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Brain Research, ISSN 0006-8993, 2016, Volume 1648, Issue Pt B, pp. 603 - 616
Abstract In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological... 
Neurology | Wolfram syndrome | Ischemia | Glioblastoma | ER stress | Hormesis | Parkinson׳s disease | Autophagy | Proteasome | Parkinson's disease | UBIQUITIN-PROTEASOME SYSTEM | TISSUE-PLASMINOGEN ACTIVATOR | ER-STRESS | TRANSCRIPTION FACTOR XBP1 | ENDOPLASMIC-RETICULUM STRESS | NEUROSCIENCES | BETA-CELL FUNCTION | UNFOLDED PROTEIN RESPONSE | CENTRAL-NERVOUS-SYSTEM | TRANSIENT CEREBRAL-ISCHEMIA | PARKINSONS-DISEASE | Health aspects | Nervous system diseases | Analysis | Index Medicus | Life Sciences | ATF4, activating transcription factor 4 | CDNF, cerebral dopamine neurotrophic factor | glutamate antiporter | ATF6α, activating transcription factor 6α | S1P, site 1 protease | CIRBP, cold-inducible RNA binding protein | Ca2+ ATPase | tPA, tissue plasminogen activator | Wfs1, wolframin | PERK, protein kinase RNA-like ER kinase | OGD, oxygen and glucose deprivation | UPR, unfolded protein response | CHOP, C | DA, dopaminergic | BI-1, Bax-inhibitor-1 | LRRK2, leucine-rich repeat kinase 2 | GRP78, binding immunoglobulin protein | IRE1, inositol-requiring enzyme 1 | JNK, Jun amino terminal kinase | ASK1, apoptosis signal regulating kinase 1 | EGFR, epidermal growth factor receptor | HIF-1, hypoxia-inducible transcription factor-1 | 3-MA, 3-methyladenine | SNpc, substantia nigra pars compacta | Ub, ubiquitin | 6-OHDA, 6-hydroxydopamine | BDNF, brain-derived neurotrophic factor | SERCA, sarcoplasmic-ER Mg2 | eIF2α, eukaryotic translation initiation factor 2α | ARE, anti-oxidant response element | PD, Parkinson’s disease | PUMA, p53 upregulated modulator of apoptosis | BiP | PMD, protein misfolding disorder | nAChRs, nicotinic acetylcholine receptors | XBP1, x-box binding protein 1 | ERAD, ER-associated protein degradation | Bim, Bcl-2-interacting mediator of cell death | MCAO, middle cerebral artery occlusion | ROS, reactive oxygen species | Hsp70, heat shock protein 70 | xCT, cystine | GADD34, growth arrest and DNA damage–inducible 34 | iPSC, induced pluripotent stem cell | UPS, ubiquitin proteasome system | PHD, prolyl-hydroxylases | MPTP, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | RIDD, regulated IRE1-dependent decay | MANF, mesencephalic astrocyte-derived neurotrophic factor | RBM3, RNA binding motif 3 | SOD, superoxide dismutase | S2P, site 2 protease | GEF, guanine nucleotide exchange factor | EBP-homologous protein | IRI, ischemia reperfusion injury | ER, endoplasmic reticulum | HD, Huntington’s disease | HO-1, heme oxygenase-1 | NF-KB, nuclear factor-kappa B
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0168359
The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of... 
MAMMALIAN TARGET | INDUCED GENE-EXPRESSION | RESVERATROL | APOPTOSIS | UNFOLDED PROTEIN RESPONSE | TUBEROUS SCLEROSIS COMPLEX | ALPHA-SUBUNIT | ER STRESS | MULTIDISCIPLINARY SCIENCES | CELL-SURVIVAL | TRANSLATION | Protein Phosphatase 1 - physiology | Cell Survival - drug effects | Endoplasmic Reticulum Stress - drug effects | TOR Serine-Threonine Kinases - metabolism | Humans | RNA, Small Interfering - pharmacology | Cells, Cultured | Cell Survival - genetics | Down-Regulation - drug effects | Autophagy - drug effects | Hep G2 Cells | Down-Regulation - physiology | Protein Phosphatase 1 - antagonists & inhibitors | Signal Transduction - drug effects | HEK293 Cells | Protein Phosphatase 1 - genetics | Signal Transduction - physiology | Autophagy - genetics | Endoplasmic Reticulum Stress - physiology | Physiological aspects | Autophagy (Cytology) | Genetic aspects | Research | Protein kinases | Endoplasmic reticulum | TOR protein | Phosphorylation | Transcription factors | Crosstalk | Tunicamycin | Homeostasis | Activation | Kinases | Inactivation | AMP-activated protein kinase | Phosphatase | Autophagy | Proteins | Thapsigargin | Transfection | Protein folding | Proteolysis | Resveratrol | Inhibition | Stresses | Cell survival | Deactivation | Threonine | AMP | GADD34 protein | Protein biosynthesis | Rapamycin | Metabolism | Survival | Stress | Protein synthesis | Cell death | Protein-serine/threonine kinase | Molecular biology | Phagocytosis | Apoptosis
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, p. e28946
Single large doses of methamphetamine ( METH) cause endoplasmic reticulum ( ER) stress and mitochondrial dysfunctions in rodent striata. The dopamine D-1... 
