Pyrazoles - metabolism | Recombinant Proteins - biosynthesis | Oxazoles - chemistry | Pyrazoles - chemistry | Animals | Insecticides - metabolism | Oxazoles - toxicity | Receptors, GABA - chemistry | Pyrazoles - toxicity |
Resistance | Insecticide | Isoxazolines | Macrocyclic lactones | Phenylpyrazoles | Toxicity | Metadiamides | GABA receptor | Polychlorocycloalkanes | Cyclodienes | cyclodienes | isoxazolines | toxicity | FIPRONIL | CHEMISTRY, MEDICINAL | COCKROACH NEURONS | APIS-MELLIFERA | BIOCHEMISTRY & MOLECULAR BIOLOGY | insecticide | resistance | ANTENNAL LOBES | phenylpyrazoles | DROSOPHILA CELL-LINE | metadiamides | GENOME SEQUENCE | INSECTS | PHARMACOLOGY & PHARMACY | macrocyclic lactones | GAMMA-AMINOBUTYRIC-ACID | MELANOGASTER | GATED CHLORIDE CHANNELS | GABA Antagonists - metabolism | Insecticides - chemistry | Oxazoles - metabolism | GABA Antagonists - toxicity | Receptors, GABA - genetics | Humans | Recombinant Proteins - chemistry | Drug Resistance - drug effects | Pyrazoles - metabolism | Recombinant Proteins - biosynthesis | Oxazoles - chemistry | Pyrazoles - chemistry | Animals | Insecticides - metabolism | Oxazoles - toxicity | Receptors, GABA - chemistry | Pyrazoles - toxicity |