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Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 07/2015, Volume 764, pp. 497 - 507
Novel 2,3-benzodiazepine and related isoquinoline derivatives, substituted at position 1 with a 2-benzothiophenyl moiety, were synthesized to produce compounds... 
Benzothiophene | Nootropic agents | GABA | GABA A antagonist | Isoquinoline | Extrasynaptic receptors | 2,3-Benzodiazepine | Object recognition test | SUBTYPES | GARA | SUBUNIT COMPOSITION | A RECEPTORS | PYRAMIDAL NEURONS | GABA(A) antagonist | PHARMACOLOGY | ANIMAL-MODELS | ION-CHANNEL | PHARMACOLOGY & PHARMACY | RAT-BRAIN | ANTAGONISTS | TONIC INHIBITION | Capillary Permeability | Seizures - prevention & control | Benzodiazepines - chemical synthesis | Nootropic Agents - metabolism | Humans | Motor Activity - drug effects | Male | Structure-Activity Relationship | GABA-A Receptor Antagonists - metabolism | Anticonvulsants - pharmacology | Seizures - chemically induced | Dose-Response Relationship, Drug | HEK293 Cells | Receptors, GABA-A - drug effects | Behavior, Animal - drug effects | Molecular Structure | Benzodiazepines - metabolism | Disease Models, Animal | GABA-A Receptor Antagonists - pharmacology | Benzodiazepines - pharmacology | Anticonvulsants - chemical synthesis | Xenopus laevis | Anticonvulsants - metabolism | Nootropic Agents - chemical synthesis | Rats, Sprague-Dawley | Anticonvulsants - toxicity | Blood-Brain Barrier - metabolism | GABA-A Receptor Antagonists - chemical synthesis | Nootropic Agents - toxicity | Animals | Recognition (Psychology) - drug effects | Benzodiazepines - toxicity | Receptors, GABA-A - genetics | Mice | Pentylenetetrazole | Receptors, GABA-A - metabolism | GABA-A Receptor Antagonists - toxicity | Nootropic Agents - pharmacology
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2016, Volume 59, Issue 23, pp. 10800 - 10806
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2006, Volume 103, Issue 13, pp. 5185 - 5190
Journal Article
The Journal of Physiology, ISSN 0022-3751, 07/2011, Volume 589, Issue 14, pp. 3641 - 3658
Non‐technical summary  Shivering is an involuntary somatic motor response that occurs in skeletal muscles to produce heat during exposure to cold environments... 
PHYSIOLOGY | NONSHIVERING THERMOGENESIS | 5-HT1A RECEPTORS | SYMPATHETIC PREMOTOR NEURONS | SPINAL-CORD | DORSOMEDIAL HYPOTHALAMUS | BROWN ADIPOSE-TISSUE | EXPRESSING PREOPTIC NEURONS | BODY-TEMPERATURE | NEUROSCIENCES | PROSTAGLANDIN EP3 RECEPTOR | RAPHE PALLIDUS | Skin Temperature - physiology | Neural Pathways - drug effects | Efferent Pathways - physiology | Fever - metabolism | Male | Preoptic Area - metabolism | Neural Pathways - physiology | Fever - physiopathology | N-Methylaspartate - pharmacology | Neurons - metabolism | Medulla Oblongata - physiology | Preoptic Area - physiology | Dinoprostone - pharmacology | Body Temperature Regulation - physiology | Shivering - physiology | Rats | Mediodorsal Thalamic Nucleus - drug effects | Tachycardia - metabolism | Raphe Nuclei - drug effects | Raphe Nuclei - physiology | Neural Pathways - metabolism | Adipose Tissue, Brown - drug effects | Receptors, GABA-A - metabolism | Muscimol - pharmacology | Rats, Wistar | Preoptic Area - drug effects | Sympathetic Nervous System - drug effects | GABA-A Receptor Antagonists - metabolism | Sympathetic Nervous System - metabolism | Raphe Nuclei - metabolism | Thermogenesis - physiology | Heart Rate - drug effects | Mediodorsal Thalamic Nucleus - metabolism | Sympathetic Nervous System - physiology | Shivering - drug effects | Neurons - physiology | Heart Rate - physiology | Blood Pressure - drug effects | Blood Pressure - physiology | Tachycardia - pathology | Mediodorsal Thalamic Nucleus - physiology | Neurons - drug effects | Receptor, Serotonin, 5-HT1A - metabolism | Cold Temperature | Medulla Oblongata - drug effects | Medulla Oblongata - metabolism | Adipose Tissue, Brown - physiology | 8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology | Efferent Pathways - metabolism | Animals | Thermogenesis - drug effects | GABA | Heart beat | Neurons | Analysis | Prostaglandins E | Heart rate | Skin | Cooling | Thermogenesis | Cold | Rodents | Integrative
Journal Article
Journal Article