INDUCED NEURONAL APOPTOSIS | UNFOLDED-PROTEIN RESPONSE | MESSENGER-RNA | HYBRIDIZATION HISTOCHEMISTRY | INDUCED HYPERTHERMIA | BIOLOGY | INDUCED NEUROTOXICITY | RAT-BRAIN | HEAT-SHOCK-PROTEIN | CELL-DEATH | TRANSGENIC MICE | Fever - metabolism | Male | Endoplasmic Reticulum Stress - genetics | RNA, Messenger - metabolism | Receptors, Dopamine D2 - metabolism | Receptors, Dopamine D1 - metabolism | Mitochondria - genetics | Neostriatum - drug effects | Time Factors | Neostriatum - metabolism | Raclopride - pharmacology | Stress, Physiological - drug effects | Fever - pathology | Biomarkers - metabolism | Methamphetamine - pharmacology | HSP40 Heat-Shock Proteins - metabolism | Endoplasmic Reticulum Stress - drug effects | Stress, Physiological - genetics | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Rats | Mitochondria - metabolism | Benzazepines - pharmacology | Mitochondria - drug effects | Rats, Sprague-Dawley | HSP70 Heat-Shock Proteins - metabolism | Up-Regulation - drug effects | Animals | Methamphetamine - administration & dosage | Cytochrome c | Proteins | Dopamine | Genes | Methamphetamine | Phenols | Heat shock proteins | Dopamine receptors | Cytochrome | Bax protein | Bcl-2 protein | Caspase-12 | Gene regulation | Activation | Kinases | Receptors | Mitochondria | Pathways | Methamphetamines | Rodents | Animal tissues | Neostriatum | Dopamine D2 receptors | Raclopride | Activating transcription factor 3 | GADD34 protein | Caspase | Gene expression | Stress | Studies | Polymerase chain reaction | Dopamine D1 receptors | Stress proteins | Endoplasmic reticulum | CHOP protein | Apoptosis | Heat shock
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2011, Volume 6, Issue 10, p. e25589
Background: Endoplasmic reticulum (ER) stress has been suggested to play a role in inflammatory bowel disease (IBD). The three branches (ATF6, IRE1 and PERK)... 
INTESTINAL INFLAMMATION | UNFOLDED-PROTEIN RESPONSE | ER STRESS | KINASE | IRE1 | BIOLOGY | XBP1 MESSENGER-RNA | TRANSLATION | ATF6 | EXPRESSION | TUNICAMYCIN | Crohn Disease - genetics | Interleukin-8 - genetics | Endoribonucleases - genetics | Ileum - pathology | Intestinal Mucosa - metabolism | Humans | Middle Aged | Colitis, Ulcerative - genetics | Transcriptome | Crohn Disease - metabolism | Ileum - metabolism | Male | Endoplasmic Reticulum Stress - genetics | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Case-Control Studies | Young Adult | Heat-Shock Proteins - genetics | Crohn Disease - diagnosis | Adult | Membrane Proteins - metabolism | Interleukin-8 - metabolism | Child | Protein-Serine-Threonine Kinases - metabolism | Unfolded Protein Response - drug effects | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Unfolded Protein Response - genetics | Colon - pathology | Membrane Proteins - genetics | Colitis, Ulcerative - metabolism | Heat-Shock Proteins - metabolism | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Endoscopy, Gastrointestinal | Colitis, Ulcerative - pathology | Colon - metabolism | Activating Transcription Factor 6 - metabolism | Colitis, Ulcerative - diagnosis | Crohn Disease - pathology | Tunicamycin - pharmacology | Adolescent | Aged | Intestinal Mucosa - pathology | RNA | Ulcerative colitis | Transcription factors | Phosphorylation | Inflammatory bowel diseases | Laboratories | Mucosa | Genes | Tunicamycin | Homeostasis | Genomes | mRNA | Activation | Kinases | Immunology | Protein folding | Intestine | Rodents | Gastroenterology | Initiation factor eIF-2 | Colon | Sensors | Stress response | Stresses | Carbohydrates | GRP78 protein | GADD34 protein | Inflammation | Gene expression | Patients | Disease control | Ileum | Stress | Studies | Inflammatory bowel disease | Crohn's Disease | Biopsy | Endoplasmic reticulum | Apoptosis
Journal Article